MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Bronchial Hyperreactivity

(UMLS:C0085129)

Definition:: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
UMLS ID:: C0085129
MeSH ID:: D016535

Classification:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.127.210

Synonym(s)

Bronchial Hyperreactivity

BHR - Bronchial hyperreactivity

Bronchial hyperreactivity

Bronchial hyperresponsiveness

Bronchial hypersensitivity

bronchial hyperactivity

bronchial hyperreactivity

bronchial hyperresponsiveness

bronchial hypersensitivity

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ondansetron	FAERS: 23		US FAERS
2	Propranolol	FAERS: 14		US FAERS
3	Alendronate	FAERS: 11		US FAERS
4	NuvaRing	FAERS: 10		US FAERS
5	Propranolol	FAERS: 10		US FAERS
6	Paroxetine	FAERS: 9		US FAERS
7	Amlodipine	FAERS: 7		SIDER US FAERS
8	Morphine	FAERS: 7		US FAERS
9	Dexamethasone	FAERS: 6	15330010 22776411	CTD US FAERS
10	Budesonide	FAERS: 4	30189237	CTD US FAERS
11	Finasteride	FAERS: 4		US FAERS
12	Sertraline	FAERS: 4		US FAERS
13	teriflunomide	FAERS: 4		US FAERS
14	Acetaminophen	FAERS: 3		US FAERS
15	Albuterol	FAERS: 3		US FAERS
16	Lenalidomide	FAERS: 3		SIDER US FAERS
17	Levofloxacin	FAERS: 3		US FAERS
18	Rosiglitazone	FAERS: 3		US FAERS
19	tofacitinib	FAERS: 3		US FAERS
20	Ciprofloxacin	FAERS: 2		US FAERS
21	Fluoxetine	FAERS: 2		US FAERS
22	Glatiramer Acetate	FAERS: 2		US FAERS
23	Hydrochlorothiazide	FAERS: 2		US FAERS
24	Ibandronic Acid	FAERS: 2		US FAERS
25	Isotretinoin	FAERS: 2		US FAERS
26	Methylphenidate	FAERS: 2		US FAERS
27	Moxifloxacin	FAERS: 2		US FAERS
28	Sitagliptin Phosphate	FAERS: 2		US FAERS
29	Thyroxine	FAERS: 2		US FAERS
30	Tobramycin	FAERS: 2		US FAERS
31	Varenicline	FAERS: 2		US FAERS
32	Vilazodone Hydrochloride	FAERS: 2		US FAERS
33	apremilast	FAERS: 2		US FAERS
34	pomalidomide	FAERS: 2		US FAERS
35	4-hydroxybutyric acid	FAERS: 1		US FAERS
36	Amitriptyline	FAERS: 1		US FAERS
37	Amlodipine	FAERS: 1		US FAERS
38	Aspirin	FAERS: 1	16340173	CTD US FAERS
39	Aztreonam	FAERS: 1		US FAERS
40	Bortezomib	FAERS: 1		SIDER US FAERS
41	Bosentan	FAERS: 1		US FAERS
42	Breo Ellipta	FAERS: 1		US FAERS
43	Bromocriptine	FAERS: 1		US FAERS
44	Carbamazepine	FAERS: 1		US FAERS
45	Clozapine	FAERS: 1		US FAERS
46	Desvenlafaxine Succinate	FAERS: 1		US FAERS
47	Enalapril	FAERS: 1		US FAERS
48	Everolimus	FAERS: 1		US FAERS
49	Fingolimod Hydrochloride	FAERS: 1		US FAERS
50	Fluticasone-Salmeterol Drug Combination	FAERS: 1		US FAERS
51	Iloprost	FAERS: 1		US FAERS
52	Isoniazid	FAERS: 1		US FAERS
53	Ivabradine	FAERS: 1		US FAERS
54	Mannitol	FAERS: 1		US FAERS
55	Maxepa	FAERS: 1		US FAERS
56	Methylprednisolone Hemisuccinate	FAERS: 1		US FAERS
57	Mometasone Furoate	FAERS: 1		US FAERS
58	Nicotine	FAERS: 1		US FAERS
59	Oxymorphone	FAERS: 1		US FAERS
60	Pramipexole	FAERS: 1		US FAERS
61	Sevelamer	FAERS: 1		US FAERS
62	Tacrolimus	FAERS: 1		US FAERS
63	Tiotropium Bromide	FAERS: 1		US FAERS
64	Tramadol hydrochloride and acetaminophen	FAERS: 1		US FAERS
65	Valsartan	FAERS: 1		US FAERS
66	aliskiren	FAERS: 1		US FAERS
67	brinzolamide	FAERS: 1		SIDER US FAERS
68	ecallantide	FAERS: 1		US FAERS
69	etonogestrel	FAERS: 1		US FAERS
70	indacaterol	FAERS: 1		US FAERS
71	ponatinib	FAERS: 1		US FAERS
72	regorafenib	FAERS: 1		US FAERS
73	treprostinil	FAERS: 1		US FAERS
74	4,4'-diphenylmethane diisocyanate		8156442	CTD
75	AWD 12-281		12944497	CTD
76	Acetylcholine		10550748 17336541	CTD
77	Albuterol	Canada Vigilance: 1		Canada Vigilance
78	Aluminum		11948057	CTD
79	Aminophylline			SIDER
80	Aripiprazole			SIDER
81	Beclomethasone		17336541 18391481 18577381	CTD
82	Chlorine		23146759 30189237	CTD
83	Cilomilast		12944497	CTD
84	Clodronic Acid		23377347	CTD
85	Cocaine		11948057	CTD
86	Dinoprostone		15700024	CTD
87	Fluticasone/salmeterol			SIDER
88	Formaldehyde		14656365 16463957	CTD
89	Formoterol Fumarate		17336541	CTD
90	Goserelin			SIDER
91	Heroin		11948057	CTD
92	Hydrochloric Acid		12378975	CTD
93	Ipratropium			SIDER
94	Itraconazole			SIDER
95	LY 171883		12654629	CTD
96	Lasofoxifene			SIDER
97	Leukotriene B4		12654629 12794006	CTD
98	Leukotriene C4		12654629	CTD
99	Leukotriene D4		12654629 12794006	CTD
100	Leukotriene E4		12654629	CTD
101	Linagliptin			SIDER
102	Melphalan		22776411	CTD
103	Memantine			SIDER
104	Methacholine Chloride		View details 12944497 15700024 17343743 18775882 30189237	CTD
105	Methotrexate			SIDER
106	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine		21364313	CTD
107	Naltrexone			SIDER
108	Nitrogen Dioxide		8534489	CTD
109	Ofloxacin			SIDER
110	Oxandrolone			SIDER
111	Ozone		View details 14754758 15516495 16777450 17626835 18315731 18417511 19059883 23434795	CTD
112	PH 163		12654629	CTD
113	Parathion		23377347	CTD
114	Pramipexole			SIDER
115	Prednisolone		18391481 18577381	CTD
116	Propafenone			SIDER
117	RTKI cpd		12794006	CTD
118	Rivastigmine			SIDER
119	Strontium			SIDER
120	Terbutaline		10550748	CTD
121	Testosterone			SIDER
122	Toluene 2,4-Diisocyanate		View details 8156442 12507178 15590891 19150644 31071364	CTD
123	acetylsalicylic acid lysinate		1811646	CTD
124	beta-Glucans		24905346	CTD
125	bisphenol A		20123615	CTD
126	cevimeline			SIDER
127	perfluorooctanoic acid		17369199	CTD
128	regadenoson			SIDER
129	titanium dioxide		25456268	CTD
130	trimellitic anhydride		18775882	CTD
131	verlukast		12654629	CTD
132	zileuton		12388339 12654629 12794006	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Bronchospasm	42.9%
2	Bronchiectasis	42.9%
3	Bronchitis	33.3%
4	Bronchopneumonia	31%
5	Tracheobronchomegaly	28.2%
6	Bronchial Fistula	27.8%
7	Asthma	26.2%
8	Bronchial Neoplasms	25.5%
9	Bronchiolitis	24.4%
10	Lung diseases	23.1%
11	Pleural Diseases	23.1%
12	Respiration Disorders	23.1%
13	Thoracic Diseases	23.1%
14	Tracheal Diseases	23.1%
15	Bronchitis, Chronic	22.7%
16	Bronchiolitis Obliterans	21.5%
17	Asthma, Exercise-Induced	20.1%
18	Status Asthmaticus	20.1%
19	Pleurisy	19%
20	Pneumonia	19%
21	Lobar Pneumonia	19%
22	Respiratory Distress Syndrome, Adult	19%
23	Tracheitis	19%
24	Pneumonitis	19%
25	Asthma, Occupational	16.7%
26	Pleuropneumonia	16.2%
27	Laryngeal Diseases	15.8%
28	Nose Diseases	15.8%
29	Respiratory Tract Infections	15%
30	Granuloma, Respiratory Tract	14.6%
31	Respiratory Hypersensitivity	14.6%
32	Respiratory Tract Fistula	14.6%
33	Altitude Sickness	14.3%
34	Atelectasis	14.3%
35	Chylothorax	14.3%
36	Hydropneumothorax	14.3%
37	Hydrothorax	14.3%
38	Pulmonary Hypertension	14.3%
39	Laryngitis	14.3%
40	Lung Diseases, Fungal	14.3%
41	Pneumothorax	14.3%
42	Pulmonary Alveolar Proteinosis	14.3%
43	Pulmonary Edema	14.3%
44	Pulmonary Fibrosis	14.3%
45	Respiratory Insufficiency	14.3%
46	Rhinitis	14.3%
47	Tracheal Stenosis	14.3%
48	Hamman-Rich syndrome	14.3%
49	Lung Diseases, Interstitial	14.3%
50	Respiratory Depression	14.3%
51	Lung Diseases, Obstructive	14.3%
52	Vocal Cord Dysfunction	14.3%
53	Respiratory Failure	14.3%
54	Respiratory Distress Syndrome, Newborn	14%
55	Lung Abscess	13.9%
56	Lung Neoplasms	13.9%
57	Pleural Neoplasms	13.9%
58	Tuberculosis, Pulmonary	13.8%
59	Aspiration Pneumonia	13.6%
60	Asthma, Aspirin-Induced	13.5%
61	Granuloma, Laryngeal	12.7%
62	Idiopathic Pulmonary Fibrosis	12.4%
63	Sinusitis	12.1%
64	Pleural Effusion, Malignant	12%
65	Bronchomalacia	12%
66	Choanal Atresia	11.3%
67	Laryngocele	11.3%
68	Pneumonia, Lipid	11.1%
69	Tracheal Neoplasms	11%
70	Pneumoconiosis	10.7%
71	Pneumonia, Viral	10.7%
72	Aspergillosis, Allergic Bronchopulmonary	10.6%
73	Airway Obstruction	10.3%
74	Pneumonia, Bacterial	10.3%
75	Choking	10.3%
76	Epiglottitis	10.3%
77	Chronic Obstructive Airway Disease	10.3%
78	Mediastinitis	10.3%
79	Middle Lobe Syndrome	10.3%
80	Acute Lung Injury	10.3%
81	Laryngospasm	10.2%
82	Hyaline Membrane Disease	10.1%
83	Multiple Pulmonary Nodules	10%
84	Granuloma, Lethal Midline	9.5%
85	Laryngeal Edema	9.5%
86	Nose Deformities, Acquired	9.5%
87	Lung Injury	9.5%
88	Hepatopulmonary Syndrome	9.5%
89	Respiratory Aspiration	9.5%
90	Laryngeal neoplasm	9.4%
91	Apnea	9.3%
92	Cheyne-Stokes Respiration	9.3%
93	Common Cold	9.3%
94	Dyspnea	9.3%
95	Hemothorax	9.3%
96	Hyperventilation	9.3%
97	Influenza	9.3%
98	Mouth Breathing	9.3%
99	Tachypnea	9.3%
100	Catarrh	9.3%
101	Pulmonary Embolism	9.2%
102	Pulmonary Eosinophilia	9.1%
103	Severe Acute Respiratory Syndrome	9.1%
104	Eosinophilic Pneumonia	9.1%
105	Laryngopharyngeal Reflux	9.1%
106	Kartagener Syndrome	8.8%
107	Primary Ciliary Dyskinesia	8.8%
108	Asbestosis	8.5%
109	Berylliosis	8.5%
110	Pulmonary Emphysema	8.5%
111	Silicosis	8.5%
112	Radiation Pneumonitis	8.2%
113	Radiation Fibrosis	8.2%
114	Meconium Aspiration Syndrome	8.1%
115	Scimitar Syndrome	7.9%
116	Acute Chest Syndrome	7.7%
117	Paranasal Sinus Neoplasms	7.5%
118	Farmer's Lung	7.4%
119	Hay fever	7.3%
120	Rhinitis, Allergic, Perennial	7.3%
121	Pharyngitis	7.1%
122	Laryngostenosis	7%
123	Nasal Polyps	7%
124	Mediastinal Cyst	7%
125	Pericardial Cyst	7%
126	Persistent Fetal Circulation Syndrome	7%
127	Thymic Cyst	7%
128	Hemoptysis	6.9%
129	Nose Neoplasms	6.9%
130	Pertussis	6.8%
131	Croup	6.8%
132	Histiocytosis, Langerhans-Cell	6.8%
133	Mediastinal Emphysema	6.8%
134	Rhinitis, Vasomotor	6.8%
135	Pulmonary Aspergillosis	6.8%
136	Bronchopulmonary Aspergillosis	6.8%
137	Hypoventilation	6.8%
138	Rhinoscleroma	6.8%
139	Hoarseness	6.8%
140	Acidosis, Respiratory	6.7%
141	Alkalosis, Respiratory	6.7%
142	Sarcoidosis, Pulmonary	6.7%
143	Sleep Apnea Syndromes	6.7%
144	Pulmonary Infarction	6.7%
145	Maxillary Sinus Neoplasms	6.1%
146	Blastomycosis	5.7%
147	Cystic Fibrosis	5.7%
148	Voice Disorders	5.6%
149	Voice Disturbance	5.6%
150	Bronchopulmonary Dysplasia	5.6%
151	Epistaxis	5.6%
152	Sleep Apnea, Obstructive	5.5%
153	Sleep Apnea, Central	5.5%
154	Tonsillitis	5.1%
155	Dyspnea, Paroxysmal	5%
156	Respiratory Paralysis	5%
157	Granulomatosis with polyangiitis	5%
158	Laryngomalacia	4.7%
159	Vocal Cord Paralysis	4.6%
160	Transfusion-Related Acute Lung Injury	4.3%
161	Invasive Pulmonary Aspergillosis	4.2%
162	Aphonia	4%
163	Retropharyngeal Abscess	4%
164	Dysphonia	4%
165	Anti-Glomerular Basement Membrane Disease	4%
166	Tracheomalacia	4%
167	Nasopharyngitis	3.4%
168	Peritonsillar Abscess	3.3%
169	Eosinophilic Granuloma	2.8%

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