MetaADEDB 2.0 @ LMMD
Amikacin
(LKCWBDHBTVXHDL-RMDFUYIESA-N)
Structure
SMILES
NCC[C@@H](C(=O)N[C@@H]1C[C@H](N)[C@H]([C@@H]([C@H]1O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)N)O)O)O[C@H]1O[C@H](CN)[C@H]([C@@H]([C@H]1O)O)O)O
Type(s)
Approved; Investigational; Vet_approved
ATC code(s)
D06AX12; J01GB06; J01RA06; S01AA21
Molecular Formula:
C22H43N5O13
Molecular Weight:
585.603
Log P:
-5.2321
Hydrogen Bond Acceptor:
18
Hydrogen Bond Donor:
13
TPSA:
331.94
CAS Number(s):
37517-28-5
Synonym(s)
1.
Amikacin
2.
A.M.K
3.
Amikacin Sulfate
4.
Amikacina Medical
5.
Amikacina Normon
6.
Amikafur
7.
Amikalem
8.
Amikason's
9.
Amikayect
10.
Amikin
11.
Amiklin
12.
Amukin
13.
BB-K 8
14.
BB-K8
15.
Biclin
16.
Biklin
17.
Gamikal
18.
Kanbine
19.
Oprad
20.
Yectamid
21.
BB K 8
22.
BB K8
23.
BBK 8
24.
BBK8
25.
Medical, Amikacina
26.
Normon, Amikacina
27.
Sulfate, Amikacin
External Link(s)
MeSHD000583
PubChem Compound37768
BindingDB50237603
ChEBI2637
CHEMBLCHEMBL177
DrugBankDB00479
DrugCentral157
KEGGcpd:C06820
dr:D02543
Therapeutic Target DatabaseD0Y3MO
ZINC8214483
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1TinnitusFAERS: 12US FAERS
2DeafnessFAERS: 10SIDER
US FAERS
3Drug dispensing errorFAERS: 4US FAERS
4Incorrect route of drug administrationFAERS: 4US FAERS
5OtotoxicityFAERS: 3
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
6Blood creatinine increasedFAERS: 2OFFSIDES
US FAERS
7Chest PainFAERS: 2US FAERS
8Drug prescribing errorFAERS: 2OFFSIDES
US FAERS
9Medication ErrorFAERS: 2US FAERS
10PruritusFAERS: 2US FAERS
11Stevens-Johnson SyndromeFAERS: 2US FAERS
12Toxicity to various agentsFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
13Wrong drug administeredFAERS: 2US FAERS
14Acute prerenal failureFAERS: 1US FAERS
15AstheniaFAERS: 1US FAERS
16BlepharospasmFAERS: 1US FAERS
17BlindnessFAERS: 1SIDER
US FAERS
18Blood creatine phosphokinase increasedFAERS: 1US FAERS
19Blood urea increasedFAERS: 1OFFSIDES
US FAERS
20Culture urine positiveFAERS: 1US FAERS
21Disseminated Intravascular CoagulationFAERS: 1OFFSIDES
US FAERS
22DizzinessFAERS: 1US FAERS
23Drug administration errorFAERS: 1US FAERS
24Drug dose omissionFAERS: 1US FAERS
25Drug ineffectiveFAERS: 1US FAERS
26Ear discomfortFAERS: 1US FAERS
27EpistaxisFAERS: 1US FAERS
28ErythemaFAERS: 1US FAERS
29FatigueFAERS: 1US FAERS
30HypotensionFAERS: 116983943CTD
SIDER
US FAERS
31HypoxiaFAERS: 1US FAERS
32Injection site painFAERS: 1US FAERS
33Intentional product misuseFAERS: 1US FAERS
34LaryngitisFAERS: 1US FAERS
35Lymphocyte count increasedFAERS: 1US FAERS
36MeningitisFAERS: 16688276CTD
US FAERS
37MyositisFAERS: 1US FAERS
38NeutropeniaFAERS: 1US FAERS
39PneumoniaFAERS: 1319355
1108649		CTD
US FAERS
40Product use issueFAERS: 1US FAERS
41Renal tubular necrosisFAERS: 1US FAERS
42Retinal infarctionFAERS: 1US FAERS
43SepsisFAERS: 11108649
10223137
14993721		CTD
US FAERS
44SyncopeFAERS: 1US FAERS
45Urinary tract infectionFAERS: 1US FAERS
46VomitingFAERS: 16688276CTD
SIDER
US FAERS
47Wrong technique in product usage processFAERS: 1US FAERS
48Acid fast bacilli infectionOFFSIDES
49Acute kidney injuryCanada Vigilance: 1

View details

342789
1491509
2385448
19709328
 		CTD
Canada Vigilance
50Acute left ventricular failureOFFSIDES
51Acute vestibular syndromeOFFSIDES
52Adrenal atrophyOFFSIDES
53Agranulocytosis3521269CTD
54Alanine Aminotransferase IncreasedOFFSIDES
55AlbuminuriaSIDER
56Alkalosis19884751CTD
57Altered state of consciousnessOFFSIDES
58Analgesic drug level above therapeuticOFFSIDES
59AnorexiaOFFSIDES
60Anticonvulsant drug level below therapeuticOFFSIDES
61Apnea10775086CTD
62Application site cellulitisOFFSIDES
63Arteriovenous graft thrombosisOFFSIDES
64ArthralgiaSIDER
65Arthritis, Infectious10223137CTD
66AscitesOFFSIDES
67AspergillosisOFFSIDES
68Autoantibody positiveOFFSIDES
69Azotemia1108649
1778878		CTD
70Bacteremia

View details

319355
868908
868909
3521269
3880819
6366126
 		CTD
71Bacteria stool identifiedOFFSIDES
72Bacterial Infections586099
9799062		CTD
73Bacteriuria16983943CTD
74Bilirubin conjugated increasedOFFSIDES
75Blood GlucoseOFFSIDES
76Blood albumin decreasedOFFSIDES
77Blood alkaline phosphatase decreasedOFFSIDES
78Blood alkaline phosphatase increasedOFFSIDES
79Blood chloride decreasedOFFSIDES
80Blood glucose decreasedOFFSIDES
81Blood lactate dehydrogenase increasedOFFSIDES
82Blood sodiumOFFSIDES
83Blood uric acidOFFSIDES
84BradycardiaOFFSIDES
85BronchiectasisOFFSIDES
86Bronchoalveolar LavageOFFSIDES
87Bronchopneumonia9576415CTD
OFFSIDES
88C-reactive protein decreasedOFFSIDES
89CYTOMEGALOVIRUS ANTIGENOFFSIDES
90CalciphylaxisOFFSIDES
91Capillary Leak SyndromeOFFSIDES
92Cauda Equina SyndromeOFFSIDES
93Choking sensationOFFSIDES
94CholangiolitisOFFSIDES
95Chronic respiratory failureOFFSIDES
96Clostridium difficile colitisOFFSIDES
97Cochlear Diseases6282040CTD
98Culture positiveOFFSIDES
99CyanosisOFFSIDES
100Cystic Fibrosis18613859
19747007		CTD
101Cytolytic hepatitisOFFSIDES
102Cytomegalovirus testOFFSIDES
103DEAFNESS, AMINOGLYCOSIDE-INDUCED23416261CTD
104Denervation atrophyOFFSIDES
105Depressed Level of ConsciousnessOFFSIDES
106DermatitisSIDER
107Device related thrombosisCanada Vigilance: 2Canada Vigilance
108DiverticulosisOFFSIDES
109Drug ineffective for unapproved indicationCanada Vigilance: 1Canada Vigilance
110Drug resistanceCanada Vigilance: 1Canada Vigilance
OFFSIDES
111Drug toxicityOFFSIDES
112Endocarditis12604535CTD
113Endophthalmitis9199746CTD
114Enterococcal infectionOFFSIDES
115EosinophiliaSIDER
116Eosinophilic myocarditisOFFSIDES
117ErysipelasOFFSIDES
118Escherichia coli Infections3880819
6366126
16983943		CTD
119Escherichia sepsisOFFSIDES
120Factor V deficiencyCanada Vigilance: 1Canada Vigilance
121Febrile NeutropeniaOFFSIDES
122Fever9597260CTD
123Fungal DNA test positiveOFFSIDES
124Fungal peritonitisOFFSIDES
125Fungus serology test positiveOFFSIDES
126Gamma-Glutamyltransferase IncreasedOFFSIDES
127Gastrointestinal toxicityOFFSIDES
128General physical conditionOFFSIDES
129Gram-Negative Bacterial Infections

View details

511416
868908
868909
1108649
1778878
3521269
7020413
 		CTD
130Gram-Positive Bacterial Infections511416CTD
131Granulocyte count decreasedOFFSIDES
132GranulocytosisOFFSIDES
133HaematotoxicityOFFSIDES
134HeadacheSIDER
135Hearing Loss, Bilateral484567
938024
12102302		CTD
136Hearing Loss, High-Frequency938024
7064947		CTD
137Hearing Loss, Unilateral7064947CTD
138Hearing Loss

View details

868905
1108649
1607336
1856146
2360443
2764235
6688276
7607992
9425382
9799062
15170574
 		CTD
139Heart-lung transplant rejectionOFFSIDES
140HepatitisCanada Vigilance: 1Canada Vigilance
141Hepatomegaly9597260CTD
142HepatosplenomegalyOFFSIDES
143Histiocytosis haematophagicOFFSIDES
144Hypertensive heart diseaseOFFSIDES
145Hypoalbuminemia856439CTD
146Hypocalcemia856439
19884751		CTD
147Hypokalemia856439
8950843
19884751		CTD
148Hypomagnesemia 2, renal19884751CTD
149Immune reconstitution syndromeOFFSIDES
150Infantile apnoeic attackOFFSIDES
151InfarctionSIDER
152Intestinal infarctionOFFSIDES
153Ischemia9199746CTD
154Kidney Diseases

View details

70900
319355
475363
518078
580391
868908
868909
1340440
1588766
2267454
2270367
2739356
2764548
2791871
3521269
3906418
3950060
4436950
6797359
7020413
7064947
7950209
8079062
8226435
9425382
9799062
12102302
12604535
12739987
18356633
19212910
19500072
 		CTD
155Kidney FailureOFFSIDES
156Klebsiella Infections6366126
6912860		CTD
157Leukopenia neonatalOFFSIDES
158Lymphatic Diseases9597260CTD
159Lymphocyte count decreasedOFFSIDES
160Meningitis, Bacterial10223137CTD
161Meningitis, Listeria15119370CTD
162Mental status changesOFFSIDES
163Metabolic acidosisOFFSIDES
164Mononucleosis syndromeOFFSIDES
165Muscle necrosisOFFSIDES
166Musculoskeletal discomfortSIDER
167Musculoskeletal stiffnessOFFSIDES
168Mycobacterium abscessus InfectionOFFSIDES
169NauseaSIDER
170Neisseriaceae Infections10223137CTD
171Neurotoxicity Syndromes3335815CTD
172Neutropenic sepsisOFFSIDES
173Neutrophil count decreasedOFFSIDES
174Olfaction Disorders14676161CTD
175OliguriaOFFSIDES
SIDER
176OverdoseOFFSIDES
177PallorOFFSIDES
178Pancreatic CystOFFSIDES
179Pelvic Inflammatory Disease1856146CTD
180Pericardial effusionOFFSIDES
181Pericarditis20622739CTD
182Peripheral embolismOFFSIDES
183PeritonitisOFFSIDES
184PleurisyOFFSIDES
185Poisoning23416261CTD
186Polyuria19884751CTD
187Procedural complicationOFFSIDES
188Product use in unapproved indicationCanada Vigilance: 6Canada Vigilance
189Protein total increasedOFFSIDES
190Proteinuria518078CTD
191Pseudomonas Infections6366126
9412416		CTD
192Red man syndromeOFFSIDES
193Renal Insufficiency868905
6366126		CTD
194Respiratory FailureOFFSIDES
195Reticulocyte count decreasedOFFSIDES
196Retinal Diseases9199746CTD
197Seizures9190241CTD
198Septic ShockOFFSIDES
199Septic embolusOFFSIDES
200SilicosisOFFSIDES
201Staphylococcal Infections3880819
6366126
20622739		CTD
202Staphylococcal Skin Infections3165976CTD
203Streptococcal Infections3880819
9199746		CTD
204Substance Withdrawal Syndrome9597260CTD
205Tetany20392363CTD
206Toxicologic test abnormalOFFSIDES
207Transaminases increasedOFFSIDES
208TremorSIDER
209Tuberculosis12102302CTD
210Unspecified visual lossSIDER
211Urination Disorders1856146CTD
212Ventricular FibrillationOFFSIDES
213Vestibular Diseases868905
3485932		CTD
214Wound infection fungalOFFSIDES
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