MetaADEDB 2.0 @ LMMD
Sulindac
(MLKXDPUZXIRXEP-MFOYZWKCSA-N)
Structure
SMILES
OC(=O)CC1=C(C)/C(=C/c2ccc(cc2)S(=O)C)/c2c1cc(F)cc2
Type(s)
Approved; Investigational
ATC code(s)
M01AB02
Molecular Formula:
C20H17FO3S
Molecular Weight:
356.411
Log P:
5.2312
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
73.58
CAS Number(s):
32004-68-5; 38194-50-2
Synonym(s)
1.
Sulindac
2.
Aclin
3.
Apo-Sulin
4.
Arthrobid
5.
Arthrocine
6.
Chibret
7.
Clinoril
8.
Copal
9.
Kenalin
10.
Klinoril
11.
MK-231
12.
Novo-Sundac
13.
Nu-Sulindac
14.
Sulindal
15.
Apo Sulin
16.
MK 231
17.
MK231
18.
Novo Sundac
19.
Nu Sulindac
External Link(s)
MeSHD013467
PubChem Compound1548887
BindingDB50103504
50012899
ChEBI9352
93811
CHEMBLCHEMBL15770
DrugBankDB00605
DrugCentral2534
IUPHAR/BPS Guide to PHARMACOLOGY5425
KEGGcpd:C01531
dr:D00120
Therapeutic Target DatabaseD0Z5IU
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1VomitingFAERS: 8
Canada Vigilance: 4		6612404
6614684		CTD
SIDER
Canada Vigilance
US FAERS
2Acute kidney injuryFAERS: 77897758CTD
US FAERS
3Drug ineffectiveFAERS: 6US FAERS
4AstheniaFAERS: 5
Canada Vigilance: 5		Canada Vigilance
OFFSIDES
SIDER
US FAERS
5Chest PainFAERS: 5
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
6DizzinessFAERS: 5
Canada Vigilance: 6		Canada Vigilance
SIDER
US FAERS
7Drug exposure during pregnancyFAERS: 5US FAERS
8Suicide attemptFAERS: 5US FAERS
9Anaphylactic shockFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
10CholangitisFAERS: 43623432CTD
US FAERS
11Dry gangreneFAERS: 4US FAERS
12Gastrointestinal mucosal disorderFAERS: 4US FAERS
13HeadacheFAERS: 4
Canada Vigilance: 2

View details

6612404
6614684
7053720
17703306
 		CTD
SIDER
Canada Vigilance
US FAERS
14HypersensitivityFAERS: 4SIDER
US FAERS
15NauseaFAERS: 4
Canada Vigilance: 7		6612404
17703306
20013860		CTD
SIDER
Canada Vigilance
US FAERS
16PainFAERS: 43291741
6305373		CTD
US FAERS
17PruritusFAERS: 4
Canada Vigilance: 10		7053720
7450449		CTD
SIDER
Canada Vigilance
US FAERS
18Stevens-Johnson SyndromeFAERS: 48256166
25811541		CTD
SIDER
US FAERS
19Toxic Epidermal NecrolysisFAERS: 4SIDER
US FAERS
20ConstipationFAERS: 3SIDER
US FAERS
21Duodenal UlcerFAERS: 3OFFSIDES
US FAERS
22EnteritisFAERS: 3US FAERS
23FatigueFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
24OverdoseFAERS: 3US FAERS
25Pharmaceutical product complaintFAERS: 3US FAERS
26Portal venous gasFAERS: 3US FAERS
27Weight decreasedFAERS: 3US FAERS
28Abdominal PainFAERS: 2
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
29Abdominal discomfortFAERS: 2OFFSIDES
US FAERS
30AcidosisFAERS: 2US FAERS
31Adverse eventFAERS: 2US FAERS
32AnuriaFAERS: 2US FAERS
33Back PainFAERS: 2US FAERS
34BlindnessFAERS: 2US FAERS
35Blood alkaline phosphatase increasedFAERS: 2OFFSIDES
US FAERS
36ChillsFAERS: 2
Canada Vigilance: 2		7450449CTD
SIDER
Canada Vigilance
US FAERS
37CystFAERS: 2US FAERS
38Drug toxicityFAERS: 2US FAERS
39Drug withdrawal syndromeFAERS: 2US FAERS
40DyspepsiaFAERS: 2OFFSIDES
SIDER
US FAERS
41Gastric ulcerFAERS: 2OFFSIDES
US FAERS
42HirsutismFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
43HypertrophyFAERS: 2US FAERS
44HypotensionFAERS: 2SIDER
US FAERS
45Ileal ulcer perforationFAERS: 2US FAERS
46MalaiseFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
47Myocardial InfarctionFAERS: 2US FAERS
48Neonatal respiratory depressionFAERS: 2US FAERS
49Oculomucocutaneous syndromeFAERS: 2US FAERS
50Polysubstance dependenceFAERS: 2US FAERS
51Pre-EclampsiaFAERS: 2US FAERS
52PresyncopeFAERS: 2US FAERS
53Pulse waveform abnormalFAERS: 2US FAERS
54Self MutilationFAERS: 2US FAERS
55UrticariaFAERS: 2
Canada Vigilance: 4		Canada Vigilance
SIDER
US FAERS
56Abdominal rigidityFAERS: 1US FAERS
57AgitationFAERS: 1US FAERS
58Alanine Aminotransferase IncreasedFAERS: 1OFFSIDES
US FAERS
59Alcohol poisoningFAERS: 1US FAERS
60AnxietyFAERS: 1OFFSIDES
US FAERS
61ArthralgiaFAERS: 1
Canada Vigilance: 1		6612404CTD
SIDER
Canada Vigilance
US FAERS
62Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
63Blood creatinine increasedFAERS: 1US FAERS
64Blood glucose increasedFAERS: 1US FAERS
65Blood pressure inadequately controlledFAERS: 1US FAERS
66Blood urea increasedFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
67Burning sensationFAERS: 1US FAERS
68Cardiac ArrestFAERS: 1US FAERS
69Cerebrovascular accidentFAERS: 1US FAERS
70Chest discomfortFAERS: 1US FAERS
71ChokingFAERS: 1US FAERS
72CholelithiasisFAERS: 110445564CTD
SIDER
US FAERS
73CholestasisFAERS: 13866535
7117907		CTD
SIDER
US FAERS
74Cholestatic liver injuryFAERS: 1US FAERS
75ChromaturiaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
76Completed SuicideFAERS: 1US FAERS
77Coronary Artery DiseaseFAERS: 1US FAERS
78Disease ProgressionFAERS: 1US FAERS
79Disseminated Intravascular CoagulationFAERS: 1OFFSIDES
SIDER
US FAERS
80Drug dispensing errorFAERS: 1US FAERS
81Dry skinFAERS: 1US FAERS
82Duodenal ulcer perforationFAERS: 1US FAERS
83DysphoniaFAERS: 1US FAERS
84Economic problemFAERS: 1US FAERS
85ErythemaFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
86Feeling ColdFAERS: 1US FAERS
87Feeling abnormalFAERS: 1OFFSIDES
SIDER
US FAERS
88Gastrointestinal erosionFAERS: 1US FAERS
89Gastrointestinal perforationFAERS: 1SIDER
US FAERS
90HepatomegalyFAERS: 17450449CTD
US FAERS
91Impaired work abilityFAERS: 1US FAERS
92Joint Range of Motion DecreasedFAERS: 1US FAERS
93LeukocytosisFAERS: 1SIDER
US FAERS
94LeukopeniaFAERS: 1SIDER
US FAERS
95MeningitisFAERS: 1US FAERS
96Musculoskeletal PainFAERS: 1US FAERS
97Musculoskeletal stiffnessFAERS: 1OFFSIDES
US FAERS
98MyocarditisFAERS: 1US FAERS
99NephrolithiasisFAERS: 1SIDER
US FAERS
100NervousnessFAERS: 1SIDER
US FAERS
101PancreatitisFAERS: 1
Canada Vigilance: 1		3623432CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
102PancytopeniaFAERS: 16107481CTD
SIDER
US FAERS
103Pelvic massFAERS: 1US FAERS
104Pharyngolaryngeal PainFAERS: 1US FAERS
105PiloerectionFAERS: 1US FAERS
106PolyhydramniosFAERS: 1US FAERS
107PregnancyFAERS: 1US FAERS
108Rash erythematousFAERS: 1
Canada Vigilance: 5		Canada Vigilance
US FAERS
109RestlessnessFAERS: 1US FAERS
110ShockFAERS: 1SIDER
US FAERS
111Skin necrosisFAERS: 1US FAERS
112SwellingFAERS: 1US FAERS
113Therapeutic product contaminationFAERS: 1US FAERS
114Therapeutic product ineffectiveFAERS: 1US FAERS
115Therapeutic response unexpected with drug substitutionFAERS: 1US FAERS
116Thermal burnFAERS: 1US FAERS
117ThrombocytopeniaFAERS: 1SIDER
US FAERS
118TinnitusFAERS: 1OFFSIDES
SIDER
US FAERS
119TremorFAERS: 1US FAERS
120TrismusFAERS: 1US FAERS
121Troponin increasedFAERS: 1OFFSIDES
US FAERS
122UlcerFAERS: 1US FAERS
123UnemploymentFAERS: 1US FAERS
124Ventricular FibrillationFAERS: 1US FAERS
125WheezingFAERS: 1US FAERS
126White blood cell count abnormalFAERS: 1US FAERS
127White blood cell count decreasedFAERS: 1US FAERS
128jaundiceFAERS: 1
Canada Vigilance: 1		7117907CTD
SIDER
Canada Vigilance
US FAERS
129Abdominal Neoplasms14745880CTD
130Aberrant Crypt Foci29999212CTD
131AcarodermatitisOFFSIDES
132Accidental exposureOFFSIDES
133Acid refluxOFFSIDES
134AcromegalyOFFSIDES
135ActinomycosisOFFSIDES
136Acute psychosisSIDER
137Acute respiratory failureOFFSIDES
138Acute sinusitisOFFSIDES
139AdenitisSIDER
140Adenocarcinoma11910360CTD
141Adenomatous Polyposis Coli

View details

11535846
11874996
12394442
15623613
16460482
17611924
19003578
 		CTD
142Adenomatous Polyps10213222CTD
143Adenoma10223192CTD
144AgeusiaOFFSIDES
SIDER
145AgranulocytosisSIDER
146AgraphiaOFFSIDES
147Albuminuria2203262CTD
148Allergic sinusitisOFFSIDES
149AlopeciaSIDER
150AlveoloplastyOFFSIDES
151Amylase increasedCanada Vigilance: 1Canada Vigilance
152Anemia, Hemolytic17381629CTD
153AngioedemaCanada Vigilance: 1Canada Vigilance
SIDER
154AnhidrosisOFFSIDES
155AnorexiaSIDER
156ArthritisCanada Vigilance: 16291491CTD
OFFSIDES
SIDER
Canada Vigilance
157AscitesOFFSIDES
158AtelectasisOFFSIDES
159Autoimmune hepatitisOFFSIDES
160Autoimmune thrombocytopeniaOFFSIDES
161Band neutrophil percentage increasedOFFSIDES
162Biliary SludgeSIDER
163Biopsy breast abnormalOFFSIDES
164Blood GlucoseOFFSIDES
165Blood cholesterolOFFSIDES
166Blood ketone bodyOFFSIDES
167Blood lactate dehydrogenase increasedOFFSIDES
168Blood potassium increasedOFFSIDES
169Blood urine presentOFFSIDES
170Blurred visionOFFSIDES
171Bone lesionOFFSIDES
172Bone marrow depressionSIDER
173Bone painOFFSIDES
174Bowen's Disease11207687CTD
175Brain DeathOFFSIDES
176Brain Diseases2936673CTD
177Bronchoalveolar LavageOFFSIDES
178BronchospasmSIDER
179Cardiac enzymes increasedOFFSIDES
180Catalepsy6409656CTD
181CataractOFFSIDES
182Cerebral circulatory failureOFFSIDES
183Chemical and Drug Induced Liver Injury

View details

3866535
7117907
18524759
19074762
20371263
22019926
24085192
24136188
28437613
 		CTD
184Choking sensationOFFSIDES
185CholangiolitisOFFSIDES
186CholecystitisSIDER
187CirrhosisOFFSIDES
188ColitisSIDER
189Colonic Neoplasms

View details

10500066
11809530
12458338
12902858
15884131
26335331
 		CTD
190Colorectal Neoplasms

View details

10666051
11076880
11197048
18059344
 		CTD
191ConjunctivitisSIDER
192Corneal UlcerOFFSIDES
193CrystalluriaSIDER
194DeafnessOFFSIDES
195Decreased LibidoOFFSIDES
196DehydrationOFFSIDES
197Delirium7359747CTD
198Demyelinating Diseases6291491CTD
199Dental abscessOFFSIDES
200Dental alveolar anomalyOFFSIDES
201Dental prosthesis placementOFFSIDES
202Depressed Level of ConsciousnessOFFSIDES
SIDER
203DermatitisCanada Vigilance: 1Canada Vigilance
SIDER
204Device related infectionOFFSIDES
205DiabetesOFFSIDES
206Diabetes mellitus inadequate controlOFFSIDES
207Diabetic Neuropathies8000974CTD
208Diabetic Retinopathy12861449
17621415		CTD
OFFSIDES
209DiarrheaOFFSIDES
210DiscomfortSIDER
211Drug ToleranceOFFSIDES
212Drug dose omissionOFFSIDES
213Drug withdrawal headacheOFFSIDES
214DysgeusiaCanada Vigilance: 1Canada Vigilance
SIDER
215Dyspnea7053720CTD
216Dysthymic DisorderOFFSIDES
217DysuriaSIDER
218EcchymosisSIDER
219Edema29999212CTD
220Ejection Fraction DecreasedOFFSIDES
221Electromechanical dissociationOFFSIDES
222Emotional distressOFFSIDES
223EndocarditisOFFSIDES
224Endometriosis15652904CTD
225Eosinophilia20013860CTD
SIDER
226EpistaxisSIDER
227Erythema MultiformeCanada Vigilance: 1Canada Vigilance
SIDER
228Esophageal Neoplasms12235107CTD
229Essential HypertensionOFFSIDES
230Exanthema7450449CTD
231Exophthalmos6409656CTD
232Fatty Liver20013860CTD
233Fever

View details

6409656
6614684
7053720
7450449
20013860
 		CTD
234Fibromatosis, Abdominal14745880CTD
235Fibromatosis, Aggressive19069698CTD
236FlatulenceOFFSIDES
SIDER
237FlushingCanada Vigilance: 320013860CTD
SIDER
Canada Vigilance
238Gamma-Glutamyltransferase IncreasedOFFSIDES
239Gastric mucosal lesionOFFSIDES
240GastritisCanada Vigilance: 1Canada Vigilance
SIDER
241GastroenteritisOFFSIDES
SIDER
242Gastrointestinal PainSIDER
243Gastrointestinal crampsSIDER
244GlossitisSIDER
245GranulomaOFFSIDES
246Hallucinations2147293CTD
247Hearing Loss19139001CTD
248Helicobacter pylori identification test positiveOFFSIDES
249Hepatic congestionOFFSIDES
250Hepatitis B positiveOFFSIDES
251HepatitisCanada Vigilance: 2

View details

3866535
7117907
7450449
20013860
 		CTD
OFFSIDES
SIDER
Canada Vigilance
252HostilityOFFSIDES
253HydronephrosisOFFSIDES
254Hyperkalemia3560096CTD
255HyperkeratosisOFFSIDES
256Hyperplasia29999212CTD
257Hypersensitive syndromeSIDER
258Hypertensive heart diseaseOFFSIDES
259Hypoxia19074762CTD
260Ileal ulcerOFFSIDES
261ImmobileOFFSIDES
262Implantable defibrillator insertionOFFSIDES
263Inflammation3291741CTD
264Injection site urticariaOFFSIDES
265Intervertebral disc disorderOFFSIDES
266Intestinal Neoplasms

View details

10213222
10223192
12351151
12584176
12628509
12663524
17474863
26335331
 		CTD
267Intestinal Polyps11245490
12351151
12394442		CTD
268Jaundice, Obstructive7083082CTD
269Joint sprainOFFSIDES
270Kidney Failure, Chronic3884224CTD
271Kidney FailureOFFSIDES
272Kidney Papillary Necrosis6126946CTD
273Lactose IntoleranceOFFSIDES
274Large intestine perforationOFFSIDES
275Leukocytoclastic vasculitisSIDER
276Leukopenia neonatalOFFSIDES
277Ligament ruptureOFFSIDES
278Listeria sepsisOFFSIDES
279Liver AbscessOFFSIDES
280Liver diseases

View details

8256166
14566034
14986274
16867024
 		CTD
281Loose toothOFFSIDES
282Lung Neoplasms15713900
19359593		CTD
283LymphadenitisSIDER
284LymphadenopathyCanada Vigilance: 1Canada Vigilance
285MalariaOFFSIDES
286MastectomyOFFSIDES
287Memory Disorders17266991CTD
288Meningism6612404CTD
289Mental impairmentOFFSIDES
290Metabolic acidosisOFFSIDES
291Mixed Connective Tissue Disease8256166CTD
292MononeuritisOFFSIDES
293Muscle Cramp6305373CTD
294Muscle Weakness6305373CTD
295Musculoskeletal chest painOFFSIDES
296Musculoskeletal discomfortSIDER
297MyalgiaSIDER
298MyopiaOFFSIDES
299Necrosis29999212CTD
300Neoplasms, Experimental12627504
15884131
17401459		CTD
301Nephritic syndromeSIDER
302Nephritis, Interstitial3208459
6585720
6842802		CTD
303Nephrocalcinosis6126946CTD
304Nephrotic SyndromeCanada Vigilance: 13208459
7453761		CTD
SIDER
Canada Vigilance
305Nervous tensionOFFSIDES
306NeuritisSIDER
307NeutropeniaSIDER
308OsteomyelitisOFFSIDES
309OsteosclerosisOFFSIDES
310PalpitationsSIDER
311Pancreatic PseudocystOFFSIDES
312Paresthesia6093724CTD
313Patellofemoral Pain SyndromeOFFSIDES
314Peptic UlcerSIDER
315Peripheral Nervous System Diseases6093724
6291491
6305373		CTD
316PeritonitisOFFSIDES
317PetechiaeCanada Vigilance: 1Canada Vigilance
318PharyngitisCanada Vigilance: 1Canada Vigilance
319Photophobia7053720CTD
320Pneumocystis jiroveci pneumoniaOFFSIDES
321PneumoniaSIDER
322Postmenopausal bleedingOFFSIDES
323Precancerous Conditions11809530
18156308		CTD
324Precancerous skin lesionOFFSIDES
325PresbyopiaOFFSIDES
326Prostate examination abnormalOFFSIDES
327Protein total decreasedOFFSIDES
328Protein urine presentSIDER
329ProteinuriaSIDER
330PsoriasisOFFSIDES
331Psychoses, Substance-Induced2147293CTD
332PurpuraSIDER
333Purulent dischargeOFFSIDES
334Renal Insufficiency3208459CTD
335RhinitisOFFSIDES
336Right atrial dilatationOFFSIDES
337Seizures6433367CTD
338SequestrectomyOFFSIDES
339Serum SicknessCanada Vigilance: 1Canada Vigilance
340Sinus headacheOFFSIDES
341SomnolenceCanada Vigilance: 2Canada Vigilance
SIDER
342Stitch abscessOFFSIDES
343StomatitisCanada Vigilance: 1Canada Vigilance
SIDER
344StressOFFSIDES
345StuporSIDER
346Supraventricular tachycardiaOFFSIDES
347SweatingSIDER
348SyncopeSIDER
349TachycardiaSIDER
350Tardive DyskinesiaOFFSIDES
351TendinitisOFFSIDES
352TenosynovitisOFFSIDES
353TensionSIDER
354Tinea PedisOFFSIDES
355Tobacco userOFFSIDES
356Uterine Neoplasms18645019CTD
357Vascular purpuraSIDER
358VertigoSIDER
359Vision Disorders7053720CTD
360Visual ImpairmentCanada Vigilance: 1Canada Vigilance
SIDER
361Visual disturbanceOFFSIDES
SIDER
362Vulvovaginal mycotic infectionOFFSIDES
363Weight GainOFFSIDES
364Wound ComplicationOFFSIDES
365anaphylaxis6731964CTD
366melanoma16642371CTD
367prostatitisOFFSIDES
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