MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Radiation Pneumonitis

(UMLS:C0206063)

Definition:: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.
UMLS ID:: C0206063
MeSH ID:: D017564

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.483.675|C08.381.520.734

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.733.762

Classification 3:

Name:

Physical Phenomena
MeSH Tree Number(s):: G01.750.748.500.762

Synonym(s)

Radiation Pneumonitis

PNEUMONITIS RADIATION

Pulmonary radiation alveolitis

RADIATION PNEUMONIA

RADIATION PNEUMONITIS

Radiation pneumonitis

Radiation-Induced Pneumonitis

pneumonia; radiation

pneumonitis radiations

10.

pneumonitis; radiation

11.

radiation pneumonia

12.

radiation pneumonitis

13.

radiation; pneumonia

14.

radiation; pneumonitis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Erlotinib Hydrochloride	FAERS: 10	US FAERS
2	Erlotinib Hydrochloride	FAERS: 8	US FAERS
3	Sodium iodide I 131	FAERS: 7	US FAERS
4	Crizotinib	FAERS: 4	US FAERS
5	Etoposide	FAERS: 4	OFFSIDES US FAERS
6	Pemetrexed	FAERS: 4	OFFSIDES SIDER US FAERS
7	Sunitinib	FAERS: 4	US FAERS
8	Letrozole	FAERS: 3	OFFSIDES US FAERS
9	Tadalafil	FAERS: 3	US FAERS
10	Anastrozole	FAERS: 2	US FAERS
11	Cabozantinib S-malate	FAERS: 2	US FAERS
12	Gefitinib	FAERS: 2 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
13	Lenalidomide	FAERS: 2	US FAERS
14	Paclitaxel	FAERS: 2	SIDER US FAERS
15	osimertinib	FAERS: 2	US FAERS
16	5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine	FAERS: 1	US FAERS
17	Afatinib	FAERS: 1	US FAERS
18	Amiodarone	FAERS: 1	US FAERS
19	Axitinib	FAERS: 1	US FAERS
20	CH5424802	FAERS: 1	US FAERS
21	Capecitabine	FAERS: 1	US FAERS
22	Carboplatin	FAERS: 1	US FAERS
23	Dasatinib	FAERS: 1	US FAERS
24	Docetaxel	FAERS: 1	OFFSIDES SIDER US FAERS
25	Irinotecan	FAERS: 1	US FAERS
26	Sorafenib	FAERS: 1	SIDER US FAERS
27	Sunitinib	FAERS: 1	US FAERS
28	Thalidomide	FAERS: 1	US FAERS
29	Topotecan	FAERS: 1	US FAERS
30	Topotecan	FAERS: 1	OFFSIDES US FAERS
31	Vemurafenib	FAERS: 1	US FAERS
32	Vinorelbine	FAERS: 1	US FAERS
33	Zoledronic Acid	FAERS: 1	US FAERS
34	exemestane	FAERS: 1	US FAERS
35	gemcitabine	FAERS: 1	US FAERS
36	gemcitabine	FAERS: 1	OFFSIDES US FAERS
37	indacaterol	FAERS: 1	US FAERS
38	macitentan	FAERS: 1	US FAERS
39	palbociclib	FAERS: 1	US FAERS
40	venetoclax	FAERS: 1	US FAERS
41	Ambroxol		OFFSIDES
42	Bleomycin		SIDER
43	Bortezomib		OFFSIDES
44	Carbamazepine		OFFSIDES
45	Codeine		OFFSIDES
46	Dactinomycin		OFFSIDES
47	Fluorouracil		OFFSIDES
48	Hydrocodone		OFFSIDES
49	Ifosfamide		OFFSIDES
50	Leucovorin		OFFSIDES
51	Lovastatin		OFFSIDES
52	Medroxyprogesterone		OFFSIDES
53	Methylprednisolone		OFFSIDES
54	Mianserin		OFFSIDES
55	Miconazole		OFFSIDES
56	Minoxidil		OFFSIDES
57	Mitomycin		OFFSIDES
58	Nateglinide		OFFSIDES
59	Octreotide	Canada Vigilance: 1	Canada Vigilance
60	Prednisolone		OFFSIDES
61	Pyridoxine		OFFSIDES
62	Rabeprazole		OFFSIDES
63	Sulpiride		OFFSIDES
64	Tamoxifen		OFFSIDES
65	Tranexamic Acid		OFFSIDES
66	Triamterene		OFFSIDES
67	Vinblastine		OFFSIDES
68	Vindesine		OFFSIDES
69	Vitamin B 12		OFFSIDES
70	azasetron		OFFSIDES
71	fenoterol, ipratropium drug combination		OFFSIDES
72	fexofenadine		OFFSIDES
73	geranylgeranylacetone		OFFSIDES
74	itopride		OFFSIDES
75	loxoprofen		OFFSIDES
76	mitiglinide		OFFSIDES
77	sennoside A&B		OFFSIDES
78	tulobuterol		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Pneumoconiosis	39.4%
2	Osteoradionecrosis	30.3%
3	Idiopathic Pulmonary Fibrosis	30%
4	Asbestosis	28.7%
5	Berylliosis	28.7%
6	Silicosis	28.7%
7	Pneumonia	27.4%
8	Lobar Pneumonia	27.4%
9	Respiratory Distress Syndrome, Adult	27.4%
10	Pneumonitis	27.4%
11	Acute Lung Injury	26.8%
12	Neoplasms, Radiation-Induced	26.7%
13	Atelectasis	24.5%
14	Pulmonary Hypertension	24.5%
15	Pulmonary Alveolar Proteinosis	24.5%
16	Pulmonary Edema	24.5%
17	Pulmonary Fibrosis	24.5%
18	Hamman-Rich syndrome	24.5%
19	Lung Diseases, Obstructive	24.5%
20	Lung Diseases, Fungal	23.6%
21	Bronchitis	23.4%
22	Respiratory Distress Syndrome, Newborn	23.4%
23	Lung Abscess	23.3%
24	Lung Neoplasms	23.3%
25	Tuberculosis, Pulmonary	23.2%
26	Cardiotoxicity	23.1%
27	Leukemia, Radiation-Induced	22.9%
28	Histiocytosis, Langerhans-Cell	22.3%
29	Sarcoidosis, Pulmonary	22.2%
30	Bronchitis, Chronic	21.6%
31	Bronchopneumonia	21.3%
32	Hepatopulmonary Syndrome	20.6%
33	Asthma	20.3%
34	Pulmonary Embolism	20.2%
35	Pulmonary Eosinophilia	20.2%
36	Eosinophilic Pneumonia	20.2%
37	Pleuropneumonia	20.1%
38	Abnormalities, Radiation-Induced	20.1%
39	Radiation Injuries, Experimental	19.9%
40	Meconium Aspiration Syndrome	19.8%
41	Granulomatosis with polyangiitis	19%
42	Aspiration Pneumonia	17.9%
43	Hemoptysis	17.4%
44	Bronchopulmonary Dysplasia	16.7%
45	Anti-Glomerular Basement Membrane Disease	16.6%
46	Scimitar Syndrome	16.3%
47	Bronchiolitis	16.2%
48	Chronic Obstructive Airway Disease	16.1%
49	Middle Lobe Syndrome	16.1%
50	Acute Chest Syndrome	16%
51	Farmer's Lung	15.9%
52	Pneumonia, Viral	15.8%
53	Cystic Fibrosis	15.6%
54	Pneumonia, Bacterial	15.5%
55	Tracheobronchomegaly	15.5%
56	Hyaline Membrane Disease	15.2%
57	Multiple Pulmonary Nodules	15.2%
58	Lung Injury	14.9%
59	Transfusion-Related Acute Lung Injury	14.4%
60	Aspergillosis, Allergic Bronchopulmonary	14.1%
61	Bronchial Diseases	14%
62	Pleural Diseases	14%
63	Respiration Disorders	14%
64	Thoracic Diseases	14%
65	Tracheal Diseases	14%
66	Pleurisy	13.7%
67	Tracheitis	13.7%
68	Persistent Fetal Circulation Syndrome	13.6%
69	Pulmonary Aspergillosis	13.4%
70	Bronchopulmonary Aspergillosis	13.4%
71	Pulmonary Infarction	13.3%
72	Pneumonia, Lipid	13.3%
73	Lung Diseases, Interstitial	12.2%
74	Granuloma, Laryngeal	12.1%
75	Pulmonary Emphysema	12%
76	Laryngeal Diseases	12%
77	Nose Diseases	12%
78	Laryngitis	11.8%
79	Rhinitis	11.8%
80	Vocal Cord Dysfunction	11.8%
81	Frostbite	11.7%
82	Respiratory Tract Infections	11.7%
83	Bronchial Fistula	11.7%
84	Pleural Neoplasms	11.7%
85	Bronchiolitis Obliterans	11.6%
86	Granuloma, Respiratory Tract	11.6%
87	Respiratory Hypersensitivity	11.6%
88	Respiratory Tract Fistula	11.6%
89	Eosinophilic Granuloma	11.1%
90	Blastomycosis	10.6%
91	Choanal Atresia	10.3%
92	Laryngocele	10.3%
93	Tracheal Neoplasms	10.2%
94	Radiation Pneumonitis	10.1%
95	Radiation Fibrosis	10.1%
96	Pleural Effusion, Malignant	10%
97	Hip Fractures	9.7%
98	Sinusitis	9.7%
99	Bronchial Neoplasms	9.6%
100	Laryngeal neoplasm	9.2%
101	Crush syndrome	9.1%
102	Femoral Fractures	9.1%
103	Tibial Fractures	9.1%
104	Primary Ciliary Dyskinesia	8.8%
105	Invasive Pulmonary Aspergillosis	8.5%
106	Athletic Injuries	8.4%
107	Hand Injuries	8.4%
108	Soft Tissue Injuries	8.4%
109	Sprain	8.4%
110	Sprains and Strains	8.4%
111	Tendon Injuries	8.4%
112	Laceration	8.4%
113	Wounds, Penetrating	8.4%
114	Heat Cramps	8.4%
115	Rupture	8.4%
116	Altitude Sickness	8.2%
117	Bronchospasm	8.2%
118	Bronchiectasis	8.2%
119	Chylothorax	8.2%
120	Hydropneumothorax	8.2%
121	Hydrothorax	8.2%
122	Pneumothorax	8.2%
123	Respiratory Insufficiency	8.2%
124	Tracheal Stenosis	8.2%
125	Bronchial Hyperreactivity	8.2%
126	Respiratory Depression	8.2%
127	Respiratory Failure	8.2%
128	Chilblains	7.9%
129	Spinal Fractures	7.9%
130	Hip Dislocation	7.8%
131	Shoulder Dislocation	7.8%
132	Splenic Rupture	7.8%
133	Hip Dysplasia	7.8%
134	Laryngospasm	7.7%
135	Asthma, Exercise-Induced	7.6%
136	Status Asthmaticus	7.6%
137	Nose Neoplasms	7.4%
138	Rhinoscleroma	7.4%
139	Paranasal Sinus Neoplasms	7.3%
140	Trauma, Nervous System	7.2%
141	Bites and Stings	7%
142	Extravasation of Diagnostic and Therapeutic Materials	7%
143	Vascular System Injuries	7%
144	Tympanic Membrane Perforation	7%
145	Tooth Injuries	7%
146	Asphyxia	6.9%
147	Esophageal Perforation	6.9%
148	Shock, Traumatic	6.9%
149	Self Mutilation	6.9%
150	Granuloma, Lethal Midline	6.9%
151	Laryngeal Edema	6.9%
152	Nose Deformities, Acquired	6.9%
153	Respiratory Aspiration	6.9%
154	Asthma, Occupational	6.8%
155	Apnea	6.8%
156	Cheyne-Stokes Respiration	6.8%
157	Common Cold	6.8%
158	Dyspnea	6.8%
159	Hemothorax	6.8%
160	Hyperventilation	6.8%
161	Influenza	6.8%
162	Mouth Breathing	6.8%
163	Tachypnea	6.8%
164	Catarrh	6.8%
165	Severe Acute Respiratory Syndrome	6.7%
166	Laryngopharyngeal Reflux	6.7%
167	Hoarseness	6.7%
168	Iliotibial Band Syndrome	6.7%
169	Kartagener Syndrome	6.7%
170	Spinal Cord Injuries	6%
171	Eye Burns	6%
172	Asthma, Aspirin-Induced	5.9%
173	Drowning	5.9%
174	Pharyngitis	5.9%
175	Laryngostenosis	5.9%
176	Nasal Polyps	5.9%
177	Hay fever	5.8%
178	Rhinitis, Allergic, Perennial	5.8%
179	Pertussis	5.8%
180	Splenosis	5.7%
181	Human Bite	5.4%
182	Contusions	5.4%
183	Decompression Sickness	5.4%
184	Finger Injuries	5.4%
185	Flail Chest	5.4%
186	Fractures, Closed	5.4%
187	Pathological fracture	5.4%
188	Heart Injuries	5.4%
189	Heat Exhaustion	5.4%
190	Heat Stroke	5.4%
191	Knee Injuries	5.4%
192	Foot Injuries	5.4%
193	Decapitation	5.4%
194	Ankle Fracture	5.4%
195	Avulsion fracture	5.4%
196	Compression fracture	5.4%
197	Osteoporotic Fractures	5.4%
198	Airway Obstruction	5.4%
199	Choking	5.4%
200	Epiglottitis	5.4%
201	Mediastinitis	5.4%
202	Maxillary Sinus Neoplasms	5.3%
203	Voice Disorders	5.2%
204	Voice Disturbance	5.2%
205	Epistaxis	5.1%
206	Brain Concussion	5.1%
207	Craniocerebral Trauma	4.6%
208	Tendinitis	4.6%
209	Tendinopathy	4.6%
210	Laryngomalacia	4.6%
211	Foreign-Body Reaction	4.5%
212	Insect Bites and Stings	4.5%
213	Mediastinal Cyst	4.5%
214	Paralysis, Obstetric	4.5%
215	Pericardial Cyst	4.5%
216	Sunburn	4.5%
217	Thymic Cyst	4.5%
218	Tooth Avulsion	4.5%
219	Conus Medullaris Syndrome	4.5%
220	Vocal Cord Paralysis	4.5%
221	Near Drowning	4.5%
222	Croup	4.5%
223	Mediastinal Emphysema	4.5%
224	Rhinitis, Vasomotor	4.5%
225	Hypoventilation	4.5%
226	Acidosis, Respiratory	4.4%
227	Alkalosis, Respiratory	4.4%
228	Sleep Apnea Syndromes	4.4%
229	Brain Contusion	4.3%
230	Pseudarthrosis	4%
231	Smoke Inhalation Injury	4%
232	Peripheral Nerve Injuries	3.9%
233	Medial Tibial Stress Syndrome	3.9%
234	Uterine Rupture	3.8%
235	Central Cord Syndrome	3.8%
236	Tonsillitis	3.8%
237	Dyspnea, Paroxysmal	3.8%
238	Respiratory Paralysis	3.8%
239	Facial Injuries	3.4%
240	Granuloma, Foreign-Body	3.4%
241	Enthesopathy	3.4%
242	Aortic Rupture	3.3%
243	Aphonia	3.3%
244	Retropharyngeal Abscess	3.3%
245	Dysphonia	3.3%
246	Uterine Perforation	3.3%
247	Bronchomalacia	3.3%
248	Tracheomalacia	3.3%
249	Sleep Apnea, Obstructive	3.3%
250	Sleep Apnea, Central	3.3%
251	Nasopharyngitis	3%
252	Brain Hemorrhage, Traumatic	3%
253	Brain Injuries	2.9%
254	Coma, Post-Head Injury	2.8%
255	Carpal Tunnel Syndrome	2.8%
256	Peritonsillar Abscess	2.5%
257	Eye Injuries	2.4%
258	Brain Injuries, Diffuse	2.4%
259	Traumatic Brain Injury	2.4%
260	Cubital Tunnel Syndrome	2.3%
261	Vertebral Artery Dissection	2.2%
262	Diffuse Axonal Injury	2.1%
263	Pneumocephalus	2.1%
264	Olfactory Nerve Injuries	2.1%
265	Cerebrospinal Fluid Otorrhea	2.1%
266	Cerebrospinal Fluid Rhinorrhea	2.1%
267	Epilepsy, Post-Traumatic	2.1%
268	Carotid Artery Injuries	2%
269	Corneal Scar	1.9%
270	Facial Nerve Injuries	1.8%
271	Corneal Perforation	1.8%
272	Hematoma, Subdural	1.6%
273	Hematoma, Epidural, Cranial	1.6%
274	Subarachnoid Hemorrhage, Traumatic	1.5%
275	Carotid Artery, Internal, Dissection	1.5%
276	Hematoma, Subdural, Intracranial	1.5%
277	Hematoma, Subdural, Chronic	1.5%
278	Hematoma, Subdural, Acute	1.5%

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