MetaADEDB 2.0 @ LMMD
Folic Acid
(OVBPIULPVIDEAO-LBPRGKRZSA-N)
Structure
SMILES
OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)NCc1cnc2c(n1)c(=O)[nH]c(n2)N
Type(s)
Approved; Nutraceutical; Vet_approved
ATC code(s)
B03AE01; B03AE02; B03BB01; B03BB51
Molecular Formula:
C19H19N7O6
Molecular Weight:
441.397
Log P:
1.0003
Hydrogen Bond Acceptor:
12
Hydrogen Bond Donor:
6
TPSA:
213.28
CAS Number(s):
59-30-3
Synonym(s)
1.
Folic Acid
2.
Pteroylglutamic Acid
3.
Vitamin M
4.
Folacin
5.
Folate
6.
Folic Acid, (D)-Isomer
7.
Folic Acid, (DL)-Isomer
8.
Folic Acid, Calcium Salt (1:1)
9.
Folic Acid, Monopotassium Salt
10.
Folic Acid, Monosodium Salt
11.
Folic Acid, Potassium Salt
12.
Folic Acid, Sodium Salt
13.
Folvite
14.
Vitamin B9
15.
B9, Vitamin
External Link(s)
MeSHD005492
PubChem Compound6037
135398658
BindingDB50367343
50237629
ChEBI27470
CHEMBLCHEMBL1622
DrugBankDB00158
DrugCentral1231
IUPHAR/BPS Guide to PHARMACOLOGY4562
4563
KEGGcpd:C00504
dr:D00070
Therapeutic Target DatabaseD0Z0DW
D09BGR
D08OTA
ZINC8577218
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1MeningomyeloceleFAERS: 1825885259CTD
US FAERS
2AnencephalyFAERS: 1212397633
15846825		CTD
US FAERS
3EncephaloceleFAERS: 12US FAERS
4Toxicity to various agentsFAERS: 11US FAERS
5Low birth weight babyFAERS: 8
Canada Vigilance: 3		Canada Vigilance
US FAERS
6Spina BifidaFAERS: 8US FAERS
7Completed SuicideFAERS: 7US FAERS
8Cerebral ventricle dilatationFAERS: 6US FAERS
9HydrocephalusFAERS: 614324085CTD
US FAERS
10Maternal exposure during pregnancyFAERS: 6US FAERS
11NauseaFAERS: 6
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
12DizzinessFAERS: 53214955CTD
OFFSIDES
US FAERS
13Drug ineffectiveFAERS: 5US FAERS
14MeningoceleFAERS: 5US FAERS
15Vascular insufficiencyFAERS: 5US FAERS
16Gestational DiabetesFAERS: 4US FAERS
17HypersensitivityFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
18Intellectual DisabilityFAERS: 4US FAERS
19Intentional product misuseFAERS: 4US FAERS
20DementiaFAERS: 37527320CTD
US FAERS
21Hepatic necrosisFAERS: 3US FAERS
22HypersomniaFAERS: 3US FAERS
23MalaiseFAERS: 3SIDER
US FAERS
24PalpitationsFAERS: 3US FAERS
25PruritusFAERS: 3SIDER
US FAERS
26Renal tubular necrosisFAERS: 3US FAERS
27TremorFAERS: 3US FAERS
28Anaphylactic shockFAERS: 2SIDER
US FAERS
29AnxietyFAERS: 2US FAERS
30Aortic AneurysmFAERS: 2OFFSIDES
US FAERS
31Drug dispensing errorFAERS: 2US FAERS
32Drug prescribing errorFAERS: 2US FAERS
33FatigueFAERS: 2OFFSIDES
US FAERS
34Gastrointestinal perforationFAERS: 2US FAERS
35HeadacheFAERS: 23214955CTD
US FAERS
36Medication ErrorFAERS: 2US FAERS
37Metabolic acidosisFAERS: 2US FAERS
38Oropharyngeal painFAERS: 2US FAERS
39OverdoseFAERS: 2OFFSIDES
US FAERS
40Product use issueFAERS: 2US FAERS
41ShockFAERS: 2US FAERS
42Spina Bifida OccultaFAERS: 2US FAERS
43Symptom maskedFAERS: 2US FAERS
44UrticariaFAERS: 2US FAERS
45Abdominal discomfortFAERS: 1OFFSIDES
US FAERS
46Abortion earlyFAERS: 1US FAERS
47Accidental overdoseFAERS: 1US FAERS
48Acute polyneuropathyFAERS: 1US FAERS
49AlopeciaFAERS: 1US FAERS
50AphoniaFAERS: 1US FAERS
51Blood alkaline phosphatase increasedFAERS: 1US FAERS
52Carcinogenic effect in offspringFAERS: 1US FAERS
53Congenital cystic kidney diseaseFAERS: 1US FAERS
54ConstipationFAERS: 1US FAERS
55DeliriumFAERS: 1US FAERS
56Disease ProgressionFAERS: 1US FAERS
57Drug administration errorFAERS: 1US FAERS
58Drug exposure during pregnancyFAERS: 1OFFSIDES
US FAERS
59Drug ineffective for unapproved indicationFAERS: 1US FAERS
60Drug level fluctuatingFAERS: 1US FAERS
61Drug level increasedFAERS: 1US FAERS
62DyspepsiaFAERS: 1SIDER
US FAERS
63ErythemaFAERS: 1SIDER
US FAERS
64FlushingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
65Head discomfortFAERS: 1US FAERS
66HypotensionFAERS: 1US FAERS
67Insulin ResistanceFAERS: 130153273CTD
US FAERS
68LeukopeniaFAERS: 1US FAERS
69MacrocytosisFAERS: 1US FAERS
70MetrorrhagiaFAERS: 1US FAERS
71Peripheral swellingFAERS: 1US FAERS
72Prescribed overdoseFAERS: 1US FAERS
73Product dispensing errorFAERS: 1US FAERS
74Product substitution issueFAERS: 1US FAERS
75Rash erythematousFAERS: 1US FAERS
76RhinitisFAERS: 1US FAERS
77Skin reactionFAERS: 1US FAERS
78Sudden onset of sleepFAERS: 1US FAERS
79Temperature regulation disorderFAERS: 1US FAERS
80Unevaluable eventFAERS: 1US FAERS
81Visual ImpairmentFAERS: 1US FAERS
82Weight decreasedFAERS: 1US FAERS
83Abdominal PainOFFSIDES
84Abdominal tendernessOFFSIDES
85Abnormal visionOFFSIDES
86Abnormalities, Drug-Induced11096168
16112698		CTD
87AbscessOFFSIDES
88Accidental exposureOFFSIDES
89Acid refluxOFFSIDES
90AcidosisOFFSIDES
91Actinic keratosisOFFSIDES
92Acute kidney injury

View details

135854
562503
745638
851170
1068326
2566606
4142233
5070373
7531211
8594875
10980121
11532093
15149334
15625121
16316344
16595132
17003819
18480750
18626492
19552531
24275386
 		CTD
93Acute left ventricular failureOFFSIDES
94AdenocarcinomaOFFSIDES
95Adenoma16963246CTD
96Ageusia3214955CTD
97AgitationSIDER
98Albuminuria22647887CTD
99Alcohol Withdrawal Delirium7220787CTD
100AlveolitisOFFSIDES
101Anemia, Hemolytic5774135CTD
102Anemia, Macrocytic

View details

167444
1243953
9169341
15955964
 		CTD
103Anemia, Megaloblastic

View details

601569
1922593
2535199
4169978
4175396
4264432
4627864
4729182
5618821
6021848
8349867
14227437
16353713
19110522
 		CTD
104Anemia, Sickle Cell18593679CTD
105Anemia

View details

523178
749158
939927
2414185
5530036
12187553
15249150
16454396
 		CTD
106AnhedoniaOFFSIDES
107AnhidrosisOFFSIDES
108AnisocoriaOFFSIDES
109Ankle FractureOFFSIDES
110Annular pancreasCanada Vigilance: 1Canada Vigilance
111Anorectal discomfortOFFSIDES
112AnorexiaSIDER
113Anticonvulsant drug level decreasedOFFSIDES
114Anuria851170CTD
115Application site erythemaOFFSIDES
116Application site necrosisOFFSIDES
117Application site scabOFFSIDES
118Application site vesiclesOFFSIDES
119Arteriosclerosis17118406CTD
120Arthritis, Psoriatic17190135CTD
121ArthritisOFFSIDES
122AstheniaOFFSIDES
123Ataxia7442434CTD
124Atrial FlutterOFFSIDES
125Atrial tachycardiaOFFSIDES
126Auricular swellingOFFSIDES
127Autistic Disorder21388746
24676906		CTD
128Autoimmune hepatitisOFFSIDES
129BK virus infectionOFFSIDES
130Bacteria wound identifiedOFFSIDES
131Bacterial sepsisOFFSIDES
132Band neutrophil percentage decreasedOFFSIDES
133Benign NeoplasmOFFSIDES
134Biopsy bone marrow abnormalOFFSIDES
135Bipolar Disorder20636639CTD
OFFSIDES
136Birth Weight29129240CTD
137BlepharospasmOFFSIDES
138Blood GlucoseOFFSIDES
139Blood albumin decreasedOFFSIDES
140Blood chloride decreasedOFFSIDES
141Blood creatine phosphokinase MB increasedOFFSIDES
142Blood creatinine decreasedOFFSIDES
143Blood creatinine increasedOFFSIDES
144Blood fibrinogen increasedOFFSIDES
145Blood immunoglobulin G increasedOFFSIDES
146Blood magnesium decreasedOFFSIDES
147Blood parathyroid hormoneOFFSIDES
148Blood potassium decreasedOFFSIDES
149Blood potassium increasedOFFSIDES
150Blood sodiumOFFSIDES
151Blood urea increasedOFFSIDES
152Bone lesionOFFSIDES
153Bone marrow depressionOFFSIDES
154Bone painOFFSIDES
155Bone swellingOFFSIDES
156BradycardiaOFFSIDES
157Brain Damage, Chronic23690582CTD
158Brain Diseases4504035
6824947
7279316		CTD
159BronchitisOFFSIDES
160BronchopneumoniaOFFSIDES
161BronchospasmSIDER
162Burning sensationOFFSIDES
163BursitisOFFSIDES
164C-reactive protein abnormalOFFSIDES
165Cardiac asthmaOFFSIDES
166Cardioactive drug level increasedOFFSIDES
167Cardiomyopathies29068127CTD
168Cardiovascular Abnormalities11096168CTD
169Cardiovascular Diseases16755160CTD
170Cataract operationOFFSIDES
171Cataract11438049CTD
172Catheter placementOFFSIDES
173Catheter related complicationOFFSIDES
174CellulitisOFFSIDES
175Cerebellar Ataxia4022349CTD
176Cerebellar infarctionOFFSIDES
177Cervicogenic HeadacheOFFSIDES
178Chemical and Drug Induced Liver Injury15338491
20548288		CTD
179Cholecystitis infectiveOFFSIDES
180Choroidal DetachmentOFFSIDES
181Chronic Obstructive Airway DiseaseOFFSIDES
182Cleft Palate8946559
21254359		CTD
OFFSIDES
183Cognition Disorders

View details

15824266
16315636
23690582
30153273
 		CTD
184Colonic StenosisOFFSIDES
185Colorectal Neoplasms

View details

16963246
16985020
17087956
17116713
17245555
 		CTD
186Complex partial seizuresOFFSIDES
187Compression fractureOFFSIDES
188Compression stockings applicationOFFSIDES
189Congenital tricuspid valve incompetenceOFFSIDES
190Coronary Restenosis15215483CTD
191Coronary angioplastyOFFSIDES
192Cubital Tunnel SyndromeOFFSIDES
193DehydrationOFFSIDES
194Denture wearerOFFSIDES
195Depressive disorder7527320CTD
196DermatitisSIDER
197DermatomyositisOFFSIDES
198DiarrheaOFFSIDES
199DiscomfortSIDER
200Diverticular perforationOFFSIDES
201DiverticulitisOFFSIDES
202Drug ToleranceOFFSIDES
203Drug dose omissionOFFSIDES
204Drug exposure via breast milkOFFSIDES
205Drug level below therapeuticOFFSIDES
206Drug withdrawal headacheOFFSIDES
207Dry skinOFFSIDES
208Duodenal sphincterotomyOFFSIDES
209DuodenitisOFFSIDES
210DysgeusiaSIDER
211DysuriaOFFSIDES
212Electrocardiogram ST segment abnormalOFFSIDES
213Embryo Loss26993217CTD
214EndocarditisOFFSIDES
215Endodontic procedureOFFSIDES
216Endometrial Neoplasms17301261CTD
217Eosinophilic myocarditisOFFSIDES
218Epidural AbscessOFFSIDES
219Epilepsy1115018
4169978
4212019		CTD
220EpistaxisOFFSIDES
221ErysipelasOFFSIDES
222Escherichia sepsisOFFSIDES
223Eustachian tube disorderOFFSIDES
224Exfoliation Syndrome16504073CTD
225Extremity contractureOFFSIDES
226Eye laser surgeryOFFSIDES
227Fatty Liver, Alcoholic20118189CTD
228Febrile NeutropeniaOFFSIDES
229Feeling abnormalSIDER
230Fetal Alcohol Spectrum Disorders22666445CTD
231Fetal Growth Retardation24177262CTD
232FlatulenceOFFSIDES
SIDER
233Folic Acid Deficiency5359954
5694067
30153273		CTD
234Gamma-Glutamyltransferase IncreasedOFFSIDES
235GangreneOFFSIDES
236Gastritis17171786CTD
237Gastroenteritis norovirusOFFSIDES
238General physical health deteriorationOFFSIDES
239Genital Diseases, Male15013062CTD
240Gingival HypertrophyOFFSIDES
241Glaucoma16504073CTD
242HIV Seropositivity17209195CTD
243HemiparesisOFFSIDES
244HemiplegiaOFFSIDES
245Heparin-induced thrombocytopeniaOFFSIDES
246Hepatitis B positiveOFFSIDES
247HydronephrosisOFFSIDES
248Hyperhomocysteinemia

View details

11598393
15493348
15847747
16395265
16397167
16433478
16755160
16865747
20116427
20406136
21893018
22647887
 		CTD
249HyperpigmentationOFFSIDES
250Hypoplastic Left Heart SyndromeCanada Vigilance: 1Canada Vigilance
251Hypospadias19270804CTD
OFFSIDES
252Infusion site mobility decreasedOFFSIDES
253Injection site erythemaOFFSIDES
254Injection site irritationOFFSIDES
255Injection site phlebitisOFFSIDES
256Injection site pruritusOFFSIDES
257Injection site urticariaOFFSIDES
258Intervertebral Disc DegenerationOFFSIDES
259Intervertebral disc disorderOFFSIDES
260Intestinal ObstructionOFFSIDES
261Intestinal PerforationOFFSIDES
262Intestinal infarctionOFFSIDES
263Joint Range of Motion DecreasedOFFSIDES
264Joint dislocation postoperativeOFFSIDES
265Kidney Diseases

View details

160016
193486
1482756
2386429
2840627
4336412
11832423
14633603
18633340
19435794
19934081
20116427
20406136
21647593
22647887
 		CTD
266Kidney Failure, Chronic4810836CTD
267Left Ventricular HypertrophyOFFSIDES
268Leukopenia neonatalOFFSIDES
269Limb operationOFFSIDES
270Liver diseases16877991CTD
271Loose toothOFFSIDES
272Lung consolidationOFFSIDES
273Lupus Erythematosus, Systemic9758264
17718048		CTD
274MacrognathiaOFFSIDES
275Malaria, Falciparum4922770CTD
276Malignant neoplasm progressionOFFSIDES
277MastoiditisOFFSIDES
278Maxillofacial Abnormalities16832597CTD
279Memory Disorders30153273CTD
280Mental status changesOFFSIDES
281Monoclonal immunoglobulin presentOFFSIDES
282Monocyte percentage increasedOFFSIDES
283MorpheaOFFSIDES
284Mucosal erosionOFFSIDES
285Multiple MyelomaOFFSIDES
286Muscle WeaknessOFFSIDES
287Musculoskeletal chest painOFFSIDES
288Nasopharyngeal Neoplasms21941485CTD
289NasopharyngitisOFFSIDES
290Neoplasms, Experimental10449194CTD
291Neoplasms6061664CTD
292Nephritis, Interstitial15013062CTD
293Nephrogenic Fibrosing DermopathyOFFSIDES
294NephrolithiasisOFFSIDES
295Neural Tube Defects

View details

8605127
10452927
10612975
12660568
14598335
16112698
17438019
17688467
19180646
20060418
24177262
 		CTD
296NeuralgiaOFFSIDES
297Neutropenia3265540
16322990		CTD
298Neutropenic sepsisOFFSIDES
299Non-alcoholic Fatty Liver Disease20548288
22872676
29127188		CTD
300Obesity30153273CTD
301Ocular HypertensionOFFSIDES
302Ocular icterusOFFSIDES
303OliguriaOFFSIDES
304Oropharyngeal candidiasisOFFSIDES
305Orthostatic intoleranceOFFSIDES
306Osteomalacia4148461CTD
307OsteomyelitisOFFSIDES
308OsteopeniaOFFSIDES
309OsteoporosisOFFSIDES
310OveractivitySIDER
311PainOFFSIDES
312Panic DisorderOFFSIDES
313ParotitisOFFSIDES
314Peripheral Nervous System Diseases7527320CTD
315PeritonitisOFFSIDES
316Physical assaultOFFSIDES
317Physical examination abnormalOFFSIDES
318PlasmacytomaOFFSIDES
319PleuropericarditisOFFSIDES
320Pneumocystis jiroveci pneumoniaOFFSIDES
321PneumothoraxOFFSIDES
322Polycystic Ovary Syndrome26545973CTD
323Polymyalgia RheumaticaOFFSIDES
324Post procedural headacheOFFSIDES
325Postoperative infectionOFFSIDES
326Postoperative wound complicationOFFSIDES
327Prenatal Exposure Delayed Effects26993217CTD
328Prenatal Injuries

View details

16112698
20544798
23787444
24177262
 		CTD
329Primary sequestrumOFFSIDES
330Procedural nauseaOFFSIDES
331Product quality issueOFFSIDES
332ProstatismOFFSIDES
333Protein total decreasedOFFSIDES
334Proteinuria20116427CTD
335Pseudomonas bronchitisOFFSIDES
336Psoriasis15807694CTD
OFFSIDES
337Psychophysiologic Disorders4169978CTD
338Psychotic Disorders25729574CTD
339Red man syndromeOFFSIDES
340Renal Insufficiency

View details

4082191
14661866
15013062
15728788
 		CTD
341Renal tubular atrophyOFFSIDES
342Salmonella sepsisOFFSIDES
343Schizophrenia16641680
25729574		CTD
344Scotoma15937433CTD
345Seizures

View details

1463588
6462463
6824947
7279316
9758264
9806067
 		CTD
346Septic ShockOFFSIDES
347Sinus Thrombosis, Intracranial18786290CTD
348Skin IndurationOFFSIDES
349Skin hypertrophyOFFSIDES
350Skin lacerationOFFSIDES
351Skin necrosisOFFSIDES
352Skin tightnessOFFSIDES
353Soft tissue inflammationOFFSIDES
354Spinal Cord Diseases7527320
16361298		CTD
355Spinal column stenosisOFFSIDES
356Splenic InfarctionOFFSIDES
357SpondylitisOFFSIDES
358SpondylolisthesisOFFSIDES
359Sprue, Tropical4951496CTD
360Squamous cell carcinoma of skinOFFSIDES
361Stem cell transplantOFFSIDES
362Stomach Neoplasms17171786CTD
363Superinfection bacterialOFFSIDES
364Thoracic vertebral fractureOFFSIDES
365ThoracotomyOFFSIDES
366Thrombocytopenia8958188CTD
367ThrombophlebitisOFFSIDES
368ThyroidectomyOFFSIDES
369TinnitusOFFSIDES
370Tobacco userOFFSIDES
371Tooth ExtractionOFFSIDES
372Toxoplasmosis8228015CTD
373Transaminases increasedOFFSIDES
374Umbilical herniaOFFSIDES
375Uremia4082191CTD
376Urinary bladder abscessOFFSIDES
377Vasculitic rashOFFSIDES
378Venous InsufficiencyOFFSIDES
379Ventricular FibrillationOFFSIDES
380VertebroplastyOFFSIDES
381Walking aid userOFFSIDES
382Weight GainOFFSIDES
383Wound DebridementOFFSIDES
384Wound dehiscenceOFFSIDES
385XerosisOFFSIDES
386bad tasteSIDER
387melanoma10663624CTD
388prostatitisOFFSIDES
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