MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Gingival Hyperplasia

(UMLS:C0017566)

Definition:: Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)
UMLS ID:: C0017566
MeSH ID:: D005885

Classification:

Name:

Stomatognathic Diseases
MeSH Tree Number(s):: C07.465.714.258.428.250

Synonym(s)

Gingival Hyperplasia

GINGIVAL HYPERPLASIA

GUM HYPERPLASIA

Gingival hyperplasia

Hyperplasia of gingiva

Hyperplasia of gingivae

Hyperplastic gingiva

enlargement gingival

gingiva hyperplasia

10.

gingiva; hyperplasia

11.

gingival enlargement

12.

gingival hyperplasia

13.

gum hyperplasia

14.

gum; hyperplasia

15.

hyperplasia gingival

16.

hyperplasia; gingiva

17.

hyperplasia; gum

18.

thickening; gingival

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Amlodipine	FAERS: 96	10429995	CTD SIDER US FAERS
2	Amlodipine	FAERS: 26		US FAERS
3	Phenytoin	FAERS: 15	View details 1246508 3142761 6035961 6773400 8369003 9029455 10655531	CTD SIDER US FAERS
4	Cyclosporine	FAERS: 9	8708960 9889429 10665942	CTD US FAERS
5	Valproic Acid	FAERS: 9		US FAERS
6	Nifedipine	FAERS: 6	View details 8369003 9889429 10665942 11023675	CTD SIDER US FAERS
7	Alendronate	FAERS: 5		US FAERS
8	Atomoxetine Hydrochloride	FAERS: 5		US FAERS
9	Tacrolimus	FAERS: 4		US FAERS
10	Valproic Acid	FAERS: 4		US FAERS
11	Valsartan	FAERS: 4		US FAERS
12	Anastrozole	FAERS: 3		US FAERS
13	Verapamil	FAERS: 3		SIDER US FAERS
14	benazepril	FAERS: 3		US FAERS
15	Acitretin	FAERS: 2		SIDER US FAERS
16	Carbamazepine	FAERS: 2		OFFSIDES US FAERS
17	Felodipine	FAERS: 2	8369003	CTD SIDER US FAERS
18	Isotretinoin	FAERS: 2		US FAERS
19	N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	FAERS: 2		US FAERS
20	Phenytoin	FAERS: 2		US FAERS
21	Ramipril	FAERS: 2		US FAERS
22	Valproic Acid	FAERS: 2		US FAERS
23	Zoledronic Acid	FAERS: 2		OFFSIDES US FAERS
24	Adzenys XR-ODT	FAERS: 1		US FAERS
25	Amlodipine mixture with Benazepril	FAERS: 1		US FAERS
26	Carvedilol	FAERS: 1		US FAERS
27	Cibadrex	FAERS: 1		US FAERS
28	Dabigatran	FAERS: 1		US FAERS
29	Deferasirox	FAERS: 1		US FAERS
30	Diovan Hct	FAERS: 1		US FAERS
31	Ethylene Glycol	FAERS: 1		US FAERS
32	Ezetimibe	FAERS: 1		US FAERS
33	Finasteride	FAERS: 1		US FAERS
34	Imatinib Mesylate	FAERS: 1		US FAERS
35	Irbesartan	FAERS: 1		US FAERS
36	Lamotrigine	FAERS: 1		SIDER US FAERS
37	Metoprolol	FAERS: 1		US FAERS
38	Mycophenolic Acid	FAERS: 1		US FAERS
39	Nadolol	FAERS: 1		US FAERS
40	Paroxetine	FAERS: 1		SIDER US FAERS
41	Quetiapine Fumarate	FAERS: 1		US FAERS
42	Risedronic Acid	FAERS: 1		US FAERS
43	Rivaroxaban	FAERS: 1		US FAERS
44	Sitagliptin Phosphate	FAERS: 1		US FAERS
45	Spironolactone	FAERS: 1		US FAERS
46	Sunitinib	FAERS: 1		US FAERS
47	Topiramate	FAERS: 1		SIDER US FAERS
48	Varenicline	FAERS: 1		US FAERS
49	Vemurafenib	FAERS: 1		US FAERS
50	apixaban	FAERS: 1		US FAERS
51	candesartan cilexetil	FAERS: 1		US FAERS
52	hydrochlorothiazide, lisinopril drug combination	FAERS: 1		US FAERS
53	mirabegron	FAERS: 1		US FAERS
54	Aspartic Acid			OFFSIDES
55	Atomoxetine Hydrochloride			OFFSIDES
56	Biperiden			OFFSIDES
57	Budesonide			OFFSIDES
58	Calcium Carbonate			OFFSIDES
59	Celecoxib			OFFSIDES
60	Chlorhexidine			OFFSIDES SIDER
61	Clonidine			OFFSIDES
62	Clotrimazole			OFFSIDES
63	Diltiazem			SIDER
64	Erythromycin			OFFSIDES
65	Flurazepam			OFFSIDES
66	Fosinopril			OFFSIDES
67	Fulvestrant			OFFSIDES
68	Ibuprofen			OFFSIDES
69	Isradipine			SIDER
70	Letrozole			OFFSIDES
71	Losartan			OFFSIDES
72	Meperidine			OFFSIDES
73	Mephenytoin			SIDER
74	Methotrimeprazine			OFFSIDES
75	Molsidomine			OFFSIDES
76	Mycophenolic Acid			SIDER
77	Naloxone			OFFSIDES
78	Nisoldipine			OFFSIDES SIDER
79	Nitrofurantoin			OFFSIDES
80	Oseltamivir			OFFSIDES
81	Oxcarbazepine			SIDER
82	Pamidronate			OFFSIDES
83	Penicillin V			OFFSIDES
84	Pentamidine			OFFSIDES
85	Pimozide			SIDER
86	Pregabalin			SIDER
87	Primidone			OFFSIDES
88	Salmeterol Xinafoate			OFFSIDES
89	Scopolamine			OFFSIDES
90	Sertraline			SIDER
91	Sirolimus			SIDER
92	Sumatriptan			OFFSIDES
93	Tamoxifen			OFFSIDES
94	Terbutaline			OFFSIDES
95	Tiagabine			SIDER
96	Tretinoin			OFFSIDES
97	Vardenafil Dihydrochloride			OFFSIDES
98	Voriconazole			OFFSIDES SIDER
99	Warfarin			OFFSIDES
100	Zonisamide			SIDER
101	bicalutamide			OFFSIDES
102	brotizolam			OFFSIDES
103	cevimeline			OFFSIDES SIDER
104	chlorhexidine gluconate			OFFSIDES
105	fexofenadine			OFFSIDES
106	levocabastine			OFFSIDES
107	propoxyphene napsylate			OFFSIDES
108	terconazole			OFFSIDES
109	tranilast			OFFSIDES
110	zotepine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Gingival Hypertrophy	49.2%
2	Gingivitis	36%
3	Pericoronitis	36%
4	Gingival Recession	35.3%
5	Gingival Atrophy	35.3%
6	Periodontitis	28.5%
7	Peri-Implantitis	28.5%
8	Tooth Loss	24.6%
9	Gingival Hemorrhage	24.3%
10	Burning Mouth Syndrome	22.7%
11	Lip Diseases	22.7%
12	Microglossia	22.7%
13	Oral Submucous Fibrosis	22.7%
14	Salivary Gland Diseases	22.7%
15	Stomatitis	22.7%
16	Tongue Diseases	22.7%
17	Oral Ulcer	22.7%
18	Giant Cell Epulis	18.2%
19	Facial Hemiatrophy	17.6%
20	Melkersson-Rosenthal Syndrome	17.6%
21	Aggressive Periodontitis	16.8%
22	Facial Nerve Diseases	15.4%
23	Granulomatosis, Orofacial	15.4%
24	Mouth Abnormalities	15.3%
25	Tooth Diseases	15.3%
26	Oral candidiasis	15.1%
27	Mouth Neoplasms	15.1%
28	Oral Fistula	15.1%
29	Lichen Planus, Oral	14.8%
30	Bell Palsy	14%
31	Salivary Gland Fistula	12.2%
32	Salivary Gland Neoplasms	12.2%
33	Ulcerative stomatitis	12.2%
34	Tongue Neoplasms	12.2%
35	Cheilitis	12.2%
36	Drooling	12.2%
37	Glossitis	12.2%
38	Macroglossia	12.2%
39	Sialadenitis	12.2%
40	Sialometaplasia, Necrotizing	12.2%
41	Sialorrhea	12.2%
42	Aphthous Stomatitis	12.2%
43	Xerostomia	12.2%
44	Glossoptosis	12.2%
45	Alveolar Bone Loss	11.4%
46	Facial paralysis	11.2%
47	Facial Paresis	11.2%
48	Hemifacial Spasm	11.1%
49	Jaw Diseases	10.7%
50	Pharyngeal Diseases	10.7%
51	Parotitis	9.6%
52	Parotid Neoplasms	8.7%
53	Facial Neuralgia	8.2%
54	Macrostomia	8.2%
55	Microstomia	8.2%
56	Dental Fistula	8.1%
57	Oroantral Fistula	8.1%
58	Bruxism	7.6%
59	Dental Leakage	7.6%
60	Hypercementosis	7.6%
61	Malocclusion	7.6%
62	Tooth Crowding	7.6%
63	Tooth Discoloration	7.6%
64	Tooth Demineralization	7.6%
65	Tooth Ankylosis	7.6%
66	Radicular Cyst	7.5%
67	Glossitis, Benign Migratory	7.2%
68	Vesicular Stomatitis	6.4%
69	Behcet Syndrome	6.4%
70	Temporomandibular Joint Disorders	5.7%
71	Tooth Injuries	5.4%
72	Maxillary Diseases	5.1%
73	Tooth Resorption	5.1%
74	Mobius Syndrome	5%
75	Herpes Zoster Oticus	5%
76	Toothache	4.9%
77	Leukoplakia, Oral	4.9%
78	Herpes Labialis	4.9%
79	Trigeminal Nerve Disorder	4.8%
80	Palatal Neoplasms	4.6%
81	Cleft Palate	4.5%
82	Facial Nerve Injuries	4.1%
83	Dental Enamel Hypoplasia	4.1%
84	Hypodontia	4.1%
85	Dental caries	4.1%
86	Dental Plaque	4.1%
87	Dental Pulp Calcification	4.1%
88	Pulpitis	4.1%
89	Tooth Erosion	4.1%
90	Pharyngitis	3.9%
91	Toxic Epidermal Necrolysis	3.5%
92	Stevens-Johnson Syndrome	3.5%
93	Jaw Abnormalities	3.3%
94	Mumps	3.2%
95	Trigeminal Neuralgia	3.2%
96	Pharyngeal Neoplasms	3.1%
97	Maxillofacial Abnormalities	3%
98	Tooth Avulsion	2.8%
99	Nasopharyngitis	2.8%
100	Dental Pulp Necrosis	2.7%
101	Retrognathia	2.6%
102	Temporomandibular Joint Dysfunction Syndrome	2.6%
103	Nasopharyngeal Neoplasms	2.3%
104	Prognathism	2.3%
105	Lemierre Syndrome	2.1%
106	Sicca Syndrome	2.1%
107	Sjogren's Syndrome	2.1%
108	Tonsillitis	2.1%
109	Sleep Bruxism	2.1%
110	Micrognathism	1.8%
111	Pierre Robin Syndrome	1.8%
112	Retropharyngeal Abscess	1.6%
113	Hypopharyngeal Neoplasms	1.6%
114	Hypopharyngeal Cancer	1.6%
115	Nasopharyngeal carcinoma	1.2%
116	Peritonsillar Abscess	1%
117	Tonsillar Neoplasms	1%
118	Basal Cell Nevus Syndrome	0.5%

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