Captopril
(FAKRSMQSSFJEIM-RQJHMYQMSA-N)
Structure
- SMILES
- SC[C@H](C(=O)N1CCC[C@H]1C(=O)O)C
- Type(s)
- Approved
- ATC code(s)
- C09AA01; C09BA01
- Molecular Formula:
- C9H15NO3S
- Molecular Weight:
- 217.285
- Log P:
- 0.5658
- Hydrogen Bond Acceptor:
- 5
- Hydrogen Bond Donor:
- 2
- TPSA:
- 96.41
- CAS Number(s):
- 62571-86-2
Synonym(s)
1.
Captopril
2.
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
3.
Capoten
4.
Lopirin
5.
SQ-14,225
6.
SQ-14,534
7.
SQ-14225
8.
SQ-14534
9.
SQ 14,225
10.
SQ 14,534
11.
SQ 14225
12.
SQ 14534
13.
SQ14,225
14.
SQ14,534
15.
SQ14225
16.
SQ14534
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Angioedema | FAERS: 21 Canada Vigilance: 4 | Canada Vigilance SIDER US FAERS | |
| 2 | Hypersensitivity | FAERS: 9 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 3 | Insulin autoimmune syndrome | FAERS: 8 | US FAERS | |
| 4 | Pharmaceutical product complaint | FAERS: 8 | US FAERS | |
| 5 | Respiratory distress | FAERS: 8 | US FAERS | |
| 6 | Drug ineffective | FAERS: 7 | US FAERS | |
| 7 | Vomiting | FAERS: 7 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 8 | Wheezing | FAERS: 7 | US FAERS | |
| 9 | Blood pressure inadequately controlled | FAERS: 6 | OFFSIDES US FAERS | |
| 10 | Hypotension | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 11 | Rash erythematous | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 12 | Urticaria | FAERS: 6 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 13 | Diabetes Mellitus | FAERS: 5 | SIDER US FAERS | |
| 14 | Lip swelling | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 15 | Muscle tightness | FAERS: 5 | US FAERS | |
| 16 | Overdose | FAERS: 5 | US FAERS | |
| 17 | Product quality issue | FAERS: 5 | US FAERS | |
| 18 | Pruritus | FAERS: 5 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 19 | Dizziness | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 20 | Medication Error | FAERS: 4 | US FAERS | |
| 21 | Asthma | FAERS: 3 | US FAERS | |
| 22 | Chest Pain | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 23 | Cholestatic liver injury | FAERS: 3 | US FAERS | |
| 24 | Documented hypersensitivity to administered product | FAERS: 3 | US FAERS | |
| 25 | Headache | FAERS: 3 Canada Vigilance: 5 | Canada Vigilance SIDER US FAERS | |
| 26 | Idiosyncratic drug reaction | FAERS: 3 | US FAERS | |
| 27 | Malaise | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 28 | Sinus Tachycardia | FAERS: 3 | US FAERS | |
| 29 | Anaphylactic shock | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 30 | Asthenia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 31 | Atrial Fibrillation | FAERS: 2 | US FAERS | |
| 32 | Bradyphrenia | FAERS: 2 | US FAERS | |
| 33 | Cutis Laxa | FAERS: 2 | US FAERS | |
| 34 | Discomfort | FAERS: 2 | SIDER US FAERS | |
| 35 | Dysgeusia | FAERS: 2 Canada Vigilance: 3 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 36 | Endotracheal intubation complication | FAERS: 2 | US FAERS | |
| 37 | Joint swelling | FAERS: 2 | US FAERS | |
| 38 | Lung consolidation | FAERS: 2 | US FAERS | |
| 39 | Mouth swelling | FAERS: 2 | US FAERS | |
| 40 | Myalgia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 41 | Nausea | FAERS: 2 Canada Vigilance: 5 | Canada Vigilance SIDER US FAERS | |
| 42 | Oral pruritus | FAERS: 2 | US FAERS | |
| 43 | Pemphigus | FAERS: 2 | SIDER US FAERS | |
| 44 | Product use issue | FAERS: 2 | US FAERS | |
| 45 | Swelling | FAERS: 2 | US FAERS | |
| 46 | Therapeutic response unexpected with drug substitution | FAERS: 2 | US FAERS | |
| 47 | Tremor | FAERS: 2 | US FAERS | |
| 48 | Accidental exposure | FAERS: 1 | US FAERS | |
| 49 | Acute kidney injury | FAERS: 1 | US FAERS | |
| 50 | Adverse event | FAERS: 1 | US FAERS | |
| 51 | Ageusia | FAERS: 1 | SIDER US FAERS | |
| 52 | Anosmia | FAERS: 1 | US FAERS | |
| 53 | Arthropathy | FAERS: 1 | OFFSIDES US FAERS | |
| 54 | Ascites | FAERS: 1 | US FAERS | |
| 55 | Blindness | FAERS: 1 | US FAERS | |
| 56 | Blood cholesterol increased | FAERS: 1 | US FAERS | |
| 57 | Blood creatinine increased | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 58 | Blood sodium decreased | FAERS: 1 | US FAERS | |
| 59 | Bradycardia | FAERS: 1 | OFFSIDES US FAERS | |
| 60 | Bronchitis | FAERS: 1 | US FAERS | |
| 61 | Burning sensation | FAERS: 1 | US FAERS | |
| 62 | Cerebrovascular accident | FAERS: 1 | SIDER US FAERS | |
| 63 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 64 | Chorea | FAERS: 1 | US FAERS | |
| 65 | Chromaturia | FAERS: 1 | US FAERS | |
| 66 | Constipation | FAERS: 1 | SIDER US FAERS | |
| 67 | Drug Dependence | FAERS: 1 | US FAERS | |
| 68 | Drug dispensing error | FAERS: 1 | US FAERS | |
| 69 | Drug exposure during pregnancy | FAERS: 1 | US FAERS | |
| 70 | Dysarthria | FAERS: 1 | US FAERS | |
| 71 | Dysphonia | FAERS: 1 | US FAERS | |
| 72 | Erythema | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 73 | Essential Hypertension | FAERS: 1 | US FAERS | |
| 74 | Feeling abnormal | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 75 | Formication | FAERS: 1 | US FAERS | |
| 76 | Guillain-Barre Syndrome | FAERS: 1 | US FAERS | |
| 77 | Hemiparesis | FAERS: 1 | OFFSIDES US FAERS | |
| 78 | Incorrect dose administered | FAERS: 1 | US FAERS | |
| 79 | Intercepted drug dispensing error | FAERS: 1 | US FAERS | |
| 80 | Lethargy | FAERS: 1 | OFFSIDES US FAERS | |
| 81 | Lichen Planus | FAERS: 1 | US FAERS | |
| 82 | Mental impairment | FAERS: 1 | US FAERS | |
| 83 | Nasopharyngitis | FAERS: 1 | OFFSIDES US FAERS | |
| 84 | Neutrophil count decreased | FAERS: 1 | US FAERS | |
| 85 | No adverse effect | FAERS: 1 | US FAERS | |
| 86 | Osteoporosis | FAERS: 1 | US FAERS | |
| 87 | Oxygen saturation abnormal | FAERS: 1 | US FAERS | |
| 88 | Pain of skin | FAERS: 1 | US FAERS | |
| 89 | Pancreatitis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 90 | Photosensitivity allergic reaction | FAERS: 1 | US FAERS | |
| 91 | Pneumonia | FAERS: 1 | US FAERS | |
| 92 | Proteinuria | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 93 | Pulmonary Eosinophilia | FAERS: 1 | SIDER US FAERS | |
| 94 | Renal Artery Stenosis | FAERS: 1 | US FAERS | |
| 95 | Renal artery occlusion | FAERS: 1 | US FAERS | |
| 96 | Respiratory arrest | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 97 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 98 | Skin lesion | FAERS: 1 | US FAERS | |
| 99 | Somnolence | FAERS: 1 | SIDER US FAERS | |
| 100 | Syncope | FAERS: 1 | SIDER US FAERS | |
| 101 | Tachycardia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 102 | Thrombocytopenia | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 103 | Toxic Epidermal Necrolysis | FAERS: 1 | US FAERS | |
| 104 | Weight decreased | FAERS: 1 | SIDER US FAERS | |
| 105 | White blood cell count decreased | FAERS: 1 | US FAERS | |
| 106 | effusion | FAERS: 1 | OFFSIDES US FAERS | |
| 107 | Abasia | OFFSIDES | ||
| 108 | Abdominal Pain | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 109 | Abdominal discomfort | Canada Vigilance: 1 | Canada Vigilance OFFSIDES | |
| 110 | Abuse | OFFSIDES | ||
| 111 | Accidental overdose | OFFSIDES | ||
| 112 | Acidosis | SIDER | ||
| 113 | Acute Coronary Syndrome | OFFSIDES | ||
| 114 | Acute bronchitis | OFFSIDES | ||
| 115 | Acute myocardial infarction | OFFSIDES | ||
| 116 | Acute respiratory failure | OFFSIDES | ||
| 117 | Adenocarcinoma | OFFSIDES | ||
| 118 | Agnosia | OFFSIDES | ||
| 119 | Agranulocytosis | SIDER | ||
| 120 | Agraphia | OFFSIDES | ||
| 121 | Akinesia | OFFSIDES | ||
| 122 | Alanine Aminotransferase Increased | Canada Vigilance: 1 | Canada Vigilance | |
| 123 | Alopecia | OFFSIDES SIDER | ||
| 124 | Amnesia | OFFSIDES | ||
| 125 | Amphetamines | OFFSIDES | ||
| 126 | Anaphylactoid Reaction | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 127 | Anger | OFFSIDES | ||
| 128 | Angina Pectoris | SIDER | ||
| 129 | Anorexia | SIDER | ||
| 130 | Anuria | SIDER | ||
| 131 | Aphthous Stomatitis | OFFSIDES SIDER | ||
| 132 | Appendicitis | OFFSIDES | ||
| 133 | Application site inflammation | OFFSIDES | ||
| 134 | Application site pruritus | OFFSIDES | ||
| 135 | Application site swelling | OFFSIDES | ||
| 136 | Arteriosclerosis | OFFSIDES | ||
| 137 | Arthralgia | SIDER | ||
| 138 | Aspartate Aminotransferase Increased | Canada Vigilance: 1 | Canada Vigilance | |
| 139 | Asterixis | OFFSIDES | ||
| 140 | Ataxia | SIDER | ||
| 141 | Atelectasis | OFFSIDES | ||
| 142 | Benign Prostatic Hyperplasia | OFFSIDES | ||
| 143 | Biopsy | OFFSIDES | ||
| 144 | Bipolar I disorder | OFFSIDES | ||
| 145 | Blood cholesterol abnormal | OFFSIDES | ||
| 146 | Blood cholesterol | OFFSIDES | ||
| 147 | Blood potassium increased | SIDER | ||
| 148 | Blood testosterone increased | OFFSIDES | ||
| 149 | Blood uric acid decreased | OFFSIDES | ||
| 150 | Blood urine present | OFFSIDES | ||
| 151 | Blurred vision | OFFSIDES | ||
| 152 | Bone pain | OFFSIDES | ||
| 153 | Brain scan abnormal | OFFSIDES | ||
| 154 | Bronchopneumonia | OFFSIDES | ||
| 155 | Bronchospasm | SIDER | ||
| 156 | Bunion | OFFSIDES | ||
| 157 | Cardiac Arrest | SIDER | ||
| 158 | Cardiac Hypertrophy | OFFSIDES | ||
| 159 | Cardiac enzymes increased | OFFSIDES | ||
| 160 | Cataract | OFFSIDES | ||
| 161 | Central line infection | OFFSIDES | ||
| 162 | Cerebellar Ataxia | OFFSIDES | ||
| 163 | Cerebral atrophy | OFFSIDES | ||
| 164 | Cervical dysplasia | OFFSIDES | ||
| 165 | Chest discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 166 | Choking sensation | OFFSIDES | ||
| 167 | Cholestasis | SIDER | ||
| 168 | Chronic Fatigue Syndrome | OFFSIDES | ||
| 169 | Chronic Obstructive Airway Disease | OFFSIDES | ||
| 170 | Cleft Palate | Canada Vigilance: 1 | Canada Vigilance | |
| 171 | Clostridium colitis | OFFSIDES | ||
| 172 | Clubbing | OFFSIDES | ||
| 173 | Colonic Stenosis | OFFSIDES | ||
| 174 | Confabulation | OFFSIDES | ||
| 175 | Congenital heart disease | OFFSIDES | ||
| 176 | Congenital tricuspid valve incompetence | OFFSIDES | ||
| 177 | Contracture | OFFSIDES | ||
| 178 | Cyanosis | OFFSIDES | ||
| 179 | Dehydration | OFFSIDES | ||
| 180 | Dengue Fever | OFFSIDES | ||
| 181 | Denture wearer | OFFSIDES | ||
| 182 | Dermatitis | SIDER | ||
| 183 | Device related infection | OFFSIDES | ||
| 184 | Diabetes | OFFSIDES | ||
| 185 | Diabetes mellitus inadequate control | OFFSIDES | ||
| 186 | Diabetic | SIDER | ||
| 187 | Diplopia | OFFSIDES | ||
| 188 | Disease Progression | OFFSIDES | ||
| 189 | Disease recurrence | Canada Vigilance: 1 | Canada Vigilance | |
| 190 | Diverticular perforation | OFFSIDES | ||
| 191 | Diverticulitis | OFFSIDES | ||
| 192 | Drowsiness | OFFSIDES | ||
| 193 | Drug addict | OFFSIDES | ||
| 194 | Drug withdrawal headache | OFFSIDES | ||
| 195 | Dyspepsia | SIDER | ||
| 196 | Dysthymic Disorder | OFFSIDES | ||
| 197 | Dystonia | OFFSIDES | ||
| 198 | Dysuria | OFFSIDES | ||
| 199 | Ejection Fraction Decreased | OFFSIDES | ||
| 200 | Emotional distress | OFFSIDES | ||
| 201 | Endometrial hypertrophy | OFFSIDES | ||
| 202 | Enterococcal infection | OFFSIDES | ||
| 203 | Eosinophilia | SIDER | ||
| 204 | Epigastric discomfort | SIDER | ||
| 205 | Epilepsy | OFFSIDES | ||
| 206 | Epistaxis | OFFSIDES | ||
| 207 | Erectile dysfunction | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 208 | Erosive gastritis | OFFSIDES | ||
| 209 | Erythema Multiforme | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 210 | Eye inflammation | OFFSIDES | ||
| 211 | Fatigue | SIDER | ||
| 212 | Fatty Liver | OFFSIDES | ||
| 213 | Femoral arterial stenosis | OFFSIDES | ||
| 214 | Flank Pain | OFFSIDES | ||
| 215 | Flushing | SIDER | ||
| 216 | Gastric Lavage | OFFSIDES | ||
| 217 | Gastric irritation | SIDER | ||
| 218 | Gastroduodenitis | OFFSIDES | ||
| 219 | Gastrointestinal Pain | SIDER | ||
| 220 | Gastrointestinal infection | OFFSIDES | ||
| 221 | General physical health deterioration | OFFSIDES | ||
| 222 | Genital Herpes | OFFSIDES | ||
| 223 | Glaucoma | OFFSIDES | ||
| 224 | Glioblastoma Multiforme | OFFSIDES | ||
| 225 | Glossitis | SIDER | ||
| 226 | Goiter | OFFSIDES | ||
| 227 | Graft dysfunction | OFFSIDES | ||
| 228 | Grip strength | OFFSIDES | ||
| 229 | Hepatic necrosis | SIDER | ||
| 230 | Hepatitis | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 231 | Hypertrichosis | Canada Vigilance: 1 | Canada Vigilance | |
| 232 | Hyponatraemic | SIDER | ||
| 233 | Hypotensive | SIDER | ||
| 234 | Hysteroscopy | OFFSIDES | ||
| 235 | Inappropriate affect | OFFSIDES | ||
| 236 | Intermittent Claudication | OFFSIDES | ||
| 237 | Irreversible renal failure | SIDER | ||
| 238 | Joint sprain | OFFSIDES | ||
| 239 | Kidney Failure | OFFSIDES | ||
| 240 | Leukopenia neonatal | OFFSIDES | ||
| 241 | Limb discomfort | OFFSIDES | ||
| 242 | Lip exfoliation | OFFSIDES | ||
| 243 | Locked-In Syndrome | OFFSIDES | ||
| 244 | Long QT Syndrome | OFFSIDES | ||
| 245 | Lymphadenopathy | SIDER | ||
| 246 | Malignant Hypertension | OFFSIDES | ||
| 247 | Mental disorder due to a general medical condition | OFFSIDES | ||
| 248 | Metabolic acidosis | OFFSIDES | ||
| 249 | Microcephaly | SIDER | ||
| 250 | Monoparesis | OFFSIDES | ||
| 251 | Monoplegia | OFFSIDES | ||
| 252 | Motor retardation | OFFSIDES | ||
| 253 | Mucosal Infection | OFFSIDES | ||
| 254 | Muscle Spasticity | Canada Vigilance: 1 | Canada Vigilance | |
| 255 | Musculoskeletal discomfort | SIDER | ||
| 256 | Myeloblastoma | OFFSIDES | ||
| 257 | Necrosis | SIDER | ||
| 258 | Nephritis | SIDER | ||
| 259 | Nephrogenic Fibrosing Dermopathy | OFFSIDES | ||
| 260 | Nephrotic Syndrome | SIDER | ||
| 261 | Nervous tension | OFFSIDES | ||
| 262 | Nervousness | SIDER | ||
| 263 | Neutropenia | SIDER | ||
| 264 | Nodule | OFFSIDES | ||
| 265 | Obstruction | OFFSIDES | ||
| 266 | Oligohydramnios | SIDER | ||
| 267 | Oliguria | SIDER | ||
| 268 | Pain | Canada Vigilance: 1 | Canada Vigilance | |
| 269 | Pallor | OFFSIDES SIDER | ||
| 270 | Palpitations | Canada Vigilance: 2 | Canada Vigilance SIDER | |
| 271 | Pancreatic Neoplasm | OFFSIDES | ||
| 272 | Pancytopenia | SIDER | ||
| 273 | Panic Disorder | OFFSIDES | ||
| 274 | Paranoia | OFFSIDES | ||
| 275 | Paraparesis | OFFSIDES | ||
| 276 | Patent ductus arteriosus | SIDER | ||
| 277 | Peptic Ulcer | SIDER | ||
| 278 | Persistent dry cough | SIDER | ||
| 279 | Pharyngitis | SIDER | ||
| 280 | Pleurisy | OFFSIDES | ||
| 281 | Pneumocystis jiroveci pneumonia | OFFSIDES | ||
| 282 | Pneumonia herpes viral | OFFSIDES | ||
| 283 | Polyuria | SIDER | ||
| 284 | Pregnancy | SIDER | ||
| 285 | Prescribed overdose | OFFSIDES | ||
| 286 | Protein urine present | SIDER | ||
| 287 | Pulmonary Infarction | OFFSIDES | ||
| 288 | Pulmonary Valve Stenosis | OFFSIDES | ||
| 289 | Pulmonary congestion | OFFSIDES | ||
| 290 | QRS axis abnormal | OFFSIDES | ||
| 291 | Quadriparesis | OFFSIDES | ||
| 292 | Rales | SIDER | ||
| 293 | Retinal vascular occlusion | OFFSIDES | ||
| 294 | Rhinitis | SIDER | ||
| 295 | Screaming | OFFSIDES | ||
| 296 | Septic Shock | OFFSIDES | ||
| 297 | Serum Sickness | SIDER | ||
| 298 | Serum potassium increased | SIDER | ||
| 299 | Shock | SIDER | ||
| 300 | Sinus bradycardia | OFFSIDES | ||
| 301 | Skin Induration | OFFSIDES | ||
| 302 | Skull hypoplasia | SIDER | ||
| 303 | Stevens-Johnson Syndrome | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 304 | Stomatitis | Canada Vigilance: 1 | Canada Vigilance SIDER | |
| 305 | Suicide attempt | Canada Vigilance: 2 | Canada Vigilance | |
| 306 | Temperature regulation disorder | OFFSIDES | ||
| 307 | Tension | SIDER | ||
| 308 | Thermal burn | SIDER | ||
| 309 | Tracheobronchitis | OFFSIDES | ||
| 310 | Traumatic liver injury | SIDER | ||
| 311 | Ulcer | SIDER | ||
| 312 | Urinary Incontinence | Canada Vigilance: 1 | Canada Vigilance | |
| 313 | Urine output increased | SIDER | ||
| 314 | Vasculitis | SIDER | ||
| 315 | Venous Insufficiency | OFFSIDES | ||
| 316 | Ventricular Fibrillation | OFFSIDES | ||
| 317 | Vulvovaginal pruritus | OFFSIDES | ||
| 318 | Wrong drug administered | OFFSIDES | ||
| 319 | Xanthoma | OFFSIDES | ||
| 320 | jaundice | Canada Vigilance: 1 | Canada Vigilance SIDER |
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