MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Leucovorin

(VVIAGPKUTFNRDU-ABLWVSNPSA-N)

Structure

SMILES: O=CN1C(CNc2ccc(cc2)C(=O)N[C@H](C(=O)O)CCC(=O)O)CNc2c1c(=O)[nH]c(n2)N
Type(s): Approved
ATC code(s): V03AF03; V03AF06
Molecular Formula:: C20H23N7O7
Molecular Weight:: 473.439
Log P:: 1.1529
Hydrogen Bond Acceptor:: 13
Hydrogen Bond Donor:: 7
TPSA:: 219.84
CAS Number(s):: 58-05-9; 1492-18-8; 21314

Synonym(s)

Leucovorin

Calcium Leucovorin

Citrovorum Factor

Folinic Acid

N(5)-Formyltetrahydrofolate

5-Formyltetrahydrofolate

5-Formyltetrahydropteroylglutamate

Calcium Folinate

Folinic Acid-SF

10.

Leucovorin, (D)-Isomer

11.

Leucovorin, (DL)-Isomer

12.

Leucovorin, (R)-Isomer

13.

Leucovorin, Calcium (1:1) Salt

14.

Leucovorin, Calcium (1:1) Salt, (DL)-Isomer

15.

Leucovorin, Calcium (1:1) Salt, Pentahydrate

16.

Leucovorin, Monosodium Salt

17.

Leukovorin

18.

Leukovorum

19.

Wellcovorin

20.

5 Formyltetrahydrofolate

21.

5 Formyltetrahydropteroylglutamate

22.

Acid, Folinic

23.

Factor, Citrovorum

24.

Folinate, Calcium

25.

Folinic Acid SF

26.

Leucovorin, Calcium

27.

Monosodium Salt Leucovorin

External Link(s)

MeSH	D002955
PubChem Compound	135403648 6006
BindingDB	50039121
ChEBI	15640
CHEMBL	CHEMBL1679
DrugBank	DB00650
DrugCentral	1232
IUPHAR/BPS Guide to PHARMACOLOGY	6690 4816
KEGG	cpd:C03479 dr:D07986
Therapeutic Target Database	D0R4PS

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Nausea	FAERS: 4	View details 8673994 9229321 17679458 18211984	CTD OFFSIDES SIDER US FAERS
2	Asthenia	FAERS: 3		OFFSIDES SIDER US FAERS
3	Drug ineffective	FAERS: 3		US FAERS
4	Erythema	FAERS: 3 Canada Vigilance: 1	19330576	CTD SIDER Canada Vigilance US FAERS
5	Flushing	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
6	Disease Progression	FAERS: 2		OFFSIDES SIDER US FAERS
7	Fatigue	FAERS: 2		SIDER US FAERS
8	Headache	FAERS: 2		US FAERS
9	Intestinal Obstruction	FAERS: 2		OFFSIDES US FAERS
10	Malaise	FAERS: 2		SIDER US FAERS
11	Pulmonary Embolism	FAERS: 2		US FAERS
12	Abdominal Pain	FAERS: 1		OFFSIDES SIDER US FAERS
13	Abdominal discomfort	FAERS: 1		US FAERS
14	Acute respiratory failure	FAERS: 1		US FAERS
15	Anxiety	FAERS: 1		US FAERS
16	Atelectasis	FAERS: 1		OFFSIDES US FAERS
17	Back Pain	FAERS: 1		US FAERS
18	Cardiac Tamponade	FAERS: 1		US FAERS
19	Chills	FAERS: 1		SIDER US FAERS
20	Deep Vein Thrombosis	FAERS: 1		US FAERS
21	Drug dispensing error	FAERS: 1		US FAERS
22	Dyspepsia	FAERS: 1		SIDER US FAERS
23	Extravasation	FAERS: 1		SIDER US FAERS
24	Flatulence	FAERS: 1		US FAERS
25	Gastrointestinal sounds abnormal	FAERS: 1		US FAERS
26	Hypersensitivity	FAERS: 1		SIDER US FAERS
27	Malignant neoplasm progression	FAERS: 1		US FAERS
28	Medication Error	FAERS: 1		US FAERS
29	Neutrophil count decreased	FAERS: 1		OFFSIDES US FAERS
30	Pericardial effusion	FAERS: 1		US FAERS
31	Pneumonia	FAERS: 1		US FAERS
32	Product preparation error	FAERS: 1		US FAERS
33	Pruritus	FAERS: 1		SIDER US FAERS
34	Pulmonary Fibrosis	FAERS: 1		US FAERS
35	Pulmonary thrombosis	FAERS: 1		OFFSIDES US FAERS
36	Respiratory Failure	FAERS: 1		OFFSIDES US FAERS
37	Retching	FAERS: 1		US FAERS
38	Somnolence	FAERS: 1		US FAERS
39	Therapy cessation	FAERS: 1		US FAERS
40	Thrombosis	FAERS: 1		US FAERS
41	Urticaria	FAERS: 1		SIDER US FAERS
42	Vascular pain	FAERS: 1		US FAERS
43	Vasculitis	FAERS: 1		US FAERS
44	Vomiting	FAERS: 1	View details 8673994 9229321 9348575 11202810 12119460 12963697 17679458 18211984	CTD SIDER US FAERS
45	White blood cell count decreased	FAERS: 1		US FAERS
46	Wrong technique in product usage process	FAERS: 1		US FAERS
47	Abdominal Abscess			OFFSIDES
48	Abdominal Infection			OFFSIDES
49	Abdominal adhesions			OFFSIDES
50	Abdominal hernia obstructive			OFFSIDES
51	Abdominal sepsis			OFFSIDES
52	Abdominal tenderness			SIDER
53	Abortion early			OFFSIDES
54	Accidental needle stick			OFFSIDES
55	Acne			OFFSIDES
56	Acute Coronary Syndrome			OFFSIDES
57	Acute kidney injury		View details 1838364 9638991 15984523 16326413 17519458 17609630 19131789	CTD SIDER
58	Acute myocardial infarction			OFFSIDES
59	Adenocarcinoma		19295247	CTD
60	Agranulocytosis		8120554	CTD
61	Alcohol interaction			OFFSIDES
62	Alopecia			SIDER
63	Anal Fissure			OFFSIDES
64	Anal Fistula			OFFSIDES
65	Anal inflammation			OFFSIDES
66	Anaphylactic shock			SIDER
67	Anaphylactoid Reaction			SIDER
68	Anastomotic Leak			OFFSIDES
69	Anastomotic complication			OFFSIDES
70	Anastomotic ulcer			OFFSIDES
71	Anemia, Megaloblastic		View details 4005162 8124920 21310276 21310277	CTD
72	Anemia		View details 2283895 4560141 8673994 15274380 16531713 17679458 18211984	CTD
73	Angina Pectoris		15668828 15701780	CTD
74	Anisocoria			OFFSIDES
75	Anorexia		6603024 16531713	CTD OFFSIDES SIDER
76	Anti-HBe antibody positive			OFFSIDES
77	Antidepressant drug clearance decreased			OFFSIDES
78	Antiphospholipid antibodies positive			OFFSIDES
79	Aortic embolus			OFFSIDES
80	Aphagia			OFFSIDES
81	Arteriovenous fistula thrombosis			OFFSIDES
82	Ascites		20180123	CTD
83	Aspermia			OFFSIDES
84	Astrocytoma			OFFSIDES
85	Ataxia		6584197	CTD
86	Athetosis			OFFSIDES
87	Autoimmune thrombocytopenia			OFFSIDES
88	Axillary vein thrombosis			OFFSIDES
89	Bacillus infection			OFFSIDES
90	Bacteria stool identified			OFFSIDES
91	Bacteria urine identified			OFFSIDES
92	Bacterial sepsis			OFFSIDES
93	Belligerence			OFFSIDES
94	Bile Duct Stenosis			OFFSIDES
95	Bile culture positive			OFFSIDES
96	Biliary Fistula			OFFSIDES
97	Biliary cancer metastatic			OFFSIDES
98	Biopsy			OFFSIDES
99	Bipolar I disorder			OFFSIDES
100	Blood albumin decreased			OFFSIDES
101	Blood amylase decreased			OFFSIDES
102	Blood bilirubin abnormal			OFFSIDES
103	Blood calcitonin increased			OFFSIDES
104	Blood chloride increased			OFFSIDES
105	Blood creatinine increased			SIDER
106	Blood fibrinogen increased			OFFSIDES
107	Blood magnesium increased			OFFSIDES
108	Blood potassium decreased			OFFSIDES
109	Blood sodium increased			OFFSIDES
110	Body Temperature			OFFSIDES
111	Bone Diseases, Developmental		18976724	CTD
112	Bone Marrow Diseases		666479	CTD
113	Bone callus excessive			OFFSIDES
114	Bone fistula			OFFSIDES
115	Bone marrow depression			OFFSIDES
116	Bone marrow toxicity			OFFSIDES
117	Bone neoplasms		740209 6970616	CTD
118	Bone scan abnormal			OFFSIDES
119	Botulism			OFFSIDES
120	Brain Diseases		View details 2428491 4504035 6584197 7503095 8228015	CTD
121	Bronchial Fistula			OFFSIDES
122	Bulbar palsy			OFFSIDES
123	Burkitt Lymphoma		18782177	CTD
124	Butterfly rash			OFFSIDES
125	Calcific deposits removal			OFFSIDES
126	Capillary Leak Syndrome			OFFSIDES
127	Carcinoembryonic antigen increased			OFFSIDES
128	Carcinoma		8673994	CTD
129	Cardiac Death			OFFSIDES
130	Cardioactive drug level			OFFSIDES
131	Cardiomyopathies		15272225	CTD
132	Cardiotoxicity			OFFSIDES
133	Cardiovascular insufficiency			OFFSIDES
134	Carotid artery occlusion			OFFSIDES
135	Catheter bacteraemia			OFFSIDES
136	Catheter related complication			OFFSIDES
137	Catheter related infection			OFFSIDES
138	Catheter site cellulitis			OFFSIDES
139	Catheter site discharge			OFFSIDES
140	Catheter site inflammation			OFFSIDES
141	Catheter site related reaction			OFFSIDES
142	Cerebral Amyloid Angiopathy			OFFSIDES
143	Cerebral disorder			OFFSIDES
144	Cerebral hypoperfusion			OFFSIDES
145	Cerebral parenchymal calcification			OFFSIDES
146	Cervical gland tuberculosis			OFFSIDES
147	Cervical laser therapy			OFFSIDES
148	Chemical and Drug Induced Liver Injury		18173932	CTD
149	Chemical burn of skin			OFFSIDES
150	Choking sensation			OFFSIDES
151	Cholecystitis			OFFSIDES
152	Chronic ulcerative colitis			OFFSIDES
153	Chylothorax			OFFSIDES
154	Citrobacter sepsis			OFFSIDES
155	Clostridium difficile colitis			OFFSIDES
156	Cold sweat			OFFSIDES
157	Colitis			OFFSIDES
158	Colon cancer recurrent			OFFSIDES
159	Colonic Neoplasms		6603024 9412948 17166623	CTD
160	Colonic Stenosis			OFFSIDES
161	Colorectal Neoplasms		View details 7503095 7583711 7738622 8622018 9229321 11166918 11432626 15274380 15746067 16303861 16317265 16531713 17255274 17401013 17405895 17430663 17454858 17594712 20501625	CTD
162	Colorectal cancer recurrent			OFFSIDES
163	Complex partial seizures			OFFSIDES
164	Confusion		7858459	CTD
165	Congenital diaphragmatic hernia			OFFSIDES
166	Constipation			SIDER
167	Conus Medullaris Syndrome			OFFSIDES
168	Corneal Ulcer			OFFSIDES
169	Craniofacial Abnormalities		16925845	CTD
170	Culture positive			OFFSIDES
171	Cutaneous Candidiasis			OFFSIDES
172	Cytology abnormal			OFFSIDES
173	Cytotoxic cardiomyopathy			OFFSIDES
174	Dehydration		12963697	CTD OFFSIDES
175	Delirium febrile			OFFSIDES
176	Demyelinating Diseases		8032957	CTD
177	Dental Plaque			OFFSIDES
178	Dental abscess			OFFSIDES
179	Depression suicidal			OFFSIDES
180	Dermatitis			SIDER
181	Device migration			OFFSIDES
182	Diabetic Nephropathy			OFFSIDES
183	Diabetic foot infection			OFFSIDES
184	Diarrhea		View details 8673994 9229321 9348575 11432626 11822757 11863117 12119460 12963697 16531713 17679458	CTD OFFSIDES
185	Diffuse Large B-Cell Lymphoma			OFFSIDES
186	Diffuse alveolar damage			OFFSIDES
187	Dihydropyrimidine Dehydrogenase Deficiency			OFFSIDES
188	Diplopia			OFFSIDES
189	Discomfort			SIDER
190	Disease complication			OFFSIDES
191	Disuse syndrome			OFFSIDES
192	Dizziness			SIDER
193	Drug Eruptions		18997139	CTD
194	Drug Overdose		9174236	CTD
195	Drug toxicity			OFFSIDES
196	Duodenal perforation			OFFSIDES
197	Duodenal ulcer perforation			OFFSIDES
198	Dysgeusia			SIDER
199	Dysphasia			OFFSIDES
200	Dyspnea		15668828	CTD
201	Ectropion			OFFSIDES
202	Ejection Fraction Decreased			OFFSIDES
203	Electrocardiogram ST segment abnormal			OFFSIDES
204	Electrocardiogram ST-T segment abnormal			OFFSIDES
205	Electrocardiogram T wave amplitude increased			OFFSIDES
206	Embolism			OFFSIDES
207	Empty Sella Syndrome			OFFSIDES
208	Endophthalmitis			OFFSIDES
209	Enteritis			OFFSIDES
210	Enterococcal infection			OFFSIDES
211	Enterocolitis			OFFSIDES
212	Enterocutaneous Fistula			OFFSIDES
213	Enterovesical Fistula			OFFSIDES
214	Epilepsy			OFFSIDES
215	Epileptic aura			OFFSIDES
216	Epistaxis			OFFSIDES
217	Erythema Infectiosum			OFFSIDES
218	Erythrosis			OFFSIDES
219	Escherichia infection			OFFSIDES
220	Escherichia vaginitis			OFFSIDES
221	Esophageal Perforation			OFFSIDES
222	Exanthema		6607976	CTD
223	Eyelid Function Disorder			OFFSIDES
224	Failure to Thrive			OFFSIDES
225	Febrile Neutropenia			OFFSIDES SIDER
226	Feeling abnormal			SIDER
227	Femoral artery occlusion			OFFSIDES
228	Femoral pulse decreased			OFFSIDES
229	Fetal Resorption		9578686	CTD
230	Fibroadenoma of breast			OFFSIDES
231	Flank Pain			OFFSIDES
232	Fluid imbalance			OFFSIDES
233	Focal Nodular Hyperplasia			OFFSIDES
234	Folliculitis			OFFSIDES
235	Formication			OFFSIDES
236	Fungus sputum test positive			OFFSIDES
237	Gastric outlet obstruction			OFFSIDES
238	Gastrointestinal Diseases		17430663	CTD
239	Gastrointestinal Neoplasms		2236732 8518040 15272225	CTD
240	Gastrointestinal Pain			SIDER
241	Gastrointestinal cancer metastatic			OFFSIDES
242	Gastrointestinal mucosal disorder			OFFSIDES
243	Gastrointestinal mucosal exfoliation			OFFSIDES
244	Gastrointestinal obstruction			OFFSIDES
245	Gastrointestinal perforation			OFFSIDES
246	Gastrointestinal stoma complication			OFFSIDES
247	Gastrointestinal toxicity			OFFSIDES
248	General nutrition disorder			OFFSIDES
249	General physical health deterioration			OFFSIDES
250	Glioma		3465876	CTD
251	Gram stain positive			OFFSIDES
252	Granulocyte count decreased			OFFSIDES
253	Granulocytes maturation arrest			OFFSIDES
254	Haematotoxicity			OFFSIDES
255	Head and Neck Neoplasms		8569964	CTD
256	Heart Diseases		15153089	CTD
257	Heart failure		8374883 11057817	CTD
258	Hemolytic-Uremic Syndrome		12119460	CTD
259	Hepatic enzyme decreased			OFFSIDES
260	Hepatic infection bacterial			OFFSIDES
261	Hiccough			OFFSIDES
262	Histology			OFFSIDES
263	Hodgkin Disease		3465876	CTD
264	Hydronephrosis			OFFSIDES
265	Hyperammonemia		18173932	CTD
266	Hypercreatininaemia			OFFSIDES
267	Hyperosmolar state			OFFSIDES
268	Hypertensive emergency			OFFSIDES
269	Hypertensive hydrocephalus			OFFSIDES
270	Hypertrophic Cardiomyopathy			OFFSIDES
271	Hypoglycemia		18173932	CTD
272	Hypokinesia		11057817	CTD
273	Hypoxia			OFFSIDES
274	Ileal ulcer			OFFSIDES
275	Ileitis			OFFSIDES
276	Implant site extravasation			OFFSIDES
277	Incision site abscess			OFFSIDES
278	Incorrect drug administration rate			OFFSIDES
279	Infection			OFFSIDES SIDER
280	Infective spondylitis			OFFSIDES
281	Inguinal mass			OFFSIDES
282	Injection site dermatitis			OFFSIDES
283	Injection site discomfort			OFFSIDES
284	Injection site infection			OFFSIDES
285	Intestinal Neoplasms		8032957	CTD
286	Intestinal Perforation			OFFSIDES
287	Intestinal anastomosis complication			OFFSIDES
288	Intestinal stoma complication			OFFSIDES
289	Investigation abnormal			OFFSIDES
290	Ischemia		10023329	CTD
291	Jejunal ulcer			OFFSIDES
292	Kidney Diseases		2236732	CTD
293	Lactobacillus infection			OFFSIDES
294	Large intestine perforation			OFFSIDES
295	Laryngospasm			OFFSIDES
296	Lesion excision			OFFSIDES
297	Lethargy			SIDER
298	Leukodystrophy			OFFSIDES
299	Leukoencephalomyelitis			OFFSIDES
300	Leukopenia neonatal			OFFSIDES
301	Leukopenia		View details 6607976 8673994 9229321 12119460 15274380 16531713	CTD SIDER
302	Limb operation			OFFSIDES
303	Liver neoplasms		21208846	CTD
304	Localised intraabdominal fluid collection			OFFSIDES
305	Lung Abscess			OFFSIDES
306	Lung Neoplasms		6603024	CTD
307	Lymphoid tissue hyperplasia			OFFSIDES
308	Lymphoma, Non-Hodgkin		4551303 12172056	CTD
309	Lymphoma		1519928	CTD
310	Malaria, Falciparum		4922770	CTD
311	Malignant Hypertension			OFFSIDES
312	Malignant ascites			OFFSIDES
313	Markedly reduced dietary intake			OFFSIDES
314	Medical device pain			OFFSIDES
315	Medulloblastoma		3465876	CTD
316	Megacolon			OFFSIDES
317	Mental disorder due to a general medical condition			OFFSIDES
318	Mental status changes			OFFSIDES
319	Metastases to abdominal cavity			OFFSIDES
320	Metastases to salivary gland			OFFSIDES
321	Metastatic Neoplasm			OFFSIDES
322	Mitochondrial Encephalomyopathies		18058625	CTD
323	Mole excision			OFFSIDES
324	Molluscum Contagiosum			OFFSIDES
325	Monocyte percentage increased			OFFSIDES
326	Mononeuritis			OFFSIDES
327	Morphea			OFFSIDES
328	Murder			OFFSIDES
329	Muscle abscess			OFFSIDES
330	Muscle necrosis			OFFSIDES
331	Nail Diseases		2283895	CTD
332	Nail Infection			OFFSIDES
333	Neoplasm Metastasis		9348575 11202810 21208846	CTD
334	Neoplasms, Experimental		2316090	CTD
335	Neoplasms		12963697 19934304	CTD
336	Neural Tube Defects		1810574 3110521 12692401	CTD
337	Neuritis		17430663	CTD
338	Neuroborreliosis			OFFSIDES
339	Neuropathy			SIDER
340	Neutropenia		View details 8673994 9071336 11432626 11822757 12963697 15274380 17679458 18211984	CTD
341	Neutropenic infection			OFFSIDES
342	Neutropenic sepsis			OFFSIDES
343	Neutrophil count abnormal			OFFSIDES
344	Nodule			OFFSIDES
345	Nystagmus			OFFSIDES
346	Obstruction			OFFSIDES
347	Ocular Motility Disorders		6584197	CTD
348	Ocular Toxicity			OFFSIDES
349	Oral mucosal petechiae			OFFSIDES
350	Orchitis			OFFSIDES
351	Oropharyngeal spasm			OFFSIDES
352	Osteosarcoma		View details 310278 3461742 3465876 3875390 6582805 6602269 6971958 7949255 8569964 16164401	CTD
353	Ovarian adenoma			OFFSIDES
354	Oxygen saturation abnormal			OFFSIDES
355	PCO2 decreased			OFFSIDES
356	Pachymeningitis			OFFSIDES
357	Pancytopenia		7741386 21310276	CTD
358	Paraparesis		19821069	CTD
359	Paresis		6584197	CTD
360	Paresthesia		12963697	CTD
361	Parotid Neoplasms		6603024	CTD
362	Pelvic Infection			OFFSIDES
363	Pelvic abscess			OFFSIDES
364	Pelvic venous thrombosis			OFFSIDES
365	Penile Diseases		19330576	CTD
366	Percussion test abnormal			OFFSIDES
367	Performance status decreased			OFFSIDES
368	Perianal abscess			OFFSIDES
369	Perinephric collection			OFFSIDES
370	Peripheral Nervous System Diseases		11432626 15274380	CTD
371	Perirectal abscess			OFFSIDES
372	Peritoneal perforation			OFFSIDES
373	Peritonitis			OFFSIDES
374	Pharyngolaryngeal Pain			OFFSIDES
375	Photodermatosis			OFFSIDES
376	Physical examination abnormal			OFFSIDES
377	Platelet count abnormal			OFFSIDES
378	Pneumatosis Cystoides Intestinalis			OFFSIDES
379	Pneumoperitoneum			OFFSIDES
380	Portal venous gas			OFFSIDES
381	Positron emission tomogram abnormal			OFFSIDES
382	Post procedural complication			OFFSIDES
383	Post procedural fistula			OFFSIDES
384	Post procedural nausea			OFFSIDES
385	Postoperative abscess			OFFSIDES
386	Posturing			OFFSIDES
387	Pre-existing condition improved			OFFSIDES
388	Priapism			OFFSIDES
389	Proctitis			OFFSIDES
390	Prolonged expiration			OFFSIDES
391	Pseudomonal sepsis			OFFSIDES
392	Psoas Abscess			OFFSIDES
393	Pulmonary Eosinophilia			OFFSIDES
394	Pulmonary Infarction			OFFSIDES
395	Pulmonary artery thrombosis			OFFSIDES
396	Pulmonary radiation injury			OFFSIDES
397	Quadriplegia			OFFSIDES
398	Radiation Pneumonitis			OFFSIDES
399	Radiation hepatitis			OFFSIDES
400	Radiculitis			OFFSIDES
401	Raynaud Disease		10023329	CTD
402	Rectal Obstruction			OFFSIDES
403	Red blood cell anisocytes present			OFFSIDES
404	Red blood cell schistocytes present			OFFSIDES
405	Red man syndrome			OFFSIDES
406	Refusal of treatment by relative			OFFSIDES
407	Renal Insufficiency		9164227	CTD
408	Reperfusion Injury		17295595	CTD
409	Respiratory tract irritation			OFFSIDES
410	Retinal artery spasm			OFFSIDES
411	Retinal vascular occlusion			OFFSIDES
412	Retroperitoneal abscess			OFFSIDES
413	Retroperitoneal fibrosis			OFFSIDES
414	Sarcoma		6603024 6970616	CTD
415	Scan abdomen abnormal			OFFSIDES
416	Scleroderma			OFFSIDES
417	Secretion discharge			OFFSIDES
418	Seizures		7666465 15794179 16458834	CTD
419	Sense of oppression			OFFSIDES
420	Sepsis		8673994 11822757	CTD
421	Septic Shock			OFFSIDES
422	Shock			SIDER
423	Sigmoid Neoplasms		15494386 19151582 19330576	CTD
424	Sinoatrial Block			OFFSIDES
425	Sinus bradycardia			OFFSIDES
426	Sinus polyp			OFFSIDES
427	Skin neoplasm excision			OFFSIDES
428	Skin toxicity			OFFSIDES
429	Snoring			OFFSIDES
430	Soft Tissue Neoplasms		6970616	CTD
431	Soft tissue necrosis			OFFSIDES
432	Sopor			OFFSIDES
433	Speech Disorders		6584197	CTD
434	Spinal Cord Diseases		19821069	CTD
435	Staphylococcal abscess			OFFSIDES
436	Stoma site reaction			OFFSIDES
437	Stomach Neoplasms		View details 6603024 12119460 17679458 18211984 22452940	CTD
438	Stomatitis		6607976 12119460	CTD SIDER
439	Stridor			OFFSIDES
440	Subileus			OFFSIDES
441	Sudden Cardiac Death			OFFSIDES
442	Sudden death			OFFSIDES
443	Superior Vena Cava Syndrome			OFFSIDES
444	Supraventricular tachycardia			OFFSIDES
445	Suture line infection			OFFSIDES
446	Syncope			SIDER
447	Systemic mycosis			OFFSIDES
448	Temperature intolerance			OFFSIDES
449	Tetany			OFFSIDES
450	Therapy non-responder			OFFSIDES
451	Thrombocytopenia		View details 6607976 8673994 9229321 12119460 15274380 17679458 19031966	CTD SIDER
452	Thrombophlebitis		15452397	CTD
453	Toxoplasmosis			OFFSIDES
454	Transaminases abnormal			OFFSIDES
455	Troponin I increased			OFFSIDES
456	Troponin I			OFFSIDES
457	Trousseau's syndrome			OFFSIDES
458	Tuberculosis test positive			OFFSIDES
459	Tumor Lysis Syndrome		7503095	CTD
460	Tympanic Membrane Perforation			OFFSIDES
461	Unresponsive to pain stimuli			OFFSIDES
462	Urine human chorionic gonadotropin increased			OFFSIDES
463	Urine sodium decreased			OFFSIDES
464	Uterine Neoplasms		6603024	CTD
465	Vaginal mycosis			OFFSIDES
466	Vascular Access Complication			OFFSIDES
467	Venous Thrombosis		8120554	CTD
468	Venous occlusion			OFFSIDES
469	Venous stasis			OFFSIDES
470	Ventricular Dysfunction, Left		11057817	CTD
471	Ventricular Fibrillation			OFFSIDES
472	Visceral congestion			OFFSIDES
473	Visual brightness			OFFSIDES
474	Vocal Cord Paralysis			OFFSIDES
475	Vulvovaginal discomfort			OFFSIDES
476	Wheezing			SIDER
477	White blood cell count abnormal			OFFSIDES
478	Wound Infection			OFFSIDES
479	Wound abscess			OFFSIDES
480	Wound decomposition			OFFSIDES
481	Wound dehiscence			OFFSIDES
482	Xerosis			OFFSIDES
483	liposarcoma			OFFSIDES
484	pH urine decreased			OFFSIDES

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