MetaADEDB 2.0 @ LMMD
Alendronate
(CAKRAHQRJGUPIG-UHFFFAOYSA-M)
Structure
SMILES
NCCCC(P(=O)(O)O)(P(=O)(O)[O-])O.[Na+]
Molecular Formula:
C4H12NNaO7P2
Molecular Weight:
271.078
Log P:
-0.1347
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
5
TPSA:
183.76
CAS Number(s):
129318-43-0
Synonym(s)
1.
Alendronate
2.
4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate
3.
Alendronate Monosodium Salt, Trihydrate
4.
Alendronate Sodium
5.
Aminohydroxybutane Bisphosphonate
6.
Fosamax
7.
MK-217
8.
MK 217
9.
MK217
External Link(s)
MeSHD019386
PubChem Compound16760285
58788844
62958
BindingDB50247920
CHEMBLCHEMBL675
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PainFAERS: 363US FAERS
2Emotional distressFAERS: 280US FAERS
3Low turnover osteopathyFAERS: 252US FAERS
4ArthralgiaFAERS: 149US FAERS
5Osteonecrosis of JawFAERS: 135
Canada Vigilance: 1
Canada Vigilance
US FAERS
6AnxietyFAERS: 124US FAERS
7FractureFAERS: 108US FAERS
8Quality of life decreasedFAERS: 103US FAERS
9MyalgiaFAERS: 86US FAERS
10Drug dose omissionFAERS: 79US FAERS
11Atypical femur fractureFAERS: 74US FAERS
12AnhedoniaFAERS: 70US FAERS
13Bone painFAERS: 67US FAERS
14NauseaFAERS: 63US FAERS
15Osteogenesis ImperfectaFAERS: 61US FAERS
16Back PainFAERS: 50
Canada Vigilance: 1
Canada Vigilance
US FAERS
17Bone density decreasedFAERS: 43US FAERS
18Pathological fractureFAERS: 43US FAERS
19Chest PainFAERS: 42US FAERS
20DyspepsiaFAERS: 42US FAERS
21HeadacheFAERS: 41US FAERS
22AstheniaFAERS: 33US FAERS
23Musculoskeletal PainFAERS: 32US FAERS
24DizzinessFAERS: 31US FAERS
25Abdominal discomfortFAERS: 29US FAERS
26Drug ineffectiveFAERS: 28US FAERS
27Inappropriate schedule of drug administrationFAERS: 27US FAERS
28Unevaluable eventFAERS: 27US FAERS
29Oropharyngeal painFAERS: 24US FAERS
30ConstipationFAERS: 23US FAERS
31Feeling abnormalFAERS: 22US FAERS
32Neck PainFAERS: 22US FAERS
33Tooth ExtractionFAERS: 22US FAERS
34Intramedullary rod insertionFAERS: 21
Canada Vigilance: 1
Canada Vigilance
US FAERS
35MalaiseFAERS: 21US FAERS
36OsteomyelitisFAERS: 21US FAERS
37Product quality issueFAERS: 21US FAERS
38Product substitution issueFAERS: 21US FAERS
39PruritusFAERS: 21US FAERS
40Abdominal PainFAERS: 20US FAERS
41VomitingFAERS: 20US FAERS
42No adverse eventFAERS: 19US FAERS
43Activities of daily living impairedFAERS: 18US FAERS
44Atrial FibrillationFAERS: 16US FAERS
45Joint swellingFAERS: 16US FAERS
46Adverse eventFAERS: 15US FAERS
47SwellingFAERS: 15US FAERS
48ToothacheFAERS: 15US FAERS
49DehydrationFAERS: 14US FAERS
50UrticariaFAERS: 14US FAERS
51AlopeciaFAERS: 13US FAERS
52FlatulenceFAERS: 13US FAERS
53Joint stiffnessFAERS: 13US FAERS
54OsteoporosisFAERS: 13US FAERS
55Throat irritationFAERS: 13US FAERS
56AbasiaFAERS: 12US FAERS
57FatigueFAERS: 12US FAERS
58StomatitisFAERS: 12US FAERS
59Gastric ulcerFAERS: 11US FAERS
60OverdoseFAERS: 11US FAERS
61Weight decreasedFAERS: 11US FAERS
62Accidental overdoseFAERS: 10US FAERS
63Drug administration errorFAERS: 10US FAERS
64DysphoniaFAERS: 10US FAERS
65ErythemaFAERS: 10US FAERS
66Eye painFAERS: 10US FAERS
67Medication ErrorFAERS: 10US FAERS
68Mental impairmentFAERS: 10US FAERS
69Musculoskeletal stiffnessFAERS: 10US FAERS
70Wrong technique in product usage processFAERS: 10US FAERS
71Loose toothFAERS: 9US FAERS
72Peripheral swellingFAERS: 9US FAERS
73GingivitisFAERS: 8US FAERS
74Lip swellingFAERS: 8US FAERS
75Musculoskeletal chest painFAERS: 8US FAERS
76OsteitisFAERS: 8US FAERS
77Pharmaceutical product complaintFAERS: 8US FAERS
78Product solubility abnormalFAERS: 8US FAERS
79Terminal stateFAERS: 8US FAERS
80ArthropathyFAERS: 7US FAERS
81Chest discomfortFAERS: 7US FAERS
82ChillsFAERS: 7US FAERS
83DiscomfortFAERS: 7US FAERS
84HypersensitivityFAERS: 7US FAERS
85OsteosclerosisFAERS: 7US FAERS
86PalpitationsFAERS: 7US FAERS
87PneumoniaFAERS: 7US FAERS
88Tooth LossFAERS: 7US FAERS
89Ankle FractureFAERS: 6US FAERS
90ArthritisFAERS: 6US FAERS
91Atypical fractureFAERS: 6US FAERS
92Burning sensationFAERS: 6US FAERS
93BursitisFAERS: 6US FAERS
94Cerebrovascular accidentFAERS: 6US FAERS
95ChokingFAERS: 6US FAERS
96DeliriumFAERS: 6US FAERS
97DysgeusiaFAERS: 6US FAERS
98Economic problemFAERS: 6US FAERS
99Emotional disorderFAERS: 6US FAERS
100Hypertensive emergencyFAERS: 6US FAERS
101OsteopeniaFAERS: 6US FAERS
102PolyarthritisFAERS: 6US FAERS
103PurulenceFAERS: 6US FAERS
104VertigoFAERS: 6US FAERS
105Walking aid userFAERS: 6US FAERS
106Wrong technique in drug usage processFAERS: 6US FAERS
107Erythema MultiformeFAERS: 5US FAERS
108InflammationFAERS: 5US FAERS
109ParophthalmiaFAERS: 5US FAERS
110Product use complaintFAERS: 5US FAERS
111SequestrectomyFAERS: 5US FAERS
112SyncopeFAERS: 5US FAERS
113AbscessFAERS: 4US FAERS
114AgeusiaFAERS: 4US FAERS
115CryingFAERS: 4US FAERS
116EczemaFAERS: 4US FAERS
117Gas GangreneFAERS: 4US FAERS
118GastritisFAERS: 4US FAERS
119Impaired work abilityFAERS: 4US FAERS
120Inappropriate schedule of product administrationFAERS: 4US FAERS
121Incorrect dose administeredFAERS: 4US FAERS
122InfectionFAERS: 4US FAERS
123Mastication disorderFAERS: 4US FAERS
124Middle insomniaFAERS: 4US FAERS
125Musculoskeletal discomfortFAERS: 4US FAERS
126Nasal PolypsFAERS: 4US FAERS
127NasopharyngitisFAERS: 4US FAERS
128Open reduction of fractureFAERS: 4US FAERS
129Oroantral FistulaFAERS: 4US FAERS
130Product dose omissionFAERS: 4US FAERS
131Restless Legs SyndromeFAERS: 4US FAERS
132SciaticaFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
133StressFAERS: 4US FAERS
134SynovitisFAERS: 4US FAERS
135Therapeutic response unexpected with drug substitutionFAERS: 4US FAERS
136Accidental exposure to productFAERS: 3US FAERS
137AphoniaFAERS: 3US FAERS
138Choking sensationFAERS: 3US FAERS
139Compression fractureFAERS: 3US FAERS
140Corneal lesionFAERS: 3US FAERS
141DebridementFAERS: 3US FAERS
142Dental cariesFAERS: 3US FAERS
143Diabetes MellitusFAERS: 3US FAERS
144DroolingFAERS: 3US FAERS
145DysuriaFAERS: 3US FAERS
146Erectile dysfunctionFAERS: 3US FAERS
147EructationFAERS: 3US FAERS
148Exposed bone in jawFAERS: 3US FAERS
149Impaired driving abilityFAERS: 3US FAERS
150LymphadenopathyFAERS: 3US FAERS
151Muscle strainFAERS: 3US FAERS
152Myocardial InfarctionFAERS: 3US FAERS
153Optic NeuritisFAERS: 3US FAERS
154OsteomalaciaFAERS: 3US FAERS
155Physical disabilityFAERS: 3US FAERS
156Product coating issueFAERS: 3US FAERS
157Purulent dischargeFAERS: 3US FAERS
158Rash erythematousFAERS: 3US FAERS
159SepsisFAERS: 3US FAERS
160SinusitisFAERS: 3US FAERS
161Skeletal injuryFAERS: 3US FAERS
162SomnolenceFAERS: 3US FAERS
163Squamous cell carcinomaFAERS: 3US FAERS
164TinnitusFAERS: 3US FAERS
165Tooth InfectionFAERS: 3US FAERS
166Toxicity to various agentsFAERS: 3US FAERS
167Traumatic fractureFAERS: 3US FAERS
168Visual ImpairmentFAERS: 3US FAERS
169AlveolitisFAERS: 2US FAERS
170AphagiaFAERS: 2US FAERS
171AphasiaFAERS: 2US FAERS
172AppendicitisFAERS: 2US FAERS
173ArteriosclerosisFAERS: 2US FAERS
174BlindnessFAERS: 2US FAERS
175Blood cholesterol increasedFAERS: 2US FAERS
176Blood creatine phosphokinase increasedFAERS: 2US FAERS
177Bone formation decreasedFAERS: 2US FAERS
178BronchitisFAERS: 2US FAERS
179CalcinosisFAERS: 2US FAERS
180CataractFAERS: 2US FAERS
181Cerebral InfarctionFAERS: 2US FAERS
182Chemical injuryFAERS: 2US FAERS
183Device related infectionFAERS: 2US FAERS
184DisorientationFAERS: 2US FAERS
185Duodenal ulcer perforationFAERS: 2US FAERS
186ExophthalmosFAERS: 2US FAERS
187Facial PainFAERS: 2US FAERS
188Foreign body in respiratory tractFAERS: 2US FAERS
189Foreign body traumaFAERS: 2US FAERS
190Gastrointestinal PainFAERS: 2US FAERS
191HypotensionFAERS: 2US FAERS
192HypoxiaFAERS: 2US FAERS
193HysterectomyFAERS: 2US FAERS
194Implant site reactionFAERS: 2US FAERS
195Increased upper airway secretionFAERS: 2US FAERS
196InfluenzaFAERS: 2US FAERS
197LaryngitisFAERS: 2US FAERS
198Limb asymmetryFAERS: 2US FAERS
199Myasthenia GravisFAERS: 2US FAERS
200Nerve injuryFAERS: 2US FAERS
201OnychoclasisFAERS: 2US FAERS
202Oral Cavity FistulaFAERS: 2US FAERS
203Oropharyngeal blisteringFAERS: 2US FAERS
204PancreatitisFAERS: 2US FAERS
205PeriodontitisFAERS: 2US FAERS
206PolyuriaFAERS: 2US FAERS
207Product use in unapproved indicationFAERS: 2US FAERS
208Productive CoughFAERS: 2US FAERS
209Pupillary light reflex tests abnormalFAERS: 2US FAERS
210Renal painFAERS: 2US FAERS
211SclerotherapyFAERS: 2US FAERS
212TracheobronchitisFAERS: 2US FAERS
213TremorFAERS: 2US FAERS
214TrismusFAERS: 2US FAERS
215Upper airway obstructionFAERS: 2US FAERS
216Urinary tract infectionFAERS: 2US FAERS
217Wrong doseFAERS: 2US FAERS
218X-ray of pelvis and hip abnormalFAERS: 2US FAERS
219treatment failureFAERS: 2US FAERS
220AcneFAERS: 1US FAERS
221ActinomycosisFAERS: 1US FAERS
222AgranulocytosisFAERS: 1US FAERS
223Alopecia AreataFAERS: 1US FAERS
224Altered visual depth perceptionFAERS: 1US FAERS
225Amaurosis FugaxFAERS: 1US FAERS
226AngioedemaFAERS: 1US FAERS
227AnorexiaFAERS: 1US FAERS
228AnosmiaFAERS: 1US FAERS
229Anti-thyroid antibody positiveFAERS: 1US FAERS
230Aphthous StomatitisFAERS: 1US FAERS
231AscitesFAERS: 1US FAERS
232AsthmaFAERS: 1US FAERS
233Atrial FlutterFAERS: 1US FAERS
234Autonomic nervous system imbalanceFAERS: 1US FAERS
235Back disorderFAERS: 1US FAERS
236Bacterial allergyFAERS: 1US FAERS
237Bacterial culture positiveFAERS: 1US FAERS
238Bacterial sepsisFAERS: 1US FAERS
239Blood glucose increasedFAERS: 1US FAERS
240Blood magnesium increasedFAERS: 1US FAERS
241Blood phosphorusFAERS: 1US FAERS
242Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
243Bone callus excessiveFAERS: 1US FAERS
244Bone erosionFAERS: 1US FAERS
245Bone fistulaFAERS: 1US FAERS
246Bone fragmentationFAERS: 1US FAERS
247Bone lesionFAERS: 1US FAERS
248Bone scan abnormalFAERS: 1US FAERS
249Bowel movement irregularityFAERS: 1US FAERS
250Bronchial irritationFAERS: 1US FAERS
251BruxismFAERS: 1US FAERS
252C-telopeptide increasedFAERS: 1US FAERS
253Callus formation delayedFAERS: 1US FAERS
254Cardiac FlutterFAERS: 1US FAERS
255Carpal Tunnel SyndromeFAERS: 1US FAERS
256Caustic injuryFAERS: 1US FAERS
257CellulitisFAERS: 1US FAERS
258Chemical burn of gastrointestinal tractFAERS: 1US FAERS
259Chemical burn of respiratory tractFAERS: 1US FAERS
260Cholecystitis infectiveFAERS: 1US FAERS
261CholelithiasisFAERS: 1US FAERS
262ChorioretinitisFAERS: 1US FAERS
263ChoroiditisFAERS: 1US FAERS
264ChromaturiaFAERS: 1US FAERS
265Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
266Clostridium difficile colitisFAERS: 1US FAERS
267Coating in mouthFAERS: 1US FAERS
268ConjunctivitisFAERS: 1US FAERS
269Contraindicated drug prescribedFAERS: 1US FAERS
270DeafnessFAERS: 1US FAERS
271Deep Vein ThrombosisFAERS: 1US FAERS
272DementiaFAERS: 1US FAERS
273Dental Restoration FailureFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
274Depressed Level of ConsciousnessFAERS: 1US FAERS
275DermatitisFAERS: 1US FAERS
276DermatomyositisFAERS: 1US FAERS
277Device FailureFAERS: 1US FAERS
278Device breakageFAERS: 1US FAERS
279Diastolic dysfunctionFAERS: 1US FAERS
280DissociationFAERS: 1US FAERS
281Diverticular perforationFAERS: 1US FAERS
282Drug dispensing errorFAERS: 1US FAERS
283Drug dispensing issueFAERS: 1US FAERS
284Drug effect incompleteFAERS: 1US FAERS
285Drug ineffective for unapproved indicationFAERS: 1US FAERS
286Drug level changedFAERS: 1US FAERS
287Drug prescribing errorFAERS: 1US FAERS
288Dry skinFAERS: 1US FAERS
289Duodenal UlcerFAERS: 1US FAERS
290DysarthriaFAERS: 1US FAERS
291Ear discomfortFAERS: 1US FAERS
292EmpyemaFAERS: 1US FAERS
293EndophthalmitisFAERS: 1US FAERS
294EpicondylitisFAERS: 1US FAERS
295EpiglottitisFAERS: 1US FAERS
296Extra dose administeredFAERS: 1US FAERS
297Eye inflammationFAERS: 1US FAERS
298Eye irritationFAERS: 1US FAERS
299Eyelid exfoliationFAERS: 1US FAERS
300Eyelid painFAERS: 1US FAERS
301Facial ParesisFAERS: 1US FAERS
302Fanconi SyndromeFAERS: 1US FAERS
303FibromyalgiaFAERS: 1US FAERS
304Flank PainFAERS: 1US FAERS
305FlushingFAERS: 1US FAERS
306Foreign body aspirationFAERS: 1US FAERS
307Foreign body sensation in eyesFAERS: 1US FAERS
308FormicationFAERS: 1US FAERS
309Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
310Gastric DilatationFAERS: 1US FAERS
311Gastric FistulaFAERS: 1US FAERS
312Gastrointestinal endoscopic therapyFAERS: 1US FAERS
313General physical condition decreasedFAERS: 1US FAERS
314Gingival RecessionFAERS: 1US FAERS
315Gingival discomfortFAERS: 1US FAERS
316Gingival erythemaFAERS: 1US FAERS
317GlossitisFAERS: 1US FAERS
318Grip strength decreasedFAERS: 1US FAERS
319Head discomfortFAERS: 1US FAERS
320Hip surgeryFAERS: 1US FAERS
321HirsutismFAERS: 1US FAERS
322HyperchlorhydriaFAERS: 1US FAERS
323HyperparathyroidismFAERS: 1US FAERS
324Hypoaesthesia facialFAERS: 1US FAERS
325HypothyroidismFAERS: 1US FAERS
326Iliotibial Band SyndromeFAERS: 1US FAERS
327ImmobileFAERS: 1US FAERS
328Inadequate analgesiaFAERS: 1US FAERS
329IncontinenceFAERS: 1US FAERS
330Incorrect drug administration durationFAERS: 1US FAERS
331Incorrect route of drug administrationFAERS: 1US FAERS
332Intentional dose omissionFAERS: 1US FAERS
333Intentional product misuseFAERS: 1US FAERS
334Intervertebral disc compressionFAERS: 1US FAERS
335IridocyclitisFAERS: 1US FAERS
336Irritable Bowel SyndromeFAERS: 1US FAERS
337Jejunal ulcerFAERS: 1US FAERS
338Joint injuryFAERS: 1US FAERS
339LacerationFAERS: 1US FAERS
340LethargyFAERS: 1US FAERS
341LeukopeniaFAERS: 1US FAERS
342Ligament painFAERS: 1US FAERS
343Limb discomfortFAERS: 1US FAERS
344Limb injuryFAERS: 1US FAERS
345Limb massFAERS: 1US FAERS
346Loss of personal independence in daily activitiesFAERS: 1US FAERS
347MalocclusionFAERS: 1US FAERS
348Maxillofacial operationFAERS: 1US FAERS
349Memory impairmentFAERS: 1US FAERS
350Mental status changesFAERS: 1US FAERS
351Morbid thoughtsFAERS: 1US FAERS
352Multiple SclerosisFAERS: 1US FAERS
353Muscle FatigueFAERS: 1US FAERS
354Muscle tightnessFAERS: 1US FAERS
355Nail bed tendernessFAERS: 1US FAERS
356NecrosisFAERS: 1US FAERS
357NephritisFAERS: 1US FAERS
358NephrolithiasisFAERS: 1US FAERS
359Nephrotic SyndromeFAERS: 1US FAERS
360NervousnessFAERS: 1US FAERS
361Occult blood positiveFAERS: 1US FAERS
362Ocular discomfortFAERS: 1US FAERS
363Optic NeuropathyFAERS: 1US FAERS
364Oral infectionFAERS: 1US FAERS
365Oral mucosal erythemaFAERS: 1US FAERS
366Oral mucosal exfoliationFAERS: 1US FAERS
367Oral painFAERS: 1US FAERS
368Oral pruritusFAERS: 1US FAERS
369Oropharyngeal plaqueFAERS: 1US FAERS
370OsteolysisFAERS: 1US FAERS
371Osteoma cutisFAERS: 1US FAERS
372OsteorrhagiaFAERS: 1US FAERS
373OsteosarcomaFAERS: 1US FAERS
374Pain of skinFAERS: 1US FAERS
375PancytopeniaFAERS: 1US FAERS
376Pelvic PainFAERS: 1US FAERS
377Pelvic discomfortFAERS: 1US FAERS
378PeriostitisFAERS: 1US FAERS
379PeritonitisFAERS: 1US FAERS
380Pharyngeal erosionFAERS: 1US FAERS
381PhlebitisFAERS: 1US FAERS
382PhotophobiaFAERS: 1US FAERS
383PneumonitisFAERS: 1US FAERS
384PoisoningFAERS: 1US FAERS
385Poor quality drug administeredFAERS: 1US FAERS
386Poor quality sleepFAERS: 1US FAERS
387Prescription drug used without a prescriptionFAERS: 1US FAERS
388Product administered to patient of inappropriate ageFAERS: 1US FAERS
389Product formulation issueFAERS: 1US FAERS
390Product packaging issueFAERS: 1US FAERS
391Product shape issueFAERS: 1US FAERS
392Product size issueFAERS: 1US FAERS
393Product use issueFAERS: 1US FAERS
394ProteinuriaFAERS: 1US FAERS
395PsoriasisFAERS: 1US FAERS
396Pulmonary EmbolismFAERS: 1US FAERS
397Pyoderma GangrenosumFAERS: 1US FAERS
398Reaction to drug excipientsFAERS: 1US FAERS
399RegurgitationFAERS: 1US FAERS
400Renal massFAERS: 1US FAERS
401Respiratory DepressionFAERS: 1US FAERS
402Respiratory distressFAERS: 1US FAERS
403RetinitisFAERS: 1US FAERS
404ScabFAERS: 1US FAERS
405ScleritisFAERS: 1US FAERS
406ScreamingFAERS: 1US FAERS
407Seizure like phenomenaFAERS: 1US FAERS
408Septic arthritis staphylococcalFAERS: 1US FAERS
409Septic embolusFAERS: 1US FAERS
410Skin WrinklingFAERS: 1US FAERS
411Skin reactionFAERS: 1US FAERS
412SluggishnessFAERS: 1US FAERS
413Soft tissue inflammationFAERS: 1US FAERS
414SomnambulismFAERS: 1US FAERS
415SunburnFAERS: 1US FAERS
416SuperinfectionFAERS: 1US FAERS
417TachycardiaFAERS: 1US FAERS
418TenosynovitisFAERS: 1US FAERS
419Tension HeadacheFAERS: 1US FAERS
420Therapy cessationFAERS: 1US FAERS
421Therapy non-responderFAERS: 1US FAERS
422ThirstFAERS: 1US FAERS
423ThrombosisFAERS: 1US FAERS
424Thyroid NeoplasmFAERS: 1US FAERS
425Tongue eruptionFAERS: 1US FAERS
426Tracheal StenosisFAERS: 1US FAERS
427Transcription medication errorFAERS: 1US FAERS
428Trigeminal NeuralgiaFAERS: 1US FAERS
429UlcerFAERS: 1US FAERS
430UnemploymentFAERS: 1US FAERS
431Unresponsive to stimuliFAERS: 1US FAERS
432Upper airway necrosisFAERS: 1US FAERS
433Urinary IncontinenceFAERS: 1US FAERS
434VIIth nerve paralysisFAERS: 1US FAERS
435Vitamin B6 increasedFAERS: 1US FAERS
436Wheelchair userFAERS: 1US FAERS
437WheezingFAERS: 1US FAERS
438White blood cell count decreasedFAERS: 1US FAERS
439Wound sepsisFAERS: 1US FAERS
440YawningFAERS: 1US FAERS
441Dental prosthesis placementCanada Vigilance: 1Canada Vigilance
442Fracture treatmentCanada Vigilance: 1Canada Vigilance
443Medical device removalCanada Vigilance: 1Canada Vigilance
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