MetaADEDB 2.0 @ LMMD
ivacaftor
(PURKAOJPTOLRMP-UHFFFAOYSA-N)
Structure
SMILES
O=C(c1c[nH]c2c(c1=O)cccc2)Nc1cc(O)c(cc1C(C)(C)C)C(C)(C)C
Type(s)
Approved
ATC code(s)
R07AX02; R07AX30; R07AX31
Molecular Formula:
C24H28N2O3
Molecular Weight:
392.491
Log P:
5.1540
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
3
TPSA:
82.19
CAS Number(s):
873054-44-5
Synonym(s)
1.
ivacaftor
2.
3-quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-
3.
Kalydeco
4.
N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
5.
N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
6.
VX-770
External Link(s)
MeSHC545203
PubChem Compound16220172
BindingDB50032693
ChEBI66901
CHEMBLCHEMBL2010601
DrugBankDB08820
DrugCentral4228
IUPHAR/BPS Guide to PHARMACOLOGY4342
KEGGdr:D09916
Therapeutic Target DatabaseD0W7WC
ZINC52509463
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Infective pulmonary exacerbation of cystic fibrosisFAERS: 151
Canada Vigilance: 3
Canada Vigilance
US FAERS
2NasopharyngitisFAERS: 105
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
3HeadacheFAERS: 95SIDER
US FAERS
4MalaiseFAERS: 91
Canada Vigilance: 2
Canada Vigilance
US FAERS
5Drug dose omissionFAERS: 84US FAERS
6PneumoniaFAERS: 69US FAERS
7Pulmonary function test decreasedFAERS: 63US FAERS
8InfluenzaFAERS: 60US FAERS
9SinusitisFAERS: 58US FAERS
10Drug ineffectiveFAERS: 44US FAERS
11InfectionFAERS: 44SIDER
US FAERS
12DizzinessFAERS: 40SIDER
US FAERS
13VomitingFAERS: 35US FAERS
14NauseaFAERS: 33SIDER
US FAERS
15FatigueFAERS: 31US FAERS
16ConstipationFAERS: 30US FAERS
17Weight decreasedFAERS: 30US FAERS
18Abdominal PainFAERS: 27
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
19Oropharyngeal painFAERS: 27SIDER
US FAERS
20Abdominal discomfortFAERS: 26US FAERS
21Cystic fibrosis respiratory infection suppressionFAERS: 25US FAERS
22Chest PainFAERS: 23US FAERS
23Productive CoughFAERS: 23US FAERS
24ArthralgiaFAERS: 21SIDER
US FAERS
25PancreatitisFAERS: 21US FAERS
26Cystic FibrosisFAERS: 20

View details

CTD
US FAERS
27Feeling abnormalFAERS: 16US FAERS
28Lower respiratory tract infectionFAERS: 14US FAERS
29Chest discomfortFAERS: 13US FAERS
30DehydrationFAERS: 13US FAERS
31AsthmaFAERS: 12US FAERS
32Visual ImpairmentFAERS: 12US FAERS
33AstheniaFAERS: 11US FAERS
34BronchitisFAERS: 11US FAERS
35General physical health deteriorationFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
36PainFAERS: 11US FAERS
37Product dose omissionFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
38WheezingFAERS: 11SIDER
US FAERS
39PneumothoraxFAERS: 10US FAERS
40Sinus operationFAERS: 10US FAERS
41AcneFAERS: 9US FAERS
42Antibiotic ProphylaxisFAERS: 9US FAERS
43MyalgiaFAERS: 9SIDER
US FAERS
44NephrolithiasisFAERS: 9US FAERS
45UrticariaFAERS: 9US FAERS
46AnxietyFAERS: 8US FAERS
47ArthritisFAERS: 8US FAERS
48EpistaxisFAERS: 8US FAERS
49HypersensitivityFAERS: 8US FAERS
50Pseudomonas test positiveFAERS: 8US FAERS
51Blood glucose increasedFAERS: 7SIDER
US FAERS
52Incorrect dose administeredFAERS: 7US FAERS
53Infectious MononucleosisFAERS: 7US FAERS
54Insurance issueFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
55AlopeciaFAERS: 6US FAERS
56Inappropriate schedule of drug administrationFAERS: 6US FAERS
57Intestinal ObstructionFAERS: 6US FAERS
58Sweat test abnormalFAERS: 6US FAERS
59ThrombosisFAERS: 6US FAERS
60TinnitusFAERS: 6SIDER
US FAERS
61Antibiotic therapyFAERS: 5US FAERS
62Back PainFAERS: 5US FAERS
63Cystic fibrosis related diabetesFAERS: 5US FAERS
64Increased bronchial secretionFAERS: 5US FAERS
65Medication ErrorFAERS: 5US FAERS
66Memory impairmentFAERS: 5US FAERS
67Nasal PolypsFAERS: 5US FAERS
68Pulmonary congestionFAERS: 5US FAERS
69Respiratory FailureFAERS: 5US FAERS
70Secretion dischargeFAERS: 5US FAERS
71Sinus headacheFAERS: 5SIDER
US FAERS
72SomnolenceFAERS: 5US FAERS
73UlcerFAERS: 5US FAERS
74Urinary tract infectionFAERS: 5US FAERS
75Alanine Aminotransferase IncreasedFAERS: 4US FAERS
76Aspartate Aminotransferase IncreasedFAERS: 4SIDER
US FAERS
77Blood alkaline phosphatase increasedFAERS: 4US FAERS
78Bronchial secretion retentionFAERS: 4US FAERS
79BronchospasmFAERS: 4US FAERS
80ChromaturiaFAERS: 4US FAERS
81Depressed moodFAERS: 4US FAERS
82Diabetes MellitusFAERS: 4US FAERS
83Distal intestinal obstruction syndromeFAERS: 4US FAERS
84DyspepsiaFAERS: 4US FAERS
85EczemaFAERS: 4US FAERS
86FlushingFAERS: 4US FAERS
87PharyngitisFAERS: 4US FAERS
88PruritusFAERS: 4US FAERS
89Staphylococcus test positiveFAERS: 4US FAERS
90Throat irritationFAERS: 4US FAERS
91Upper-airway cough syndromeFAERS: 4US FAERS
92AbscessFAERS: 3US FAERS
93Acute kidney injuryFAERS: 3US FAERS
94Ankle FractureFAERS: 3US FAERS
95AtelectasisFAERS: 3US FAERS
96Atrial FibrillationFAERS: 3US FAERS
97Bacterial test positiveFAERS: 3US FAERS
98Blood glucose decreasedFAERS: 3US FAERS
99BronchopneumoniaFAERS: 3US FAERS
100CataractFAERS: 3US FAERS
101ChillsFAERS: 3US FAERS
102DysphoniaFAERS: 3US FAERS
103Emotional disorderFAERS: 3US FAERS
104Feeling ColdFAERS: 3US FAERS
105HepatitisFAERS: 3US FAERS
106HypersomniaFAERS: 3US FAERS
107HypothyroidismFAERS: 3US FAERS
108Impaired gastric emptyingFAERS: 3US FAERS
109Increased upper airway secretionFAERS: 3US FAERS
110InflammationFAERS: 3US FAERS
111LaryngitisFAERS: 3US FAERS
112No adverse eventFAERS: 3US FAERS
113Pulmonary EmbolismFAERS: 3US FAERS
114Skin PapillomaFAERS: 3US FAERS
115SyncopeFAERS: 3US FAERS
116Therapy cessationFAERS: 3US FAERS
117TonsillitisFAERS: 3US FAERS
118Transaminases increasedFAERS: 3SIDER
US FAERS
119TremorFAERS: 3US FAERS
120Accidental exposure to product by childFAERS: 2US FAERS
121Accidental overdoseFAERS: 2US FAERS
122Activities of daily living impairedFAERS: 2US FAERS
123Acute respiratory failureFAERS: 2US FAERS
124AgitationFAERS: 2US FAERS
125Allergic sinusitisFAERS: 2US FAERS
126AngerFAERS: 2US FAERS
127AphagiaFAERS: 2US FAERS
128AphoniaFAERS: 2US FAERS
129ArthropathyFAERS: 2US FAERS
130Bacterial disease carrierFAERS: 2US FAERS
131ConjunctivitisFAERS: 2US FAERS
132Croup infectiousFAERS: 2US FAERS
133DeafnessFAERS: 2US FAERS
134Diabetes mellitus inadequate controlFAERS: 2US FAERS
135DiscomfortFAERS: 2US FAERS
136Disease ProgressionFAERS: 2US FAERS
137Drug dispensing errorFAERS: 2US FAERS
138ErythemaFAERS: 2US FAERS
139Extra dose administeredFAERS: 2US FAERS
140Eye InfectionFAERS: 2US FAERS
141Eye irritationFAERS: 2US FAERS
142Eye painFAERS: 2US FAERS
143Feeling jitteryFAERS: 2US FAERS
144Food PoisoningFAERS: 2US FAERS
145Gamma-Glutamyltransferase IncreasedFAERS: 2US FAERS
146GastroenteritisFAERS: 2US FAERS
147Gestational DiabetesFAERS: 2US FAERS
148HerniaFAERS: 2US FAERS
149Hospice CareFAERS: 2US FAERS
150Impaired driving abilityFAERS: 2US FAERS
151Inability to afford medicationFAERS: 2US FAERS
152Irritable Bowel SyndromeFAERS: 2US FAERS
153Joint injuryFAERS: 2US FAERS
154Joint swellingFAERS: 2US FAERS
155LethargyFAERS: 2US FAERS
156Limb operationFAERS: 2US FAERS
157Mechanical urticariaFAERS: 2US FAERS
158Mood swingsFAERS: 2US FAERS
159Musculoskeletal chest painFAERS: 2SIDER
US FAERS
160NeuralgiaFAERS: 2US FAERS
161Night sweatsFAERS: 2US FAERS
162Oral candidiasisFAERS: 2US FAERS
163Personality ChangeFAERS: 2US FAERS
164PleurisyFAERS: 2US FAERS
165Product distribution issueFAERS: 2US FAERS
166Product prescribing errorFAERS: 2US FAERS
167RalesFAERS: 2US FAERS
168Respiratory TherapyFAERS: 2US FAERS
169Respiratory tract irritationFAERS: 2US FAERS
170SluggishnessFAERS: 2US FAERS
171SneezingFAERS: 2US FAERS
172StressFAERS: 2US FAERS
173Suicide attemptFAERS: 2US FAERS
174Therapy changeFAERS: 2US FAERS
175Tooth InfectionFAERS: 2US FAERS
176Unevaluable eventFAERS: 2US FAERS
177Viral sinusitisFAERS: 2US FAERS
178AbasiaFAERS: 1US FAERS
179Accidental deathFAERS: 1US FAERS
180Acute myocardial infarctionFAERS: 1US FAERS
181Adenoidal disorderFAERS: 1US FAERS
182AdenoidectomyFAERS: 1US FAERS
183Adverse eventFAERS: 1US FAERS
184AmnesiaFAERS: 1US FAERS
185Angina PectorisFAERS: 1US FAERS
186Antinuclear antibody increasedFAERS: 1US FAERS
187Arrhythmogenic Right Ventricular DysplasiaFAERS: 1US FAERS
188Arthropod stingFAERS: 1US FAERS
189AsphyxiaFAERS: 1US FAERS
190AstigmatismFAERS: 1US FAERS
191Atypical mycobacterial lower respiratory tract infectionFAERS: 1US FAERS
192Atypical pneumoniaFAERS: 1US FAERS
193Back disorderFAERS: 1US FAERS
194Bipolar DisorderFAERS: 1US FAERS
195BlepharospasmFAERS: 1US FAERS
196Blood chloride decreasedFAERS: 1US FAERS
197Blood count abnormalFAERS: 1US FAERS
198Blood creatine phosphokinase increasedFAERS: 1US FAERS
199Blood creatinine increasedFAERS: 1US FAERS
200Blood glucose abnormalFAERS: 1US FAERS
201Blood immunoglobulin M increasedFAERS: 1US FAERS
202Blood iron decreasedFAERS: 1US FAERS
203Blood prolactin increasedFAERS: 1US FAERS
204Blood triglycerides increasedFAERS: 1US FAERS
205Blood urea increasedFAERS: 1US FAERS
206Blood uric acid abnormalFAERS: 1US FAERS
207Body height below normalFAERS: 1US FAERS
208Bone density decreasedFAERS: 1US FAERS
209Bone painFAERS: 1US FAERS
210Brain AbscessFAERS: 1US FAERS
211Bronchopulmonary AspergillosisFAERS: 1US FAERS
212BronchoscopyFAERS: 1US FAERS
213Carbon dioxide increasedFAERS: 1US FAERS
214Cardiac ArrestFAERS: 1US FAERS
215Cardiac monitoringFAERS: 1US FAERS
216Cerebral cystFAERS: 1US FAERS
217Cerebrovascular accidentFAERS: 1US FAERS
218CheilitisFAERS: 1US FAERS
219CholelithiasisFAERS: 1US FAERS
220Chronic sinusitisFAERS: 1US FAERS
221ClumsinessFAERS: 1US FAERS
222CryingFAERS: 1US FAERS
223CyanosisFAERS: 1US FAERS
224Cystic fibrosis hepatic diseaseFAERS: 1US FAERS
225DeliriumFAERS: 1US FAERS
226Device related infectionFAERS: 1US FAERS
227Diabetic KetoacidosisFAERS: 1US FAERS
228Dialysis related complicationFAERS: 1US FAERS
229DisabilityFAERS: 1US FAERS
230Disease complicationFAERS: 1US FAERS
231DisorientationFAERS: 1US FAERS
232DiverticulitisFAERS: 1US FAERS
233Duodenal UlcerFAERS: 1US FAERS
234DysgeusiaFAERS: 1US FAERS
235EmpyemaFAERS: 1US FAERS
236Epigastric discomfortFAERS: 1US FAERS
237EpilepsyFAERS: 1US FAERS
238EructationFAERS: 1US FAERS
239Eustachian tube disorderFAERS: 1US FAERS
240Exposure during breast feedingFAERS: 1US FAERS
241False negative investigation resultFAERS: 1US FAERS
242FlatulenceFAERS: 1US FAERS
243Food cravingFAERS: 1US FAERS
244Forced expiratory volume abnormalFAERS: 1US FAERS
245Forced expiratory volume increasedFAERS: 1US FAERS
246Foreign body in respiratory tractFAERS: 1US FAERS
247Gastric BypassFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
248Gastric infectionFAERS: 1US FAERS
249GastritisFAERS: 1US FAERS
250Gastroenteritis pseudomonasFAERS: 1US FAERS
251Gastrointestinal PainFAERS: 1SIDER
US FAERS
252Gastrointestinal inflammationFAERS: 1US FAERS
253Gastrointestinal motility disorderFAERS: 1US FAERS
254Gastrointestinal obstructionFAERS: 1US FAERS
255Gastrointestinal sounds abnormalFAERS: 1US FAERS
256Growing painsFAERS: 1US FAERS
257Head discomfortFAERS: 1US FAERS
258Head titubationFAERS: 1US FAERS
259HepatomegalyFAERS: 1US FAERS
260HungerFAERS: 1US FAERS
261HyperandrogenismFAERS: 1US FAERS
262HypoxiaFAERS: 1US FAERS
263Impaired work abilityFAERS: 1US FAERS
264Inappropriate affectFAERS: 1US FAERS
265Incision site infectionFAERS: 1US FAERS
266Incorrect drug administration durationFAERS: 1US FAERS
267Incorrect product formulation administeredFAERS: 1US FAERS
268Increased viscosity of bronchial secretionFAERS: 1US FAERS
269Increased viscosity of upper respiratory secretionFAERS: 1US FAERS
270Infective exacerbation of bronchiectasisFAERS: 1US FAERS
271Infrequent bowel movementsFAERS: 1US FAERS
272Injection Site ReactionFAERS: 1US FAERS
273Intentional product misuseFAERS: 1US FAERS
274Intentional product use issueFAERS: 1US FAERS
275Intentional self-injuryFAERS: 1US FAERS
276Joint InstabilityFAERS: 1US FAERS
277Joint stiffnessFAERS: 1US FAERS
278Latent TuberculosisFAERS: 1US FAERS
279Ligament injuryFAERS: 1US FAERS
280Ligament ruptureFAERS: 1US FAERS
281Limb injuryFAERS: 1US FAERS
282Lip swellingFAERS: 1US FAERS
283Lower respiratory tract infection bacterialFAERS: 1US FAERS
284Lower respiratory tract infection fungalFAERS: 1US FAERS
285Lung AbscessFAERS: 1US FAERS
286Lung infection pseudomonalFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
287Lung transplant rejectionFAERS: 1US FAERS
288Lyme DiseaseFAERS: 1US FAERS
289Macular fibrosisFAERS: 1US FAERS
290MalabsorptionFAERS: 1US FAERS
291MalnutritionFAERS: 1US FAERS
292Mucosal InfectionFAERS: 1US FAERS
293Multiple allergiesFAERS: 1US FAERS
294Muscle strainFAERS: 1US FAERS
295Musculoskeletal discomfortFAERS: 1SIDER
US FAERS
296Mycobacterium test positiveFAERS: 1US FAERS
297Myocardial InfarctionFAERS: 1US FAERS
298Nerve injuryFAERS: 1US FAERS
299Nonspecific reactionFAERS: 1US FAERS
300Oral pustuleFAERS: 1US FAERS
301OrchitisFAERS: 1US FAERS
302Orthostatic hypertensionFAERS: 1US FAERS
303Otitis MediaFAERS: 1US FAERS
304PCO2 increasedFAERS: 1US FAERS
305PallorFAERS: 1US FAERS
306Pancreatic CystFAERS: 1US FAERS
307Pancreatic InsufficiencyFAERS: 1US FAERS
308Pancreatic NeoplasmFAERS: 1US FAERS
309PancytopeniaFAERS: 1US FAERS
310PapuleFAERS: 1US FAERS
311Paranasal cystFAERS: 1US FAERS
312Paranasal sinus discomfortFAERS: 1US FAERS
313Paranasal sinus hypersecretionFAERS: 1US FAERS
314ParanoiaFAERS: 1US FAERS
315PericarditisFAERS: 1US FAERS
316Peripheral swellingFAERS: 1US FAERS
317PertussisFAERS: 1US FAERS
318PhotophobiaFAERS: 1US FAERS
319Pleuritic painFAERS: 1SIDER
US FAERS
320PneumonitisFAERS: 1US FAERS
321PolyarthritisFAERS: 1US FAERS
322Poor quality drug administeredFAERS: 1US FAERS
323Product size issueFAERS: 1US FAERS
324Product taste abnormalFAERS: 1US FAERS
325Pulmonary function test increasedFAERS: 1US FAERS
326Pulmonary painFAERS: 1US FAERS
327Pulmonary thrombosisFAERS: 1US FAERS
328Renal painFAERS: 1US FAERS
329Respiratory distressFAERS: 1US FAERS
330Respiratory tract congestionFAERS: 1US FAERS
331Respiratory tract infection viralFAERS: 1US FAERS
332RetchingFAERS: 1US FAERS
333Rheumatoid ArthritisFAERS: 1US FAERS
334Rhinovirus infectionFAERS: 1US FAERS
335Rotator cuff syndromeFAERS: 1US FAERS
336School refusalFAERS: 1US FAERS
337ScreamingFAERS: 1US FAERS
338Self-induced vomitingFAERS: 1US FAERS
339SepsisFAERS: 1US FAERS
340Shunt malfunctionFAERS: 1US FAERS
341Skin irritationFAERS: 1US FAERS
342SomnambulismFAERS: 1US FAERS
343SplenomegalyFAERS: 1US FAERS
344Steroid therapyFAERS: 1US FAERS
345TachyarrhythmiaFAERS: 1US FAERS
346TachycardiaFAERS: 1US FAERS
347Tension HeadacheFAERS: 1US FAERS
348Therapeutic response unexpectedFAERS: 1US FAERS
349ThirstFAERS: 1US FAERS
350Tongue discomfortFAERS: 1US FAERS
351TonsillectomyFAERS: 1US FAERS
352Tooth ExtractionFAERS: 1US FAERS
353ToothacheFAERS: 1US FAERS
354TorticollisFAERS: 1US FAERS
355TuberculosisFAERS: 1US FAERS
356Upper respiratory tract congestionFAERS: 1US FAERS
357Urine oxalate increasedFAERS: 1US FAERS
358Vascular calcificationFAERS: 1US FAERS
359Vena cava injuryFAERS: 1US FAERS
360Viral pharyngitisFAERS: 1US FAERS
361Vitreous floatersFAERS: 1US FAERS
362White blood cell count decreasedFAERS: 1US FAERS
363Wound InfectionFAERS: 1US FAERS
364DermatitisSIDER
365Ear and labyrinth disordersSIDER
366Ear congestionSIDER
367Ear discomfortSIDER
368InfestationSIDER
369MastitisSIDER
370Nipple painSIDER
371RhinitisSIDER
372nervous system disorderSIDER
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