MetaADEDB 2.0 @ LMMD
Dinoprostone
(XEYBRNLFEZDVAW-ARSRFYASSA-N)
Structure
SMILES
CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O
Type(s)
Approved
ATC code(s)
G02AD02
Molecular Formula:
C20H32O5
Molecular Weight:
352.465
Log P:
3.2511
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
3
TPSA:
94.83
CAS Number(s):
363-24-6
Synonym(s)
1.
Dinoprostone
2.
PGE2
3.
PGE2alpha
4.
Prostaglandin E2
5.
Prostaglandin E2alpha
6.
PGE2 alpha
7.
Prepidil Gel
8.
Prostaglandin E2 alpha
9.
Prostenon
10.
E2 alpha, Prostaglandin
11.
E2, Prostaglandin
12.
E2alpha, Prostaglandin
13.
Gel, Prepidil
14.
alpha, PGE2
15.
alpha, Prostaglandin E2
External Link(s)
MeSHD015232
PubChem Compound5280360
BindingDB35847
50125414
ChEBI15551
CHEMBLCHEMBL548
DrugBankDB00917
DrugCentral913
IUPHAR/BPS Guide to PHARMACOLOGY1883
1916
KEGGcpd:C00584
dr:D00079
Therapeutic Target DatabaseD06FEA
ZINC3830713
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug exposure during pregnancyFAERS: 111US FAERS
2Disseminated Intravascular CoagulationFAERS: 35
Canada Vigilance: 1		11093878
15547535		CTD
Canada Vigilance
US FAERS
3Uterine RuptureFAERS: 30
Canada Vigilance: 9		Canada Vigilance
US FAERS
4Complications of maternal exposure to therapeutic drugsFAERS: 24US FAERS
5Anaphylactoid syndrome of pregnancyFAERS: 23US FAERS
6Drug ineffectiveFAERS: 16
Canada Vigilance: 4		Canada Vigilance
US FAERS
7Maternal exposure during pregnancyFAERS: 15US FAERS
8Vulvovaginal swellingFAERS: 11US FAERS
9MalaiseFAERS: 10US FAERS
10VomitingFAERS: 10
Canada Vigilance: 3		16844111CTD
Canada Vigilance
US FAERS
11Cardiac ArrestFAERS: 9US FAERS
12HypersensitivityFAERS: 9US FAERS
13HypotensionFAERS: 91908582
2240500
6963085		CTD
US FAERS
14NauseaFAERS: 9
Canada Vigilance: 4		3464525CTD
Canada Vigilance
US FAERS
15Product use issueFAERS: 9US FAERS
16Abdominal PainFAERS: 8
Canada Vigilance: 1		Canada Vigilance
US FAERS
17TachycardiaFAERS: 8
Canada Vigilance: 2		12648744CTD
Canada Vigilance
US FAERS
18Blood pH decreasedFAERS: 7
Canada Vigilance: 1		Canada Vigilance
US FAERS
19InfectionFAERS: 7US FAERS
20PainFAERS: 7
Canada Vigilance: 1

View details

8773445
12077577
16730668
20018876
21043369
 		CTD
Canada Vigilance
US FAERS
21Vulvovaginal painFAERS: 7US FAERS
22DizzinessFAERS: 6
Canada Vigilance: 1		Canada Vigilance
US FAERS
23HysterectomyFAERS: 6US FAERS
24Maternal exposure during deliveryFAERS: 6US FAERS
25ShockFAERS: 6US FAERS
26StillbirthFAERS: 6US FAERS
27TremorFAERS: 6
Canada Vigilance: 3		Canada Vigilance
US FAERS
28BradycardiaFAERS: 5
Canada Vigilance: 2		1655886CTD
Canada Vigilance
US FAERS
29Cerebral PalsyFAERS: 5US FAERS
30Contraindicated product administeredFAERS: 5US FAERS
31Drug administration errorFAERS: 5US FAERS
32Feeling abnormalFAERS: 5US FAERS
33OverdoseFAERS: 5US FAERS
34Vulvovaginal discomfortFAERS: 5US FAERS
35Incorrect drug administration durationFAERS: 4US FAERS
36Sinus TachycardiaFAERS: 4US FAERS
37Uterine TachysystoleFAERS: 4US FAERS
38AbasiaFAERS: 3US FAERS
39Anaphylactic shockFAERS: 3US FAERS
40Anaphylactoid ReactionFAERS: 3US FAERS
41AnxietyFAERS: 3US FAERS
42Back PainFAERS: 3US FAERS
43ChillsFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
44Complication of deliveryFAERS: 3US FAERS
45CyanosisFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
46Device expulsionFAERS: 3US FAERS
47Diabetes MellitusFAERS: 3US FAERS
48DiscomfortFAERS: 3US FAERS
49MetrorrhagiaFAERS: 3US FAERS
50Neonatal disorderFAERS: 3US FAERS
51Obstetric procedure complicationFAERS: 3US FAERS
52PallorFAERS: 3US FAERS
53Pharmaceutical product complaintFAERS: 3US FAERS
54Placental InsufficiencyFAERS: 3US FAERS
55Product quality issueFAERS: 3US FAERS
56StressFAERS: 3US FAERS
57Sudden infant death syndromeFAERS: 3US FAERS
58Troponin increasedFAERS: 3US FAERS
59Vulvovaginal burning sensationFAERS: 3US FAERS
60Vulvovaginal drynessFAERS: 3US FAERS
61Vulvovaginal pruritusFAERS: 3US FAERS
62Apparent deathFAERS: 2US FAERS
63Application site painFAERS: 2US FAERS
64AstheniaFAERS: 2US FAERS
65AsthmaFAERS: 2US FAERS
66Blood pressure immeasurableFAERS: 2US FAERS
67Broad ligament tearFAERS: 2US FAERS
68Complication of device removalFAERS: 2US FAERS
69DehydrationFAERS: 2US FAERS
70Device dislocationFAERS: 2US FAERS
71Disabled relativeFAERS: 2US FAERS
72Drug monitoring procedure incorrectly performedFAERS: 2US FAERS
73DysgeusiaFAERS: 2US FAERS
74Forceps deliveryFAERS: 2US FAERS
75Foreign body traumaFAERS: 2US FAERS
76Gait inabilityFAERS: 2US FAERS
77HyperkinesiaFAERS: 2US FAERS
78Hypocoagulable stateFAERS: 2US FAERS
79HypokinesiaFAERS: 2US FAERS
80HypoxiaFAERS: 2US FAERS
81Incorrect dose administeredFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
82InfarctionFAERS: 2US FAERS
83Maternal death during childbirthFAERS: 2US FAERS
84Neonatal aspirationFAERS: 2US FAERS
85Pelvic PainFAERS: 2US FAERS
86Procedural complicationFAERS: 2US FAERS
87Product packaging issueFAERS: 2US FAERS
88Respiratory FailureFAERS: 2US FAERS
89SyncopeFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
90Therapy non-responderFAERS: 2US FAERS
91Unevaluable eventFAERS: 2US FAERS
92Urinary RetentionFAERS: 27202987CTD
US FAERS
93Uterine spasmFAERS: 2
Canada Vigilance: 3		Canada Vigilance
US FAERS
94Vulvovaginal erythemaFAERS: 2US FAERS
95Abdominal discomfortFAERS: 1US FAERS
96Accidental exposure to productFAERS: 1US FAERS
97Acute kidney injuryFAERS: 1513486
3547511		CTD
US FAERS
98AgitationFAERS: 1US FAERS
99Antithrombin III decreasedFAERS: 1US FAERS
100Apallic syndromeFAERS: 1US FAERS
101Apparent life threatening eventFAERS: 1US FAERS
102Application site discomfortFAERS: 1US FAERS
103Artificial rupture of membranesFAERS: 1US FAERS
104Blood fibrinogen increasedFAERS: 1US FAERS
105Blood gases abnormalFAERS: 1US FAERS
106Blood lactate dehydrogenase increasedFAERS: 1US FAERS
107BronchospasmFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
108Burning sensationFAERS: 1US FAERS
109Cerebral InfarctionFAERS: 1US FAERS
110Chest PainFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
111Chest discomfortFAERS: 1US FAERS
112Congenital brain damageFAERS: 1US FAERS
113ConstipationFAERS: 1US FAERS
114Depressed Level of ConsciousnessFAERS: 1US FAERS
115Device breakageFAERS: 1US FAERS
116DisorientationFAERS: 1US FAERS
117DysarthriaFAERS: 1US FAERS
118Echocardiogram abnormalFAERS: 1US FAERS
119EclampsiaFAERS: 1US FAERS
120EpilepsyFAERS: 1US FAERS
121Escherichia infectionFAERS: 1US FAERS
122Facial ParesisFAERS: 1US FAERS
123Failure to suspend medicationFAERS: 1US FAERS
124FatigueFAERS: 1US FAERS
125FibrinolysisFAERS: 1US FAERS
126FlushingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
127Gastrointestinal PainFAERS: 1US FAERS
128General physical condition abnormalFAERS: 1US FAERS
129Genital swellingFAERS: 1US FAERS
130Incorrect route of drug administrationFAERS: 1US FAERS
131Intentional drug misuseFAERS: 1US FAERS
132Intentional product misuseFAERS: 1US FAERS
133LethargyFAERS: 1US FAERS
134LeukocytosisFAERS: 13464525CTD
US FAERS
135Medication ErrorFAERS: 1US FAERS
136MenorrhagiaFAERS: 1US FAERS
137Metabolic acidosisFAERS: 1US FAERS
138MonoparesisFAERS: 1US FAERS
139Multi-organ disorderFAERS: 1US FAERS
140Muscle RigidityFAERS: 1US FAERS
141Musculoskeletal PainFAERS: 1US FAERS
142Neonatal multi-organ failureFAERS: 1US FAERS
143Neonatal pneumoniaFAERS: 1US FAERS
144Neonatal respiratory depressionFAERS: 1US FAERS
145NervousnessFAERS: 1US FAERS
146No adverse eventFAERS: 1US FAERS
147OligohydramniosFAERS: 1US FAERS
148Oxygen consumption decreasedFAERS: 1US FAERS
149PCO2 increasedFAERS: 1US FAERS
150Perineal painFAERS: 1US FAERS
151Post procedural complicationFAERS: 1US FAERS
152Pre-EclampsiaFAERS: 1US FAERS
153PregnancyFAERS: 1US FAERS
154Prescribed overdoseFAERS: 1US FAERS
155PresyncopeFAERS: 1US FAERS
156Product dispensing errorFAERS: 1US FAERS
157Product monitoring errorFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
158Product physical issueFAERS: 1US FAERS
159Product shape issueFAERS: 1US FAERS
160Product use in unapproved indicationFAERS: 1US FAERS
161Respiratory arrestFAERS: 1US FAERS
162Respiratory distressFAERS: 1US FAERS
163SepsisFAERS: 1US FAERS
164SomnolenceFAERS: 1US FAERS
165TachyarrhythmiaFAERS: 1US FAERS
166TalipesFAERS: 1US FAERS
167TetanyFAERS: 1US FAERS
168ThrombocytopeniaFAERS: 13464525
6587802		CTD
US FAERS
169TinnitusFAERS: 1US FAERS
170Uterine contractions during pregnancyFAERS: 1
Canada Vigilance: 6		Canada Vigilance
US FAERS
171Uterine inflammationFAERS: 1US FAERS
172Venous oxygen saturation decreasedFAERS: 1US FAERS
173VertigoFAERS: 1US FAERS
174Vulvovaginal inflammationFAERS: 1US FAERS
175Wrong drug administeredFAERS: 1US FAERS
176Wrong product administeredFAERS: 1US FAERS
177effusionFAERS: 1US FAERS
178treatment failureFAERS: 1US FAERS
179Adenomatous Polyposis Coli17942926CTD
180Anxiety Disorders12893632CTD
181Aortic Aneurysm, Abdominal10388637CTD
182Aortic Aneurysm10231640CTD
183Application site reactionCanada Vigilance: 2Canada Vigilance
184Arthritis, Experimental22450443CTD
185Atherosclerosis17242161CTD
186Brain Injuries3249309
20810888		CTD
187Bronchial Hyperreactivity15700024CTD
188Carcinoma12189197CTD
189Catalepsy

View details

1378634
3463941
3862460
6679984
 		CTD
190Cerebral atrophyCanada Vigilance: 1Canada Vigilance
191Cerebrovascular accidentCanada Vigilance: 1Canada Vigilance
192Colorectal Neoplasms15753380
17640974		CTD
193Conjunctival Diseases16252016CTD
194Cystitis3422144
6587802		CTD
195Depressive disorder19356723CTD
196Diarrhea7237001
10446763
11488427		CTD
197Dyskinesia, Drug-Induced3862460CTD
198Dyspnea3464525CTD
199Edema16240498
16644903		CTD
200Electrolyte imbalanceCanada Vigilance: 1Canada Vigilance
201EmbolismCanada Vigilance: 1Canada Vigilance
202Erectile dysfunction10368209CTD
203Erythema74166
1371395		CTD
204Esophageal Neoplasms12189197CTD
205Extravasation of Diagnostic and Therapeutic Materials1461920CTD
206Fanconi Syndrome3153322CTD
207Fever11852909
12648744
16997862		CTD
208Glaucoma16252016CTD
209Headache19187340CTD
210Hematuria6587802CTD
211Hemorrhage6587802CTD
212Hydronephrosis30641090CTD
213Hyperalgesia

View details

230543
1425939
1722888
2322844
2502301
2557556
2833584
2998815
3014543
3061568
3475494
6278540
6963550
7493622
7606458
7715785
7830882
7881729
8371142
8577488
8684612
8834407
8907337
9113374
9133408
9714424
9720808
10401557
10499367
10543429
10813554
10877451
10920437
11181927
11375261
11454025
12151517
12582831
14622681
14666255
14984413
15063156
15126118
15275794
15621379
15626726
15814086
15836982
15910182
16026475
16240498
16472913
16793879
18234883
18297109
18509033
19646975
20457222
21521205
26141506
 		CTD
214Hyperesthesia8190269CTD
215Idiopathic Pulmonary Fibrosis28434932CTD
216Immune Complex Diseases159314CTD
217Immunologic Deficiency Syndromes19726579CTD
218Inflammation11181422
18297109
23795810		CTD
219Intestinal Diseases16944022CTD
220Kidney Diseases1963649
3458551		CTD
221Liver Cirrhosis, Experimental15816358CTD
222Liver diseases15816358CTD
223Multiple Myeloma8520508CTD
224Muscle Hypertonia4135526CTD
225MyopiaCanada Vigilance: 1Canada Vigilance
226Necrosis11713899CTD
227Nephrotic Syndrome3166326CTD
228Obstetric Labor Complications8113646CTD
229Osteoarthropathy, Secondary Hypertrophic18500342CTD
230Pain, Postoperative8123399CTD
231Pancreatitis11321505CTD
232Pleurisy11181422CTD
233Postpartum Hemorrhage1610638
2240500		CTD
234Pregnancy, Prolonged

View details

4135526
17877293
19467806
21043369
 		CTD
235Product lot number issueCanada Vigilance: 1Canada Vigilance
236Pruritus74166
12077577		CTD
237Pulmonary EmbolismCanada Vigilance: 1Canada Vigilance
238Reperfusion Injury10594344
20609232		CTD
239Respiratory tract congestionCanada Vigilance: 1Canada Vigilance
240Sarcoma2248514CTD
241Seizures952799
3109689		CTD
242Stereotypic Movement Disorder3463941CTD
243Throat irritationCanada Vigilance: 1Canada Vigilance
244Thrombosis17242161CTD
245Ureteral obstruction26207612CTD
246Uterine cervix dilation procedureCanada Vigilance: 2Canada Vigilance
247Vasculitis159314CTD
248VasospasmCanada Vigilance: 1Canada Vigilance
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