MetaADEDB 2.0 @ LMMD
Brimonidine Tartrate
(XYLJNLCSTIOKRM-UHFFFAOYSA-N)
Structure
SMILES
Brc1c(ccc2c1nccn2)NC1=NCCN1
Type(s)
Approved
ATC code(s)
D11AX21; S01EA05
Molecular Formula:
C11H10BrN5
Molecular Weight:
292.135
Log P:
1.6008
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
62.2
CAS Number(s):
59803-98-4
Synonym(s)
1.
Brimonidine Tartrate
2.
5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate
3.
5-bromo-6-(imidazolidinylideneamino)quinoxaline
4.
5-bromo-6-(imidazolin-2-ylamino)quinoxaline
5.
AGN 190342
6.
AGN-190342
7.
Alphagan
8.
Alphagan P
9.
Brimonidine
10.
Brimonidine Purite
11.
Brimonidine Tartrate (1:1)
12.
Brimonidine Tartrate (1:1), (S-(R*,R*))-Isomer
13.
Brimonidine Tartrate, (R-(R*,R*))-Isomer
14.
Bromoxidine
15.
Mirvaso
16.
Ratio-Brimonidine
17.
Sanrosa
18.
UK 14,304
19.
UK 14,304-18
20.
UK 14304
21.
UK 14308
22.
UK-14,304-18
23.
UK-14,308
24.
UK-14304
25.
AGN190342
26.
Ratio Brimonidine
27.
UK 14,304 18
28.
UK 14,30418
29.
UK 14,308
30.
UK14,30418
31.
UK14,308
32.
UK14304
External Link(s)
MeSHD000068438
PubChem Compound2435
BindingDB34572
ChEBI3175
CHEMBLCHEMBL844
DrugBankDB00484
DrugCentral395
IUPHAR/BPS Guide to PHARMACOLOGY520
5386
KEGGcpd:C07886
dr:D07540
Therapeutic Target DatabaseD0GD9D
D0AE3X
D03ACG
ZINC21303210
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Eye irritationFAERS: 23
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
2Eye painFAERS: 16
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
3HypersensitivityFAERS: 16
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
4Drug ineffectiveFAERS: 15
Canada Vigilance: 3
Canada Vigilance
OFFSIDES
US FAERS
5ConjunctivitisFAERS: 10
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
6DizzinessFAERS: 8OFFSIDES
SIDER
US FAERS
7Toxicity to various agentsFAERS: 8US FAERS
8Eye allergyFAERS: 7US FAERS
9FatigueFAERS: 7OFFSIDES
SIDER
US FAERS
10SomnolenceFAERS: 7SIDER
US FAERS
11ErythemaFAERS: 6
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
12Incorrect dose administeredFAERS: 6US FAERS
13Product container issueFAERS: 6US FAERS
14Product quality issueFAERS: 6US FAERS
15UveitisFAERS: 6US FAERS
16Accidental exposure to productFAERS: 5SIDER
US FAERS
17HypotensionFAERS: 5SIDER
US FAERS
18Product substitution issueFAERS: 5
Canada Vigilance: 4
Canada Vigilance
US FAERS
19Depressed Level of ConsciousnessFAERS: 4US FAERS
20Incorrect route of drug administrationFAERS: 4US FAERS
21Visual ImpairmentFAERS: 4
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
22Abdominal discomfortFAERS: 3OFFSIDES
US FAERS
23AstheniaFAERS: 3OFFSIDES
SIDER
US FAERS
24HeadacheFAERS: 3SIDER
US FAERS
25InflammationFAERS: 3US FAERS
26IridocyclitisFAERS: 3OFFSIDES
SIDER
US FAERS
27NauseaFAERS: 3SIDER
US FAERS
28Product packaging quantity issueFAERS: 3US FAERS
29Product storage errorFAERS: 3US FAERS
30Product use complaintFAERS: 3US FAERS
31Reaction to preservativesFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
32Respiratory DepressionFAERS: 3SIDER
US FAERS
33VomitingFAERS: 3US FAERS
34treatment failureFAERS: 3US FAERS
35Accidental overdoseFAERS: 2US FAERS
36BlindnessFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
37BradycardiaFAERS: 2OFFSIDES
SIDER
US FAERS
38Burning sensationFAERS: 2SIDER
US FAERS
39Chest PainFAERS: 2SIDER
US FAERS
40Contraindicated product administeredFAERS: 2US FAERS
41CyanosisFAERS: 2SIDER
US FAERS
42DiscomfortFAERS: 2
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
43Drug administration errorFAERS: 2OFFSIDES
US FAERS
44Drug ineffective for unapproved indicationFAERS: 2US FAERS
45Eye BurnsFAERS: 2OFFSIDES
US FAERS
46Eyelid exfoliationFAERS: 2OFFSIDES
US FAERS
47Inappropriate schedule of product administrationFAERS: 2US FAERS
48Incorrect route of product administrationFAERS: 2US FAERS
49LethargyFAERS: 2SIDER
US FAERS
50PalpitationsFAERS: 2SIDER
US FAERS
51PruritusFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
52Punctate keratitisFAERS: 2SIDER
US FAERS
53Respiratory FailureFAERS: 2OFFSIDES
SIDER
US FAERS
54Accidental exposure to product by childFAERS: 1US FAERS
55Activities of daily living impairedFAERS: 1OFFSIDES
US FAERS
56AmnesiaFAERS: 1US FAERS
57AnxietyFAERS: 1OFFSIDES
SIDER
US FAERS
58AsthenopiaFAERS: 1US FAERS
59Bladder painFAERS: 1US FAERS
60BlepharitisFAERS: 1OFFSIDES
SIDER
US FAERS
61BlepharospasmFAERS: 1US FAERS
62Blood pressure inadequately controlledFAERS: 1US FAERS
63CataractFAERS: 1OFFSIDES
SIDER
US FAERS
64Cerebrovascular accidentFAERS: 1US FAERS
65Chest discomfortFAERS: 1US FAERS
66DermatitisFAERS: 1SIDER
US FAERS
67Disease ProgressionFAERS: 1OFFSIDES
US FAERS
68Disseminated Intravascular CoagulationFAERS: 1US FAERS
69Drug dispensing errorFAERS: 1OFFSIDES
US FAERS
70EructationFAERS: 1US FAERS
71Expired product administeredFAERS: 1US FAERS
72Eye InfectionFAERS: 1OFFSIDES
SIDER
US FAERS
73Eyelid irritationFAERS: 1OFFSIDES
US FAERS
74Eyelids pruritusFAERS: 1OFFSIDES
SIDER
US FAERS
75Feeling abnormalFAERS: 1US FAERS
76Feeling jitteryFAERS: 1US FAERS
77FlatulenceFAERS: 1US FAERS
78FlushingFAERS: 1SIDER
US FAERS
79Foreign body sensation in eyesFAERS: 1OFFSIDES
US FAERS
80FormicationFAERS: 1US FAERS
81Gastrocardiac syndromeFAERS: 1US FAERS
82General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
83HypophagiaFAERS: 1OFFSIDES
US FAERS
84Inappropriate schedule of drug administrationFAERS: 1US FAERS
85Intestinal ObstructionFAERS: 1OFFSIDES
US FAERS
86KeratitisFAERS: 1SIDER
US FAERS
87LaryngitisFAERS: 1US FAERS
88MalaiseFAERS: 1US FAERS
89Medication ErrorFAERS: 1US FAERS
90Mental status changesFAERS: 1OFFSIDES
US FAERS
91MetamorphopsiaFAERS: 1US FAERS
92Ocular discomfortFAERS: 1OFFSIDES
US FAERS
93PallorFAERS: 1OFFSIDES
SIDER
US FAERS
94Peripheral swellingFAERS: 1US FAERS
95PneumoniaFAERS: 1US FAERS
96Prescription drug used without a prescriptionFAERS: 1US FAERS
97Product dispensing errorFAERS: 1US FAERS
98Product dropper issueFAERS: 1US FAERS
99Respiratory arrestFAERS: 1US FAERS
100Retinal DetachmentFAERS: 1US FAERS
101ShockFAERS: 1SIDER
US FAERS
102Sinus TachycardiaFAERS: 1US FAERS
103Skin irritationFAERS: 1SIDER
US FAERS
104SneezingFAERS: 1US FAERS
105SwellingFAERS: 1SIDER
US FAERS
106TachycardiaFAERS: 1SIDER
US FAERS
107Therapeutic response unexpectedFAERS: 1US FAERS
108Unevaluable eventFAERS: 1OFFSIDES
US FAERS
109Vascular insufficiencyFAERS: 1US FAERS
110VertigoFAERS: 1US FAERS
111Wrong drug administeredFAERS: 1US FAERS
112Abnormal visionOFFSIDES
SIDER
113AbscessOFFSIDES
114Accidental ingestionSIDER
115AcneSIDER
116Activated partial thromboplastin time shortenedOFFSIDES
117Acute bronchitisOFFSIDES
118Acute prerenal failureOFFSIDES
119Acute respiratory failureOFFSIDES
120AdenomaOFFSIDES
121AgraphiaOFFSIDES
122Alanine Aminotransferase IncreasedOFFSIDES
123AlveolitisOFFSIDES
124AmphetaminesOFFSIDES
125AmputationOFFSIDES
126AnalgesiaOFFSIDES
127Angle Closure GlaucomaOFFSIDES
128AnhedoniaOFFSIDES
129AnisocoriaOFFSIDES
130Anoxic EncephalopathyOFFSIDES
131Anterior uveitisSIDER
132Apallic syndromeOFFSIDES
133ApneaOFFSIDES
134AppendicitisOFFSIDES
135Application site burnOFFSIDES
136Application site erythemaCanada Vigilance: 1Canada Vigilance
137Application site irritationCanada Vigilance: 2Canada Vigilance
138Application site scabOFFSIDES
139ArteriosclerosisOFFSIDES
140ArthralgiaSIDER
141ArthritisSIDER
142ArthropathySIDER
143Arthropod biteOFFSIDES
144AscitesOFFSIDES
145Aspiration PneumoniaOFFSIDES
146AstigmatismOFFSIDES
147Asymptomatic bacteriuriaOFFSIDES
148AtelectasisOFFSIDES
149Atrial FlutterOFFSIDES
150Atrioventricular extrasystolesOFFSIDES
151Bacteria blood identifiedOFFSIDES
152Basal cell carcinomaOFFSIDES
153Benign Prostatic HyperplasiaOFFSIDES
154BereavementOFFSIDES
155BlanchingSIDER
156BlepharoconjunctivitisSIDER
157BlepharopachynsisOFFSIDES
158BlepharoptosisOFFSIDES
159Blood GlucoseOFFSIDES
160Blood blisterOFFSIDES
161Blood cholesterol abnormalOFFSIDES
162Blood creatine increasedOFFSIDES
163Blood creatine phosphokinase abnormalOFFSIDES
164Blood creatinine increasedOFFSIDES
165Blood glucose decreasedOFFSIDES
166Blood iron decreasedOFFSIDES
167Blood magnesium increasedOFFSIDES
168Blood potassium decreasedOFFSIDES
169Blood potassiumOFFSIDES
170Blood sodiumOFFSIDES
171Blood triglyceridesOFFSIDES
172Blood urea increasedOFFSIDES
173Blurred visionOFFSIDES
174Body TemperatureOFFSIDES
175Bone density decreasedOFFSIDES
176Bone fissureOFFSIDES
177Brain natriuretic peptide increasedOFFSIDES
178Breast hyperplasiaOFFSIDES
179BronchitisOFFSIDES
SIDER
180BruxismOFFSIDES
181Bunion operationOFFSIDES
182Burning Mouth SyndromeOFFSIDES
183Burning sensation in eyeSIDER
184BursitisOFFSIDES
185C-reactive protein abnormalOFFSIDES
186Carbohydrate antigen 27.29 increasedOFFSIDES
187Cardioactive drug level increasedOFFSIDES
188Carotid artery occlusionOFFSIDES
189Carotid bruitOFFSIDES
190Cataract operationOFFSIDES
191Cataract operation complicationOFFSIDES
192Catheter placementOFFSIDES
193Catheter related complicationOFFSIDES
194Catheter related infectionOFFSIDES
195CellulitisOFFSIDES
196Cerebral ArteriosclerosisOFFSIDES
197Cerebral artery occlusionOFFSIDES
198Cerebral atrophyOFFSIDES
199Choking sensationOFFSIDES
200Choroidal DetachmentOFFSIDES
201Chronic Obstructive Airway DiseaseOFFSIDES
202Circumstance or information capable of leading to medication errorOFFSIDES
203Cleft PalateOFFSIDES
204Clostridium difficile colitisOFFSIDES
205ClumsinessOFFSIDES
206Common ColdSIDER
207ConfabulationOFFSIDES
208Conjunctival depositOFFSIDES
209Conjunctival dischargeSIDER
210Conjunctival primary acquired melanosisOFFSIDES
211Cor pulmonaleOFFSIDES
212Corneal ScarOFFSIDES
213Corneal UlcerOFFSIDES
214Corneal erosionSIDER
215Corneal thinningOFFSIDES
216Corneal touchOFFSIDES
217Culture positiveOFFSIDES
218CyanopsiaOFFSIDES
219Cyst removalOFFSIDES
220Dacryostenosis acquiredOFFSIDES
221DeafnessOFFSIDES
222DebridementOFFSIDES
223Decreased LibidoOFFSIDES
224DehydrationOFFSIDES
225DellenOFFSIDES
226DemyelinationOFFSIDES
227Dental abscessOFFSIDES
228Depressed moodOFFSIDES
229Device malfunctionOFFSIDES
230DiabetesOFFSIDES
231Diabetes MellitusSIDER
232Diabetes mellitus inadequate controlOFFSIDES
233Diabetic RetinopathyOFFSIDES
234DiplopiaOFFSIDES
235DiverticulitisOFFSIDES
236DiverticulosisOFFSIDES
237Documented hypersensitivity to administered drugOFFSIDES
238DrowsinessOFFSIDES
SIDER
239Drug prescribing errorOFFSIDES
240Drug toxicityOFFSIDES
241Dry skinOFFSIDES
SIDER
242DysgeusiaOFFSIDES
SIDER
243DyspepsiaSIDER
244DysphoniaOFFSIDES
245DysuriaOFFSIDES
246Ear discomfortOFFSIDES
247Economic problemOFFSIDES
248EctropionOFFSIDES
249Ejection Fraction DecreasedOFFSIDES
250Electrocardiogram ST segment abnormalOFFSIDES
251Electrocardiogram ST-T changeOFFSIDES
252Electrocardiogram changeOFFSIDES
253Electrocardiogram poor R-wave progressionOFFSIDES
254Electromechanical dissociationOFFSIDES
255Emotional distressOFFSIDES
256EndarterectomyOFFSIDES
257EndophthalmitisSIDER
258EntropionOFFSIDES
259EpistaxisOFFSIDES
260Escherichia infectionOFFSIDES
261ExcoriationOFFSIDES
262Expired drug administeredOFFSIDES
263Eye RednessOFFSIDES
SIDER
264Eye inflammationCanada Vigilance: 1Canada Vigilance
OFFSIDES
265Eyelash thickeningOFFSIDES
266Eyelid DiseasesOFFSIDES
267Eyelid margin crustingOFFSIDES
268Failure to ThriveOFFSIDES
269Febrile NeutropeniaOFFSIDES
270Femoral arterial stenosisOFFSIDES
271Fistula dischargeOFFSIDES
272Follicular conjunctivitisSIDER
273Full blood count decreasedOFFSIDES
274GangreneOFFSIDES
275Gastrointestinal ulcerOFFSIDES
276General nutrition disorderOFFSIDES
277Genital dischargeOFFSIDES
278Glaucoma surgeryOFFSIDES
279GlaucomaOFFSIDES
SIDER
280GlobulinuriaOFFSIDES
281GoiterOFFSIDES
282GoutOFFSIDES
283GranulocytosisOFFSIDES
284Growth of eyelashesOFFSIDES
285Hay feverOFFSIDES
286HemiparesisOFFSIDES
287HemiplegiaOFFSIDES
288High frequency ablationOFFSIDES
289Hip DysplasiaOFFSIDES
290HordeolumSIDER
291HypercapniaOFFSIDES
292HyperkeratosisOFFSIDES
293HypertrophySIDER
294Hypoaesthesia facialOFFSIDES
295Hypocoagulable stateOFFSIDES
296HypokinesiaOFFSIDES
297HyporeflexiaOFFSIDES
298HypoventilationSIDER
299HypoxiaOFFSIDES
SIDER
300HysterectomyOFFSIDES
301Impaired driving abilityOFFSIDES
302IncontinenceOFFSIDES
303IndurationOFFSIDES
304InfectionSIDER
305InfluenzaSIDER
306Infusion site painOFFSIDES
307Injection site warmthOFFSIDES
308Injury asphyxiationOFFSIDES
309Intermittent ClaudicationOFFSIDES
310Intraocular inflammationOFFSIDES
311Intraocular lens dislocationOFFSIDES
312Intraocular pressure fluctuationOFFSIDES
313Intraocular pressure test abnormalCanada Vigilance: 1Canada Vigilance
314Intraocular pressure testOFFSIDES
315IridoceleOFFSIDES
316IritisOFFSIDES
SIDER
317Joint sprainOFFSIDES
318Keratitis siccaOFFSIDES
319Keratoconjunctivitis SiccaSIDER
320KeratorhexisOFFSIDES
321LacrimationSIDER
322Life expectancy shortenedOFFSIDES
323Limb crushing injuryOFFSIDES
324Limb injuryOFFSIDES
325Lung consolidationOFFSIDES
326Lupus pneumonitisOFFSIDES
327Mastication disorderOFFSIDES
328Medical device complicationOFFSIDES
329Metastatic NeoplasmOFFSIDES
330Middle insomniaOFFSIDES
331Multiple SclerosisOFFSIDES
332Multiple allergiesOFFSIDES
333Muscle WeaknessOFFSIDES
334Muscle relaxant therapySIDER
335Muscular DystrophyOFFSIDES
336Musculoskeletal discomfortOFFSIDES
SIDER
337MyalgiaSIDER
338MyopiaOFFSIDES
339Nasal discomfortOFFSIDES
340NasopharyngitisOFFSIDES
SIDER
341Nephritis allergicOFFSIDES
342NeuralgiaOFFSIDES
343Neuropathic ulcerOFFSIDES
344NocturiaOFFSIDES
345Non-cardiac chest painOFFSIDES
346Ocular HypertensionOFFSIDES
347Ocular stingingSIDER
348OnychoclasisOFFSIDES
349Open reduction of fractureOFFSIDES
350Open woundOFFSIDES
351Optic AtrophyOFFSIDES
352Oropharyngeal painOFFSIDES
353Orthosis userOFFSIDES
354OsteolysisOFFSIDES
355OsteomaOFFSIDES
356Osteomyelitis drainageOFFSIDES
357OsteomyelitisOFFSIDES
358OsteopeniaOFFSIDES
359OsteoporosisSIDER
360Pain of skinSIDER
361PainOFFSIDES
SIDER
362Panic disorder with agoraphobiaOFFSIDES
363Partner stressOFFSIDES
364Pelvic massOFFSIDES
365Pericarditis lupusOFFSIDES
366PharyngitisSIDER
367PhotophobiaSIDER
368Physical disabilityOFFSIDES
369Polymyalgia RheumaticaOFFSIDES
370Poor peripheral circulationOFFSIDES
371Poor quality drug administeredOFFSIDES
372Post procedural complicationOFFSIDES
373Primary sequestrumOFFSIDES
374Product contaminationOFFSIDES
375PseudophaeochromocytomaOFFSIDES
376PseudophakiaOFFSIDES
377Pulmonary function test decreasedSIDER
378Purulent dischargeOFFSIDES
379QuadriplegiaOFFSIDES
380Renal cystOFFSIDES
381Renal tubular necrosisOFFSIDES
382Retinal Vein OcclusionOFFSIDES
383Retinal aneurysmOFFSIDES
384Retinal exudatesOFFSIDES
385Retinal scarOFFSIDES
386RetinitisOFFSIDES
387Rheumatoid factor increasedOFFSIDES
388RhinitisSIDER
389RosaceaSIDER
390ScabOFFSIDES
SIDER
391ScotomaOFFSIDES
SIDER
392Secretion dischargeOFFSIDES
393Senile dementiaOFFSIDES
394SinusitisOFFSIDES
SIDER
395Skeletal injuryOFFSIDES
396Skin IndurationOFFSIDES
397Skin discomfortSIDER
398Skin neoplasm excisionOFFSIDES
399Skin toxicityOFFSIDES
400SnoringOFFSIDES
401Spinal column stenosisOFFSIDES
402Splenic InfarctionOFFSIDES
403Stevens-Johnson SyndromeOFFSIDES
404Superficial punctate keratopathySIDER
405Supraventricular tachycardiaOFFSIDES
406SyncopeSIDER
407Synovial CystOFFSIDES
408SynovitisOFFSIDES
409Systemic allergic reactionSIDER
410TalipesOFFSIDES
411TenosynovitisOFFSIDES
412Terminal dribblingOFFSIDES
413Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
414ThrombophlebitisOFFSIDES
415ThyroiditisOFFSIDES
416TinnitusOFFSIDES
417TonsillitisOFFSIDES
418Tooth ExtractionOFFSIDES
419TrabeculectomyOFFSIDES
420TrichiasisOFFSIDES
421Troponin increasedOFFSIDES
422Unresponsive to stimuliOFFSIDES
423Unspecified visual lossSIDER
424Urine flow decreasedOFFSIDES
425Urine output increasedOFFSIDES
426Vaginal ProlapseOFFSIDES
427Vasodilation procedureSIDER
428VasodilationSIDER
429Visual disturbanceOFFSIDES
SIDER
430Vital dye staining cornea presentSIDER
431Vitreous DetachmentOFFSIDES
SIDER
432Vitreous floatersSIDER
433Wound DebridementOFFSIDES
434effusionOFFSIDES
435nervous system disorderSIDER
436prostatitisOFFSIDES
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