Pamidronate
(CEYUIFJWVHOCPP-UHFFFAOYSA-L)
Structure
- SMILES
- NCCC(P(=O)(O)[O-])(P(=O)(O)[O-])O.[Na+].[Na+]
- Molecular Formula:
- C3H9NNa2O7P2
- Molecular Weight:
- 279.033
- Log P:
- -0.0866
- Hydrogen Bond Acceptor:
- 8
- Hydrogen Bond Donor:
- 4
- TPSA:
- 186.59
- CAS Number(s):
- 57248-88-1
Synonym(s)
1.
Pamidronate
2.
(3-Amino-1-hydroxypropylidene)-1,1-biphosphonate
3.
1-Hydroxy-3-aminopropane-1,1-diphosphonic acid
4.
AHPrBP
5.
Amidronate
6.
Amino-1-hydroxypropane-1,1-diphosphonate
7.
Aminohydroxypropylidene Diphosphonate
8.
Aminopropanehydroxydiphosphonate
9.
Aredia
10.
Pamidronate Calcium
11.
Pamidronate Disodium
12.
Pamidronate Monosodium
13.
Pamidronic Acid
14.
1 Hydroxy 3 aminopropane 1,1 diphosphonic acid
15.
Amino 1 hydroxypropane 1,1 diphosphonate
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Pain | FAERS: 449 Canada Vigilance: 14 | Canada Vigilance US FAERS | |
| 2 | Osteonecrosis of Jaw | FAERS: 353 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 3 | Anxiety | FAERS: 203 | US FAERS | |
| 4 | Tooth Extraction | FAERS: 142 | US FAERS | |
| 5 | Anhedonia | FAERS: 117 | US FAERS | |
| 6 | Infection | FAERS: 93 | US FAERS | |
| 7 | Osteomyelitis | FAERS: 84 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 8 | Disability | FAERS: 80 | US FAERS | |
| 9 | Deformity | FAERS: 67 | US FAERS | |
| 10 | Sequestrectomy | FAERS: 50 | US FAERS | |
| 11 | Physical disability | FAERS: 48 | US FAERS | |
| 12 | Emotional distress | FAERS: 45 | US FAERS | |
| 13 | General physical health deterioration | FAERS: 43 | US FAERS | |
| 14 | Overdose | FAERS: 37 | US FAERS | |
| 15 | Wound Debridement | FAERS: 35 | US FAERS | |
| 16 | Back Pain | FAERS: 31 | US FAERS | |
| 17 | Blood creatinine increased | FAERS: 26 | US FAERS | |
| 18 | Swelling | FAERS: 26 | US FAERS | |
| 19 | Primary sequestrum | FAERS: 25 | US FAERS | |
| 20 | Arthralgia | FAERS: 24 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 21 | Atelectasis | FAERS: 23 | US FAERS | |
| 22 | Bone lesion | FAERS: 23 | US FAERS | |
| 23 | Erythema | FAERS: 23 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 24 | Nausea | FAERS: 23 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 25 | Fracture | FAERS: 22 | US FAERS | |
| 26 | Life expectancy shortened | FAERS: 21 | US FAERS | |
| 27 | Osteolysis | FAERS: 20 | US FAERS | |
| 28 | Bone pain | FAERS: 19 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 29 | Cellulitis | FAERS: 19 | US FAERS | |
| 30 | Discomfort | FAERS: 19 | US FAERS | |
| 31 | Intervertebral Disc Degeneration | FAERS: 19 | US FAERS | |
| 32 | Fatigue | FAERS: 18 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 33 | Lymphadenopathy | FAERS: 18 | US FAERS | |
| 34 | Chest Pain | FAERS: 17 | US FAERS | |
| 35 | Myalgia | FAERS: 17 | US FAERS | |
| 36 | Malignant neoplasm progression | FAERS: 16 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 37 | Oral pain | FAERS: 16 | US FAERS | |
| 38 | Pathological fracture | FAERS: 16 | US FAERS | |
| 39 | Weight decreased | FAERS: 16 | US FAERS | |
| 40 | Actinomycosis | FAERS: 15 | US FAERS | |
| 41 | Headache | FAERS: 15 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 42 | Nephrotic Syndrome | FAERS: 15 | US FAERS | |
| 43 | Toothache | FAERS: 15 | US FAERS | |
| 44 | Chills | FAERS: 14 | US FAERS | |
| 45 | Conjunctivitis | FAERS: 14 | US FAERS | |
| 46 | Inflammation | FAERS: 14 | US FAERS | |
| 47 | Osteopenia | FAERS: 14 | US FAERS | |
| 48 | Vomiting | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 49 | Bone swelling | FAERS: 13 | US FAERS | |
| 50 | Soft Tissue Infection | FAERS: 13 | US FAERS | |
| 51 | Bone density decreased | FAERS: 12 | US FAERS | |
| 52 | Hypophagia | FAERS: 12 | US FAERS | |
| 53 | Mastication disorder | FAERS: 12 | US FAERS | |
| 54 | Wound dehiscence | FAERS: 12 | US FAERS | |
| 55 | Abdominal Pain | FAERS: 11 | US FAERS | |
| 56 | Cardiomegaly | FAERS: 11 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 57 | Dizziness | FAERS: 11 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 58 | Endodontic procedure | FAERS: 11 | US FAERS | |
| 59 | Osteitis | FAERS: 11 | US FAERS | |
| 60 | Pneumonia | FAERS: 11 | US FAERS | |
| 61 | Soft tissue inflammation | FAERS: 11 | US FAERS | |
| 62 | Tooth Loss | FAERS: 11 | US FAERS | |
| 63 | Alopecia | FAERS: 10 | US FAERS | |
| 64 | Blood parathyroid hormone increased | FAERS: 10 | US FAERS | |
| 65 | Bronchitis | FAERS: 10 | US FAERS | |
| 66 | Constipation | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 67 | Debridement | FAERS: 10 | US FAERS | |
| 68 | Extravasation | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 69 | Multiple Myeloma | FAERS: 10 | US FAERS | |
| 70 | Osteoporosis | FAERS: 10 | US FAERS | |
| 71 | Tinnitus | FAERS: 10 | US FAERS | |
| 72 | Blood lactate dehydrogenase increased | FAERS: 9 | US FAERS | |
| 73 | Neck Pain | FAERS: 9 | US FAERS | |
| 74 | Proteinuria | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 75 | Respiratory distress | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 76 | Thrombophlebitis | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 77 | Asthenia | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 78 | Blood alkaline phosphatase increased | FAERS: 8 | US FAERS | |
| 79 | Drug administration error | FAERS: 8 | US FAERS | |
| 80 | Fistula repair | FAERS: 8 | US FAERS | |
| 81 | Malaise | FAERS: 8 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 82 | Medication Error | FAERS: 8 | US FAERS | |
| 83 | Musculoskeletal Pain | FAERS: 8 | US FAERS | |
| 84 | Oral Cavity Fistula | FAERS: 8 | US FAERS | |
| 85 | Pericardial effusion | FAERS: 8 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 86 | Tooth Infection | FAERS: 8 | US FAERS | |
| 87 | Alanine Aminotransferase Increased | FAERS: 7 | US FAERS | |
| 88 | Arteriosclerosis | FAERS: 7 | US FAERS | |
| 89 | Arthritis | FAERS: 7 | US FAERS | |
| 90 | Aspartate Aminotransferase Increased | FAERS: 7 | US FAERS | |
| 91 | Blindness | FAERS: 7 | US FAERS | |
| 92 | Cataract | FAERS: 7 | US FAERS | |
| 93 | Deep Vein Thrombosis | FAERS: 7 | US FAERS | |
| 94 | Dental caries | FAERS: 7 | US FAERS | |
| 95 | Exposed bone in jaw | FAERS: 7 | US FAERS | |
| 96 | Focal glomerulosclerosis | FAERS: 7 | US FAERS | |
| 97 | Renal cyst | FAERS: 7 | US FAERS | |
| 98 | Atypical femur fracture | FAERS: 6 Canada Vigilance: 19 | Canada Vigilance US FAERS | |
| 99 | Cholecystitis | FAERS: 6 | US FAERS | |
| 100 | Compression fracture | FAERS: 6 | US FAERS | |
| 101 | Disease Progression | FAERS: 6 | US FAERS | |
| 102 | Diverticulum | FAERS: 6 | US FAERS | |
| 103 | Drug exposure during pregnancy | FAERS: 6 | US FAERS | |
| 104 | Dyspepsia | FAERS: 6 | US FAERS | |
| 105 | Febrile Neutropenia | FAERS: 6 | US FAERS | |
| 106 | Infusion site reaction | FAERS: 6 | US FAERS | |
| 107 | Injection Site Reaction | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 108 | Injection site extravasation | FAERS: 6 | US FAERS | |
| 109 | Musculoskeletal chest pain | FAERS: 6 | US FAERS | |
| 110 | Oral infection | FAERS: 6 | US FAERS | |
| 111 | Osteosclerosis | FAERS: 6 | US FAERS | |
| 112 | Purulence | FAERS: 6 | US FAERS | |
| 113 | Stomatitis | FAERS: 6 | US FAERS | |
| 114 | Tachycardia | FAERS: 6 | US FAERS | |
| 115 | Thrombosis | FAERS: 6 | US FAERS | |
| 116 | Atrial Fibrillation | FAERS: 5 | US FAERS | |
| 117 | Blood albumin decreased | FAERS: 5 | US FAERS | |
| 118 | Blood chloride decreased | FAERS: 5 | US FAERS | |
| 119 | Blood phosphorus increased | FAERS: 5 | US FAERS | |
| 120 | Blood urea increased | FAERS: 5 | US FAERS | |
| 121 | Bone trimming | FAERS: 5 | US FAERS | |
| 122 | Bradycardia | FAERS: 5 | US FAERS | |
| 123 | Depressed Level of Consciousness | FAERS: 5 | US FAERS | |
| 124 | Drug ineffective | FAERS: 5 Canada Vigilance: 13 | Canada Vigilance US FAERS | |
| 125 | Eye pain | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 126 | Failure to Thrive | FAERS: 5 | US FAERS | |
| 127 | Leukocytosis | FAERS: 5 | US FAERS | |
| 128 | Lymphangitis | FAERS: 5 | US FAERS | |
| 129 | Necrosis | FAERS: 5 | US FAERS | |
| 130 | Neutropenia | FAERS: 5 | US FAERS | |
| 131 | Osteotomy | FAERS: 5 | US FAERS | |
| 132 | Pancytopenia | FAERS: 5 | US FAERS | |
| 133 | Pelvic Pain | FAERS: 5 | US FAERS | |
| 134 | Purulent discharge | FAERS: 5 | US FAERS | |
| 135 | Sinusitis | FAERS: 5 | US FAERS | |
| 136 | Skin discomfort | FAERS: 5 | US FAERS | |
| 137 | Thrombocytopenia | FAERS: 5 | US FAERS | |
| 138 | X-ray abnormal | FAERS: 5 | US FAERS | |
| 139 | Abscess | FAERS: 4 | US FAERS | |
| 140 | Acquired diaphragmatic eventration | FAERS: 4 | US FAERS | |
| 141 | Bone marrow depression | FAERS: 4 | US FAERS | |
| 142 | Creatinine renal clearance decreased | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 143 | Cyst | FAERS: 4 | US FAERS | |
| 144 | Deafness | FAERS: 4 | US FAERS | |
| 145 | Delirium | FAERS: 4 | US FAERS | |
| 146 | Dental discomfort | FAERS: 4 | US FAERS | |
| 147 | Diastolic hypertension | FAERS: 4 | US FAERS | |
| 148 | Dysuria | FAERS: 4 | US FAERS | |
| 149 | Epistaxis | FAERS: 4 | US FAERS | |
| 150 | Hypotension | FAERS: 4 | US FAERS | |
| 151 | Lipase increased | FAERS: 4 | US FAERS | |
| 152 | Lymphopenia | FAERS: 4 | US FAERS | |
| 153 | Oral candidiasis | FAERS: 4 | US FAERS | |
| 154 | Oropharyngeal pain | FAERS: 4 | US FAERS | |
| 155 | Osteitis Deformans | FAERS: 4 | US FAERS | |
| 156 | Pharyngitis | FAERS: 4 | US FAERS | |
| 157 | Pleurisy | FAERS: 4 | US FAERS | |
| 158 | Pneumonitis | FAERS: 4 | US FAERS | |
| 159 | Polydipsia | FAERS: 4 | US FAERS | |
| 160 | Presyncope | FAERS: 4 | US FAERS | |
| 161 | Pruritus | FAERS: 4 | US FAERS | |
| 162 | Pulmonary congestion | FAERS: 4 | US FAERS | |
| 163 | Renal tubular necrosis | FAERS: 4 | US FAERS | |
| 164 | Tetany | FAERS: 4 | US FAERS | |
| 165 | Ulcer | FAERS: 4 | US FAERS | |
| 166 | Urinary Retention | FAERS: 4 | US FAERS | |
| 167 | Urticaria | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 168 | Ventricular hypokinesia | FAERS: 4 | US FAERS | |
| 169 | kyphosis | FAERS: 4 | US FAERS | |
| 170 | Actinic keratosis | FAERS: 3 | US FAERS | |
| 171 | Alveoloplasty | FAERS: 3 | US FAERS | |
| 172 | Anorexia | FAERS: 3 | US FAERS | |
| 173 | Atrial Flutter | FAERS: 3 | US FAERS | |
| 174 | Basal cell carcinoma | FAERS: 3 | US FAERS | |
| 175 | Benign bone neoplasm | FAERS: 3 | US FAERS | |
| 176 | Biopsy bone abnormal | FAERS: 3 | US FAERS | |
| 177 | Blood magnesium decreased | FAERS: 3 | US FAERS | |
| 178 | Blood potassium decreased | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 179 | Blood sodium decreased | FAERS: 3 | US FAERS | |
| 180 | Bone Sarcoma | FAERS: 3 | US FAERS | |
| 181 | Bone density increased | FAERS: 3 | US FAERS | |
| 182 | Bone erosion | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 183 | Bronchospasm | FAERS: 3 | US FAERS | |
| 184 | Cerebrovascular accident | FAERS: 3 | US FAERS | |
| 185 | Chronic sinusitis | FAERS: 3 | US FAERS | |
| 186 | Denture wearer | FAERS: 3 | US FAERS | |
| 187 | Device breakage | FAERS: 3 | US FAERS | |
| 188 | Drug exposure before pregnancy | FAERS: 3 | US FAERS | |
| 189 | Drug toxicity | FAERS: 3 | US FAERS | |
| 190 | Duodenal Ulcer | FAERS: 3 | US FAERS | |
| 191 | Engraftment syndrome | FAERS: 3 | US FAERS | |
| 192 | Folliculitis | FAERS: 3 | US FAERS | |
| 193 | Gamma-Glutamyltransferase Increased | FAERS: 3 | US FAERS | |
| 194 | Glaucoma | FAERS: 3 | US FAERS | |
| 195 | Hepatitis | FAERS: 3 | US FAERS | |
| 196 | Hypercapnia | FAERS: 3 | US FAERS | |
| 197 | Hyperkeratosis | FAERS: 3 | US FAERS | |
| 198 | Hypersensitivity | FAERS: 3 | US FAERS | |
| 199 | Implant site inflammation | FAERS: 3 | US FAERS | |
| 200 | Infusion site pain | FAERS: 3 | US FAERS | |
| 201 | Infusion site swelling | FAERS: 3 | US FAERS | |
| 202 | Injection site necrosis | FAERS: 3 | US FAERS | |
| 203 | Irritable Bowel Syndrome | FAERS: 3 | US FAERS | |
| 204 | Joint swelling | FAERS: 3 | US FAERS | |
| 205 | Lipoma | FAERS: 3 | US FAERS | |
| 206 | Loose tooth | FAERS: 3 | US FAERS | |
| 207 | Medical device removal | FAERS: 3 | US FAERS | |
| 208 | Myeloma recurrence | FAERS: 3 | US FAERS | |
| 209 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 210 | Nephrosclerosis | FAERS: 3 | US FAERS | |
| 211 | Oropharyngeal candidiasis | FAERS: 3 | US FAERS | |
| 212 | Pneumothorax | FAERS: 3 | US FAERS | |
| 213 | Post procedural complication | FAERS: 3 | US FAERS | |
| 214 | Postoperative infection | FAERS: 3 | US FAERS | |
| 215 | Product use issue | FAERS: 3 | US FAERS | |
| 216 | Protein total decreased | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 217 | Protein urine present | FAERS: 3 | US FAERS | |
| 218 | Renal interstitial fibrosis | FAERS: 3 | US FAERS | |
| 219 | Shock | FAERS: 3 | US FAERS | |
| 220 | Stem cell transplant | FAERS: 3 | US FAERS | |
| 221 | Syncope | FAERS: 3 | US FAERS | |
| 222 | Urethral Stenosis | FAERS: 3 | US FAERS | |
| 223 | Uveitis | FAERS: 3 | US FAERS | |
| 224 | Vasculitis | FAERS: 3 | US FAERS | |
| 225 | Ventricular hypertrophy | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 226 | Visual Impairment | FAERS: 3 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 227 | White blood cell count decreased | FAERS: 3 | US FAERS | |
| 228 | Abasia | FAERS: 2 | US FAERS | |
| 229 | Agranulocytosis | FAERS: 2 | US FAERS | |
| 230 | Amnesia | FAERS: 2 | US FAERS | |
| 231 | Anaphylactic shock | FAERS: 2 | US FAERS | |
| 232 | Anaplastic large cell lymphoma T- and null-cell types | FAERS: 2 | US FAERS | |
| 233 | Angioedema | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 234 | Ankylosing spondylitis | FAERS: 2 | US FAERS | |
| 235 | Aphasia | FAERS: 2 | US FAERS | |
| 236 | Ascites | FAERS: 2 | US FAERS | |
| 237 | Atrial tachycardia | FAERS: 2 | US FAERS | |
| 238 | Atrophic vulvovaginitis | FAERS: 2 | US FAERS | |
| 239 | Biopsy site unspecified abnormal | FAERS: 2 | US FAERS | |
| 240 | Biopsy | FAERS: 2 | US FAERS | |
| 241 | Blood amylase increased | FAERS: 2 | US FAERS | |
| 242 | Blood creatine phosphokinase increased | FAERS: 2 | US FAERS | |
| 243 | Blood glucose increased | FAERS: 2 | US FAERS | |
| 244 | Blood potassium increased | FAERS: 2 | US FAERS | |
| 245 | Blood pressure immeasurable | FAERS: 2 | US FAERS | |
| 246 | Burning sensation | FAERS: 2 | US FAERS | |
| 247 | Bursitis | FAERS: 2 | US FAERS | |
| 248 | Calcinosis | FAERS: 2 | US FAERS | |
| 249 | Cardiac Tamponade | FAERS: 2 | US FAERS | |
| 250 | Carpal Tunnel Syndrome | FAERS: 2 | US FAERS | |
| 251 | Cholelithiasis | FAERS: 2 | US FAERS | |
| 252 | Colitis | FAERS: 2 | US FAERS | |
| 253 | Concomitant disease progression | FAERS: 2 | US FAERS | |
| 254 | Dental examination abnormal | FAERS: 2 | US FAERS | |
| 255 | Depressed mood | FAERS: 2 | US FAERS | |
| 256 | Diabetes Mellitus | FAERS: 2 | US FAERS | |
| 257 | Diplopia | FAERS: 2 | US FAERS | |
| 258 | Eczema | FAERS: 2 | US FAERS | |
| 259 | Electrolyte imbalance | FAERS: 2 | US FAERS | |
| 260 | Empyema | FAERS: 2 | US FAERS | |
| 261 | Endocarditis | FAERS: 2 | US FAERS | |
| 262 | Erectile dysfunction | FAERS: 2 | US FAERS | |
| 263 | Excoriation | FAERS: 2 | US FAERS | |
| 264 | Eye irritation | FAERS: 2 | US FAERS | |
| 265 | Feeling abnormal | FAERS: 2 | US FAERS | |
| 266 | Gastritis | FAERS: 2 | US FAERS | |
| 267 | Gingival Recession | FAERS: 2 | US FAERS | |
| 268 | Granuloma | FAERS: 2 | US FAERS | |
| 269 | Growth retardation | FAERS: 2 | US FAERS | |
| 270 | Hip surgery | FAERS: 2 | US FAERS | |
| 271 | Hypoaesthesia facial | FAERS: 2 | US FAERS | |
| 272 | Hypokinesia | FAERS: 2 | US FAERS | |
| 273 | Hyporeflexia | FAERS: 2 | US FAERS | |
| 274 | Ileus | FAERS: 2 | US FAERS | |
| 275 | Incontinence | FAERS: 2 | US FAERS | |
| 276 | Induration | FAERS: 2 | US FAERS | |
| 277 | Inflammatory pain | FAERS: 2 | US FAERS | |
| 278 | Infusion Site Extravasation | FAERS: 2 | US FAERS | |
| 279 | Injection site phlebitis | FAERS: 2 | US FAERS | |
| 280 | Intubation | FAERS: 2 | US FAERS | |
| 281 | Leukocytoclastic vasculitis | FAERS: 2 | US FAERS | |
| 282 | Lower respiratory tract infection | FAERS: 2 | US FAERS | |
| 283 | Lumbar radiculopathy | FAERS: 2 | US FAERS | |
| 284 | Lymphohistiocytosis | FAERS: 2 | US FAERS | |
| 285 | Mastoiditis | FAERS: 2 | US FAERS | |
| 286 | Mesenteritis | FAERS: 2 | US FAERS | |
| 287 | Metastases to peripheral vascular system | FAERS: 2 | US FAERS | |
| 288 | Metastasis | FAERS: 2 | US FAERS | |
| 289 | Metastatic Neoplasm | FAERS: 2 | US FAERS | |
| 290 | Mumps | FAERS: 2 | US FAERS | |
| 291 | Myositis | FAERS: 2 | US FAERS | |
| 292 | Neutropenic colitis | FAERS: 2 | US FAERS | |
| 293 | Numb chin syndrome | FAERS: 2 | US FAERS | |
| 294 | Osteogenesis Imperfecta | FAERS: 2 | US FAERS | |
| 295 | Osteopetrosis | FAERS: 2 | US FAERS | |
| 296 | Oxygen saturation abnormal | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 297 | Pancreatitis | FAERS: 2 | US FAERS | |
| 298 | Parathyroidectomy | FAERS: 2 | US FAERS | |
| 299 | Periostitis | FAERS: 2 | US FAERS | |
| 300 | Peripheral arterial occlusive disease | FAERS: 2 | US FAERS | |
| 301 | Plasmacytoma | FAERS: 2 | US FAERS | |
| 302 | Pleuritic pain | FAERS: 2 | US FAERS | |
| 303 | Polyneuropathy | FAERS: 2 | US FAERS | |
| 304 | Positron emission tomogram abnormal | FAERS: 2 | US FAERS | |
| 305 | Product use in unapproved indication | FAERS: 2 Canada Vigilance: 15 | Canada Vigilance US FAERS | |
| 306 | Psoriasis | FAERS: 2 | US FAERS | |
| 307 | Pulmonary Valve Stenosis | FAERS: 2 | US FAERS | |
| 308 | Radial nerve palsy | FAERS: 2 | US FAERS | |
| 309 | Renal tubular atrophy | FAERS: 2 | US FAERS | |
| 310 | Respiratory Failure | FAERS: 2 | US FAERS | |
| 311 | Retroperitoneal lymphadenopathy | FAERS: 2 | US FAERS | |
| 312 | Rotator cuff syndrome | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 313 | Sepsis | FAERS: 2 | US FAERS | |
| 314 | Skin Erosion | FAERS: 2 | US FAERS | |
| 315 | Skin Ulcer | FAERS: 2 | US FAERS | |
| 316 | Spondylolisthesis | FAERS: 2 | US FAERS | |
| 317 | Squamous cell carcinoma | FAERS: 2 | US FAERS | |
| 318 | Suture insertion | FAERS: 2 | US FAERS | |
| 319 | Synovitis | FAERS: 2 | US FAERS | |
| 320 | Systolic hypertension | FAERS: 2 | US FAERS | |
| 321 | T-Cell Lymphoma | FAERS: 2 | US FAERS | |
| 322 | Transaminases increased | FAERS: 2 | US FAERS | |
| 323 | Urinary tract infection | FAERS: 2 | US FAERS | |
| 324 | Vaginal Discharge | FAERS: 2 | US FAERS | |
| 325 | Venous Thrombosis | FAERS: 2 | US FAERS | |
| 326 | Vertebral foraminal stenosis | FAERS: 2 | US FAERS | |
| 327 | Visual disturbance | FAERS: 2 | US FAERS | |
| 328 | nervous system disorder | FAERS: 2 | US FAERS | |
| 329 | Abscess soft tissue | FAERS: 1 | US FAERS | |
| 330 | Acanthosis | FAERS: 1 | US FAERS | |
| 331 | Activities of daily living impaired | FAERS: 1 | US FAERS | |
| 332 | Adenocarcinoma | FAERS: 1 | US FAERS | |
| 333 | Adrenocortical insufficiency chronic | FAERS: 1 | US FAERS | |
| 334 | Agitation | FAERS: 1 | US FAERS | |
| 335 | Alanine aminotransferase abnormal | FAERS: 1 | US FAERS | |
| 336 | Anisocytosis | FAERS: 1 | US FAERS | |
| 337 | Antibiotic Prophylaxis | FAERS: 1 | US FAERS | |
| 338 | Arthropathy | FAERS: 1 | US FAERS | |
| 339 | Asthma | FAERS: 1 | US FAERS | |
| 340 | Axonal neuropathy | FAERS: 1 | US FAERS | |
| 341 | Back disorder | FAERS: 1 | US FAERS | |
| 342 | Bacterial disease carrier | FAERS: 1 | US FAERS | |
| 343 | Biopsy gingival | FAERS: 1 | US FAERS | |
| 344 | Biopsy kidney abnormal | FAERS: 1 | US FAERS | |
| 345 | Biopsy parathyroid gland abnormal | FAERS: 1 | US FAERS | |
| 346 | Biopsy skin abnormal | FAERS: 1 | US FAERS | |
| 347 | Bladder Diverticulum | FAERS: 1 | US FAERS | |
| 348 | Blood 25-hydroxycholecalciferol decreased | FAERS: 1 | US FAERS | |
| 349 | Blood alkaline phosphatase decreased | FAERS: 1 | US FAERS | |
| 350 | Blood bilirubin unconjugated increased | FAERS: 1 | US FAERS | |
| 351 | Blood calcium abnormal | FAERS: 1 | US FAERS | |
| 352 | Blood immunoglobulin M decreased | FAERS: 1 | US FAERS | |
| 353 | Blood parathyroid hormone | FAERS: 1 | US FAERS | |
| 354 | Blood parathyroid hormone decreased | FAERS: 1 | US FAERS | |
| 355 | Blood phosphorus decreased | FAERS: 1 | US FAERS | |
| 356 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 357 | Bone fragmentation | FAERS: 1 | US FAERS | |
| 358 | Cardiac Arrest | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 359 | Catheter related complication | FAERS: 1 | US FAERS | |
| 360 | Catheter sepsis | FAERS: 1 | US FAERS | |
| 361 | Central venous catheter removal | FAERS: 1 | US FAERS | |
| 362 | Cerebral Infarction | FAERS: 1 | US FAERS | |
| 363 | Cerebral atrophy | FAERS: 1 | US FAERS | |
| 364 | Cervicobrachial syndrome | FAERS: 1 | US FAERS | |
| 365 | Chest discomfort | FAERS: 1 | US FAERS | |
| 366 | Cholangitis | FAERS: 1 | US FAERS | |
| 367 | Cholestasis | FAERS: 1 | US FAERS | |
| 368 | Concomitant disease aggravated | FAERS: 1 | US FAERS | |
| 369 | Cor pulmonale | FAERS: 1 | US FAERS | |
| 370 | Coronary angioplasty | FAERS: 1 | US FAERS | |
| 371 | Cystocele | FAERS: 1 | US FAERS | |
| 372 | Cytokine storm | FAERS: 1 | US FAERS | |
| 373 | Detachment of retinal pigment epithelium | FAERS: 1 | US FAERS | |
| 374 | Device expulsion | FAERS: 1 | US FAERS | |
| 375 | Device material issue | FAERS: 1 | US FAERS | |
| 376 | Device related infection | FAERS: 1 | US FAERS | |
| 377 | Diabetic Ketoacidosis | FAERS: 1 | US FAERS | |
| 378 | Diastolic dysfunction | FAERS: 1 | US FAERS | |
| 379 | Diphtheria | FAERS: 1 | US FAERS | |
| 380 | Disease recurrence | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 381 | Disseminated Intravascular Coagulation | FAERS: 1 | US FAERS | |
| 382 | Dissociation | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 383 | Diverticulitis | FAERS: 1 | US FAERS | |
| 384 | Drug Tolerance | FAERS: 1 | US FAERS | |
| 385 | Drug exposure via breast milk | FAERS: 1 | US FAERS | |
| 386 | Duodenitis | FAERS: 1 | US FAERS | |
| 387 | Dysarthria | FAERS: 1 | US FAERS | |
| 388 | Dysgeusia | FAERS: 1 | US FAERS | |
| 389 | Dysphonia | FAERS: 1 | US FAERS | |
| 390 | Eating disorder symptom | FAERS: 1 | US FAERS | |
| 391 | Economic problem | FAERS: 1 | US FAERS | |
| 392 | Endometrial Hyperplasia | FAERS: 1 | US FAERS | |
| 393 | Endometrial hypertrophy | FAERS: 1 | US FAERS | |
| 394 | Enterococcal infection | FAERS: 1 | US FAERS | |
| 395 | Epididymitis | FAERS: 1 | US FAERS | |
| 396 | Epiduritis | FAERS: 1 | US FAERS | |
| 397 | Epiphyseal injury | FAERS: 1 | US FAERS | |
| 398 | Exploratory operation | FAERS: 1 | US FAERS | |
| 399 | Eye inflammation | FAERS: 1 | US FAERS | |
| 400 | Facial Pain | FAERS: 1 | US FAERS | |
| 401 | Failure of implant | FAERS: 1 | US FAERS | |
| 402 | Fibrosis | FAERS: 1 | US FAERS | |
| 403 | Flushing | FAERS: 1 | US FAERS | |
| 404 | Gamma-glutamyltransferase abnormal | FAERS: 1 | US FAERS | |
| 405 | Gammopathy | FAERS: 1 | US FAERS | |
| 406 | Gastrinoma | FAERS: 1 | US FAERS | |
| 407 | Gastrointestinal Pain | FAERS: 1 | US FAERS | |
| 408 | Gingivitis | FAERS: 1 | US FAERS | |
| 409 | Halitosis | FAERS: 1 | US FAERS | |
| 410 | Hepatojugular reflux | FAERS: 1 | US FAERS | |
| 411 | Hydronephrosis | FAERS: 1 | US FAERS | |
| 412 | Hyperparathyroidism | FAERS: 1 | US FAERS | |
| 413 | Hyperphagia | FAERS: 1 | US FAERS | |
| 414 | Hyperplasia | FAERS: 1 | US FAERS | |
| 415 | Hypoparathyroidism | FAERS: 1 | US FAERS | |
| 416 | Hypoxia | FAERS: 1 | US FAERS | |
| 417 | Immobile | FAERS: 1 | US FAERS | |
| 418 | Implant site discharge | FAERS: 1 | US FAERS | |
| 419 | Implant site pain | FAERS: 1 | US FAERS | |
| 420 | Inappropriate affect | FAERS: 1 | US FAERS | |
| 421 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 422 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 423 | Incorrect route of drug administration | FAERS: 1 | US FAERS | |
| 424 | Inflammatory marker increased | FAERS: 1 | US FAERS | |
| 425 | Infusion site erythema | FAERS: 1 | US FAERS | |
| 426 | Infusion site thrombosis | FAERS: 1 | US FAERS | |
| 427 | Injection site erythema | FAERS: 1 | US FAERS | |
| 428 | Injection site inflammation | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 429 | Injection site pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 430 | Injection site ulcer | FAERS: 1 | US FAERS | |
| 431 | Intentional drug misuse | FAERS: 1 | US FAERS | |
| 432 | Intertrigo | FAERS: 1 | US FAERS | |
| 433 | Iridocyclitis | FAERS: 1 | US FAERS | |
| 434 | Iritis | FAERS: 1 | US FAERS | |
| 435 | Jaw lesion excision | FAERS: 1 | US FAERS | |
| 436 | Joint Range of Motion Decreased | FAERS: 1 | US FAERS | |
| 437 | Keratopathy | FAERS: 1 | US FAERS | |
| 438 | Left Ventricular Hypertrophy | FAERS: 1 | US FAERS | |
| 439 | Left atrial dilatation | FAERS: 1 | US FAERS | |
| 440 | Leukopenia | FAERS: 1 | US FAERS | |
| 441 | Limb asymmetry | FAERS: 1 | US FAERS | |
| 442 | Limb injury | FAERS: 1 | US FAERS | |
| 443 | Lordosis | FAERS: 1 | US FAERS | |
| 444 | Lymphadenitis | FAERS: 1 | US FAERS | |
| 445 | Lymphocyte count decreased | FAERS: 1 | US FAERS | |
| 446 | MYELODYSPLASTIC SYNDROME | FAERS: 1 | US FAERS | |
| 447 | Malnutrition | FAERS: 1 | US FAERS | |
| 448 | Mastectomy | FAERS: 1 | US FAERS | |
| 449 | Maxillofacial operation | FAERS: 1 | US FAERS | |
| 450 | Mediastinal mass | FAERS: 1 | US FAERS | |
| 451 | Memory impairment | FAERS: 1 | US FAERS | |
| 452 | Meningitis herpes | FAERS: 1 | US FAERS | |
| 453 | Meningitis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 454 | Mental impairment | FAERS: 1 | US FAERS | |
| 455 | Metastases to adrenals | FAERS: 1 | US FAERS | |
| 456 | Metastases to pelvis | FAERS: 1 | US FAERS | |
| 457 | Micrographic skin surgery | FAERS: 1 | US FAERS | |
| 458 | Muscle Cramp | FAERS: 1 | US FAERS | |
| 459 | Muscle enzyme increased | FAERS: 1 | US FAERS | |
| 460 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 461 | Myocardial Infarction | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 462 | Myopathy | FAERS: 1 | US FAERS | |
| 463 | Nasal sinus drainage | FAERS: 1 | US FAERS | |
| 464 | Neonatal disorder | FAERS: 1 | US FAERS | |
| 465 | Nerve injury | FAERS: 1 | US FAERS | |
| 466 | Neuropathic ulcer | FAERS: 1 | US FAERS | |
| 467 | Nocturia | FAERS: 1 | US FAERS | |
| 468 | Noninfectious peritonitis | FAERS: 1 | US FAERS | |
| 469 | Obesity | FAERS: 1 | US FAERS | |
| 470 | Onycholysis | FAERS: 1 | US FAERS | |
| 471 | Onychomycosis | FAERS: 1 | US FAERS | |
| 472 | Oral mucosal erythema | FAERS: 1 | US FAERS | |
| 473 | Osteomalacia | FAERS: 1 | US FAERS | |
| 474 | Osteoradionecrosis | FAERS: 1 | US FAERS | |
| 475 | PCO2 increased | FAERS: 1 | US FAERS | |
| 476 | Pain of skin | FAERS: 1 | US FAERS | |
| 477 | Pallor | FAERS: 1 | US FAERS | |
| 478 | Palpitations | FAERS: 1 | US FAERS | |
| 479 | Pancreatic Neoplasm | FAERS: 1 | US FAERS | |
| 480 | Parakeratosis | FAERS: 1 | US FAERS | |
| 481 | Paraparesis | FAERS: 1 | US FAERS | |
| 482 | Pelvic prolapse | FAERS: 1 | US FAERS | |
| 483 | Peptic Ulcer | FAERS: 1 | US FAERS | |
| 484 | Performance status decreased | FAERS: 1 | US FAERS | |
| 485 | Pericarditis | FAERS: 1 | US FAERS | |
| 486 | Plastic surgery to the face | FAERS: 1 | US FAERS | |
| 487 | Polyarthritis | FAERS: 1 | US FAERS | |
| 488 | Poor dental condition | FAERS: 1 | US FAERS | |
| 489 | Post procedural infection | FAERS: 1 | US FAERS | |
| 490 | Pre-Eclampsia | FAERS: 1 | US FAERS | |
| 491 | Premature Menopause | FAERS: 1 | US FAERS | |
| 492 | Procalcitonin increased | FAERS: 1 | US FAERS | |
| 493 | Procedural complication | FAERS: 1 | US FAERS | |
| 494 | Prostatic calcification | FAERS: 1 | US FAERS | |
| 495 | Prosthesis Implantation | FAERS: 1 | US FAERS | |
| 496 | Pseudarthrosis | FAERS: 1 | US FAERS | |
| 497 | Pulmonary Embolism | FAERS: 1 | US FAERS | |
| 498 | Pulmonary Fibrosis | FAERS: 1 | US FAERS | |
| 499 | Pulmonary Hypertension | FAERS: 1 | US FAERS | |
| 500 | Pulmonary granuloma | FAERS: 1 | US FAERS | |
| 501 | Quality of life decreased | FAERS: 1 | US FAERS | |
| 502 | Radicular pain | FAERS: 1 | US FAERS | |
| 503 | Rash erythematous | FAERS: 1 | US FAERS | |
| 504 | Rectal polyp | FAERS: 1 | US FAERS | |
| 505 | Rectocele | FAERS: 1 | US FAERS | |
| 506 | Regurgitation | FAERS: 1 | US FAERS | |
| 507 | Renal cancer metastatic | FAERS: 1 | US FAERS | |
| 508 | Renal tubular disorder | FAERS: 1 | US FAERS | |
| 509 | Respiratory arrest | FAERS: 1 | US FAERS | |
| 510 | Respiratory tract congestion | FAERS: 1 | US FAERS | |
| 511 | Restrictive pulmonary disease | FAERS: 1 | US FAERS | |
| 512 | Reticulocyte count decreased | FAERS: 1 | US FAERS | |
| 513 | Salivary gland pain | FAERS: 1 | US FAERS | |
| 514 | Salmonella sepsis | FAERS: 1 | US FAERS | |
| 515 | Scleritis | FAERS: 1 | US FAERS | |
| 516 | Secondary sequestrum | FAERS: 1 | US FAERS | |
| 517 | Serotonin Syndrome | FAERS: 1 | US FAERS | |
| 518 | Skeletal dysplasia | FAERS: 1 | US FAERS | |
| 519 | Skin lesion | FAERS: 1 | US FAERS | |
| 520 | Skin necrosis | FAERS: 1 | US FAERS | |
| 521 | Soft tissue mass | FAERS: 1 | US FAERS | |
| 522 | Somnolence | FAERS: 1 | US FAERS | |
| 523 | Spinal X-ray abnormal | FAERS: 1 | US FAERS | |
| 524 | Splenomegaly | FAERS: 1 | US FAERS | |
| 525 | Stress | FAERS: 1 | US FAERS | |
| 526 | Subcutaneous nodule | FAERS: 1 | US FAERS | |
| 527 | Subileus | FAERS: 1 | US FAERS | |
| 528 | Synovial Cyst | FAERS: 1 | US FAERS | |
| 529 | Talipes | FAERS: 1 | US FAERS | |
| 530 | Teeth brittle | FAERS: 1 | US FAERS | |
| 531 | Tenosynovitis | FAERS: 1 | US FAERS | |
| 532 | Therapy non-responder | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 533 | Thirst | FAERS: 1 | US FAERS | |
| 534 | Throat irritation | FAERS: 1 | US FAERS | |
| 535 | Thyroidectomy | FAERS: 1 | US FAERS | |
| 536 | Toxic Optic Neuropathy | FAERS: 1 | US FAERS | |
| 537 | Transplant | FAERS: 1 | US FAERS | |
| 538 | Tremor | FAERS: 1 | US FAERS | |
| 539 | Trismus | FAERS: 1 | US FAERS | |
| 540 | Underweight | FAERS: 1 | US FAERS | |
| 541 | Unevaluable event | FAERS: 1 | US FAERS | |
| 542 | Unresponsive to verbal stimuli | FAERS: 1 | US FAERS | |
| 543 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 544 | Urinary hesitation | FAERS: 1 | US FAERS | |
| 545 | Vaginal mycosis | FAERS: 1 | US FAERS | |
| 546 | Vein pain | FAERS: 1 | US FAERS | |
| 547 | Venous occlusion | FAERS: 1 | US FAERS | |
| 548 | Vertebral column mass | FAERS: 1 | US FAERS | |
| 549 | Vertigo | FAERS: 1 | US FAERS | |
| 550 | Vitamin D Deficiency | FAERS: 1 | US FAERS | |
| 551 | Wheezing | FAERS: 1 | US FAERS | |
| 552 | Wound closure | FAERS: 1 | US FAERS | |
| 553 | Wrong technique in drug usage process | FAERS: 1 | US FAERS | |
| 554 | X-ray limb abnormal | FAERS: 1 | US FAERS | |
| 555 | jaundice | FAERS: 1 | US FAERS | |
| 556 | Acute kidney injury | Canada Vigilance: 1 | Canada Vigilance | |
| 557 | Drug ineffective for unapproved indication | Canada Vigilance: 13 | Canada Vigilance | |
| 558 | Fasciitis | Canada Vigilance: 1 | Canada Vigilance | |
| 559 | Hemiparesis | Canada Vigilance: 1 | Canada Vigilance | |
| 560 | Hordeolum | Canada Vigilance: 1 | Canada Vigilance | |
| 561 | Influenza | Canada Vigilance: 1 | Canada Vigilance | |
| 562 | Muscle Spasticity | Canada Vigilance: 1 | Canada Vigilance | |
| 563 | Optic Neuritis | Canada Vigilance: 2 | Canada Vigilance | |
| 564 | Orbital Myositis | Canada Vigilance: 1 | Canada Vigilance | |
| 565 | Paraplegia | Canada Vigilance: 2 | Canada Vigilance | |
| 566 | Phlebitis | Canada Vigilance: 2 | Canada Vigilance | |
| 567 | Vein collapse | Canada Vigilance: 1 | Canada Vigilance |
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