MetaADEDB 2.0 @ LMMD
Flurbiprofen
(SYTBZMRGLBWNTM-UHFFFAOYSA-N)
Structure
SMILES
OC(=O)C(c1ccc(c(c1)F)c1ccccc1)C
Type(s)
Approved; Investigational
ATC code(s)
M01AE09; M02AA19; R02AX01; S01BC04
Molecular Formula:
C15H13FO2
Molecular Weight:
244.261
Log P:
3.6808
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
1
TPSA:
37.3
CAS Number(s):
5104-49-4; 51543-38-5
Synonym(s)
1.
Flurbiprofen
2.
2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid
3.
Ansaid
4.
Apo-Flurbiprofen
5.
BTS-18322
6.
Cebutid
7.
Dobrofen
8.
E-7869
9.
Flubiprofen
10.
Flugalin
11.
Flurbiprofen Sodium
12.
Fluriproben
13.
Froben
14.
Froben SR
15.
Neo Artrol
16.
Novo-Flurprofen
17.
Nu-Flurbiprofen
18.
Ocufen
19.
Ocuflur
20.
Strefen
21.
ratio-Flurbiprofen
22.
Apo Flurbiprofen
23.
BTS 18322
24.
BTS18322
25.
E 7869
26.
E7869
27.
Novo Flurprofen
28.
Nu Flurbiprofen
29.
ratio Flurbiprofen
External Link(s)
MeSHD005480
PubChem Compound3394
BindingDB50074922
ChEBI5130
CHEMBLCHEMBL563
DrugBankDB00712
DrugCentral1219
IUPHAR/BPS Guide to PHARMACOLOGY4194
KEGGcpd:C07013
dr:D00330
Therapeutic Target DatabaseD0A1PX
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AngioedemaFAERS: 10
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
2VomitingFAERS: 8
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
3DuodenitisFAERS: 6US FAERS
4NauseaFAERS: 6
Canada Vigilance: 4		Canada Vigilance
SIDER
US FAERS
5Drug abuseFAERS: 5US FAERS
6UrticariaFAERS: 411792017CTD
SIDER
US FAERS
7Abdominal discomfortFAERS: 3
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
8PalpitationsFAERS: 3SIDER
US FAERS
9Abdominal PainFAERS: 2
Canada Vigilance: 5		3560095
4611579		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
10Anaphylactic shockFAERS: 2SIDER
US FAERS
11Chest discomfortFAERS: 2US FAERS
12DizzinessFAERS: 2
Canada Vigilance: 4		Canada Vigilance
SIDER
US FAERS
13Drug ineffectiveFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
14ErythemaFAERS: 2US FAERS
15GastritisFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
16Renal tubular necrosisFAERS: 2US FAERS
17ShockFAERS: 2SIDER
US FAERS
18Abdominal tendernessFAERS: 1US FAERS
19Acute kidney injuryFAERS: 12827563
18280012		CTD
US FAERS
20AgranulocytosisFAERS: 1SIDER
US FAERS
21Cataract operation complicationFAERS: 1OFFSIDES
US FAERS
22CataractFAERS: 1US FAERS
23Chest PainFAERS: 119041562CTD
OFFSIDES
US FAERS
24DysphoniaFAERS: 1US FAERS
25EosinophiliaFAERS: 1SIDER
US FAERS
26ExcoriationFAERS: 1OFFSIDES
US FAERS
27Gastrointestinal sounds abnormalFAERS: 1US FAERS
28HepatitisFAERS: 1SIDER
US FAERS
29InfertilityFAERS: 1US FAERS
30Intentional product misuseFAERS: 1US FAERS
31MacroglossiaFAERS: 1US FAERS
32MalaiseFAERS: 1SIDER
US FAERS
33Maternal exposure during pregnancyFAERS: 1US FAERS
34Nephritis allergicFAERS: 1US FAERS
35Nephrotic SyndromeFAERS: 1US FAERS
36OverdoseFAERS: 1US FAERS
37PancreatitisFAERS: 1SIDER
US FAERS
38PolyhydramniosFAERS: 1US FAERS
39Posterior capsule opacificationFAERS: 1US FAERS
40Product quality issueFAERS: 1US FAERS
41Product use issueFAERS: 1US FAERS
42PruritusFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
43PyelocaliectasisFAERS: 1US FAERS
44Rash erythematousFAERS: 1US FAERS
45Respiratory FailureFAERS: 1US FAERS
46RetchingFAERS: 1US FAERS
47SalpingitisFAERS: 1US FAERS
48Sense of oppressionFAERS: 1US FAERS
49Sexual DysfunctionFAERS: 1US FAERS
50SubileusFAERS: 1US FAERS
51Suicide attemptFAERS: 1US FAERS
52SyncopeFAERS: 1SIDER
US FAERS
53TachycardiaFAERS: 1SIDER
US FAERS
54Toxicity to various agentsFAERS: 1US FAERS
55AbuseOFFSIDES
56Acute Coronary SyndromeOFFSIDES
SIDER
57Adenomatous Polyposis Coli10680582CTD
58Adenoma9331093CTD
OFFSIDES
59Alanine Aminotransferase IncreasedOFFSIDES
60AlbuminuriaSIDER
61AlopeciaSIDER
62AmblyopiaSIDER
63AmnesiaCanada Vigilance: 1Canada Vigilance
SIDER
64Angina PectorisSIDER
65Angiogram cerebral abnormalOFFSIDES
66AnhedoniaOFFSIDES
67AnisocoriaOFFSIDES
68Anorectal discomfortSIDER
69Anorexia4611579CTD
OFFSIDES
SIDER
70Anticholinergic SyndromeOFFSIDES
71AnxietyOFFSIDES
SIDER
72ApathyOFFSIDES
73AppendicitisOFFSIDES
74ArthritisSIDER
75ArthropathySIDER
76AstheniaCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
77AsthmaSIDER
78AtaxiaSIDER
79Autoimmune hepatitisOFFSIDES
80Bile duct cancer stage IIIOFFSIDES
81Bladder painSIDER
82Bleeding tendencySIDER
83BlepharitisSIDER
84Blood beta-D-glucan increasedOFFSIDES
85Blood magnesium increasedOFFSIDES
86Blood potassium increasedOFFSIDES
87Blood urea increasedOFFSIDES
88BoredomOFFSIDES
89BronchitisOFFSIDES
SIDER
90Cardiac ArrestCanada Vigilance: 1Canada Vigilance
91Catheter sepsisOFFSIDES
92Cerebrovascular accidentSIDER
93Chemical and Drug Induced Liver Injury15066135
23152190
24085192		CTD
94ChillsSIDER
95CholecystitisSIDER
96Cholestasis1389551CTD
97ChromaturiaCanada Vigilance: 1Canada Vigilance
98Clostridium colitisOFFSIDES
99ColitisSIDER
100ConjunctivitisSIDER
101ConstipationCanada Vigilance: 14611579CTD
SIDER
Canada Vigilance
102Corneal OpacitySIDER
103CyanosisOFFSIDES
104CystitisSIDER
105Deafness NeurosensoryOFFSIDES
106DeafnessSIDER
107Deep Brain StimulationOFFSIDES
108Denture wearerOFFSIDES
109Depressed Level of ConsciousnessOFFSIDES
110DermatitisSIDER
111DiabetesOFFSIDES
112DiplopiaSIDER
113Discomfort rectalSIDER
114DiscomfortSIDER
115Disseminated Intravascular CoagulationOFFSIDES
116Distress gastrointestinalSIDER
117DistressSIDER
118Disturbance in sexual arousalSIDER
119DiverticulumOFFSIDES
120DrowsinessOFFSIDES
SIDER
121Drug Eruptions11792017
19041562		CTD
122Drug exposure during pregnancyOFFSIDES
123Drug prescribing errorOFFSIDES
124Dry skinSIDER
125DyspepsiaCanada Vigilance: 14595274CTD
SIDER
Canada Vigilance
126Dyspnoea exacerbatedOFFSIDES
127DysuriaSIDER
128EcchymosisSIDER
129Economic problemOFFSIDES
130EczemaSIDER
131Electroencephalogram abnormalSIDER
132Electromechanical dissociationOFFSIDES
133Emotional distressSIDER
134EndophthalmitisOFFSIDES
SIDER
135Enlargement abdomenSIDER
136EnteritisSIDER
137EnterocolitisOFFSIDES
138EpidermolysisOFFSIDES
139EpiglottitisOFFSIDES
140EpilepsyOFFSIDES
141EpistaxisSIDER
142Erectile dysfunctionSIDER
143EructationSIDER
144Erythema MultiformeSIDER
145Euphoric moodSIDER
146Exanthema4611579CTD
147Eye InfectionCanada Vigilance: 1Canada Vigilance
148Eye infection intraocularOFFSIDES
149Eye irritationSIDER
150Eye painOFFSIDES
151Eyelids pruritusOFFSIDES
152Feeling abnormalSIDER
153Fever9952427CTD
154FibromyalgiaOFFSIDES
155FibrosisSIDER
156Fistula dischargeOFFSIDES
157FlatulenceSIDER
158FlushingCanada Vigilance: 1Canada Vigilance
159Gastric ulcerCanada Vigilance: 1Canada Vigilance
OFFSIDES
160GastroenteritisSIDER
161Gastrointestinal Diseases3514310CTD
162Gastrointestinal Hemorrhage3560095
17258737		CTD
163Gastrointestinal PainSIDER
164Gastrointestinal amyloidosisOFFSIDES
165Gastrointestinal perforationSIDER
166General physical health deteriorationOFFSIDES
167GingivitisSIDER
168GlaucomaSIDER
169GlobulinuriaOFFSIDES
170GlossitisSIDER
171GoiterOFFSIDES
172HeadacheCanada Vigilance: 23514310
3560095		CTD
SIDER
Canada Vigilance
173Heart sounds abnormalOFFSIDES
174HeartburnSIDER
175Helicobacter pylori identification test positiveOFFSIDES
176Hepatic cancer metastaticOFFSIDES
177Hepatitis AOFFSIDES
178Hepatitis B surface antigen positiveOFFSIDES
179Histiocytosis haematophagicOFFSIDES
180Hypercalciuria6360294CTD
181HyperreflexiaSIDER
182HypersensitivityCanada Vigilance: 1Canada Vigilance
SIDER
183HyperventilationSIDER
184HypophagiaOFFSIDES
185HypopyonOFFSIDES
186HypotensionSIDER
187HysterectomyOFFSIDES
188IncontinenceSIDER
189InfectionSIDER
190Inflammation9952427
11099482
11291649		CTD
191InfluenzaSIDER
192Intervertebral Disc DegenerationOFFSIDES
193Intestinal Diseases16944022CTD
194Intestinal Neoplasms9331093CTD
195Intestinal PerforationOFFSIDES
196Intraocular inflammationOFFSIDES
197Iodine allergyOFFSIDES
198IritisOFFSIDES
199Jaundice, Obstructive6807485CTD
200KeratitisSIDER
201KeratoconjunctivitisSIDER
202Kidney Diseases17258737CTD
203Kidney FailureOFFSIDES
204Kidney Papillary Necrosis1949951CTD
205Laryngeal erythemaOFFSIDES
206LaryngitisSIDER
207LethargyCanada Vigilance: 1Canada Vigilance
208LeukocytosisSIDER
209LeukopeniaSIDER
210LeukorrheaSIDER
211Livedo ReticularisOFFSIDES
212Lupus-like syndromeOFFSIDES
213LymphadenopathySIDER
214Lymphocyte stimulation test positiveOFFSIDES
215LymphomaOFFSIDES
216Malignant neoplasm progressionOFFSIDES
217MeningitisSIDER
218Mental status changesOFFSIDES
219Metabolic acidosisOFFSIDES
220Middle Lobe SyndromeOFFSIDES
221Mood swingsSIDER
222MumpsOFFSIDES
223Muscle Cramp3515927CTD
224Muscle strainOFFSIDES
225Musculoskeletal discomfortSIDER
226MyalgiaSIDER
227MydriasisSIDER
228Myeloma recurrenceOFFSIDES
229Myocardial InfarctionSIDER
230Myocarditis19041562CTD
231Nephritis, Interstitial1951476
3626164		CTD
232NephritisCanada Vigilance: 1Canada Vigilance
233Nephrogenic Diabetes InsipidusOFFSIDES
234NephrolithiasisSIDER
235Nerve BlockOFFSIDES
236NervousnessSIDER
237NeuralgiaSIDER
238NeutropeniaSIDER
239Neutrophil count decreasedOFFSIDES
240Ocular ToxicityOFFSIDES
241OliguriaOFFSIDES
SIDER
242Open woundOFFSIDES
243Optic NeuritisSIDER
244Oral fungal infectionOFFSIDES
245OsteomyelitisOFFSIDES
246Pain, Postoperative3327906
3515927		CTD
247Pain3145369
9882077		CTD
SIDER
248PallorOFFSIDES
249PancytopeniaSIDER
250Peptic UlcerCanada Vigilance: 1Canada Vigilance
SIDER
251PeritonitisOFFSIDES
252PetechiaeSIDER
253Pharyngitis12011823CTD
SIDER
254PhlebitisSIDER
255PhotophobiaSIDER
256PneumoniaSIDER
257PolyuriaSIDER
258Post procedural complicationOFFSIDES
259Prostatic Neoplasms17409433CTD
260Protein urine presentSIDER
261ProteinuriaSIDER
262Prothrombin time ratio decreasedOFFSIDES
263Pulmonary EmbolismSIDER
264Pulmonary InfarctionSIDER
265Pulmonary function test decreasedSIDER
266PurpuraSIDER
267PyuriaSIDER
268Respiratory DepressionSIDER
269RhabdomyolysisOFFSIDES
270RhinitisSIDER
271Right ventricular failureSIDER
272Ruptured cerebral aneurysmOFFSIDES
273ScleritisOFFSIDES
SIDER
274Secretion dischargeOFFSIDES
275SepsisSIDER
276Septic ShockOFFSIDES
277Sick Sinus SyndromeOFFSIDES
278SinusitisSIDER
279Skeletal injuryOFFSIDES
280Skin UlcerSIDER
281SnoringOFFSIDES
282SomnolenceCanada Vigilance: 1Canada Vigilance
SIDER
283Stevens-Johnson Syndrome25811541CTD
OFFSIDES
SIDER
284StomatitisCanada Vigilance: 1Canada Vigilance
SIDER
285StridorOFFSIDES
286Submandibular massOFFSIDES
287SweatingSIDER
288Synovial CystOFFSIDES
289SynovitisOFFSIDES
290Tardive DyskinesiaOFFSIDES
291TenosynovitisSIDER
292TensionSIDER
293Thalamic infarctionOFFSIDES
294Therapy naiveOFFSIDES
295ThirstSIDER
296ThrombocytopeniaSIDER
297Thromboembolism7495106CTD
298TinnitusCanada Vigilance: 1Canada Vigilance
SIDER
299Tooth ExtractionOFFSIDES
300Toxic Epidermal NecrolysisSIDER
301Toxic anterior segment syndromeOFFSIDES
302TremorSIDER
303UlcerSIDER
304Ulnar Nerve PalsyOFFSIDES
305Urethritis noninfectiveSIDER
306UrethritisSIDER
307Urinary tract infectionSIDER
308Urine output increasedSIDER
309Uterine Diseases3515927CTD
310Vaginal DischargeSIDER
311Vascular purpuraSIDER
312Vasculitis2138443CTD
SIDER
313Vasodilation procedureSIDER
314VasodilationSIDER
315VertigoSIDER
316Visual ImpairmentSIDER
317Vitamin K DeficiencyOFFSIDES
318VitritisOFFSIDES
319VulvovaginitisSIDER
320fibromaOFFSIDES
321jaundiceSIDER
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