Fosamax plus D
(HVLYRWMHSQOCIQ-GTYZJCMKSA-M)
Structure
- SMILES
- CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CCC/C/2=C\C=C/1\C[C@@H](O)CCC1=C)C)C.NCCCC(P(=O)(O)O)(P(=O)(O)[O-])O.[Na+]
- Molecular Formula:
- C31H56NNaO8P2
- Molecular Weight:
- 655.716
- Log P:
- 7.4843
- Hydrogen Bond Acceptor:
- 9
- Hydrogen Bond Donor:
- 6
- TPSA:
- 203.99
- CAS Number(s):
- 871265-91-7
Synonym(s)
1.
Fosamax plus D
External Link(s)
| PubChem Compound | 23682309 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Arthralgia | FAERS: 49 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 2 | Myalgia | FAERS: 40 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 3 | Bone pain | FAERS: 36 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 4 | Pain | FAERS: 23 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 5 | Back Pain | FAERS: 19 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 6 | Malaise | FAERS: 16 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 7 | Asthenia | FAERS: 15 | US FAERS | |
| 8 | Chest Pain | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 9 | No adverse event | FAERS: 14 | US FAERS | |
| 10 | Fatigue | FAERS: 13 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 11 | Osteonecrosis of Jaw | FAERS: 13 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 12 | Dizziness | FAERS: 12 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 13 | Weight decreased | FAERS: 12 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 14 | Adverse event | FAERS: 10 | US FAERS | |
| 15 | Nausea | FAERS: 10 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 16 | Pruritus | FAERS: 10 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 17 | Drug dose omission | FAERS: 9 | US FAERS | |
| 18 | Headache | FAERS: 9 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 19 | Musculoskeletal Pain | FAERS: 9 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 20 | Osteomyelitis | FAERS: 9 | US FAERS | |
| 21 | Vomiting | FAERS: 9 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 22 | Musculoskeletal stiffness | FAERS: 8 | US FAERS | |
| 23 | Sepsis | FAERS: 8 | US FAERS | |
| 24 | Tachycardia | FAERS: 8 | US FAERS | |
| 25 | Atrial Fibrillation | FAERS: 7 | US FAERS | |
| 26 | Atypical femur fracture | FAERS: 7 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 27 | Drug ineffective | FAERS: 7 | US FAERS | |
| 28 | Fracture | FAERS: 7 | US FAERS | |
| 29 | Overdose | FAERS: 7 | US FAERS | |
| 30 | Chills | FAERS: 6 | US FAERS | |
| 31 | Clubbing | FAERS: 6 | US FAERS | |
| 32 | Dyspepsia | FAERS: 6 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 33 | Joint swelling | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 34 | Malabsorption | FAERS: 6 | US FAERS | |
| 35 | Musculoskeletal discomfort | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 36 | Oral pain | FAERS: 6 | US FAERS | |
| 37 | Tooth Loss | FAERS: 6 | US FAERS | |
| 38 | Arthritis | FAERS: 5 | US FAERS | |
| 39 | Bone density decreased | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 40 | Burning sensation | FAERS: 5 | US FAERS | |
| 41 | Cerebrovascular accident | FAERS: 5 | US FAERS | |
| 42 | Erythema | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 43 | Osteitis | FAERS: 5 | US FAERS | |
| 44 | Palpitations | FAERS: 5 | US FAERS | |
| 45 | Respiratory Failure | FAERS: 5 | US FAERS | |
| 46 | Acute respiratory failure | FAERS: 4 | US FAERS | |
| 47 | Alopecia | FAERS: 4 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 48 | Constipation | FAERS: 4 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 49 | Discomfort | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 50 | Electrocardiogram abnormal | FAERS: 4 | US FAERS | |
| 51 | Eye pain | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 52 | Feeling abnormal | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 53 | Gastrointestinal carcinoma | FAERS: 4 | US FAERS | |
| 54 | Gingivitis | FAERS: 4 | US FAERS | |
| 55 | Inappropriate schedule of drug administration | FAERS: 4 | US FAERS | |
| 56 | Memory impairment | FAERS: 4 | US FAERS | |
| 57 | Myocardial Infarction | FAERS: 4 | US FAERS | |
| 58 | Open reduction of fracture | FAERS: 4 | US FAERS | |
| 59 | Palmar erythema | FAERS: 4 | US FAERS | |
| 60 | Pelvic Pain | FAERS: 4 | US FAERS | |
| 61 | Pneumonia | FAERS: 4 | US FAERS | |
| 62 | Product quality issue | FAERS: 4 | US FAERS | |
| 63 | Tremor | FAERS: 4 | US FAERS | |
| 64 | Urinary tract infection | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 65 | Abasia | FAERS: 3 | US FAERS | |
| 66 | Abdominal Pain | FAERS: 3 | US FAERS | |
| 67 | Activities of daily living impaired | FAERS: 3 | US FAERS | |
| 68 | Blindness | FAERS: 3 | US FAERS | |
| 69 | Cardiac Arrest | FAERS: 3 | US FAERS | |
| 70 | Carotid artery occlusion | FAERS: 3 | US FAERS | |
| 71 | Drug administration error | FAERS: 3 | US FAERS | |
| 72 | Dysgeusia | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 73 | Feeling Cold | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 74 | Inadequate analgesia | FAERS: 3 | US FAERS | |
| 75 | Infection | FAERS: 3 | US FAERS | |
| 76 | Intervertebral disc disorder | FAERS: 3 | US FAERS | |
| 77 | Loose tooth | FAERS: 3 | US FAERS | |
| 78 | Medication Error | FAERS: 3 | US FAERS | |
| 79 | Muscle tightness | FAERS: 3 | US FAERS | |
| 80 | Osteoporosis | FAERS: 3 | US FAERS | |
| 81 | Pancreatitis | FAERS: 3 | US FAERS | |
| 82 | Rhabdomyolysis | FAERS: 3 | US FAERS | |
| 83 | Skin hypertrophy | FAERS: 3 | US FAERS | |
| 84 | Synovitis | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 85 | Toothache | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 86 | Tuberculosis | FAERS: 3 | US FAERS | |
| 87 | Urinary Retention | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 88 | Urinary Tract Pain | FAERS: 3 | US FAERS | |
| 89 | Urticaria | FAERS: 3 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 90 | Visual Impairment | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 91 | White blood cell count decreased | FAERS: 3 | US FAERS | |
| 92 | Abdominal discomfort | FAERS: 2 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 93 | Abscess | FAERS: 2 | US FAERS | |
| 94 | Angina Pectoris | FAERS: 2 | US FAERS | |
| 95 | Ankle Fracture | FAERS: 2 | US FAERS | |
| 96 | Anxiety | FAERS: 2 | US FAERS | |
| 97 | Aphasia | FAERS: 2 | US FAERS | |
| 98 | Arthropathy | FAERS: 2 | US FAERS | |
| 99 | Back disorder | FAERS: 2 | US FAERS | |
| 100 | Blood pressure fluctuation | FAERS: 2 | US FAERS | |
| 101 | Bone atrophy | FAERS: 2 | US FAERS | |
| 102 | Callus formation delayed | FAERS: 2 | US FAERS | |
| 103 | Cataract | FAERS: 2 | US FAERS | |
| 104 | Chest discomfort | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 105 | Dental caries | FAERS: 2 | US FAERS | |
| 106 | Electrocardiogram | FAERS: 2 | US FAERS | |
| 107 | Eye irritation | FAERS: 2 | US FAERS | |
| 108 | Fistula discharge | FAERS: 2 | US FAERS | |
| 109 | Flank Pain | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 110 | Flatulence | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 111 | Gastric ulcer | FAERS: 2 | US FAERS | |
| 112 | Gastritis | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 113 | Gastrointestinal Pain | FAERS: 2 | US FAERS | |
| 114 | Glaucoma | FAERS: 2 | US FAERS | |
| 115 | Hyperparathyroidism | FAERS: 2 | US FAERS | |
| 116 | Hypertensive crisis | FAERS: 2 | US FAERS | |
| 117 | Hypotension | FAERS: 2 | US FAERS | |
| 118 | Impaired work ability | FAERS: 2 | US FAERS | |
| 119 | Incorrect dose administered | FAERS: 2 | US FAERS | |
| 120 | Inflammation | FAERS: 2 | US FAERS | |
| 121 | Joint sprain | FAERS: 2 | US FAERS | |
| 122 | Joint stiffness | FAERS: 2 | US FAERS | |
| 123 | Neck Pain | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 124 | Nephrolithiasis | FAERS: 2 | US FAERS | |
| 125 | Non-cardiac chest pain | FAERS: 2 | US FAERS | |
| 126 | Oral Cavity Fistula | FAERS: 2 | US FAERS | |
| 127 | Oropharyngeal pain | FAERS: 2 | US FAERS | |
| 128 | Pathological fracture | FAERS: 2 | US FAERS | |
| 129 | Pharyngeal Stenosis | FAERS: 2 | US FAERS | |
| 130 | Poor quality drug administered | FAERS: 2 | US FAERS | |
| 131 | Rheumatoid Arthritis | FAERS: 2 | US FAERS | |
| 132 | Stomatitis | FAERS: 2 | US FAERS | |
| 133 | Swelling | FAERS: 2 | US FAERS | |
| 134 | Therapy cessation | FAERS: 2 | US FAERS | |
| 135 | Tinnitus | FAERS: 2 | US FAERS | |
| 136 | Tooth Infection | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 137 | Traumatic fracture | FAERS: 2 | US FAERS | |
| 138 | Trismus | FAERS: 2 | US FAERS | |
| 139 | Walking aid user | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 140 | Wrong technique in drug usage process | FAERS: 2 | US FAERS | |
| 141 | Wrong technique in product usage process | FAERS: 2 | US FAERS | |
| 142 | Accidental overdose | FAERS: 1 | US FAERS | |
| 143 | Agitation | FAERS: 1 | US FAERS | |
| 144 | Anaphylactic shock | FAERS: 1 | US FAERS | |
| 145 | Angioedema | FAERS: 1 | US FAERS | |
| 146 | Aphagia | FAERS: 1 | US FAERS | |
| 147 | Aphonia | FAERS: 1 | US FAERS | |
| 148 | Aphthous Stomatitis | FAERS: 1 | US FAERS | |
| 149 | Appendicitis | FAERS: 1 | US FAERS | |
| 150 | Ascites | FAERS: 1 | US FAERS | |
| 151 | Asphyxia | FAERS: 1 | US FAERS | |
| 152 | Bedridden | FAERS: 1 | US FAERS | |
| 153 | Biopsy | FAERS: 1 | US FAERS | |
| 154 | Blood cholesterol increased | FAERS: 1 | US FAERS | |
| 155 | Blood gastrin increased | FAERS: 1 | US FAERS | |
| 156 | Blood urine present | FAERS: 1 | US FAERS | |
| 157 | Bone density abnormal | FAERS: 1 | US FAERS | |
| 158 | Bone fissure | FAERS: 1 | US FAERS | |
| 159 | Bone formation decreased | FAERS: 1 | US FAERS | |
| 160 | Bone lesion | FAERS: 1 | US FAERS | |
| 161 | Bone swelling | FAERS: 1 | US FAERS | |
| 162 | Breast cancer recurrent | FAERS: 1 | US FAERS | |
| 163 | Breast cancer stage II | FAERS: 1 | US FAERS | |
| 164 | C-reactive protein normal | FAERS: 1 | US FAERS | |
| 165 | Carcinoembryonic antigen increased | FAERS: 1 | US FAERS | |
| 166 | Cardiac ventricular disorder | FAERS: 1 | US FAERS | |
| 167 | Cellulitis | FAERS: 1 | US FAERS | |
| 168 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 169 | Circumstance or information capable of leading to medication error | FAERS: 1 | US FAERS | |
| 170 | Compression fracture | FAERS: 1 | US FAERS | |
| 171 | Conjunctivitis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 172 | Cyst | FAERS: 1 | US FAERS | |
| 173 | Deafness | FAERS: 1 | US FAERS | |
| 174 | Decreased immune responsiveness | FAERS: 1 | US FAERS | |
| 175 | Dental prosthesis placement | FAERS: 1 | US FAERS | |
| 176 | Dependence | FAERS: 1 | US FAERS | |
| 177 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 178 | Dermatomyositis | FAERS: 1 | US FAERS | |
| 179 | Diplopia | FAERS: 1 | US FAERS | |
| 180 | Diverticulum | FAERS: 1 | US FAERS | |
| 181 | Drug exposure during pregnancy | FAERS: 1 | US FAERS | |
| 182 | Drug prescribing error | FAERS: 1 | US FAERS | |
| 183 | Dysarthria | FAERS: 1 | US FAERS | |
| 184 | Electrolyte imbalance | FAERS: 1 | US FAERS | |
| 185 | Epigastric discomfort | FAERS: 1 | US FAERS | |
| 186 | Epilepsy | FAERS: 1 | US FAERS | |
| 187 | Fibromyalgia | FAERS: 1 | US FAERS | |
| 188 | Gamma-Glutamyltransferase Increased | FAERS: 1 | US FAERS | |
| 189 | Gastrectomy | FAERS: 1 | US FAERS | |
| 190 | Gastroenteritis | FAERS: 1 | US FAERS | |
| 191 | Gastrointestinal infection | FAERS: 1 | US FAERS | |
| 192 | Gastrointestinal inflammation | FAERS: 1 | US FAERS | |
| 193 | Gastrointestinal stoma complication | FAERS: 1 | US FAERS | |
| 194 | Gastrostomy | FAERS: 1 | US FAERS | |
| 195 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 196 | Gingival graft | FAERS: 1 | US FAERS | |
| 197 | Head titubation | FAERS: 1 | US FAERS | |
| 198 | Hypersensitivity | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 199 | Hypophagia | FAERS: 1 | US FAERS | |
| 200 | Hypothyroidism | FAERS: 1 | US FAERS | |
| 201 | Implant site pain | FAERS: 1 | US FAERS | |
| 202 | Incision site pain | FAERS: 1 | US FAERS | |
| 203 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 204 | Incorrect route of drug administration | FAERS: 1 | US FAERS | |
| 205 | Increased tendency to bruise | FAERS: 1 | US FAERS | |
| 206 | Intentional drug misuse | FAERS: 1 | US FAERS | |
| 207 | Intestinal resection | FAERS: 1 | US FAERS | |
| 208 | Iridocyclitis | FAERS: 1 | US FAERS | |
| 209 | Iritis | FAERS: 1 | US FAERS | |
| 210 | Irritable Bowel Syndrome | FAERS: 1 | US FAERS | |
| 211 | Joint Instability | FAERS: 1 | US FAERS | |
| 212 | Joint Range of Motion Decreased | FAERS: 1 | US FAERS | |
| 213 | Joint injury | FAERS: 1 | US FAERS | |
| 214 | Laryngitis | FAERS: 1 | US FAERS | |
| 215 | Ligament rupture | FAERS: 1 | US FAERS | |
| 216 | Low turnover osteopathy | FAERS: 1 | US FAERS | |
| 217 | Musculoskeletal chest pain | FAERS: 1 | US FAERS | |
| 218 | Necrosis | FAERS: 1 | US FAERS | |
| 219 | Nephrotic Syndrome | FAERS: 1 | US FAERS | |
| 220 | Nervousness | FAERS: 1 | US FAERS | |
| 221 | Night sweats | FAERS: 1 | US FAERS | |
| 222 | Oncologic complication | FAERS: 1 | US FAERS | |
| 223 | Oral infection | FAERS: 1 | US FAERS | |
| 224 | Oropharyngeal discomfort | FAERS: 1 | US FAERS | |
| 225 | Osteodystrophy | FAERS: 1 | US FAERS | |
| 226 | Osteogenesis Imperfecta | FAERS: 1 | US FAERS | |
| 227 | Paranasal sinus discomfort | FAERS: 1 | US FAERS | |
| 228 | Peri-spinal heterotopic ossification | FAERS: 1 | US FAERS | |
| 229 | Periodontitis | FAERS: 1 | US FAERS | |
| 230 | Peripheral swelling | FAERS: 1 | US FAERS | |
| 231 | Peripheral venous disease | FAERS: 1 | US FAERS | |
| 232 | Pityriasis Rubra Pilaris | FAERS: 1 | US FAERS | |
| 233 | Plasmacytoma | FAERS: 1 | US FAERS | |
| 234 | Polymyositis | FAERS: 1 | US FAERS | |
| 235 | Poor quality sleep | FAERS: 1 | US FAERS | |
| 236 | Proctitis | FAERS: 1 | US FAERS | |
| 237 | Product adhesion issue | FAERS: 1 | US FAERS | |
| 238 | Product blister packaging issue | FAERS: 1 | US FAERS | |
| 239 | Product dose omission | FAERS: 1 | US FAERS | |
| 240 | Product packaging issue | FAERS: 1 | US FAERS | |
| 241 | Product packaging quantity issue | FAERS: 1 | US FAERS | |
| 242 | Product physical issue | FAERS: 1 | US FAERS | |
| 243 | Product supply issue | FAERS: 1 | US FAERS | |
| 244 | Product use in unapproved indication | FAERS: 1 | US FAERS | |
| 245 | Product use issue | FAERS: 1 | US FAERS | |
| 246 | Radiculopathy | FAERS: 1 | US FAERS | |
| 247 | Rash erythematous | FAERS: 1 | US FAERS | |
| 248 | Restless Legs Syndrome | FAERS: 1 | US FAERS | |
| 249 | Restlessness | FAERS: 1 | US FAERS | |
| 250 | Retinal Vasculitis | FAERS: 1 | US FAERS | |
| 251 | Retinal vascular thrombosis | FAERS: 1 | US FAERS | |
| 252 | Rheumatoid factor increased | FAERS: 1 | US FAERS | |
| 253 | Sciatica | FAERS: 1 | US FAERS | |
| 254 | Septic Shock | FAERS: 1 | US FAERS | |
| 255 | Shock | FAERS: 1 | US FAERS | |
| 256 | Skin necrosis | FAERS: 1 | US FAERS | |
| 257 | Spinal column stenosis | FAERS: 1 | US FAERS | |
| 258 | Spondylolysis | FAERS: 1 | US FAERS | |
| 259 | Syncope | FAERS: 1 | US FAERS | |
| 260 | Tachyarrhythmia | FAERS: 1 | US FAERS | |
| 261 | Tension | FAERS: 1 | US FAERS | |
| 262 | Therapeutic response unexpected | FAERS: 1 | US FAERS | |
| 263 | Throat irritation | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 264 | Tooth Extraction | FAERS: 1 | US FAERS | |
| 265 | Ulcer | FAERS: 1 | US FAERS | |
| 266 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 267 | Uterovaginal prolapse | FAERS: 1 | US FAERS | |
| 268 | Uveitis | FAERS: 1 | US FAERS | |
| 269 | Vascular pain | FAERS: 1 | US FAERS | |
| 270 | Vitamin D Deficiency | FAERS: 1 | US FAERS | |
| 271 | intensive care | FAERS: 1 | US FAERS | |
| 272 | Abnormal sleep-related event | Canada Vigilance: 1 | Canada Vigilance | |
| 273 | Bursitis | Canada Vigilance: 1 | Canada Vigilance | |
| 274 | Eye inflammation | Canada Vigilance: 1 | Canada Vigilance | |
| 275 | Facial Pain | Canada Vigilance: 1 | Canada Vigilance | |
| 276 | Impaired self-care | Canada Vigilance: 1 | Canada Vigilance | |
| 277 | Lip swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 278 | Pharyngeal swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 279 | Skin reaction | Canada Vigilance: 1 | Canada Vigilance | |
| 280 | Sleep disorder due to general medical condition, insomnia type | Canada Vigilance: 1 | Canada Vigilance |
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