MetaADEDB 2.0 @ LMMD
Cyclophosphamide
(CMSMOCZEIVJLDB-UHFFFAOYSA-N)
Structure
SMILES
ClCCN(P1(=O)NCCCO1)CCCl
Type(s)
Approved; Investigational
ATC code(s)
L01AA01
Molecular Formula:
C7H15Cl2N2O2P
Molecular Weight:
261.086
Log P:
2.2128
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
51.38
CAS Number(s):
50-18-0; 60007-95-6
Synonym(s)
1.
Cyclophosphamide
2.
(+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate
3.
B-518
4.
Cyclophosphamide Anhydrous
5.
Cyclophosphamide Monohydrate
6.
Cyclophosphamide, (R)-Isomer
7.
Cyclophosphamide, (S)-Isomer
8.
Cyclophosphane
9.
Cytophosphan
10.
Cytophosphane
11.
Cytoxan
12.
Endoxan
13.
NSC-26271
14.
Neosar
15.
Procytox
16.
Sendoxan
17.
B 518
18.
B518
19.
NSC 26271
20.
NSC26271
External Link(s)
MeSHD003520
PubChem Compound2907
BindingDB50237604
ChEBI4027
CHEMBLCHEMBL88
DrugBankDB00531
DrugCentral758
IUPHAR/BPS Guide to PHARMACOLOGY7154
KEGGcpd:C07888
dr:D07760
Therapeutic Target DatabaseD0CT9C
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 127OFFSIDES
US FAERS
2Toxicity to various agentsFAERS: 69US FAERS
3Maternal exposure before pregnancyFAERS: 52US FAERS
4No adverse eventFAERS: 51US FAERS
5NauseaFAERS: 22
Canada Vigilance: 3

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CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
6Febrile NeutropeniaFAERS: 20OFFSIDES
SIDER
US FAERS
7HeadacheFAERS: 19
Canada Vigilance: 1
7633237
10084258
CTD
SIDER
Canada Vigilance
US FAERS
8MYELODYSPLASTIC SYNDROMEFAERS: 18SIDER
US FAERS
9VomitingFAERS: 18
Canada Vigilance: 3

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CTD
SIDER
Canada Vigilance
US FAERS
10NeutropeniaFAERS: 16
Canada Vigilance: 2

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CTD
Canada Vigilance
US FAERS
11White blood cell count decreasedFAERS: 16US FAERS
12Chest discomfortFAERS: 15US FAERS
13Disease ProgressionFAERS: 15OFFSIDES
US FAERS
14Disease recurrenceFAERS: 13OFFSIDES
US FAERS
15InfectionFAERS: 1324673398CTD
OFFSIDES
SIDER
US FAERS
16PruritusFAERS: 12SIDER
US FAERS
17SepsisFAERS: 12
Canada Vigilance: 1
2227540
10526668
CTD
SIDER
Canada Vigilance
US FAERS
18MalaiseFAERS: 8SIDER
US FAERS
19Posterior reversible encephalopathy syndromeFAERS: 8SIDER
US FAERS
20treatment failureFAERS: 8US FAERS
21Blood immunoglobulin G decreasedFAERS: 7US FAERS
22DehydrationFAERS: 7US FAERS
23Medication ErrorFAERS: 7US FAERS
24AlopeciaFAERS: 6
Canada Vigilance: 3

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CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
25ExtravasationFAERS: 6SIDER
US FAERS
26LeukopeniaFAERS: 6
Canada Vigilance: 4

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CTD
SIDER
Canada Vigilance
US FAERS
27PancytopeniaFAERS: 6
Canada Vigilance: 1
15656036CTD
SIDER
Canada Vigilance
US FAERS
28Respiratory FailureFAERS: 6OFFSIDES
SIDER
US FAERS
29ThrombocytopeniaFAERS: 6
Canada Vigilance: 4

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CTD
SIDER
Canada Vigilance
US FAERS
30Urinary tract infectionFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
31Burning sensationFAERS: 5US FAERS
32Chest PainFAERS: 5
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
33Drug toxicityFAERS: 5OFFSIDES
US FAERS
34PneumoniaFAERS: 52705179CTD
SIDER
US FAERS
35Pulmonary FibrosisFAERS: 5
Canada Vigilance: 1
8185701
16636934
CTD
Canada Vigilance
US FAERS
36TremorFAERS: 5SIDER
US FAERS
37AstheniaFAERS: 4SIDER
US FAERS
38Cardiac ArrestFAERS: 4SIDER
US FAERS
39CardiotoxicityFAERS: 4
Canada Vigilance: 1
25023062CTD
SIDER
Canada Vigilance
US FAERS
40DizzinessFAERS: 4
Canada Vigilance: 1
9523741
11132226
CTD
SIDER
Canada Vigilance
US FAERS
41Drug administration errorFAERS: 4US FAERS
42ErythemaFAERS: 4OFFSIDES
SIDER
US FAERS
43Exposure via skin contactFAERS: 4US FAERS
44Eye painFAERS: 4OFFSIDES
US FAERS
45HypersensitivityFAERS: 41679512CTD
SIDER
US FAERS
46HypotensionFAERS: 4378349
2285129
8879620
CTD
SIDER
US FAERS
47LymphopeniaFAERS: 4US FAERS
48Malignant neoplasm progressionFAERS: 4
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
49MyalgiaFAERS: 4SIDER
US FAERS
50Nasal discomfortFAERS: 4SIDER
US FAERS
51PainFAERS: 4

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CTD
OFFSIDES
SIDER
US FAERS
52Pericardial effusionFAERS: 425023062CTD
SIDER
US FAERS
53Primary hypogonadismFAERS: 4US FAERS
54ShockFAERS: 4SIDER
US FAERS
55Sinus headacheFAERS: 4US FAERS
56Squamous cell carcinoma of skinFAERS: 4US FAERS
57Transaminases increasedFAERS: 4US FAERS
58Unevaluable eventFAERS: 4OFFSIDES
US FAERS
59VasculitisFAERS: 41392448
3060893
8580559
CTD
SIDER
US FAERS
60WheezingFAERS: 4US FAERS
61Abdominal PainFAERS: 3
Canada Vigilance: 1
10861821CTD
OFFSIDES
Canada Vigilance
US FAERS
62Accidental exposure to productFAERS: 3US FAERS
63Accidental exposureFAERS: 3US FAERS
64Acute kidney injuryFAERS: 3

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CTD
US FAERS
65Atrial FibrillationFAERS: 39676843
16247745
CTD
SIDER
US FAERS
66Basal cell carcinomaFAERS: 3US FAERS
67BronchospasmFAERS: 3SIDER
US FAERS
68ChillsFAERS: 3SIDER
US FAERS
69ColitisFAERS: 3SIDER
US FAERS
70Drug dispensing errorFAERS: 3US FAERS
71DysgeusiaFAERS: 3SIDER
US FAERS
72ErysipelasFAERS: 3US FAERS
73FatigueFAERS: 36293321CTD
SIDER
US FAERS
74FlushingFAERS: 3SIDER
US FAERS
75HepatotoxicityFAERS: 3SIDER
US FAERS
76HypophagiaFAERS: 3OFFSIDES
US FAERS
77Myocardial InfarctionFAERS: 3
Canada Vigilance: 1
7572766
9415359
9817266
CTD
SIDER
Canada Vigilance
US FAERS
78MyocarditisFAERS: 3

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CTD
SIDER
US FAERS
79Neutropenic sepsisFAERS: 3OFFSIDES
US FAERS
80Ovarian failureFAERS: 3OFFSIDES
SIDER
US FAERS
81Peripheral swellingFAERS: 3US FAERS
82Polyomavirus test positiveFAERS: 3US FAERS
83Premature MenopauseFAERS: 3US FAERS
84Respiratory arrestFAERS: 3US FAERS
85Squamous cell carcinomaFAERS: 3US FAERS
86TachycardiaFAERS: 31679512CTD
SIDER
US FAERS
87Therapy cessationFAERS: 3US FAERS
88Wrong drug administeredFAERS: 3US FAERS
89jaundiceFAERS: 35454367CTD
SIDER
US FAERS
90Abdominal discomfortFAERS: 2OFFSIDES
SIDER
US FAERS
91AgranulocytosisFAERS: 2
Canada Vigilance: 1
4512147CTD
SIDER
Canada Vigilance
US FAERS
92Alanine Aminotransferase IncreasedFAERS: 2US FAERS
93AnorexiaFAERS: 2

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CTD
SIDER
US FAERS
94BK virus infectionFAERS: 2US FAERS
95BradykinesiaFAERS: 2US FAERS
96BronchiectasisFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
97Cardiac TamponadeFAERS: 2378349
7235784
9248329
CTD
SIDER
US FAERS
98Central nervous system lesionFAERS: 2US FAERS
99Cerebrovascular accidentFAERS: 2US FAERS
100Cervix carcinomaFAERS: 2US FAERS
101CholestasisFAERS: 217786148CTD
SIDER
US FAERS
102Cytomegalovirus test positiveFAERS: 2OFFSIDES
US FAERS
103DeafnessFAERS: 2OFFSIDES
SIDER
US FAERS
104DisorientationFAERS: 2US FAERS
105Drug exposure before pregnancyFAERS: 2US FAERS
106Ejection Fraction DecreasedFAERS: 2OFFSIDES
US FAERS
107EosinophiliaFAERS: 24551437
11006010
CTD
US FAERS
108Facial PainFAERS: 2US FAERS
109Hepatitis BFAERS: 219008178CTD
OFFSIDES
US FAERS
110Jaw inflammationFAERS: 2US FAERS
111Joint swellingFAERS: 2US FAERS
112LymphomaFAERS: 2

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CTD
OFFSIDES
SIDER
US FAERS
113Mental status changesFAERS: 2US FAERS
114Myelodysplastic syndrome transformationFAERS: 2US FAERS
115Neutrophil count decreasedFAERS: 2OFFSIDES
US FAERS
116Optic NeuropathyFAERS: 2US FAERS
117Oral fungal infectionFAERS: 2US FAERS
118Oropharyngeal painFAERS: 2OFFSIDES
SIDER
US FAERS
119PneumothoraxFAERS: 2US FAERS
120PregnancyFAERS: 2SIDER
US FAERS
121Productive CoughFAERS: 2US FAERS
122Pulmonary toxicityFAERS: 2SIDER
US FAERS
123Septic ShockFAERS: 2
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
124SyncopeFAERS: 2US FAERS
125Therapy non-responderFAERS: 2US FAERS
126Throat irritationFAERS: 2US FAERS
127Treatment related secondary malignancyFAERS: 2OFFSIDES
US FAERS
128Urinary RetentionFAERS: 2US FAERS
129Urinary bladder atrophyFAERS: 2US FAERS
130UrticariaFAERS: 2
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
131Water IntoxicationFAERS: 27633237CTD
SIDER
US FAERS
132AbscessFAERS: 1OFFSIDES
US FAERS
133Accidental needle stickFAERS: 1US FAERS
134AcidosisFAERS: 1US FAERS
135Actinic keratosisFAERS: 1US FAERS
136Acute Lung InjuryFAERS: 1US FAERS
137Acute respiratory failureFAERS: 1US FAERS
138AgeusiaFAERS: 1US FAERS
139AgitationFAERS: 1SIDER
US FAERS
140Altered state of consciousnessFAERS: 1US FAERS
141Anal sphincter atonyFAERS: 1US FAERS
142AngerFAERS: 1OFFSIDES
US FAERS
143AngioedemaFAERS: 1US FAERS
144AnosmiaFAERS: 1US FAERS
145Antibody test abnormalFAERS: 1US FAERS
146AnxietyFAERS: 1OFFSIDES
US FAERS
147AphasiaFAERS: 1US FAERS
148ArthritisFAERS: 1US FAERS
149AspergillosisFAERS: 1US FAERS
150AsthmaFAERS: 1US FAERS
151Atrial FlutterFAERS: 1US FAERS
152Atrial hypertrophyFAERS: 1US FAERS
153Atrial tachycardiaFAERS: 1OFFSIDES
US FAERS
154Autonomic nervous system imbalanceFAERS: 1US FAERS
155AzoospermiaFAERS: 1

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CTD
SIDER
US FAERS
156Bacillus infectionFAERS: 1US FAERS
157Back PainFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
158Bladder spasmFAERS: 1SIDER
US FAERS
159Blood count abnormalFAERS: 1US FAERS
160Blood phosphorus increasedFAERS: 1US FAERS
161Blood potassium decreasedFAERS: 1US FAERS
162Blood sodium decreasedFAERS: 1US FAERS
163Blood testosterone decreasedFAERS: 1US FAERS
164Blood urine presentFAERS: 1US FAERS
165BradycardiaFAERS: 1SIDER
US FAERS
166Brain DeathFAERS: 1US FAERS
167BronchitisFAERS: 1OFFSIDES
US FAERS
168Candida test positiveFAERS: 1US FAERS
169CandidiasisFAERS: 1US FAERS
170Cardiac HypertrophyFAERS: 1US FAERS
171Catheter site cellulitisFAERS: 1US FAERS
172Catheter site painFAERS: 1US FAERS
173CellulitisFAERS: 1US FAERS
174Cerebral InfarctionFAERS: 1US FAERS
175Cervical dysplasiaFAERS: 1OFFSIDES
US FAERS
176Cholecystitis infectiveFAERS: 1US FAERS
177Colon adenomaFAERS: 1OFFSIDES
US FAERS
178ConjunctivitisFAERS: 1SIDER
US FAERS
179Consciousness fluctuatingFAERS: 1US FAERS
180Coronary Artery DiseaseFAERS: 1US FAERS
181CystitisFAERS: 1

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18149
231445
275611
433043
448907
464465
475846
516210
566262
597704
671649
758164
779796
941352
1054198
1059500
1138180
1166056
1180990
1193816
1235376
1267567
1274014
1289337
1392448
1404668
1422497
1434892
1468485
1523745
1545575
1589052
1613209
1682346
1844164
1941060
1949449
2162975
2193606
2231904
2231956
2351321
2359176
2369708
2463404
2705179
3016343
3090278
3143903
3201641
3335893
3338015
3352696
3358809
3361664
3403354
3422144
3473240
3522468
3982369
4029236
4032564
4061203
4131908
4312029
4406826
4551437
4559404
4684988
4700007
4722431
4740525
4743552
4768748
4804423
4812765
4833912
4981054
5109123
5345768
5638060
6134004
6245359
6392368
6414695
6423841
6433044
6437430
6441037
6530353
6587802
6784476
6792207
6799018
6887415
7123717
7161662
7351704
7377464
7498375
7570271
7785558
7801847
8068996
8109471
8126788
8134990
8158849
8199556
8230534
8317316
8422728
8455230
8518042
8586509
8602705
8634684
8739323
8801023
8801120
8808730
8817519
8944508
9006340
9012476
9026944
9063711
9112569
9146658
9469534
9486479
9598647
9776515
9792975
10100560
10204687
10332487
10457601
10498854
10510257
10536274
10569621
10637075
10683293
10700343
10714091
10754506
10840460
10854767
10904158
11046124
11176454
11282106
11284451
11312054
11393582
11435893
11485512
11490309
11948286
12059909
12161096
12235553
12351708
12388444
12406105
12412144
12762384
12913734
12913760
14518387
14634459
14673513
14694538
15022166
15099680
15153656
15232716
15247759
15276878
15302998
15485083
15592042
15643279
15743398
15800758
15821589
16039053
16125470
16322346
16413132
16430652
16461118
16491427
16527596
16614059
16651033
16763356
16889433
16989017
17010015
17110531
17133240
17244258
17335920
17392493
17409261
17537839
17589053
17917716
17979934
18088559
18093676
18189308
18206168
18210232
18246091
18295254
18296739
18299998
18322018
18372110
18380828
18398616
18433785
18436507
18483878
18514386
18563302
18632792
18710439
18786597
18797299
18842820
18848347
18957084
19051698
19066630
19251306
19413659
19418546
19553095
19560793
19618450
19625377
19638304
19654953
19666069
19691848
19735460
19996110
20032115
20127836
20186394
20661687
22099998
22961095
23523557
23666265
23695977
27234646
29129814
CTD
SIDER
US FAERS
182CytopeniaFAERS: 1US FAERS
183Cytotoxic cardiomyopathyFAERS: 1US FAERS
184DemyelinationFAERS: 1OFFSIDES
US FAERS
185Depressed Level of ConsciousnessFAERS: 1US FAERS
186DermatitisFAERS: 1SIDER
US FAERS
187Device leakageFAERS: 1US FAERS
188DiplopiaFAERS: 1OFFSIDES
US FAERS
189Drug effect incompleteFAERS: 1US FAERS
190Drug exposure during pregnancyFAERS: 1US FAERS
191Drug monitoring procedure incorrectly performedFAERS: 1US FAERS
192Drug prescribing errorFAERS: 1US FAERS
193DysarthriaFAERS: 1US FAERS
194DyspepsiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
195DysphoniaFAERS: 1US FAERS
196DysuriaFAERS: 1
Canada Vigilance: 3

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CTD
Canada Vigilance
US FAERS
197Echocardiogram abnormalFAERS: 1US FAERS
198Electrolyte imbalanceFAERS: 1US FAERS
199Enterococcus test positiveFAERS: 1US FAERS
200EpicondylitisFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
201EpilepsyFAERS: 1US FAERS
202Erectile dysfunctionFAERS: 1US FAERS
203Erythema NodosumFAERS: 1US FAERS
204Escherichia infectionFAERS: 1US FAERS
205Euphoric moodFAERS: 1US FAERS
206Exposure via fatherFAERS: 1US FAERS
207Eye inflammationFAERS: 1US FAERS
208Eye irritationFAERS: 1US FAERS
209Failure to ThriveFAERS: 1OFFSIDES
US FAERS
210Fanconi SyndromeFAERS: 1US FAERS
211Febrile bone marrow aplasiaFAERS: 1US FAERS
212Feeling abnormalFAERS: 1SIDER
US FAERS
213Focal Nodular HyperplasiaFAERS: 1US FAERS
214Full blood count abnormalFAERS: 1US FAERS
215Full blood count decreasedFAERS: 1US FAERS
216Gastrointestinal perforationFAERS: 1US FAERS
217General physical health deteriorationFAERS: 1US FAERS
218Genital HerpesFAERS: 1US FAERS
219Gestational DiabetesFAERS: 1US FAERS
220Graft versus host disease in gastrointestinal tractFAERS: 1US FAERS
221Graft versus host disease in liverFAERS: 1US FAERS
222Granulomatosis with polyangiitisFAERS: 1

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CTD
SIDER
US FAERS
223HaematotoxicityFAERS: 1US FAERS
224HemiparesisFAERS: 1US FAERS
225Hepatic necrosisFAERS: 1US FAERS
226Hepatitis B VirusFAERS: 1US FAERS
227HepatitisFAERS: 1SIDER
US FAERS
228HydrocephalusFAERS: 1US FAERS
229HyperpyrexiaFAERS: 1US FAERS
230Hypertensive EncephalopathyFAERS: 1US FAERS
231ImmunosuppressionFAERS: 1US FAERS
232Incorrect dose administeredFAERS: 1US FAERS
233InflammationFAERS: 1

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CTD
SIDER
US FAERS
234InfluenzaFAERS: 1US FAERS
235Labile blood pressureFAERS: 1US FAERS
236LacerationFAERS: 1US FAERS
237LaryngitisFAERS: 1US FAERS
238LeukocytosisFAERS: 1US FAERS
239Lung InjuryFAERS: 112114195
25451569
CTD
US FAERS
240Lyme DiseaseFAERS: 1US FAERS
241MetastasisFAERS: 1US FAERS
242Monocyte count increasedFAERS: 1US FAERS
243Multiple SclerosisFAERS: 1OFFSIDES
US FAERS
244Muscle RigidityFAERS: 1US FAERS
245Myasthenia GravisFAERS: 1US FAERS
246MyopathyFAERS: 1US FAERS
247Neck PainFAERS: 1US FAERS
248NecrosisFAERS: 1

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CTD
SIDER
US FAERS
249NeurodermatitisFAERS: 1US FAERS
250NeuropathyFAERS: 1US FAERS
251NoduleFAERS: 1US FAERS
252OnycholysisFAERS: 1US FAERS
253Oral candidiasisFAERS: 1US FAERS
254Oral painFAERS: 1US FAERS
255OverdoseFAERS: 1US FAERS
256Peptic UlcerFAERS: 1US FAERS
257PericarditisFAERS: 1

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CTD
SIDER
US FAERS
258Perirectal abscessFAERS: 1US FAERS
259PeritonitisFAERS: 1US FAERS
260Pharmaceutical product complaintFAERS: 1US FAERS
261Pharyngolaryngeal PainFAERS: 1US FAERS
262PhotophobiaFAERS: 1US FAERS
263Pneumocystis jiroveci pneumoniaFAERS: 1OFFSIDES
US FAERS
264PneumonitisFAERS: 1US FAERS
265PolyneuropathyFAERS: 1SIDER
US FAERS
266Poor quality drug administeredFAERS: 1US FAERS
267Poor quality sleepFAERS: 1US FAERS
268Portal hypertensive gastropathyFAERS: 1US FAERS
269Post procedural complicationFAERS: 1US FAERS
270Procedural complicationFAERS: 1US FAERS
271Product administration errorFAERS: 1US FAERS
272Product quality issueFAERS: 1US FAERS
273Product substitution issueFAERS: 1US FAERS
274Pseudomonas test positiveFAERS: 1US FAERS
275Pulmonary EmbolismFAERS: 13192036CTD
SIDER
US FAERS
276Pulmonary arterial hypertensionFAERS: 1US FAERS
277Pulmonary function test decreasedFAERS: 1US FAERS
278Punctate keratitisFAERS: 1US FAERS
279Puncture site reactionFAERS: 1US FAERS
280PurpuraFAERS: 1US FAERS
281PyelonephritisFAERS: 11488776CTD
US FAERS
282QuadriplegiaFAERS: 1US FAERS
283Remission not achievedFAERS: 1US FAERS
284Respiratory DepressionFAERS: 1US FAERS
285Respiratory distressFAERS: 1SIDER
US FAERS
286Rheumatoid ArthritisFAERS: 1US FAERS
287RhinalgiaFAERS: 1US FAERS
288Serratia sepsisFAERS: 1US FAERS
289Skin PapillomaFAERS: 1US FAERS
290Skin UlcerFAERS: 1US FAERS
291Solar lentigoFAERS: 1US FAERS
292Stem cell transplantFAERS: 1OFFSIDES
US FAERS
293StomatitisFAERS: 111019834CTD
SIDER
US FAERS
294StrongyloidiasisFAERS: 1US FAERS
295Supportive careFAERS: 1US FAERS
296Supraventricular tachycardiaFAERS: 1OFFSIDES
US FAERS
297SwellingFAERS: 1SIDER
US FAERS
298SynovitisFAERS: 13970039CTD
US FAERS
299Terminal stateFAERS: 1US FAERS
300Therapeutic response delayedFAERS: 1US FAERS
301Therapeutic response unexpectedFAERS: 1US FAERS
302Therapy changeFAERS: 1US FAERS
303Thrombocytopenic purpuraFAERS: 1US FAERS
304ThrombosisFAERS: 1SIDER
US FAERS
305ToothacheFAERS: 1US FAERS
306Troponin increasedFAERS: 1US FAERS
307UlcerFAERS: 1SIDER
US FAERS
308Unresponsive to stimuliFAERS: 1OFFSIDES
US FAERS
309Urinary IncontinenceFAERS: 13361664CTD
US FAERS
310Ventricular FibrillationFAERS: 1SIDER
US FAERS
311Ventricular failureFAERS: 1US FAERS
312Weight decreasedFAERS: 1US FAERS
313Wrong patient received medicationFAERS: 1US FAERS
314nervous system disorderFAERS: 1US FAERS
315Abdominal InfectionOFFSIDES
316Abdominal symptomOFFSIDES
317Abdominal tendernessOFFSIDES
318Abnormal visionOFFSIDES
319Abnormalities, Drug-Induced

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CTD
320AcanthosisOFFSIDES
321Achromotrichia acquiredOFFSIDES
322Acute Coronary SyndromeSIDER
323Acute cardiac toxicitySIDER
324Acute graft versus host disease in intestineOFFSIDES
325Acute graft versus host disease in liverOFFSIDES
326Acute psychosisOFFSIDES
327Acute sinusitisOFFSIDES
328AdenitisOFFSIDES
329Adenocarcinoma

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CTD
330Adenomatosis, Pulmonary391238CTD
331Alkalosis582354CTD
332Amenorrhea779796
16207182
CTD
333Anaphylactic shockSIDER
334Anaphylactoid ReactionCanada Vigilance: 1Canada Vigilance
335Anemia, Hemolytic6027686CTD
336Anemia, Macrocytic4406826CTD
337Anemia, Megaloblastic15656036CTD
338Anemia

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CTD
339Aneurysm10813312
18592134
CTD
340Angina Pectoris18849242CTD
341AnhidrosisOFFSIDES
342Anti-Glomerular Basement Membrane Disease3587472CTD
343Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis16188901CTD
344Antiphospholipid Syndrome15658543CTD
345Application site cellulitisOFFSIDES
346Arterial thrombosisOFFSIDES
347Arteriosclerosis15014928CTD
348Arteritis9829497
19078457
CTD
349ArthralgiaSIDER
350ArthropathyOFFSIDES
351AscitesCanada Vigilance: 1Canada Vigilance
SIDER
352Aseptic MeningitisOFFSIDES
353Ataxia9523741CTD
354AtelectasisOFFSIDES
355Atrioventricular Block17223814CTD
356Autoimmune Diseases6392368
18034189
CTD
357Autoimmune thrombocytopeniaOFFSIDES
358Azotemia4833837CTD
359Bacterial colonisationSIDER
360Bacterial disease carrierSIDER
361Bacterial sepsisOFFSIDES
362BalanitisOFFSIDES
363Behcet Syndrome6788612CTD
364Bile duct stent insertionOFFSIDES
365Biopsy bone abnormalOFFSIDES
366Bipolar DisorderOFFSIDES
367Bladder necrosisSIDER
368Bladder painSIDER
369Blepharophimosis10482872CTD
370BlepharospasmOFFSIDES
371Blood Platelet Disorders7498364CTD
372Blood alkaline phosphatase increasedOFFSIDES
373Blood cholesterolOFFSIDES
374Blood galactose increasedOFFSIDES
375Blood glucose decreasedSIDER
376Blood glucose increasedSIDER
377Blood lactate dehydrogenase increasedSIDER
378Blood sodium abnormalOFFSIDES
379Blood sodium increasedOFFSIDES
380Blood stem cell transplant failureOFFSIDES
381Blood triglycerides increasedOFFSIDES
382Blood urea abnormalOFFSIDES
383Blood uric acidOFFSIDES
384Bone Marrow Diseases

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CTD
385Bone Marrow Neoplasms2214347CTD
386Bone infarctionOFFSIDES
387Bone lesionOFFSIDES
388Bone marrow depressionOFFSIDES
389Bone painOFFSIDES
390Bone scan abnormalOFFSIDES
391Brain AbscessOFFSIDES
392Brain Injuries7194589CTD
393Bronchoalveolar LavageOFFSIDES
394BruxismOFFSIDES
395Burkitt Lymphoma

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CTD
396CD4 Lymphocytes DecreasedOFFSIDES
397CD8 lymphocytes decreasedOFFSIDES
398CYTOMEGALOVIRUS ANTIGENOFFSIDES
399Candida pneumoniaOFFSIDES
400Candida sepsisOFFSIDES
401Capillary Leak SyndromeOFFSIDES
402Carcinoma, Ehrlich Tumor14641813CTD
403Carcinoma, Large Cell6301671CTD
404Carcinoma, Lewis Lung10766175
16152834
16166447
CTD
405Carcinoma, Ovarian Epithelial2915238CTD
406Carcinoma, Small Cell165045CTD
407Carcinoma, Transitional Cell

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CTD
408Carcinoma

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CTD
409Carcinosarcoma346364CTD
410Cardiomegaly6250267CTD
411Cardiomyopathies

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CTD
412CarditisSIDER
413Catalepsy11180191CTD
414Catheter related infectionOFFSIDES
415Cavernous Sinus Thrombosis10713653CTD
416Central venous catheter removalOFFSIDES
417Cerebral Hemorrhage4946006CTD
418Chemical and Drug Induced Liver Injury

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CTD
419Chemical cystitisSIDER
420Choking sensationOFFSIDES
421CholangiolitisOFFSIDES
422Cholecystitis2910431
7612498
CTD
423Chromosome Aberrations17176674
31369745
CTD
424Chromosome Breakage25113976CTD
425Chronic sinusitisOFFSIDES
426Cleft Palate19851987CTD
427Cognition Disorders16914590
18506671
18777410
CTD
428Complex partial seizuresOFFSIDES
429Complications of bone marrow transplantOFFSIDES
430Compression fractureOFFSIDES
431Conjunctival depositOFFSIDES
432Consciousness Disorders11132226CTD
433Constipation10084258CTD
SIDER
434Coronary Vessel Anomalies5539280CTD
435CyanosisOFFSIDES
436Cytolytic hepatitisSIDER
437Cytomegalovirus Retinitis12488280CTD
438DebridementOFFSIDES
439Depressed moodOFFSIDES
440Depressive disorder6293321CTD
441Dermatitis, Atopic22842586CTD
442Dermatomyositis12492978
18625537
CTD
SIDER
443Desmoplastic Small Round Cell Tumor10555010CTD
444Developmental Disabilities10482872CTD
445Device related infectionOFFSIDES
446Diabetes Mellitus, Experimental10990075
11751995
15331540
CTD
447Diabetes MellitusSIDER
448Diarrhea

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CTD
OFFSIDES
449DiscomfortSIDER
450Disease complicationOFFSIDES
451Disseminated Intravascular CoagulationOFFSIDES
SIDER
452DiuresisSIDER
453Drug withdrawal headacheOFFSIDES
454Dry coughSIDER
455DysmenorrheaOFFSIDES
456Dyspnea, Paroxysmal25023062CTD
457Dyspnea6250267
11990877
CTD
458Ectrodactyly19103281CTD
459Ectromelia8870961CTD
460EczemaOFFSIDES
461Edema

View details

CTD
462Electrocardiogram abnormalCanada Vigilance: 1Canada Vigilance
463EmbolismSIDER
464Embryo Loss22454429CTD
465Emotional distressOFFSIDES
466Endodontic procedureOFFSIDES
467Endometrial Neoplasms2227540CTD
468Endomyocardial Fibrosis20014201CTD
469Endophthalmitis11232733CTD
470Engraftment syndromeOFFSIDES
471Enteritis9815949CTD
SIDER
472Enterocolitis viralOFFSIDES
473EnterocolitisSIDER
474Epidural lipomatosisOFFSIDES
475Epstein-Barr virus associated lymphoproliferative disorderOFFSIDES
476Erythema MultiformeSIDER
477Esophageal Neoplasms7844616CTD
478Exanthema1677714
1679512
CTD
479Extravasation of Diagnostic and Therapeutic Materials

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CTD
480Fetal Diseases10378468CTD
481Fever

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CTD
482Fibrosis3627313
4203163
4321778
CTD
SIDER
483Flank PainOFFSIDES
484Fluid overloadSIDER
485FolliculitisOFFSIDES
486Food PoisoningOFFSIDES
487Gastric BypassOFFSIDES
488GastroenteritisSIDER
489Gastrointestinal Diseases19274460
24673398
CTD
490Gastrointestinal Hemorrhage17009033CTD
491Gastrointestinal arteriovenous malformationOFFSIDES
492Generalized urticariaSIDER
493Genomic Instability21527772CTD
494Gingival HypertrophyOFFSIDES
495Glioma7834628
12481416
CTD
OFFSIDES
496Glomerulonephritis

View details

CTD
497Glycosuria16207182CTD
498Gonadal Disorders6392368CTD
499GranulomaOFFSIDES
500Growth Disorders10482872CTD
501Growth retardationSIDER
502Guillain-Barre Syndrome11960272CTD
503Hearing Loss

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CTD
504Heart Block4024836
8122625
CTD
505Heart Diseases

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CTD
506Heart Failure, Diastolic12227700
17562616
CTD
507Heart Failure, Systolic18462404CTD
508Heart failure

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CTD
509Hematologic Neoplasms

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CTD
510Hematoma19103281CTD
511Hematuria

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CTD
512Hemophilia A11918545CTD
513Hemorrhage

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CTD
514Hemorrhagic Disorders4543722
4700007
CTD
515Hemorrhagic colitisSIDER
516Hepatic EncephalopathySIDER
517Hepatic Veno-Occlusive Disease

View details

CTD
518Hepatitis B virus testOFFSIDES
519Hepatitis, Chronic1144250CTD
520HepatomegalyCanada Vigilance: 121439308CTD
SIDER
Canada Vigilance
521Hepatosplenic candidiasisOFFSIDES
522HepatosplenomegalyOFFSIDES
523Hilar lymphadenopathyOFFSIDES
524Histiocytosis haematophagicOFFSIDES
525Hodgkin Disease

View details

CTD
526Hydronephrosis1488776
10507982
10637075
CTD
527Hyperalgesia

View details

CTD
528Hyperbilirubinemia9815949
12406916
CTD
529Hyperemia6896169
9792975
CTD
530Hyperkalemia4833837CTD
531HyperpigmentationOFFSIDES
532Hyperplasia

View details

CTD
533Hypesthesia16414547CTD
534Hypocalcemia4833837
10637075
CTD
535HypogeusiaSIDER
536Hypokalemia582354
10637075
CTD
537Hyponatremia

View details

CTD
538HypothrombinaemiaSIDER
539Hypothyroidism10526668CTD
540HypoxemiaSIDER
541HypoxiaOFFSIDES
SIDER
542Immune System Diseases16076520
23395935
24520311
CTD
543Immunodeficiency congenitalOFFSIDES
544Incision site infectionOFFSIDES
545InfertilitySIDER
546Injection Site ReactionCanada Vigilance: 1Canada Vigilance
547Injection site painSIDER
548Intervertebral disc disorderOFFSIDES
549Intestinal PerforationCanada Vigilance: 1Canada Vigilance
550IridocyclitisOFFSIDES
551Joint Range of Motion DecreasedOFFSIDES
552Kidney Diseases

View details

CTD
553Kidney Papillary Necrosis1488776CTD
554LacrimationSIDER
555Leukemia L121010766175CTD
556Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative1349249CTD
557Leukemia, Plasma Cell4571885
9404934
CTD
558Leukemia, T-Cell11960272CTD
559Leukoencephalopathy, Progressive Multifocal9149702CTD
560Leukopenia neonatalOFFSIDES
561Life expectancy shortenedOFFSIDES
562Limb Deformities, Congenital10482872CTD
563Livedo ReticularisOFFSIDES
564Liver Abscess10861821CTD
565Liver Cirrhosis17786148CTD
566Liver Failure, Acute8946814
19008178
26718876
CTD
567Liver Failure5454367CTD
568Liver Neoplasms, Experimental20038455CTD
569Liver diseases9251722
17580253
CTD
570Liver neoplasms9523741
18298334
CTD
571Loose toothOFFSIDES
572Lumbar radiculopathyOFFSIDES
573Lung Diseases, Interstitial8976077
19653137
CTD
574Lung Neoplasms3040918
18298334
CTD
575Lung diseases9585095
18592134
CTD
576Lupus Erythematosus, Systemic

View details

CTD
577Lupus ErythematosusSIDER
578Lupus Nephritis

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CTD
579Lupus Vasculitis, Central Nervous System2056144CTD
580Lymph nodes scan abnormalOFFSIDES
581LymphangitisOFFSIDES
582Lymphocyte count decreasedOFFSIDES
583Lymphoma, AIDS-Related8697399CTD
584Lymphoma, Extranodal NK-T-Cell20839428CTD
585Lymphoma, Non-Hodgkin

View details

CTD
586Malignant ascitesOFFSIDES
587Mammary Neoplasms, Experimental9869567CTD
588Mass excisionOFFSIDES
589MastectomyOFFSIDES
590Mastication disorderOFFSIDES
591Mediastinal massOFFSIDES
592Medulloblastoma19701718CTD
593Melanoma, Experimental16388313CTD
594Memory Disorders

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CTD
595MenorrhagiaSIDER
596Menstruation Disturbances16207182CTD
597MetaplasiaOFFSIDES
598Metastases to abdominal cavityCanada Vigilance: 1Canada Vigilance
599Metastatic NeoplasmOFFSIDES
SIDER
600Micronuclei, Chromosome-Defective

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CTD
601Microscopic hematuriaSIDER
602Mitral Valve Insufficiency17562616
18548196
CTD
603Mononeuropathies9146079CTD
604Mood disorder due to a general medical conditionOFFSIDES
605MucormycosisOFFSIDES
606Multiple Myeloma

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CTD
607Multiple Sclerosis, Chronic Progressive11990877CTD
608Muscle Weakness9404148CTD
609Muscle strainCanada Vigilance: 1Canada Vigilance
610Musculoskeletal chest painOFFSIDES
611Musculoskeletal discomfortSIDER
612Myelinolysis, Central Pontine18988633CTD
613MyelitisOFFSIDES
614MyelodysplasiaOFFSIDES
615MyelosuppressionSIDER
616Myocardial Ischemia3208781CTD
617Myocardial fibrosisOFFSIDES
618Myocardial necrosisSIDER
619MyopericarditisSIDER
620MyopiaSIDER
621Nail changesSIDER
622NasopharyngitisSIDER
623Neoplasm Metastasis

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CTD
624Neoplasms, Bone Tissue278643CTD
625Neoplasms, Experimental

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CTD
626Neoplasms, Hormone-Dependent12058236CTD
627Neoplasms

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CTD
628Nephrogenic Diabetes InsipidusSIDER
629Nephrosis4961747CTD
630Nephrotic Syndrome

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CTD
631Nerve BlockOFFSIDES
632Neural Tube Defects

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CTD
633Neuralgia16414547CTD
OFFSIDES
SIDER
634Neuroblastoma

View details

CTD
635Neuroectodermal Tumors8761367
12837982
CTD
636Neuromuscular Diseases278643CTD
637Neurotoxicity Syndromes11275465CTD
638Neutropenic colitisOFFSIDES
639Neutropenic infectionOFFSIDES
640Nociceptive Pain29129814CTD
641ObstipationSIDER
642Oligospermia6788612
9166702
16517039
CTD
SIDER
643Oliguria18398616CTD
644Optic NeuritisOFFSIDES
645OrchitisOFFSIDES
646OsteolysisOFFSIDES
647Osteomyelitis drainageOFFSIDES
648OsteomyelitisOFFSIDES
649OsteoporosisOFFSIDES
650Osteosarcoma

View details

CTD
651Ovarian Diseases3130466CTD
652Oxygen consumption increasedOFFSIDES
653Palmar-plantar erythemaSIDER
654PalpitationsSIDER
655Papilloma710474
6401591
6414697
CTD
656ParanoiaOFFSIDES
657Paresthesia

View details

CTD
658Parotid gland inflammationSIDER
659Pemphigus7657447
16207182
19915258
CTD
660PeriodontitisOFFSIDES
661Peripheral Nervous System Diseases

View details

CTD
662Peritoneal DialysisOFFSIDES
663PetechiaeCanada Vigilance: 1Canada Vigilance
664PhlebitisSIDER
665Pilonidal CystOFFSIDES
666PlasmacytomaOFFSIDES
667Pleural InfectionOFFSIDES
668PleuropericarditisCanada Vigilance: 2Canada Vigilance
669Polyarteritis Nodosa2870689
9146079
10813312
CTD
670PolychondritisOFFSIDES
671Polyploidy25113976CTD
672PolyuriaOFFSIDES
SIDER
673Porphyria Cutanea Tarda3410226CTD
674Precancerous Conditions2444767CTD
675Precursor B-Cell Lymphoblastic Leukemia-Lymphoma18191947
21064136
CTD
676Precursor T-Cell Lymphoblastic Leukemia-Lymphoma20167372
20463610
CTD
677Prenatal Injuries8312451
8870961
11056294
CTD
678Primary mediastinal large B-cell lymphoma stage IIOFFSIDES
679Prinzmetal's variant angina3208781CTD
680Prolonged mensesSIDER
681Prostatic Neoplasms

View details

CTD
682Proteinuria3270085
14563468
16234291
CTD
683PrurigoSIDER
684Pseudomonal sepsisOFFSIDES
685Pulmonary Edema4833912CTD
686Pulmonary HypertensionOFFSIDES
SIDER
687Pulmonary artery thrombosisOFFSIDES
688Purulent dischargeOFFSIDES
689Pyelitis2231904
10637075
CTD
690Radiation injurySIDER
691RalesSIDER
692Recall phenomenonSIDER
693Recurrence2214347CTD
694RednessSIDER
695Reflex, Abnormal

View details

CTD
696Renal Cell CarcinomaSIDER
697Renal Insufficiency

View details

CTD
698Renal tubular disorderSIDER
699Renal tubular necrosisSIDER
700Respiratory syncytial virus test positiveOFFSIDES
701Respiratory tract congestionOFFSIDES
702Reticulocyte count increasedOFFSIDES
703Retinal DegenerationOFFSIDES
704Retinal Diseases1794789CTD
705Retinal infarctionOFFSIDES
706Retinoblastoma9616283CTD
707Retinoic acid syndromeOFFSIDES
708Rhabdomyolysis8832525CTD
SIDER
709Rhabdomyosarcoma857581
9191535
18989167
CTD
710Rheumatoid Vasculitis14691658CTD
711RhinitisSIDER
712Risus sardonicusOFFSIDES
713Sarcoidosis9916671CTD
714Sarcoma, Experimental7107385
11245434
CTD
715Sarcoma3047339
15205092
CTD
SIDER
716SclerodermaOFFSIDES
SIDER
717Seizures11042651
11132226
CTD
718Sensation Disorders12911718CTD
719SequestrectomyOFFSIDES
720Shock, Cardiogenic7707444CTD
721Sialadenitis901598CTD
722SinusitisOFFSIDES
723Skin IndurationOFFSIDES
724Skin WrinklingOFFSIDES
725Skin hypertrophyOFFSIDES
726Skin lacerationOFFSIDES
727Skin lesionOFFSIDES
728Skin tightnessOFFSIDES
729Sleep Wake Disorders12911718
20861613
CTD
730Sleep disorder due to a general medical conditionOFFSIDES
731SneezingSIDER
732Soft Tissue InfectionOFFSIDES
733Soft tissue inflammationOFFSIDES
734Spinal Cord Diseases9404148CTD
735Staphylococcal Infections27737899CTD
736Staphylococcal Scalded Skin SyndromeOFFSIDES
737Staphylococcal abscessOFFSIDES
738Status Epilepticus14631624CTD
739Stenotrophomonas infectionOFFSIDES
740Stevens-Johnson Syndrome25811541CTD
SIDER
741StillbirthSIDER
742Stress ulcerOFFSIDES
743StridorOFFSIDES
744SubileusOFFSIDES
745Superior Vena Cava Syndrome19770526CTD
746Supratentorial Neoplasms12837982CTD
747SweatingSIDER
748Synovial CystOFFSIDES
749T-Cell LymphomaOFFSIDES
750Telangiectasis

View details

CTD
751Teratoma2859431CTD
752Testicular Diseases25446862CTD
753Testicular Neoplasms5027400CTD
754ThoracotomyOFFSIDES
755ThromboembolismSIDER
756Thrombophlebitis17461902CTD
757Thrombosis in deviceOFFSIDES
758ThyroiditisOFFSIDES
759Tinnitus19415035CTD
SIDER
760Tooth ExtractionOFFSIDES
761Tooth InfectionOFFSIDES
762Toxic Epidermal NecrolysisSIDER
763Toxoplasmosis5120183CTD
764TuberculosisSIDER
765Tumor Lysis Syndrome16313266CTD
766Uremia582354CTD
767Ureteral Diseases2231904
10637075
CTD
768UreteritisSIDER
769Urethral ObstructionOFFSIDES
770Urge IncontinenceOFFSIDES
771Urinary Bladder Diseases

View details

CTD
772Urination Disorders

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CTD
773Urine flow decreasedSIDER
774Urologic Diseases67817
2810938
7148457
CTD
775Urologic Neoplasms2981619CTD
776Vanishing bile duct syndromeOFFSIDES
777Vascular Diseases7148457
17164692
CTD
778Vascular graft complicationOFFSIDES
779Vasculitis, Leukocytoclastic, Cutaneous2764806
17657683
CTD
780Venoocclusive diseaseOFFSIDES
SIDER
781Venous Thrombosis15048060
15658543
CTD
SIDER
782Ventricular Dysfunction, Left

View details

CTD
783Ventricular Outflow Obstruction20014201CTD
784Ventricular arrhythmiaSIDER
785Vesico-Ureteral Reflux6887415CTD
786Viral DNA test positiveOFFSIDES
787Viral pharyngitisOFFSIDES
788Vision Disorders

View details

CTD
789Visual ImpairmentSIDER
790Vitamin B 12 Deficiency15656036CTD
791Water-Electrolyte Imbalance582354CTD
792Weight Gain4812765CTD
793Wound ComplicationOFFSIDES
794Wound DebridementOFFSIDES
795Wound healing normalSIDER
796bone marrow fibrosisOFFSIDES
797colonoscopyOFFSIDES
798gliosarcoma9766669
11389073
CTD
799leiomyosarcoma

View details

CTD
800leukemia572348
10602166
18034189
CTD
801melanoma18298334
20423231
CTD
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