MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Colistin

(YKQOSKADJPQZHB-QNPLFGSASA-N)

Structure

SMILES: NCC[C@@H](C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)[C@H](O)C)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)CCCC(CC)C)CCN
Molecular Formula:: C52H98N16O13
Molecular Weight:: 1155.430
Log P:: 1.5352
Hydrogen Bond Acceptor:: 29
Hydrogen Bond Donor:: 18
TPSA:: 490.66
CAS Number(s):: 1066-17-7

Synonym(s)

Colistin

Polymyxin E

Colimycin

Colisticin

Colistin Sulfate

Coly-Mycin

Totazina

Sulfate, Colistin

External Link(s)

MeSH	D003091
PubChem Compound	5311054
CHEMBL	CHEMBL499783
Therapeutic Target Database	D0K7NQ

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug resistance	FAERS: 7		OFFSIDES US FAERS
2	Acinetobacter test positive	FAERS: 2		US FAERS
3	Acute kidney injury	FAERS: 2 Canada Vigilance: 1	24189134	CTD Canada Vigilance US FAERS
4	Blood creatinine increased	FAERS: 2		OFFSIDES US FAERS
5	Chills	FAERS: 1		US FAERS
6	Drug ineffective	FAERS: 1		US FAERS
7	Hypercreatinaemia	FAERS: 1		US FAERS
8	Lower respiratory tract infection	FAERS: 1		US FAERS
9	Multi-organ disorder	FAERS: 1		OFFSIDES US FAERS
10	Pneumothorax	FAERS: 1		US FAERS
11	Pregnancy	FAERS: 1		US FAERS
12	Respiratory Depression	FAERS: 1		US FAERS
13	Rhinovirus infection	FAERS: 1		US FAERS
14	Sepsis	FAERS: 1		US FAERS
15	Somnolence	FAERS: 1		US FAERS
16	Abdominal discomfort			OFFSIDES
17	Accidental death	Canada Vigilance: 1		Canada Vigilance
18	Anterior chamber flare			OFFSIDES
19	Appendectomy			OFFSIDES
20	Appendicitis			OFFSIDES
21	Blepharitis			OFFSIDES
22	Brain Diseases		4615135	CTD
23	Brain Injuries		30138604	CTD
24	Burkholderia cepacia Infection			OFFSIDES
25	Chronic Obstructive Airway Disease			OFFSIDES
26	Conjunctival deposit			OFFSIDES
27	Cystic Fibrosis		19747007	CTD
28	Cystitis		1009330	CTD
29	Cytolytic hepatitis			OFFSIDES
30	Cytomegalovirus hepatitis			OFFSIDES
31	Deafness		646445	CTD
32	Edema		30138604	CTD
33	Erosive gastritis			OFFSIDES
34	Escherichia coli Infections		1107297	CTD
35	Extravasation of Diagnostic and Therapeutic Materials		31132327	CTD
36	Eye pain			OFFSIDES
37	Eyelid infection			OFFSIDES
38	Gamma-Glutamyltransferase Increased			OFFSIDES
39	Gastroenteritis			OFFSIDES
40	Gastrointestinal toxicity			OFFSIDES
41	Gram-Negative Bacterial Infections		28842171	CTD
42	Hepatic artery thrombosis			OFFSIDES
43	Hepatotoxicity			OFFSIDES
44	Hypocalcemia		646445	CTD
45	Hypokalemia		646445	CTD
46	Kidney Diseases		30138604	CTD
47	Klebsiella Infections		1107297 4615135	CTD
48	Metabolic acidosis			OFFSIDES
49	Necrosis		30138604	CTD
50	Nerve Degeneration		28465020	CTD
51	Neurotoxicity Syndromes		28842171	CTD
52	Neutropenic colitis			OFFSIDES
53	Neutropenic sepsis			OFFSIDES
54	Non-cardiac chest pain			OFFSIDES
55	Ophthalmoplegia		4615135	CTD
56	Osteomyelitis		4615135	CTD
57	Pathogen resistance			OFFSIDES
58	Post procedural bile leak			OFFSIDES
59	Pruritus	Canada Vigilance: 1		Canada Vigilance
60	Pseudomonas Infections		1107297	CTD
61	Renal cyst			OFFSIDES
62	Respiratory Failure			OFFSIDES
63	Retinal exudates			OFFSIDES
64	Retinal infarction			OFFSIDES
65	Retinal scar			OFFSIDES
66	Scotoma			OFFSIDES
67	Sensation Disorders		5579509	CTD
68	Septic Shock			OFFSIDES
69	Tetany		646445	CTD
70	Vitrectomy			OFFSIDES
71	bone marrow fibrosis			OFFSIDES
72	treatment failure			OFFSIDES

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