MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Macroglossia

(UMLS:C0024421)

Definition:: The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)
UMLS ID:: C0024421
MeSH ID:: D008260

Classification:

Name:

Stomatognathic Diseases
MeSH Tree Number(s):: C07.465.910.460

Synonym(s)

Macroglossia

Abnormally large tongue

ENLARGED TONGUE

Enlarged tongue

Enlargement of tongue

Hyperplasia of the tongue

Hypertrophy of the tongue

Hypertrophy of tongue

Increased size of tongue

10.

Large tongue

11.

MACROGLOSSIA

12.

Tongue Enlarged

13.

Tongue enlarged

14.

Tongue hypertrophy

15.

enlarged tongue

16.

enlargement; tongue

17.

hypertrophy of tongue

18.

hypertrophy; tongue

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Amoxicillin	FAERS: 5		US FAERS
2	Atorvastatin	FAERS: 4		US FAERS
3	Levofloxacin	FAERS: 4		US FAERS
4	Lisinopril	FAERS: 4		US FAERS
5	Budesonide	FAERS: 3		US FAERS
6	Clarithromycin	FAERS: 3		US FAERS
7	Fluoxetine	FAERS: 3		US FAERS
8	Topiramate	FAERS: 3		US FAERS
9	Amoxicillin-Potassium Clavulanate Combination	FAERS: 2		US FAERS
10	Irinotecan	FAERS: 2		US FAERS
11	Metformin	FAERS: 2		US FAERS
12	Sunitinib	FAERS: 2		OFFSIDES US FAERS
13	Warfarin	FAERS: 2		US FAERS
14	iopromide	FAERS: 2		US FAERS
15	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1		US FAERS
16	Amlodipine	FAERS: 1	21330681	CTD US FAERS
17	Amoxicillin	FAERS: 1		US FAERS
18	Atorvastatin	FAERS: 1		US FAERS
19	Azithromycin	FAERS: 1		US FAERS
20	Bromocriptine	FAERS: 1		US FAERS
21	Cephalexin	FAERS: 1		US FAERS
22	Everolimus	FAERS: 1		US FAERS
23	Fluoxetine	FAERS: 1		US FAERS
24	Flurbiprofen	FAERS: 1		US FAERS
25	Haloperidol	FAERS: 1		US FAERS
26	Imatinib Mesylate	FAERS: 1		US FAERS
27	Irinotecan	FAERS: 1		US FAERS
28	Leflunomide	FAERS: 1		US FAERS
29	Levofloxacin Hemihydrate	FAERS: 1		US FAERS
30	Lopinavir/Ritonavir	FAERS: 1		US FAERS
31	Methotrexate	FAERS: 1		US FAERS
32	Oxycodone	FAERS: 1		US FAERS
33	Paliperidone Palmitate	FAERS: 1		US FAERS
34	Paroxetine	FAERS: 1		US FAERS
35	Perindopril	FAERS: 1		US FAERS
36	Propofol	FAERS: 1		US FAERS
37	Quetiapine Fumarate	FAERS: 1		US FAERS
38	Ramipril	FAERS: 1		US FAERS
39	Risperidone	FAERS: 1		US FAERS
40	Valproic Acid	FAERS: 1		US FAERS
41	Vancomycin	FAERS: 1		US FAERS
42	candesartan cilexetil	FAERS: 1		OFFSIDES US FAERS
43	Acarbose			OFFSIDES
44	Anastrozole			OFFSIDES
45	Aripiprazole			OFFSIDES
46	Bumetanide			OFFSIDES
47	Bupropion			OFFSIDES
48	Capecitabine			OFFSIDES
49	Celecoxib			OFFSIDES
50	Ciprofloxacin			OFFSIDES
51	Doxorubicin			OFFSIDES
52	Dronabinol			OFFSIDES
53	Enalapril		7968889 12173515	CTD
54	Ethosuximide			OFFSIDES
55	Glutamine			OFFSIDES
56	Letrozole			OFFSIDES
57	Melphalan			OFFSIDES
58	Mepivacaine			OFFSIDES
59	Meprobamate			OFFSIDES
60	Metoclopramide			OFFSIDES
61	Naloxone			OFFSIDES
62	Nicardipine		21330681	CTD
63	Nizatidine			OFFSIDES
64	Pamidronate			OFFSIDES
65	Penicillin V			OFFSIDES
66	Perindopril		9485152	CTD
67	Sulfamethoxazole			OFFSIDES
68	Tamoxifen			OFFSIDES
69	Tenofovir			OFFSIDES
70	Tenofovir			OFFSIDES
71	Thalidomide			OFFSIDES
72	Triiodothyronine			OFFSIDES
73	Trimethoprim			OFFSIDES
74	Varenicline			OFFSIDES
75	Vincristine			OFFSIDES
76	Vinorelbine			OFFSIDES
77	Zoledronic Acid			OFFSIDES
78	aliskiren			OFFSIDES
79	chlorhexidine gluconate			OFFSIDES
80	dolasetron			OFFSIDES
81	exemestane			OFFSIDES
82	reviparin			OFFSIDES
83	rofecoxib			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Glossitis	46.7%
2	Glossoptosis	46.7%
3	Glossitis, Benign Migratory	34.4%
4	Tongue Neoplasms	33.1%
5	Burning Mouth Syndrome	31%
6	Lip Diseases	31%
7	Oral Submucous Fibrosis	31%
8	Periodontal Diseases	31%
9	Salivary Gland Diseases	31%
10	Stomatitis	31%
11	Oral Ulcer	31%
12	Facial Hemiatrophy	25.4%
13	Melkersson-Rosenthal Syndrome	25.4%
14	Facial Nerve Diseases	20.9%
15	Granulomatosis, Orofacial	20.9%
16	Mouth Abnormalities	20.7%
17	Oral candidiasis	20.5%
18	Mouth Neoplasms	20.5%
19	Oral Fistula	20.5%
20	Tooth Loss	20.5%
21	Bell Palsy	20.3%
22	Lichen Planus, Oral	20.1%
23	Cheilitis	20%
24	Drooling	20%
25	Gingival Diseases	20%
26	Periodontitis	20%
27	Sialadenitis	20%
28	Sialometaplasia, Necrotizing	20%
29	Sialorrhea	20%
30	Aphthous Stomatitis	20%
31	Xerostomia	20%
32	Peri-Implantitis	20%
33	Salivary Gland Fistula	19.8%
34	Salivary Gland Neoplasms	19.8%
35	Gingival Recession	19.6%
36	Parotitis	19.6%
37	Gingival Atrophy	19.6%
38	Tooth Diseases	18.5%
39	Parotid Neoplasms	17.5%
40	Gingival Hemorrhage	17.2%
41	Facial paralysis	15.1%
42	Facial Paresis	15.1%
43	Hemifacial Spasm	14.9%
44	Gingivitis	14.8%
45	Pericoronitis	14.8%
46	Aggressive Periodontitis	14.8%
47	Gingival Overgrowth	14.8%
48	Facial Neuralgia	13.3%
49	Macrostomia	13.2%
50	Microstomia	13.2%
51	Dental Fistula	13.2%
52	Oroantral Fistula	13.2%
53	Jaw Diseases	12.8%
54	Pharyngeal Diseases	12.8%
55	Gingival Hyperplasia	12.2%
56	Gingival Hypertrophy	12.2%
57	Vesicular Stomatitis	10.4%
58	Bruxism	10.3%
59	Dental Leakage	10.3%
60	Hypercementosis	10.3%
61	Malocclusion	10.3%
62	Tooth Crowding	10.3%
63	Tooth Discoloration	10.3%
64	Tooth Demineralization	10.3%
65	Tooth Ankylosis	10.3%
66	Giant Cell Epulis	10.2%
67	Alveolar Bone Loss	9.9%
68	Trigeminal Nerve Disorder	9.8%
69	Behcet Syndrome	8.6%
70	Radicular Cyst	8.3%
71	Mobius Syndrome	8.1%
72	Mumps	8.1%
73	Trigeminal Neuralgia	8.1%
74	Herpes Zoster Oticus	8%
75	Leukoplakia, Oral	7.9%
76	Herpes Labialis	7.9%
77	Cleft Palate	7.5%
78	Palatal Neoplasms	7.5%
79	Temporomandibular Joint Disorders	7.5%
80	Tooth Injuries	7.3%
81	Maxillary Diseases	7%
82	Tooth Resorption	7%
83	Toothache	6.7%
84	Dental caries	6.7%
85	Dental Plaque	6.7%
86	Dental Pulp Calcification	6.7%
87	Pulpitis	6.7%
88	Tooth Erosion	6.7%
89	Dental Enamel Hypoplasia	6.6%
90	Hypodontia	6.6%
91	Facial Nerve Injuries	6.6%
92	Ulcerative stomatitis	6.2%
93	Toxic Epidermal Necrolysis	5.6%
94	Stevens-Johnson Syndrome	5.6%
95	Pharyngitis	5.3%
96	Jaw Abnormalities	4.8%
97	Tooth Avulsion	4.5%
98	Retrognathia	4.5%
99	Dental Pulp Necrosis	4.4%
100	Nasopharyngitis	4.4%
101	Sicca Syndrome	4.2%
102	Sjogren's Syndrome	4.2%
103	Pharyngeal Neoplasms	4.1%
104	Maxillofacial Abnormalities	4%
105	Temporomandibular Joint Dysfunction Syndrome	4%
106	Prognathism	4%
107	Nasopharyngeal Neoplasms	3.8%
108	Tonsillitis	3.3%
109	Sleep Bruxism	3.3%
110	Micrognathism	3.2%
111	Pierre Robin Syndrome	3.2%
112	Lemierre Syndrome	2.8%
113	Retropharyngeal Abscess	2.6%
114	Hypopharyngeal Neoplasms	2.6%
115	Hypopharyngeal Cancer	2.6%
116	Nasopharyngeal carcinoma	2.4%
117	Peritonsillar Abscess	1.9%
118	Tonsillar Neoplasms	1.9%
119	Basal Cell Nevus Syndrome	1%

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