MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Nelfinavir

(QAGYKUNXZHXKMR-HKWSIXNMSA-N)

Structure

SMILES: O[C@@H]([C@@H](NC(=O)c1cccc(c1C)O)CSc1ccccc1)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C
Type(s): Approved
ATC code(s): J05AE04
Molecular Formula:: C32H45N3O4S
Molecular Weight:: 567.782
Log P:: 5.4673
Hydrogen Bond Acceptor:: 8
Hydrogen Bond Donor:: 4
TPSA:: 127.2
CAS Number(s):: 159989-64-7

Synonym(s)

Nelfinavir

AG 1343

AG-1343

AG1343

Nelfinavir Mesylate

Nelfinavir Monomethane Sulfonate

Viracept

Mesylate, Nelfinavir

Monomethane Sulfonate, Nelfinavir

10.

Sulfonate, Nelfinavir Monomethane

External Link(s)

MeSH	D019888
PubChem Compound	64143
BindingDB	518 50061306
ChEBI	7496
CHEMBL	CHEMBL584
DrugBank	DB00220
DrugCentral	1893
KEGG	cpd:C07257 dr:D08259
Therapeutic Target Database	D08ZFL D0L3MP
ZINC	3833846

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug exposure during pregnancy	FAERS: 4		OFFSIDES US FAERS
2	Autoimmune thyroiditis	FAERS: 3		US FAERS
3	Fatigue	FAERS: 3		US FAERS
4	Sjogren's Syndrome	FAERS: 3		US FAERS
5	nervous system disorder	FAERS: 3		US FAERS
6	Arthralgia	FAERS: 2		SIDER US FAERS
7	Ascites	FAERS: 2		OFFSIDES US FAERS
8	Disease Progression	FAERS: 2		US FAERS
9	Malignant neoplasm progression	FAERS: 2		US FAERS
10	Nausea	FAERS: 2	10950090	CTD SIDER US FAERS
11	Respiratory Failure	FAERS: 2		US FAERS
12	Therapy cessation	FAERS: 2		US FAERS
13	Viral load increased	FAERS: 2		US FAERS
14	Abdominal Pain	FAERS: 1	11519908	CTD SIDER US FAERS
15	Blood alkaline phosphatase increased	FAERS: 1		OFFSIDES US FAERS
16	Blood cholesterol increased	FAERS: 1		SIDER US FAERS
17	Blood creatinine increased	FAERS: 1		US FAERS
18	Blood potassium increased	FAERS: 1		US FAERS
19	Blood urea increased	FAERS: 1		US FAERS
20	Bone pain	FAERS: 1		US FAERS
21	Cholecystitis	FAERS: 1		US FAERS
22	Cholelithiasis	FAERS: 1		US FAERS
23	Colitis	FAERS: 1		US FAERS
24	Dehydration	FAERS: 1		SIDER US FAERS
25	Delirium	FAERS: 1		US FAERS
26	Depressed Level of Consciousness	FAERS: 1		US FAERS
27	Device related infection	FAERS: 1		US FAERS
28	Disease recurrence	FAERS: 1		OFFSIDES US FAERS
29	Dizziness	FAERS: 1		SIDER US FAERS
30	Drug dose omission	FAERS: 1		US FAERS
31	Drug ineffective	FAERS: 1		OFFSIDES US FAERS
32	Dysgeusia	FAERS: 1		OFFSIDES US FAERS
33	Epistaxis	FAERS: 1		SIDER US FAERS
34	Headache	FAERS: 1		SIDER US FAERS
35	Hypercapnia	FAERS: 1		US FAERS
36	Hypothyroidism	FAERS: 1		US FAERS
37	Joint stiffness	FAERS: 1		US FAERS
38	Lichen Planus	FAERS: 1		US FAERS
39	Liposarcoma recurrent	FAERS: 1		US FAERS
40	Malaise	FAERS: 1		SIDER US FAERS
41	Manufacturing product shipping issue	FAERS: 1		US FAERS
42	Medial Tibial Stress Syndrome	FAERS: 1		US FAERS
43	Metabolic acidosis	FAERS: 1		SIDER US FAERS
44	Neonatal pneumonia	FAERS: 1		US FAERS
45	No adverse reaction	FAERS: 1		US FAERS
46	Pancreatitis	FAERS: 1		SIDER US FAERS
47	Polydactyly	FAERS: 1		OFFSIDES US FAERS
48	Poor quality sleep	FAERS: 1		US FAERS
49	Post procedural complication	FAERS: 1		US FAERS
50	Product use complaint	FAERS: 1		US FAERS
51	Pruritus	FAERS: 1		SIDER US FAERS
52	Suppressed lactation	FAERS: 1		US FAERS
53	Thirst	FAERS: 1		US FAERS
54	Transaminases increased	FAERS: 1		US FAERS
55	Tremor	FAERS: 1		US FAERS
56	Tuberculosis	FAERS: 1		US FAERS
57	Unevaluable event	FAERS: 1		US FAERS
58	Vomiting	FAERS: 1		SIDER US FAERS
59	Weight decreased	FAERS: 1		US FAERS
60	White blood cell count decreased	FAERS: 1		US FAERS
61	Wrong technique in drug usage process	FAERS: 1		US FAERS
62	17-hydroxyprogesterone increased			OFFSIDES
63	Abdominal rebound tenderness			OFFSIDES
64	Accidental overdose			OFFSIDES
65	Acidosis			OFFSIDES
66	Acquired mitochondrial DNA mutation			OFFSIDES
67	Acute Coronary Syndrome			OFFSIDES
68	Adenitis			OFFSIDES
69	Adrenogenital Syndrome			OFFSIDES
70	Agitation			SIDER
71	Alanine Aminotransferase Increased			OFFSIDES SIDER
72	Albuminuria			OFFSIDES
73	Alpha 1 foetoprotein amniotic fluid increased			OFFSIDES
74	Amniotic Band Syndrome			OFFSIDES
75	Amniotic cavity disorder			OFFSIDES
76	Amylase increased			SIDER
77	Anal Fissure			OFFSIDES
78	Anemia		12403023 16876310	CTD
79	Aneurysm			OFFSIDES
80	Angina Pectoris		18025881	CTD
81	Ankylosing spondylitis			OFFSIDES
82	Anogenital dysplasia			OFFSIDES
83	Anorexia			SIDER
84	Anxiety			SIDER
85	Aplasia Cutis Congenita			OFFSIDES
86	Appendectomy			OFFSIDES
87	Arthritis			SIDER
88	Arthropathy			OFFSIDES
89	Aspartate Aminotransferase Increased			SIDER
90	Aspiration Pneumonia			OFFSIDES
91	Asthenia			SIDER
92	Astrocytoma			OFFSIDES
93	Atherosclerosis			OFFSIDES
94	Atrial tachycardia			OFFSIDES
95	Atrioventricular Block			OFFSIDES
96	Atrioventricular Septal Defect			OFFSIDES
97	Autosomal chromosome anomaly			OFFSIDES
98	Back Pain			SIDER
99	Bacterial culture positive			OFFSIDES
100	Blepharoptosis			OFFSIDES
101	Blood 1,25-dihydroxycholecalciferol decreased			OFFSIDES
102	Blood alcohol increased			OFFSIDES
103	Blood amylase increased			OFFSIDES SIDER
104	Blood cholesterol			OFFSIDES
105	Blood creatine phosphokinase increased			SIDER
106	Blood electrolytes abnormal			OFFSIDES
107	Blood immunoglobulin E			OFFSIDES
108	Blood ketone body decreased			OFFSIDES
109	Blood lactate dehydrogenase increased			OFFSIDES
110	Blood parathyroid hormone increased			OFFSIDES
111	Blood pyruvic acid decreased			OFFSIDES
112	Blood pyruvic acid increased			OFFSIDES
113	Blood triglycerides increased			OFFSIDES SIDER
114	Blood uric acid			OFFSIDES
115	Body Temperature			OFFSIDES
116	Body fat disorder			OFFSIDES
117	Body temperature fluctuation			OFFSIDES
118	Bone infarction			OFFSIDES
119	Bone lesion			OFFSIDES
120	Bone marrow depression			OFFSIDES
121	Bone marrow toxicity			OFFSIDES
122	Bradycardia		10476763 11366874	CTD OFFSIDES
123	Brain natriuretic peptide increased			OFFSIDES
124	Bronchiolitis			OFFSIDES
125	Bronchospasm			SIDER
126	Buffalo hump			SIDER
127	Cataract			OFFSIDES
128	Catheter site inflammation			OFFSIDES
129	Cerebral disorder			OFFSIDES
130	Cerebral ventricle dilatation			OFFSIDES
131	Cervical dysplasia			OFFSIDES
132	Chemical and Drug Induced Liver Injury		10950090 11519908 23956101	CTD
133	Chills		11519908	CTD
134	Cholangiolitis			OFFSIDES
135	Cholestasis		11519908	CTD
136	Chondromatosis			OFFSIDES
137	Chordee			OFFSIDES
138	Chorioamnionitis			OFFSIDES
139	Chronic left ventricular failure			OFFSIDES
140	Cirrhosis			OFFSIDES
141	Cleft Palate			OFFSIDES
142	Clonus			OFFSIDES
143	Completed Suicide			SIDER
144	Complications of maternal exposure to therapeutic drugs			OFFSIDES
145	Concomitant disease progression			OFFSIDES
146	Congenital abdominal hernia			OFFSIDES
147	Congenital choroid plexus cyst			OFFSIDES
148	Congenital cystic kidney disease			OFFSIDES
149	Congenital cytomegalovirus infection			OFFSIDES
150	Congenital hepatomegaly			OFFSIDES
151	Congenital hydronephrosis			OFFSIDES
152	Congenital mitochondrial cytopathy			OFFSIDES
153	Congenital nystagmus			OFFSIDES
154	Congenital teratoma			OFFSIDES
155	Congenital torticollis			OFFSIDES
156	Congenital tracheomalacia			OFFSIDES
157	Congenital tricuspid valve incompetence			OFFSIDES
158	Creatinine renal clearance decreased			OFFSIDES
159	Cryptorchidism			OFFSIDES
160	Cyst			OFFSIDES
161	Cytomegalovirus antibody positive			OFFSIDES
162	Deafness Neurosensory			OFFSIDES
163	Deafness			OFFSIDES
164	Dengue Fever			OFFSIDES
165	Dependence			OFFSIDES
166	Dermatitis			SIDER
167	Diabetes			OFFSIDES
168	Diabetes Mellitus			SIDER
169	Diabetic Nephropathy			OFFSIDES
170	Diarrhea		10708286 10950090 12403023	CTD OFFSIDES
171	Diplopia			OFFSIDES
172	Discomfort			SIDER
173	Drug Eruptions		18176653 18837731	CTD
174	Drug addict			OFFSIDES
175	Drug exposure before pregnancy			OFFSIDES
176	Drug resistance			OFFSIDES
177	Drug toxicity			OFFSIDES
178	Duodenal Ulcer			OFFSIDES
179	Duodenal atresia			OFFSIDES
180	Dyspepsia			SIDER
181	Echocardiogram abnormal			OFFSIDES
182	Eclampsia			OFFSIDES
183	Ejection fraction abnormal			OFFSIDES
184	Electrocardiogram R on T phenomenon			OFFSIDES
185	Electrocardiogram ST segment abnormal			OFFSIDES
186	Electrocardiogram ST-T change			OFFSIDES
187	Eosinophilic myocarditis			OFFSIDES
188	Ependymoma			OFFSIDES
189	Epigastric pain			SIDER
190	Epilepsy			OFFSIDES
191	Erectile dysfunction			OFFSIDES
192	Erysipelas			OFFSIDES
193	Erythema Infectiosum			OFFSIDES
194	Erythema Multiforme			SIDER
195	Erythema			SIDER
196	Eustachian tube disorder			OFFSIDES
197	Exanthema		18176653	CTD
198	Eye Infection			OFFSIDES
199	Facial wasting			OFFSIDES
200	Factor VIII inhibition			OFFSIDES
201	False positive laboratory result			OFFSIDES
202	Fasciitis			OFFSIDES
203	Fat redistribution			SIDER
204	Fatty Liver			OFFSIDES
205	Feeding disorder neonatal			OFFSIDES
206	Feeling abnormal			SIDER
207	Fever		11519908	CTD
208	Fibrosarcoma			OFFSIDES
209	Flatulence			OFFSIDES SIDER
210	Foaming at mouth			OFFSIDES
211	Folliculitis			SIDER
212	Forceps delivery			OFFSIDES
213	Gamma-Glutamyltransferase Increased			OFFSIDES
214	Gastrointestinal Pain			SIDER
215	Gastroschisis			OFFSIDES
216	Genital Herpes			OFFSIDES
217	Genotype drug resistance test positive			OFFSIDES
218	Glasgow coma scale			OFFSIDES
219	Glycogen Storage Disease Type I			OFFSIDES
220	Graft dysfunction			OFFSIDES
221	HIV Infections		View details 9717687 10337948 10625032 10708286 11362904 11519908 11832739 12022250 12389881 12403023 12487385 14502007 15213559 15388451 15547198 16288408 16603854 28940894	CTD
222	HIV Wasting Syndrome			OFFSIDES
223	Head deformity			OFFSIDES
224	Hepatic congestion			OFFSIDES
225	Hepatic necrosis			OFFSIDES
226	Hepatitis B Virus			OFFSIDES
227	Hepatitis B			OFFSIDES
228	Hepatitis C		11519908 19302339	CTD OFFSIDES
229	Hepatitis			SIDER
230	Hepatomegaly		10950090 11519908	CTD
231	Hip Dysplasia			OFFSIDES
232	Human anti-mouse antibody positive			OFFSIDES
233	Human immunodeficiency virus transmission			OFFSIDES
234	Hydrocephalus			OFFSIDES
235	Hydronephrosis			OFFSIDES
236	Hypercreatininaemia			OFFSIDES
237	Hyperkinesia			SIDER
238	Hyperparathyroidism			OFFSIDES
239	Hyperplasia		16408618	CTD
240	Hypersensitivity			SIDER
241	Hypersplenism			OFFSIDES
242	Hypertensive cardiomyopathy			OFFSIDES
243	Hypertrophy of Breast			SIDER
244	Hypertrophy		16408618	CTD
245	Hypokinesia			OFFSIDES
246	Hyporeflexia			OFFSIDES
247	Hypospadias			OFFSIDES
248	Hypotension, Orthostatic		12389881	CTD
249	Inflammation			SIDER
250	Insulin Resistance			OFFSIDES SIDER
251	Intention tremor			OFFSIDES
252	Intraocular inflammation			OFFSIDES
253	Intrauterine infection			OFFSIDES
254	Iridocyclitis			OFFSIDES
255	Iritis			SIDER
256	Kidney Calculi		11832739	CTD
257	Lactate pyruvate ratio increased			OFFSIDES
258	Legionella			OFFSIDES
259	Leishmaniasis		20361030	CTD
260	Leukopenia neonatal			OFFSIDES
261	Leukopenia			SIDER
262	Light chain analysis increased			OFFSIDES
263	Lipase			OFFSIDES
264	Lipodystrophy acquired			OFFSIDES SIDER
265	Lipodystrophy			SIDER
266	Lipohypertrophy			SIDER
267	Liver transplant rejection			OFFSIDES
268	Lymphocytosis			OFFSIDES
269	Lymphoma			OFFSIDES
270	Macrocytosis			OFFSIDES
271	Malnutrition			SIDER
272	Meconium abnormal			OFFSIDES
273	Meconium peritonitis			OFFSIDES
274	Meningocele			OFFSIDES
275	Metastases to adrenals			OFFSIDES
276	Microphthalmos			OFFSIDES
277	Mitochondrial toxicity			OFFSIDES
278	Monocytosis			OFFSIDES
279	Mood swings			SIDER
280	Multi-organ disorder			OFFSIDES
281	Muscle necrosis			OFFSIDES
282	Muscle strain			OFFSIDES
283	Musculoskeletal chest pain			OFFSIDES
284	Musculoskeletal discomfort			SIDER
285	Myalgia			SIDER
286	Myasthenic Syndrome			OFFSIDES
287	Myocardial Infarction		18025881	CTD
288	Myopathy			SIDER
289	Myositis			SIDER
290	Necrosis		15577407 19106637	CTD
291	Neonatal aspiration			OFFSIDES
292	Neoplasms		18000394	CTD
293	Nephritis allergic			OFFSIDES
294	Nephrolithiasis			SIDER
295	Neuralgia			OFFSIDES
296	Neutropenia			SIDER
297	Neutrophil count decreased			OFFSIDES
298	Nodular regenerative hyperplasia			OFFSIDES
299	Nuclear magnetic resonance imaging abdominal			OFFSIDES
300	Ocular icterus			OFFSIDES
301	Oculogyration			OFFSIDES
302	Oligohydramnios			OFFSIDES
303	Ophthalmoplegia			OFFSIDES
304	Pain			SIDER
305	Pancytopenia		12403023	CTD
306	Parkinsonian rest tremor			OFFSIDES
307	Patellofemoral Pain Syndrome			OFFSIDES
308	Pathogen resistance			OFFSIDES
309	Pelvic abscess			OFFSIDES
310	Perineal fistula			OFFSIDES
311	Peripheral Nervous System Diseases		9717687 12403023	CTD
312	Peripheral nerve palsy			OFFSIDES
313	Pharyngitis			SIDER
314	Phlebitis			OFFSIDES
315	Pilonidal cyst congenital			OFFSIDES
316	Placental Insufficiency			OFFSIDES
317	Pneumocystis jiroveci pneumonia			OFFSIDES
318	Pneumonia			SIDER
319	Polysubstance abuse			OFFSIDES
320	Portal Hypertension			OFFSIDES
321	Portal hypertensive gastropathy			OFFSIDES
322	Pregnancy Complications, Infectious		15213559	CTD
323	Productive Cough			OFFSIDES
324	Prothrombin level decreased			OFFSIDES
325	Pulmonary Embolism		10625032	CTD
326	Pulmonary Fibrosis		28940894	CTD
327	Pulmonary Hypertension			OFFSIDES
328	Pulmonary Valve Stenosis			OFFSIDES
329	Pulmonary arterial pressure			OFFSIDES
330	Pulmonary artery stenosis			OFFSIDES
331	Pulmonary malformation			OFFSIDES
332	Pulmonary thrombosis			OFFSIDES
333	Pyloric Stenosis			OFFSIDES
334	Retinal Vein Occlusion			OFFSIDES
335	Retinogram abnormal			OFFSIDES
336	Retrognathia			OFFSIDES
337	Rhabdomyolysis			SIDER
338	Rhinitis			OFFSIDES SIDER
339	Right Ventricular Hypertrophy			OFFSIDES
340	Right atrial dilatation			OFFSIDES
341	Right ventricular systolic pressure increased			OFFSIDES
342	Rubella antibody positive			OFFSIDES
343	Scab			OFFSIDES
344	Seizures		10337948	CTD
345	Semen volume decreased			OFFSIDES
346	Sexual Dysfunction			SIDER
347	Shoulder Dystocia			OFFSIDES
348	Sick Sinus Syndrome			OFFSIDES
349	Sinus bradycardia			OFFSIDES
350	Sinusitis			SIDER
351	Skin Diseases, Vesiculobullous		18837731	CTD
352	Somnolence			SIDER
353	Spina Bifida			OFFSIDES
354	Stomatitis			SIDER
355	Sudden infant death syndrome			OFFSIDES
356	Suicide			SIDER
357	Sweating			SIDER
358	Syndactyly			OFFSIDES
359	Talipes			OFFSIDES
360	Thrombocytopenia			SIDER
361	Tinnitus			OFFSIDES
362	Trisomy 15			OFFSIDES
363	Trisomy 21			OFFSIDES
364	Ultrasound antenatal screen			OFFSIDES
365	Ultrasound scan abnormal			OFFSIDES
366	Umbilical hernia			OFFSIDES
367	Underweight			OFFSIDES
368	Urticaria			SIDER
369	VIIth nerve paralysis			OFFSIDES
370	Ventricular hypoplasia			OFFSIDES
371	Vestibular Neuronitis			OFFSIDES
372	Viral myocarditis			OFFSIDES
373	Visual disturbance			OFFSIDES
374	Visual tracking test abnormal			OFFSIDES
375	jaundice			SIDER
376	leukemia		20105315	CTD
377	liposarcoma		21355074	CTD OFFSIDES
378	melanoma		17283158	CTD
379	muscle injury			OFFSIDES
380	treatment failure			OFFSIDES

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