MetaADEDB 2.0 @ LMMD
sibutramine
(KFNNPQDSPLWLCX-UHFFFAOYSA-N)
Structure
SMILES
CC(CC(C1(CCC1)c1ccc(cc1)Cl)N(C)C)C.O.Cl
Molecular Formula:
C17H29Cl2NO
Molecular Weight:
334.324
Log P:
5.4757
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
2
TPSA:
12.47
CAS Number(s):
125494-59-9
Synonym(s)
1.
sibutramine
2.
(R)-DDMS
3.
BTS 54 524
4.
BTS 54524
5.
BTS-54524
6.
Meridia
7.
N-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutyl-N,N-dimethylamine HCl
8.
Reductil
9.
di-desmethylsibutramine
10.
didesmethylsibutramine
11.
mono-desmethylsibutramine
12.
sibutramine hydrochloride
External Link(s)
MeSHC058254
PubChem Compound69649162
64765
CHEMBLCHEMBL3989830
KEGGdr:D02571
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 84
Canada Vigilance: 45
Canada Vigilance
US FAERS
2HeadacheFAERS: 60
Canada Vigilance: 8
Canada Vigilance
US FAERS
3Drug exposure during pregnancyFAERS: 58US FAERS
4PalpitationsFAERS: 45
Canada Vigilance: 8
Canada Vigilance
US FAERS
5DizzinessFAERS: 37
Canada Vigilance: 7
Canada Vigilance
US FAERS
6FatigueFAERS: 36
Canada Vigilance: 1
Canada Vigilance
US FAERS
7Cerebrovascular accidentFAERS: 33
Canada Vigilance: 2
Canada Vigilance
US FAERS
8NauseaFAERS: 29
Canada Vigilance: 8
Canada Vigilance
US FAERS
9SyncopeFAERS: 25
Canada Vigilance: 1
Canada Vigilance
US FAERS
10AnxietyFAERS: 24
Canada Vigilance: 2
Canada Vigilance
US FAERS
11Chest PainFAERS: 24
Canada Vigilance: 6
Canada Vigilance
US FAERS
12Cardiac ArrestFAERS: 20US FAERS
13Feeling abnormalFAERS: 18US FAERS
14AstheniaFAERS: 17
Canada Vigilance: 2
Canada Vigilance
US FAERS
15MalaiseFAERS: 16
Canada Vigilance: 4
Canada Vigilance
US FAERS
16Myocardial InfarctionFAERS: 16
Canada Vigilance: 2
Canada Vigilance
US FAERS
17TremorFAERS: 15
Canada Vigilance: 3
Canada Vigilance
US FAERS
18AgitationFAERS: 14US FAERS
19ConstipationFAERS: 14
Canada Vigilance: 1
Canada Vigilance
US FAERS
20HungerFAERS: 14US FAERS
21VomitingFAERS: 14
Canada Vigilance: 2
Canada Vigilance
US FAERS
22PregnancyFAERS: 12US FAERS
23Ventricular FibrillationFAERS: 11US FAERS
24Abdominal PainFAERS: 10
Canada Vigilance: 2
Canada Vigilance
US FAERS
25Acute myocardial infarctionFAERS: 10US FAERS
26Back PainFAERS: 10
Canada Vigilance: 2
Canada Vigilance
US FAERS
27HypotensionFAERS: 10US FAERS
28Sudden deathFAERS: 10US FAERS
29TachycardiaFAERS: 10
Canada Vigilance: 7
Canada Vigilance
US FAERS
30Pulmonary EmbolismFAERS: 9
Canada Vigilance: 2
Canada Vigilance
US FAERS
31Chest discomfortFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
32Depressed moodFAERS: 8US FAERS
33General physical health deteriorationFAERS: 8US FAERS
34PainFAERS: 8US FAERS
35ThirstFAERS: 8US FAERS
36AnorexiaFAERS: 7US FAERS
37Mood swingsFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
38PyelonephritisFAERS: 7US FAERS
39Suicide attemptFAERS: 7US FAERS
40ThrombosisFAERS: 7US FAERS
41Atrial FibrillationFAERS: 6US FAERS
42Cerebral InfarctionFAERS: 6US FAERS
43Completed SuicideFAERS: 6US FAERS
44Ectopic PregnancyFAERS: 6US FAERS
45Erectile dysfunctionFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
46Mental impairmentFAERS: 6US FAERS
47NervousnessFAERS: 6
Canada Vigilance: 2
Canada Vigilance
US FAERS
48OverdoseFAERS: 6US FAERS
49ParanoiaFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
50PruritusFAERS: 6US FAERS
51Unevaluable eventFAERS: 6US FAERS
52AlopeciaFAERS: 5US FAERS
53Blood pH decreasedFAERS: 5US FAERS
54Deep Vein ThrombosisFAERS: 5US FAERS
55Drug screen positiveFAERS: 5US FAERS
56DysgeusiaFAERS: 5US FAERS
57Electrocardiogram abnormalFAERS: 5US FAERS
58EpilepsyFAERS: 5US FAERS
59Eye painFAERS: 5US FAERS
60Feeling jitteryFAERS: 5US FAERS
61HemiplegiaFAERS: 5US FAERS
62Hip DysplasiaFAERS: 5US FAERS
63Impaired work abilityFAERS: 5US FAERS
64InfectionFAERS: 5US FAERS
65Neonatal respiratory depressionFAERS: 5US FAERS
66SomnolenceFAERS: 5US FAERS
67StillbirthFAERS: 5US FAERS
68Urinary IncontinenceFAERS: 5US FAERS
69Alanine Aminotransferase IncreasedFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
70AngerFAERS: 4
Canada Vigilance: 3
Canada Vigilance
US FAERS
71Aspartate Aminotransferase IncreasedFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
72Brain DeathFAERS: 4US FAERS
73ChromaturiaFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
74Complications of maternal exposure to therapeutic drugsFAERS: 4US FAERS
75CyanosisFAERS: 4US FAERS
76DemyelinationFAERS: 4US FAERS
77Depressed Level of ConsciousnessFAERS: 4US FAERS
78DiscomfortFAERS: 4US FAERS
79Disseminated Intravascular CoagulationFAERS: 4US FAERS
80Drug withdrawal syndromeFAERS: 4US FAERS
81Ear discomfortFAERS: 4US FAERS
82Flank PainFAERS: 4US FAERS
83LethargyFAERS: 4US FAERS
84Medication ErrorFAERS: 4US FAERS
85Memory impairmentFAERS: 4US FAERS
86Metabolic acidosisFAERS: 4US FAERS
87NasopharyngitisFAERS: 4US FAERS
88PneumoniaFAERS: 4US FAERS
89Respiratory arrestFAERS: 4US FAERS
90TrismusFAERS: 4US FAERS
91Unresponsive to stimuliFAERS: 4US FAERS
92VertigoFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
93Activities of daily living impairedFAERS: 3US FAERS
94Acute psychosisFAERS: 3US FAERS
95Altered state of consciousnessFAERS: 3US FAERS
96AmnesiaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
97Amniotic fluid volume decreasedFAERS: 3US FAERS
98Amphetamines positiveFAERS: 3US FAERS
99Anal FissureFAERS: 3US FAERS
100AngioedemaFAERS: 3US FAERS
101ArthralgiaFAERS: 3US FAERS
102Blood cholesterol abnormalFAERS: 3US FAERS
103Blood glucose increasedFAERS: 3US FAERS
104CardiomegalyFAERS: 3US FAERS
105CholestasisFAERS: 3US FAERS
106Conversion disorderFAERS: 3US FAERS
107CryingFAERS: 3US FAERS
108DiplopiaFAERS: 3US FAERS
109EpistaxisFAERS: 3US FAERS
110ErysipelasFAERS: 3US FAERS
111Gamma-Glutamyltransferase IncreasedFAERS: 3US FAERS
112HepatitisFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
113InfarctionFAERS: 3US FAERS
114LeukopeniaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
115Maternal exposure during pregnancyFAERS: 3US FAERS
116MenorrhagiaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
117Obsessive thoughtsFAERS: 3US FAERS
118Obsessive-Compulsive DisorderFAERS: 3US FAERS
119PancreatitisFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
120PanniculitisFAERS: 3US FAERS
121PetechiaeFAERS: 3US FAERS
122Protein S DeficiencyFAERS: 3US FAERS
123Pulmonary malformationFAERS: 3US FAERS
124RestlessnessFAERS: 3US FAERS
125Sinus TachycardiaFAERS: 3US FAERS
126StressFAERS: 3US FAERS
127TinnitusFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
128Urinary tract infectionFAERS: 3US FAERS
129UrticariaFAERS: 3US FAERS
130Visual disturbanceFAERS: 3US FAERS
131Weight decreasedFAERS: 3US FAERS
132jaundiceFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
133Abdominal discomfortFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
134Accidental drug intake by childFAERS: 2US FAERS
135Accidental overdoseFAERS: 2US FAERS
136Adverse eventFAERS: 2US FAERS
137ApathyFAERS: 2US FAERS
138ArthropathyFAERS: 2US FAERS
139Bladder prolapseFAERS: 2US FAERS
140Blood pressure fluctuationFAERS: 2US FAERS
141Blood pressure inadequately controlledFAERS: 2US FAERS
142Blood prolactin increasedFAERS: 2US FAERS
143CachexiaFAERS: 2US FAERS
144Carbon Monoxide PoisoningFAERS: 2US FAERS
145CataractFAERS: 2US FAERS
146ChillsFAERS: 2
Canada Vigilance: 3
Canada Vigilance
US FAERS
147CholelithiasisFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
148Cholestasis of pregnancyFAERS: 2US FAERS
149Coronary Artery DiseaseFAERS: 2US FAERS
150Diabetes MellitusFAERS: 2US FAERS
151Drug toxicityFAERS: 2US FAERS
152EmbolismFAERS: 2US FAERS
153Emotional distressFAERS: 2US FAERS
154ErythemaFAERS: 2US FAERS
155Escherichia infectionFAERS: 2US FAERS
156ExophthalmosFAERS: 2US FAERS
157Fat necrosisFAERS: 2US FAERS
158FlatulenceFAERS: 2US FAERS
159FlushingFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
160Food cravingFAERS: 2US FAERS
161Gastrointestinal inflammationFAERS: 2US FAERS
162GoutFAERS: 2US FAERS
163HypersensitivityFAERS: 2US FAERS
164Hypertensive crisisFAERS: 2US FAERS
165Hypoaesthesia facialFAERS: 2US FAERS
166Incorrect dose administeredFAERS: 2US FAERS
167InflammationFAERS: 2US FAERS
168Initial insomniaFAERS: 2US FAERS
169Lack of satietyFAERS: 2US FAERS
170Lip swellingFAERS: 2US FAERS
171Meningitis herpesFAERS: 2US FAERS
172MonoplegiaFAERS: 2US FAERS
173Morbid thoughtsFAERS: 2US FAERS
174Musculoskeletal stiffnessFAERS: 2US FAERS
175MyocarditisFAERS: 2US FAERS
176NecrosisFAERS: 2US FAERS
177Neonatal aspirationFAERS: 2US FAERS
178NephrolithiasisFAERS: 2US FAERS
179Panic DisorderFAERS: 2US FAERS
180Parasitic gastroenteritisFAERS: 2US FAERS
181Pharyngolaryngeal PainFAERS: 2US FAERS
182PolyserositisFAERS: 2US FAERS
183Post procedural complicationFAERS: 2US FAERS
184Precancerous skin lesionFAERS: 2US FAERS
185Product counterfeitFAERS: 2US FAERS
186Product quality issueFAERS: 2US FAERS
187PurpuraFAERS: 2US FAERS
188Rash erythematousFAERS: 2US FAERS
189Sense of oppressionFAERS: 2US FAERS
190SepsisFAERS: 2US FAERS
191Sinus headacheFAERS: 2US FAERS
192Skin reactionFAERS: 2US FAERS
193Synovial CystFAERS: 2US FAERS
194TachyphreniaFAERS: 2US FAERS
195Thrombocytopenic purpuraFAERS: 2US FAERS
196Unwanted pregnancyFAERS: 2US FAERS
197Urinary RetentionFAERS: 2US FAERS
198VasospasmFAERS: 2US FAERS
199Abdominal massFAERS: 1US FAERS
200Abdominal strangulated herniaFAERS: 1US FAERS
201Abnormal weight gainFAERS: 1US FAERS
202AcneFAERS: 1US FAERS
203Acute Coronary SyndromeFAERS: 1US FAERS
204Acute left ventricular failureFAERS: 1US FAERS
205Alcohol IntoleranceFAERS: 1US FAERS
206Alcohol interactionFAERS: 1US FAERS
207Angina PectorisFAERS: 1US FAERS
208AphasiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
209ArteriosclerosisFAERS: 1US FAERS
210AscitesFAERS: 1US FAERS
211AsphyxiaFAERS: 1US FAERS
212AsthenopiaFAERS: 1US FAERS
213AsthmaFAERS: 1US FAERS
214Axillary vein thrombosisFAERS: 1US FAERS
215BlindnessFAERS: 1US FAERS
216Blood alkaline phosphatase increasedFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
217Blood amylase increasedFAERS: 1US FAERS
218Blood creatine phosphokinase increasedFAERS: 1US FAERS
219Blood glucose decreasedFAERS: 1US FAERS
220Blood human chorionic gonadotropin decreasedFAERS: 1US FAERS
221Blood iron decreasedFAERS: 1US FAERS
222Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
223Bone painFAERS: 1US FAERS
224Brain HypoxiaFAERS: 1US FAERS
225BruxismFAERS: 1US FAERS
226Burning sensationFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
227Calcium deficiencyFAERS: 1US FAERS
228CellulitisFAERS: 1US FAERS
229CholecystitisFAERS: 1US FAERS
230Cleft PalateFAERS: 1US FAERS
231Cor pulmonaleFAERS: 1US FAERS
232Coronary artery insufficiencyFAERS: 1US FAERS
233Decreased immune responsivenessFAERS: 1US FAERS
234DehydrationFAERS: 1US FAERS
235Diastolic dysfunctionFAERS: 1US FAERS
236Diet refusalFAERS: 1US FAERS
237Disease recurrenceFAERS: 1US FAERS
238DisorientationFAERS: 1US FAERS
239Dissociative disorderFAERS: 1US FAERS
240DiverticulitisFAERS: 1US FAERS
241Drug ToleranceFAERS: 1US FAERS
242Drug dose omissionFAERS: 1US FAERS
243DyspepsiaFAERS: 1US FAERS
244DysphoniaFAERS: 1US FAERS
245DysuriaFAERS: 1US FAERS
246Eating disorder symptomFAERS: 1US FAERS
247Ejection Fraction DecreasedFAERS: 1US FAERS
248Ejection fraction abnormalFAERS: 1US FAERS
249EructationFAERS: 1US FAERS
250Escherichia urinary tract infectionFAERS: 1US FAERS
251Euphoric moodFAERS: 1US FAERS
252Exaggerated startle responseFAERS: 1US FAERS
253ExcitabilityFAERS: 1US FAERS
254Eye laser surgeryFAERS: 1US FAERS
255Feeling ColdFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
256General physical condition abnormalFAERS: 1US FAERS
257GlomerulonephritisFAERS: 1US FAERS
258Guillain-Barre SyndromeFAERS: 1US FAERS
259Head discomfortFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
260Hepatic cancer metastaticFAERS: 1US FAERS
261HerniaFAERS: 1US FAERS
262HydronephrosisFAERS: 1US FAERS
263HyperacusisFAERS: 1US FAERS
264HyperphagiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
265HypersomniaFAERS: 1US FAERS
266HyperthyroidismFAERS: 1US FAERS
267HypokinesiaFAERS: 1US FAERS
268HypoperfusionFAERS: 1US FAERS
269HypophagiaFAERS: 1US FAERS
270HypospadiasFAERS: 1US FAERS
271HypothyroidismFAERS: 1US FAERS
272Impaired driving abilityFAERS: 1US FAERS
273Inappropriate affectFAERS: 1US FAERS
274Incisional herniaFAERS: 1US FAERS
275Incorrect drug administration durationFAERS: 1US FAERS
276IndurationFAERS: 1US FAERS
277InfertilityFAERS: 1US FAERS
278Intentional self-injuryFAERS: 1US FAERS
279Intestinal ObstructionFAERS: 1US FAERS
280Intracranial AneurysmFAERS: 1US FAERS
281Irritable Bowel SyndromeFAERS: 1US FAERS
282Joint stiffnessFAERS: 1US FAERS
283Joint swellingFAERS: 1US FAERS
284Labile hypertensionFAERS: 1US FAERS
285Large cell carcinoma of the respiratory tract stage unspecifiedFAERS: 1US FAERS
286Lip and/or oral cavity cancerFAERS: 1US FAERS
287Lipase increasedFAERS: 1US FAERS
288Livedo ReticularisFAERS: 1US FAERS
289LymphomaFAERS: 1US FAERS
290Medical device implantationFAERS: 1US FAERS
291MeningiomaFAERS: 1US FAERS
292MicrophthalmosFAERS: 1US FAERS
293Middle insomniaFAERS: 1US FAERS
294MurderFAERS: 1US FAERS
295MyalgiaFAERS: 1US FAERS
296MyelitisFAERS: 1US FAERS
297Necrotising granulomatous lymphadenitisFAERS: 1US FAERS
298NeutropeniaFAERS: 1US FAERS
299No adverse effectFAERS: 1US FAERS
300Nonspecific reactionFAERS: 1US FAERS
301Ocular icterusFAERS: 1US FAERS
302Opiates positiveFAERS: 1US FAERS
303Oropharyngeal painFAERS: 1US FAERS
304OsteoporosisFAERS: 1US FAERS
305OtosclerosisFAERS: 1US FAERS
306PallorFAERS: 1US FAERS
307Pancreatic carcinomaFAERS: 1US FAERS
308PancytopeniaFAERS: 1US FAERS
309Patent ductus arteriosusFAERS: 1US FAERS
310Pelvic PainFAERS: 1US FAERS
311Pelvic massFAERS: 1US FAERS
312Pelvic venous thrombosisFAERS: 1US FAERS
313Perianal abscessFAERS: 1US FAERS
314Peridiverticular abscessFAERS: 1US FAERS
315Peripheral embolismFAERS: 1US FAERS
316Personality ChangeFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
317Physical disabilityFAERS: 1US FAERS
318PolydactylyFAERS: 1US FAERS
319Pre-EclampsiaFAERS: 1US FAERS
320Premature EjaculationFAERS: 1US FAERS
321ProteinuriaFAERS: 1US FAERS
322Psychomotor AgitationFAERS: 1US FAERS
323Pulmonary HypertensionFAERS: 1US FAERS
324Pulmonary InfarctionFAERS: 1US FAERS
325Rectal polypFAERS: 1US FAERS
326Renal ColicFAERS: 1US FAERS
327Renal painFAERS: 1US FAERS
328RetchingFAERS: 1US FAERS
329Retinal DetachmentFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
330Retinal Vein OcclusionFAERS: 1US FAERS
331RetinitisFAERS: 1US FAERS
332Retrograde ejaculationFAERS: 1US FAERS
333Rheumatoid VasculitisFAERS: 1US FAERS
334Rotator cuff syndromeFAERS: 1US FAERS
335ScreamingFAERS: 1US FAERS
336SinusitisFAERS: 1US FAERS
337Skin UlcerFAERS: 1US FAERS
338Stevens-Johnson SyndromeFAERS: 1US FAERS
339TenosynovitisFAERS: 1US FAERS
340Therapeutic response unexpectedFAERS: 1US FAERS
341ThrombocytopeniaFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
342Thromboembolic strokeFAERS: 1US FAERS
343Thrombotic cerebral infarctionFAERS: 1US FAERS
344Toxicologic test abnormalFAERS: 1US FAERS
345ToxoplasmosisFAERS: 1US FAERS
346Uterovaginal prolapseFAERS: 1US FAERS
347VIIth nerve paralysisFAERS: 1US FAERS
348VasculitisFAERS: 1US FAERS
349Vibratory sense increasedFAERS: 1US FAERS
350Viral myocarditisFAERS: 1US FAERS
351Visual ImpairmentFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
352Vitreous DetachmentFAERS: 1US FAERS
353Vulvovaginal mycotic infectionFAERS: 1US FAERS
354Vulvovaginal pruritusFAERS: 1US FAERS
355WheezingFAERS: 1US FAERS
356ovarian neoplasmFAERS: 1US FAERS
357prostatitisFAERS: 1US FAERS
358Alcohol problemCanada Vigilance: 1Canada Vigilance
359DeafnessCanada Vigilance: 1Canada Vigilance
360Eye irritationCanada Vigilance: 1Canada Vigilance
361Frustration tolerance decreasedCanada Vigilance: 1Canada Vigilance
362HostilityCanada Vigilance: 1Canada Vigilance
363HyperventilationCanada Vigilance: 1Canada Vigilance
364Nasal discomfortCanada Vigilance: 1Canada Vigilance
365NystagmusCanada Vigilance: 1Canada Vigilance
366PhlebitisCanada Vigilance: 1Canada Vigilance
367Pulmonary congestionCanada Vigilance: 1Canada Vigilance
368Serotonin SyndromeCanada Vigilance: 1Canada Vigilance
369Troponin T increasedCanada Vigilance: 1Canada Vigilance
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