MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lung Injury

(UMLS:C0273115)

Definition:: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
UMLS ID:: C0273115
MeSH ID:: D055370

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.520

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.891.554

Synonym(s)

Lung Injury

Injury of lung

Traumatic lung injury

Unspecified injury of lung, NOS

injuries lung

injury lung

injury lungs

injury; lung

lung injury

10.

lung; injury

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methotrexate	FAERS: 11	23358144	CTD US FAERS
2	rofecoxib	FAERS: 11		OFFSIDES US FAERS
3	Amiodarone	FAERS: 8		US FAERS
4	Amiodarone	FAERS: 6	18801087 26477383 26781185	CTD US FAERS
5	Celecoxib	FAERS: 5		US FAERS
6	Gefitinib	FAERS: 5	19803472 20935109	CTD OFFSIDES US FAERS
7	Teriparatide	FAERS: 5		US FAERS
8	Rosiglitazone	FAERS: 4	15684285 16215386 19237016	CTD US FAERS
9	Acetaminophen	FAERS: 3		US FAERS
10	Bleomycin	FAERS: 3	View details 15684285 20686337 21998664 23523906 26093215 29256173	CTD OFFSIDES US FAERS
11	Bortezomib	FAERS: 3		OFFSIDES US FAERS
12	gemcitabine	FAERS: 3		US FAERS
13	Clopidogrel	FAERS: 2		US FAERS
14	Nebivolol	FAERS: 2		US FAERS
15	Paroxetine	FAERS: 2		US FAERS
16	Propofol	FAERS: 2		US FAERS
17	Ranolazine	FAERS: 2		OFFSIDES US FAERS
18	Salmeterol Xinafoate	FAERS: 2		US FAERS
19	Sirolimus	FAERS: 2		US FAERS
20	Arsenic Trioxide	FAERS: 1		US FAERS
21	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 1		US FAERS
22	Aspirin	FAERS: 1		US FAERS
23	Bosentan	FAERS: 1		US FAERS
24	Carbamazepine	FAERS: 1		US FAERS
25	Clozapine	FAERS: 1		US FAERS
26	Cyclophosphamide	FAERS: 1	12114195 25451569	CTD US FAERS
27	Cytarabine	FAERS: 1		OFFSIDES US FAERS
28	Dutasteride	FAERS: 1		OFFSIDES US FAERS
29	Epoprostenol	FAERS: 1		US FAERS
30	Fentanyl	FAERS: 1		US FAERS
31	Fluoxetine	FAERS: 1		US FAERS
32	Glatiramer Acetate	FAERS: 1		US FAERS
33	Hydromorphone	FAERS: 1		US FAERS
34	Iohexol	FAERS: 1		US FAERS
35	Levofloxacin	FAERS: 1		US FAERS
36	Morphine	FAERS: 1		US FAERS
37	Nitrofurantoin (monohydrate/macrocrystals)	FAERS: 1		US FAERS
38	Omeprazole	FAERS: 1		US FAERS
39	Ortho Evra	FAERS: 1		US FAERS
40	Oxycodone	FAERS: 1		US FAERS
41	Phenytoin	FAERS: 1		US FAERS
42	Sertraline	FAERS: 1		US FAERS
43	Simvastatin	FAERS: 1		US FAERS
44	Sodium iodide I 131	FAERS: 1		US FAERS
45	Succinylcholine	FAERS: 1		US FAERS
46	Thiothixene	FAERS: 1		US FAERS
47	Valsartan	FAERS: 1		US FAERS
48	liposomal doxorubicin	FAERS: 1		US FAERS
49	1,2,3-trichloropropane		21097997	CTD
50	1,5-naphthalenediamine		17311802	CTD
51	1,7-dimethylxanthine		19962977	CTD
52	1-nitronaphthalene		2384072	CTD
53	15-deoxy-delta(12,14)-prostaglandin J2		15684285	CTD
54	2''-galloylhyperin		30849337	CTD
55	2,3-pentanedione		27984136	CTD
56	2-chloro-5-nitrobenzanilide		24192212	CTD
57	2-chloroethyl ethyl sulfide		21061449 22446026	CTD
58	4-ipomeanol		2384072	CTD
59	Acetylcysteine		8603398 17010595 23900960	CTD
60	Acrolein		24211530	CTD
61	Alcohols			OFFSIDES
62	Allopurinol			OFFSIDES
63	Ampicillin			OFFSIDES
64	Asbestos, Crocidolite		17365036	CTD
65	Azithromycin			OFFSIDES
66	Benzo(a)pyrene		24657529	CTD
67	Berberine		23523906	CTD
68	Betamethasone Valerate			OFFSIDES
69	Budesonide		25313925	CTD
70	Bupropion			OFFSIDES
71	CP 96345		9950884	CTD
72	Cadmium Chloride		25313925	CTD
73	Caffeine		29055810	CTD
74	Carmustine		12114195 18528683	CTD
75	Caspofungin			OFFSIDES
76	Chlorine		17343743 20348278 24769334	CTD
77	Chlorothiazide			OFFSIDES
78	Chlorpromazine			OFFSIDES
79	Chlorthalidone			OFFSIDES
80	Ciprofloxacin		18197910	CTD
81	Clindamycin			OFFSIDES
82	Clopidogrel		30537341	CTD
83	Cobalt		25896363	CTD
84	Cocaine			OFFSIDES
85	Dapsone		21765237	CTD
86	Daunorubicin			OFFSIDES
87	Decitabine		30815999	CTD
88	Deferoxamine			OFFSIDES
89	Dexamethasone		18187276 26271896 30849337	CTD
90	Diacetyl		27984136	CTD
91	Diatomaceous Earth		17301066 25280005 30698894	CTD
92	Digoxin			OFFSIDES
93	Dimethadione		25446330	CTD
94	Diphenhydramine			OFFSIDES
95	Diquat		26785375	CTD
96	Docusate sodium			OFFSIDES
97	Edaravone		21040696	CTD
98	Epichlorohydrin		24211530	CTD
99	Erlotinib Hydrochloride			OFFSIDES
100	Ethionine		22575522	CTD
101	Eucalyptol		29789401	CTD
102	Farnesol		18793622	CTD
103	Felbamate			OFFSIDES
104	Formoterol Fumarate		25313925	CTD
105	Fosinopril			OFFSIDES
106	Hydrochloric Acid		View details 11395602 15044056 15090967 15607125 16129981 17627322 18339021 18497604 18573544 19262391 19644408 20597076 21114838 21311175	CTD
107	Ibuprofen			OFFSIDES
108	Indomethacin			OFFSIDES
109	Isoproterenol		28266775	CTD
110	Itraconazole			OFFSIDES
111	JTE 607		15044056	CTD
112	Ketoconazole		21992520	CTD
113	Lithium Carbonate			OFFSIDES
114	Magnesium Oxide		24096598	CTD
115	Mechlorethamine		26243812	CTD
116	Methocarbamol			OFFSIDES
117	Methylphenidate			OFFSIDES
118	Methylprednisolone		26093215	CTD
119	Mitoxantrone			OFFSIDES
120	Mustard Gas		View details 18852015 19061933 19464336 19682477 20659490 28402575	CTD
121	N,N-diethylphenylacetamide		30884102	CTD
122	N-benzylglucamine dithiocarbamate		8854218	CTD
123	Naproxen			OFFSIDES
124	Niacinamide			OFFSIDES
125	Niacin		15856184	CTD
126	Nickel		8854218 11919079	CTD
127	Nitric Oxide		11395602	CTD
128	Nitrofurantoin		1313237	CTD OFFSIDES
129	Nizatidine			OFFSIDES
130	Norepinephrine			OFFSIDES
131	O(6)-benzylguanine		16126841	CTD
132	O,O,S-trimethyl phosphorothioate		2384072 4060171	CTD
133	O,S,S-trimethyl phosphorodithioate		2384072	CTD
134	Olanzapine			OFFSIDES
135	Oleic Acid		15090967	CTD
136	Opalmon			OFFSIDES
137	Oxygen		View details 2518282 10781441 17010595 18339021 18941502 21745492 24657529 24893714 25703676 26272953 28201809 29180065 29432836 29939353	CTD
138	Ozone		View details 20032013 20417186 22300504 25658374 26732886 28623178 29247675 29329427 29394414	CTD
139	Paraquat		View details 15856184 18630695 19080378 19272247 19639047 20600150 21040696 21765237 22493042 22678742 23051186 29273418	CTD
140	Phosgene		18645720 19235614 21941784	CTD
141	Piperacillin			OFFSIDES
142	Potassium Acetate			OFFSIDES
143	Potassium Dichromate		22972417	CTD
144	Prednisolone		21141070	CTD
145	Progesterone			OFFSIDES
146	Pyridoxine			OFFSIDES
147	Quercetin		20600150 29432836	CTD
148	Raloxifene Hydrochloride			OFFSIDES
149	Ribavirin			OFFSIDES
150	Rolipram		18941502	CTD
151	S-methylisothiopseudouronium		18573544	CTD
152	Scopolamine		21960666	CTD
153	Skatole		20795680	CTD
154	Sodium Fluoride		29758312	CTD
155	Sodium Nitrite		28266762	CTD
156	Soman		21960666	CTD
157	Spironolactone			OFFSIDES
158	Styrene		22366341 24320693 28962520	CTD
159	Succimer		8854218	CTD
160	Sulfur Dioxide		27565714	CTD
161	Tapentadol		28499616	CTD
162	Taurocholic Acid		19237016	CTD
163	Terbinafine			OFFSIDES
164	Tetraethyl Lead		10734789	CTD
165	Tobramycin			OFFSIDES
166	Tramadol		28499616	CTD
167	Trimethoprim			OFFSIDES
168	Vinorelbine			OFFSIDES
169	Vitamin B 12			OFFSIDES
170	Vitamin D		30698894	CTD
171	Zinc Oxide		17301066 21964423	CTD
172	alfacalcidol			OFFSIDES
173	alloin		30769049	CTD
174	aspalathin		25655391	CTD
175	benidipine			OFFSIDES
176	beta-Naphthoflavone		21745492 29180065	CTD
177	bisphenol A		30997025	CTD
178	chlordiazepoxide, clidinium drug combination			OFFSIDES
179	chloropicrin		24211530	CTD
180	chromium hexavalent ion		22972417	CTD
181	cobalt sulfate		25896363	CTD
182	cypermethrin		23900960	CTD
183	decamethrin		30884102	CTD
184	desethylamiodarone		23707191	CTD
185	didecyldimethylammonium		19762220 23537712	CTD
186	dolasetron			OFFSIDES
187	efavirenz			OFFSIDES
188	hydroxysafflor yellow A		24192212	CTD
189	ilomastat		18852015	CTD
190	indium phosphide		25527823	CTD
191	naphthalene		View details 6834280 18385170 18719226 18757308 18787022 18978301 19213872 19438287 20075049 20522644 20935109 21097997 21399660 21709667 21765217 22003090 22122896	CTD
192	nickel sulfate		16166746	CTD
193	nothofagin		25655391	CTD
194	pelargonidin		30753810	CTD
195	periciazine			OFFSIDES
196	polydatin		29130132	CTD
197	polyhexamethyleneguanidine		26990641	CTD
198	posaconazole			OFFSIDES
199	protocatechuic acid methyl ester		29758312	CTD
200	pyrrolidine dithiocarbamic acid		16129981 19639047	CTD
201	quazepam			OFFSIDES
202	quinone		20499891	CTD
203	rebemide		30884102	CTD
204	rosmarinic acid		12684091	CTD
205	sirtinol		19448212	CTD
206	sodium arsenite		28843991	CTD
207	substance P, Sar(9)-Met(O2)(11)-		9950884	CTD
208	tetrandrine		21992520	CTD
209	titanium dioxide		23409001	CTD
210	tris(2,3-dibromopropyl)isocyanurate		25042629	CTD
211	vinylidene chloride		3697828	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Atelectasis	28.6%
2	Flail Chest	28.6%
3	Heart Injuries	28.6%
4	Pulmonary Hypertension	28.6%
5	Pneumonia	28.6%
6	Lobar Pneumonia	28.6%
7	Pulmonary Alveolar Proteinosis	28.6%
8	Pulmonary Edema	28.6%
9	Pulmonary Fibrosis	28.6%
10	Respiratory Distress Syndrome, Adult	28.6%
11	Hamman-Rich syndrome	28.6%
12	Lung Diseases, Interstitial	28.6%
13	Lung Diseases, Obstructive	28.6%
14	Pneumonitis	28.6%
15	Idiopathic Pulmonary Fibrosis	28.2%
16	Bronchitis	23.9%
17	Bronchitis, Chronic	23.6%
18	Lung Diseases, Fungal	22.9%
19	Respiratory Distress Syndrome, Newborn	22.5%
20	Lung Abscess	22.4%
21	Lung Neoplasms	22.4%
22	Tuberculosis, Pulmonary	22.3%
23	Bronchopneumonia	22.2%
24	Hepatopulmonary Syndrome	21.4%
25	Chronic Obstructive Airway Disease	20.9%
26	Middle Lobe Syndrome	20.9%
27	Pulmonary Embolism	20.9%
28	Pulmonary Eosinophilia	20.8%
29	Eosinophilic Pneumonia	20.8%
30	Aspiration Pneumonia	20.7%
31	Pleuropneumonia	20.5%
32	Asthma	19.7%
33	Frostbite	18.5%
34	Bronchiolitis	18.4%
35	Pulmonary Emphysema	17.2%
36	Pneumonia, Viral	17.1%
37	Pneumonia, Lipid	16.9%
38	Pneumonia, Bacterial	16.7%
39	Hemoptysis	16.7%
40	Hyaline Membrane Disease	16.3%
41	Multiple Pulmonary Nodules	16.3%
42	Persistent Fetal Circulation Syndrome	15.8%
43	Bronchiolitis Obliterans	15.6%
44	Histiocytosis, Langerhans-Cell	15.5%
45	Pulmonary Aspergillosis	15.5%
46	Bronchopulmonary Aspergillosis	15.5%
47	Sarcoidosis, Pulmonary	15.4%
48	Pulmonary Infarction	15.3%
49	Athletic Injuries	15%
50	Bronchial Diseases	15%
51	Hand Injuries	15%
52	Pleural Diseases	15%
53	Respiration Disorders	15%
54	Soft Tissue Injuries	15%
55	Sprain	15%
56	Sprains and Strains	15%
57	Tendon Injuries	15%
58	Thoracic Diseases	15%
59	Tracheal Diseases	15%
60	Laceration	15%
61	Wounds, Penetrating	15%
62	Heat Cramps	15%
63	Rupture	15%
64	Radiation Pneumonitis	14.9%
65	Radiation Fibrosis	14.9%
66	Crush syndrome	14.3%
67	Cystic Fibrosis	14.3%
68	Femoral Fractures	14.3%
69	Pleurisy	14.3%
70	Tibial Fractures	14.3%
71	Tracheitis	14.3%
72	Tracheobronchomegaly	14.1%
73	Aspergillosis, Allergic Bronchopulmonary	14%
74	Hip Fractures	13.9%
75	Scimitar Syndrome	13.9%
76	Acute Chest Syndrome	13.5%
77	Pneumoconiosis	12.9%
78	Chilblains	12.3%
79	Spinal Fractures	12.3%
80	Granulomatosis with polyangiitis	12.2%
81	Farmer's Lung	11.9%
82	Laryngeal Diseases	11.5%
83	Nose Diseases	11.5%
84	Trauma, Nervous System	11.5%
85	Laryngitis	11.4%
86	Rhinitis	11.4%
87	Vocal Cord Dysfunction	11.4%
88	Hip Dislocation	11.3%
89	Shoulder Dislocation	11.3%
90	Splenic Rupture	11.3%
91	Hip Dysplasia	11.3%
92	Bronchial Fistula	11.2%
93	Pleural Neoplasms	11.2%
94	Bites and Stings	11.1%
95	Extravasation of Diagnostic and Therapeutic Materials	11.1%
96	Respiratory Tract Infections	11.1%
97	Vascular System Injuries	11.1%
98	Tympanic Membrane Perforation	11.1%
99	Tooth Injuries	11.1%
100	Granuloma, Laryngeal	10.9%
101	Asphyxia	10.9%
102	Esophageal Perforation	10.9%
103	Granuloma, Respiratory Tract	10.9%
104	Respiratory Hypersensitivity	10.9%
105	Shock, Traumatic	10.9%
106	Respiratory Tract Fistula	10.9%
107	Self Mutilation	10.8%
108	Iliotibial Band Syndrome	10.3%
109	Asbestosis	10.3%
110	Berylliosis	10.3%
111	Silicosis	10.3%
112	Anti-Glomerular Basement Membrane Disease	10.2%
113	Pleural Effusion, Malignant	10.1%
114	Invasive Pulmonary Aspergillosis	10.1%
115	Blastomycosis	10.1%
116	Sinusitis	9.7%
117	Bronchial Neoplasms	9.6%
118	Altitude Sickness	9.5%
119	Human Bite	9.5%
120	Bronchospasm	9.5%
121	Bronchiectasis	9.5%
122	Chylothorax	9.5%
123	Contusions	9.5%
124	Decompression Sickness	9.5%
125	Finger Injuries	9.5%
126	Fractures, Closed	9.5%
127	Pathological fracture	9.5%
128	Heat Exhaustion	9.5%
129	Heat Stroke	9.5%
130	Hydropneumothorax	9.5%
131	Hydrothorax	9.5%
132	Knee Injuries	9.5%
133	Pneumothorax	9.5%
134	Respiratory Insufficiency	9.5%
135	Tracheal Stenosis	9.5%
136	Bronchial Hyperreactivity	9.5%
137	Foot Injuries	9.5%
138	Decapitation	9.5%
139	Ankle Fracture	9.5%
140	Respiratory Depression	9.5%
141	Avulsion fracture	9.5%
142	Compression fracture	9.5%
143	Osteoporotic Fractures	9.5%
144	Respiratory Failure	9.5%
145	Choanal Atresia	9.4%
146	Laryngocele	9.4%
147	Tracheal Neoplasms	9.2%
148	Spinal Cord Injuries	8.7%
149	Drowning	8.6%
150	Eye Burns	8.5%
151	Laryngospasm	8.2%
152	Splenosis	8.2%
153	Asthma, Exercise-Induced	8.1%
154	Status Asthmaticus	8.1%
155	Laryngeal neoplasm	8%
156	Primary Ciliary Dyskinesia	7.3%
157	Eosinophilic Granuloma	7.2%
158	Granuloma, Lethal Midline	7.1%
159	Craniocerebral Trauma	7.1%
160	Laryngeal Edema	7.1%
161	Nose Deformities, Acquired	7.1%
162	Tendinitis	7.1%
163	Tendinopathy	7.1%
164	Respiratory Aspiration	7.1%
165	Apnea	7%
166	Cheyne-Stokes Respiration	7%
167	Common Cold	7%
168	Dyspnea	7%
169	Foreign-Body Reaction	7%
170	Hemothorax	7%
171	Hyperventilation	7%
172	Influenza	7%
173	Insect Bites and Stings	7%
174	Mouth Breathing	7%
175	Paralysis, Obstetric	7%
176	Sunburn	7%
177	Tooth Avulsion	7%
178	Tachypnea	7%
179	Conus Medullaris Syndrome	7%
180	Catarrh	7%
181	Asthma, Occupational	7%
182	Airway Obstruction	7%
183	Choking	7%
184	Epiglottitis	7%
185	Mediastinitis	7%
186	Pseudarthrosis	7%
187	Smoke Inhalation Injury	7%
188	Near Drowning	7%
189	Osteoradionecrosis	7%
190	Radiation injury	7%
191	Severe Acute Respiratory Syndrome	6.9%
192	Laryngopharyngeal Reflux	6.9%
193	Paranasal Sinus Neoplasms	6.7%
194	Brain Concussion	6.4%
195	Nose Neoplasms	6.1%
196	Hay fever	6.1%
197	Rhinitis, Allergic, Perennial	6.1%
198	Rhinoscleroma	6.1%
199	Hoarseness	6%
200	Asthma, Aspirin-Induced	5.8%
201	Brain Contusion	5.8%
202	Neoplasms, Radiation-Induced	5.8%
203	Pharyngitis	5.7%
204	Laryngostenosis	5.6%
205	Nasal Polyps	5.6%
206	Peripheral Nerve Injuries	5.6%
207	Medial Tibial Stress Syndrome	5.6%
208	Uterine Rupture	5.5%
209	Pertussis	5.5%
210	Central Cord Syndrome	5.5%
211	Maxillary Sinus Neoplasms	5.5%
212	Kartagener Syndrome	5.3%
213	Mediastinal Cyst	5.3%
214	Pericardial Cyst	5.3%
215	Thymic Cyst	5.3%
216	Croup	5.2%
217	Facial Injuries	5.2%
218	Granuloma, Foreign-Body	5.2%
219	Mediastinal Emphysema	5.2%
220	Rhinitis, Vasomotor	5.2%
221	Enthesopathy	5.2%
222	Hypoventilation	5.2%
223	Acidosis, Respiratory	5.1%
224	Alkalosis, Respiratory	5.1%
225	Sleep Apnea Syndromes	5.1%
226	Uterine Perforation	5.1%
227	Voice Disorders	4.7%
228	Voice Disturbance	4.7%
229	Cardiotoxicity	4.7%
230	Epistaxis	4.7%
231	Leukemia, Radiation-Induced	4.6%
232	Aortic Rupture	4.5%
233	Sleep Apnea, Obstructive	4.2%
234	Sleep Apnea, Central	4.2%
235	Tonsillitis	4.1%
236	Brain Injuries	4.1%
237	Dyspnea, Paroxysmal	4.1%
238	Respiratory Paralysis	4.1%
239	Coma, Post-Head Injury	4.1%
240	Carpal Tunnel Syndrome	4%
241	Meconium Aspiration Syndrome	4%
242	Laryngomalacia	4%
243	Vocal Cord Paralysis	3.9%
244	Abnormalities, Radiation-Induced	3.9%
245	Radiation Injuries, Experimental	3.8%
246	Brain Hemorrhage, Traumatic	3.6%
247	Eye Injuries	3.5%
248	Aphonia	3.4%
249	Retropharyngeal Abscess	3.4%
250	Dysphonia	3.4%
251	Bronchomalacia	3.4%
252	Tracheomalacia	3.4%
253	Brain Injuries, Diffuse	3.4%
254	Traumatic Brain Injury	3.4%
255	Cubital Tunnel Syndrome	3.3%
256	Diffuse Axonal Injury	3%
257	Nasopharyngitis	2.9%
258	Vertebral Artery Dissection	2.9%
259	Pneumocephalus	2.8%
260	Olfactory Nerve Injuries	2.8%
261	Cerebrospinal Fluid Otorrhea	2.8%
262	Cerebrospinal Fluid Rhinorrhea	2.8%
263	Epilepsy, Post-Traumatic	2.8%
264	Peritonsillar Abscess	2.8%
265	Corneal Scar	2.6%
266	Carotid Artery Injuries	2.5%
267	Facial Nerve Injuries	2.4%
268	Corneal Perforation	2.4%
269	Hematoma, Subdural	2.1%
270	Hematoma, Epidural, Cranial	2.1%
271	Hematoma, Subdural, Intracranial	1.8%
272	Hematoma, Subdural, Chronic	1.8%
273	Hematoma, Subdural, Acute	1.8%
274	Subarachnoid Hemorrhage, Traumatic	1.8%
275	Carotid Artery, Internal, Dissection	1.8%

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