MetaADEDB 2.0 @ LMMD
difluprednate
(WYQPLTPSGFELIB-JTQPXKBDSA-N)
Structure
SMILES
CCCC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F)C(=O)COC(=O)C
Type(s)
Approved
ATC code(s)
D07AC19
Molecular Formula:
C27H34F2O7
Molecular Weight:
508.551
Log P:
3.5195
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
1
TPSA:
106.97
CAS Number(s):
23674-86-4
Synonym(s)
1.
difluprednate
2.
C.M.9155
3.
Epitopic
External Link(s)
MeSHC015808
PubChem Compound443936
ChEBI31485
CHEMBLCHEMBL1201749
DrugBankDB06781
DrugCentral3142
IUPHAR/BPS Guide to PHARMACOLOGY7474
KEGGcpd:C12695
dr:D01266
Therapeutic Target DatabaseD01ZOG
ZINC4212945
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Therapy partial responderFAERS: 160US FAERS
2Drug ineffectiveFAERS: 38
Canada Vigilance: 1		Canada Vigilance
US FAERS
3Eye irritationFAERS: 36SIDER
US FAERS
4Eye painFAERS: 27
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
5Eye inflammationFAERS: 18US FAERS
6GlaucomaFAERS: 17US FAERS
7Visual ImpairmentFAERS: 17US FAERS
8No adverse eventFAERS: 15US FAERS
9Intraocular pressure test abnormalFAERS: 13US FAERS
10HeadacheFAERS: 11SIDER
US FAERS
11Product quality issueFAERS: 9US FAERS
12Incorrect dose administeredFAERS: 8US FAERS
13Foreign body sensation in eyesFAERS: 7US FAERS
14BlindnessFAERS: 6US FAERS
15Product administration errorFAERS: 5US FAERS
16Product dropper issueFAERS: 5US FAERS
17Accidental exposure to productFAERS: 4US FAERS
18Cerebrovascular accidentFAERS: 4US FAERS
19Eye InfectionFAERS: 4SIDER
US FAERS
20HypersensitivityFAERS: 4US FAERS
21InflammationFAERS: 4US FAERS
22MalaiseFAERS: 4US FAERS
23AcneFAERS: 3OFFSIDES
US FAERS
24CataractFAERS: 3US FAERS
25Drug administration errorFAERS: 3US FAERS
26Expired product administeredFAERS: 3US FAERS
27Inappropriate schedule of drug administrationFAERS: 3US FAERS
28IritisFAERS: 3SIDER
US FAERS
29KeratitisFAERS: 3US FAERS
30Liquid product physical issueFAERS: 3US FAERS
31Ocular HypertensionFAERS: 3US FAERS
32Ocular ToxicityFAERS: 3US FAERS
33Ocular discomfortFAERS: 3US FAERS
34PhotophobiaFAERS: 3SIDER
US FAERS
35Product physical consistency issueFAERS: 3US FAERS
36Product use in unapproved indicationFAERS: 3US FAERS
37Abdominal discomfortFAERS: 2US FAERS
38AlopeciaFAERS: 2US FAERS
39AsthmaFAERS: 2US FAERS
40Back PainFAERS: 2US FAERS
41Corneal ScarFAERS: 2US FAERS
42DizzinessFAERS: 2US FAERS
43Eyelid irritationFAERS: 2SIDER
US FAERS
44Eyelid rashFAERS: 2US FAERS
45FatigueFAERS: 2US FAERS
46FlushingFAERS: 2US FAERS
47KeratopathyFAERS: 2US FAERS
48NauseaFAERS: 2US FAERS
49OverdoseFAERS: 2US FAERS
50Product administered at inappropriate siteFAERS: 2US FAERS
51Product packaging issueFAERS: 2US FAERS
52Punctate keratitisFAERS: 2SIDER
US FAERS
53Retinal DetachmentFAERS: 2US FAERS
54UrticariaFAERS: 2US FAERS
55UveitisFAERS: 2SIDER
US FAERS
56Wrong technique in product usage processFAERS: 2US FAERS
57Adverse eventFAERS: 1US FAERS
58AmnesiaFAERS: 1US FAERS
59AnxietyFAERS: 1US FAERS
60Application site inflammationFAERS: 1US FAERS
61Application site irritationFAERS: 1US FAERS
62AsthenopiaFAERS: 1US FAERS
63Bladder painFAERS: 1US FAERS
64Blood glucose increasedFAERS: 1US FAERS
65Borderline glaucomaFAERS: 1US FAERS
66Cartilage atrophyFAERS: 1US FAERS
67CellulitisFAERS: 1OFFSIDES
US FAERS
68Chest PainFAERS: 1US FAERS
69Chest discomfortFAERS: 1US FAERS
70ChillsFAERS: 1US FAERS
71ChromatopsiaFAERS: 1US FAERS
72ChromaturiaFAERS: 1US FAERS
73Conjunctival filtering bleb leakFAERS: 1US FAERS
74ConstipationFAERS: 1US FAERS
75Contraindicated drug administeredFAERS: 1US FAERS
76Corneal OpacityFAERS: 1US FAERS
77Corneal defectFAERS: 1US FAERS
78Corneal degenerationFAERS: 1US FAERS
79Corneal graft rejectionFAERS: 1US FAERS
80Corneal thinningFAERS: 1SIDER
US FAERS
81Dark circles under eyesFAERS: 1US FAERS
82DermatitisFAERS: 1US FAERS
83Diabetic KetoacidosisFAERS: 1US FAERS
84DiplopiaFAERS: 1US FAERS
85DiscomfortFAERS: 1US FAERS
86Drug ineffective for unapproved indicationFAERS: 1US FAERS
87DysarthriaFAERS: 1US FAERS
88DysgeusiaFAERS: 1US FAERS
89DysphoniaFAERS: 1US FAERS
90EndophthalmitisFAERS: 1SIDER
US FAERS
91ErythemaFAERS: 1OFFSIDES
US FAERS
92Eye BurnsFAERS: 1US FAERS
93Eye excisionFAERS: 1US FAERS
94Eyelids pruritusFAERS: 1US FAERS
95Feeling abnormalFAERS: 1US FAERS
96Feeling of body temperature changeFAERS: 1US FAERS
97HydrocephalusFAERS: 1OFFSIDES
US FAERS
98HypotensionFAERS: 1US FAERS
99Impaired driving abilityFAERS: 1US FAERS
100Incorrect drug administration durationFAERS: 1US FAERS
101Intraocular pressure testFAERS: 1US FAERS
102Irregular breathingFAERS: 1US FAERS
103LymphadenopathyFAERS: 1US FAERS
104Macular degenerationFAERS: 1US FAERS
105Malabsorption from application siteFAERS: 1US FAERS
106Maternal exposure before pregnancyFAERS: 1US FAERS
107Medication residue presentFAERS: 1US FAERS
108MyalgiaFAERS: 1US FAERS
109MydriasisFAERS: 1US FAERS
110Myocardial InfarctionFAERS: 1US FAERS
111MyopiaFAERS: 1US FAERS
112Oral dischargeFAERS: 1US FAERS
113Oral painFAERS: 1US FAERS
114Oropharyngeal painFAERS: 1US FAERS
115Pain of skinFAERS: 1US FAERS
116PainFAERS: 1US FAERS
117PalpitationsFAERS: 1US FAERS
118Paranasal sinus discomfortFAERS: 1US FAERS
119ParanoiaFAERS: 1US FAERS
120Peripheral swellingFAERS: 1US FAERS
121Poor quality drug administeredFAERS: 1US FAERS
122Post procedural infectionFAERS: 1US FAERS
123Product packaging difficult to openFAERS: 1US FAERS
124Product physical issueFAERS: 1US FAERS
125Product use complaintFAERS: 1US FAERS
126Product use issueFAERS: 1US FAERS
127PruritusFAERS: 1SIDER
US FAERS
128Reaction to preservativesFAERS: 1US FAERS
129Rebound effectFAERS: 1US FAERS
130Retinal Vein OcclusionFAERS: 1US FAERS
131ScabFAERS: 1OFFSIDES
SIDER
US FAERS
132Superficial injury of eyeFAERS: 1US FAERS
133Suture related complicationFAERS: 1US FAERS
134SyncopeFAERS: 1US FAERS
135Therapeutic product ineffective for unapproved indicationFAERS: 1US FAERS
136TinnitusFAERS: 1US FAERS
137Vitreous floatersFAERS: 1US FAERS
138VomitingFAERS: 1US FAERS
139Abdominal Compartment SyndromeOFFSIDES
140AlveolitisOFFSIDES
141Anal FistulaOFFSIDES
142Anterior chamber flareSIDER
143ApathyOFFSIDES
144Application site discomfortSIDER
145ArteritisOFFSIDES
146Band neutrophil percentage increasedOFFSIDES
147Blast cells presentOFFSIDES
148BlepharitisSIDER
149Blood albumin decreasedOFFSIDES
150Blood beta-D-glucan increasedOFFSIDES
151Blood copper decreasedOFFSIDES
152Blood creatine increasedOFFSIDES
153Blood creatinine increasedOFFSIDES
154Blood immunoglobulin G decreasedOFFSIDES
155Blood immunoglobulin M decreasedOFFSIDES
156Blood lactate dehydrogenase increasedOFFSIDES
157Blood uric acidOFFSIDES
158BradycardiaOFFSIDES
159Cardiac valve vegetationOFFSIDES
160Catheter placementOFFSIDES
161Cerebral ventricle dilatationOFFSIDES
162Cleft PalateSIDER
163Completed SuicideOFFSIDES
164Corneal pigmentationSIDER
165Cytomegalovirus hepatitisOFFSIDES
166Cytomegalovirus test positiveOFFSIDES
167Depressed Level of ConsciousnessOFFSIDES
168EndocarditisOFFSIDES
169EpiscleritisSIDER
170Erythema MultiformeOFFSIDES
171Eyelid margin crustingCanada Vigilance: 1Canada Vigilance
172Facial wastingOFFSIDES
173False positive laboratory resultOFFSIDES
174Gastrointestinal perforationOFFSIDES
175GranulocytosisOFFSIDES
176IridocyclitisSIDER
177Leukaemic infiltration brainOFFSIDES
178Lymphocyte count decreasedOFFSIDES
179MorpheaOFFSIDES
180Myoglobin blood increasedOFFSIDES
181Nerve injurySIDER
182PanophthalmitisSIDER
183Pneumocystis jiroveci pneumoniaOFFSIDES
184PoriomaniaOFFSIDES
185Posterior capsule opacificationSIDER
186Posterior subcapsular cataractSIDER
187PregnancySIDER
188Protein total decreasedOFFSIDES
189PyelonephritisOFFSIDES
190Renal abscessOFFSIDES
191Reproductive toxicitySIDER
192SclerodermaOFFSIDES
193Skin ErosionOFFSIDES
194Skin lacerationOFFSIDES
195Splenic abscessOFFSIDES
196Ventricular drainageOFFSIDES
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120269

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.