MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pulmonary Alveolar Proteinosis

(UMLS:C0034050)

Definition:: A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
UMLS ID:: C0034050
MeSH ID:: D011649

Classification:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.719

Synonym(s)

Pulmonary Alveolar Proteinosis

Alveolar proteinosis

PAP - Pulmonary alveolar proteinosis

PULMONARY ALVEOLAR PROTEINOSIS

Pulmonary alveolar proteinosis

alveolar proteinosis

alveolar; proteinosis

proteinosis alveolar

proteinosis; alveolar

10.

pulmonary alveolar proteinosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	27-hydroxycholesterol		15466366	CTD
2	cholestenoic acid		15466366	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Atelectasis	42.9%
2	Pulmonary Hypertension	42.9%
3	Pulmonary Edema	42.9%
4	Pulmonary Fibrosis	42.9%
5	Hamman-Rich syndrome	42.9%
6	Lung Diseases, Interstitial	42.9%
7	Lung Diseases, Obstructive	42.9%
8	Pneumonia	38.1%
9	Lobar Pneumonia	38.1%
10	Respiratory Distress Syndrome, Adult	38.1%
11	Pneumonitis	38.1%
12	Idiopathic Pulmonary Fibrosis	37.1%
13	Pneumoconiosis	32.1%
14	Chronic Obstructive Airway Disease	31%
15	Middle Lobe Syndrome	31%
16	Acute Lung Injury	31%
17	Bronchitis	29.8%
18	Lung Diseases, Fungal	28.6%
19	Lung Injury	28.6%
20	Hepatopulmonary Syndrome	28.6%
21	Respiratory Distress Syndrome, Newborn	28.1%
22	Bronchitis, Chronic	28%
23	Lung Abscess	27.8%
24	Lung Neoplasms	27.8%
25	Tuberculosis, Pulmonary	27.6%
26	Bronchopneumonia	27.6%
27	Pulmonary Embolism	27.6%
28	Pulmonary Eosinophilia	27.4%
29	Eosinophilic Pneumonia	27.4%
30	Aspiration Pneumonia	27.3%
31	Asbestosis	25.4%
32	Berylliosis	25.4%
33	Pulmonary Emphysema	25.4%
34	Silicosis	25.4%
35	Radiation Pneumonitis	24.5%
36	Radiation Fibrosis	24.5%
37	Pleuropneumonia	24.3%
38	Asthma	23.4%
39	Bronchial Diseases	23.1%
40	Pleural Diseases	23.1%
41	Respiration Disorders	23.1%
42	Thoracic Diseases	23.1%
43	Tracheal Diseases	23.1%
44	Bronchiolitis	22.7%
45	Pneumonia, Lipid	22.2%
46	Pneumonia, Viral	21.4%
47	Persistent Fetal Circulation Syndrome	20.9%
48	Pneumonia, Bacterial	20.7%
49	Hemoptysis	20.7%
50	Histiocytosis, Langerhans-Cell	20.5%
51	Pulmonary Aspergillosis	20.5%
52	Bronchopulmonary Aspergillosis	20.5%
53	Bronchiolitis Obliterans	20.4%
54	Sarcoidosis, Pulmonary	20.2%
55	Hyaline Membrane Disease	20.2%
56	Pulmonary Infarction	20.1%
57	Multiple Pulmonary Nodules	20.1%
58	Pleurisy	19%
59	Tracheitis	19%
60	Cystic Fibrosis	17.1%
61	Tracheobronchomegaly	16.9%
62	Bronchopulmonary Dysplasia	16.9%
63	Aspergillosis, Allergic Bronchopulmonary	16.2%
64	Laryngeal Diseases	15.8%
65	Nose Diseases	15.8%
66	Scimitar Syndrome	15.8%
67	Acute Chest Syndrome	15.3%
68	Meconium Aspiration Syndrome	15.1%
69	Granulomatosis with polyangiitis	15.1%
70	Respiratory Tract Infections	15%
71	Granuloma, Respiratory Tract	14.6%
72	Respiratory Hypersensitivity	14.6%
73	Respiratory Tract Fistula	14.6%
74	Altitude Sickness	14.3%
75	Bronchospasm	14.3%
76	Bronchiectasis	14.3%
77	Chylothorax	14.3%
78	Hydropneumothorax	14.3%
79	Hydrothorax	14.3%
80	Laryngitis	14.3%
81	Pneumothorax	14.3%
82	Respiratory Insufficiency	14.3%
83	Rhinitis	14.3%
84	Tracheal Stenosis	14.3%
85	Bronchial Hyperreactivity	14.3%
86	Respiratory Depression	14.3%
87	Vocal Cord Dysfunction	14.3%
88	Respiratory Failure	14.3%
89	Farmer's Lung	14.1%
90	Bronchial Fistula	13.9%
91	Pleural Neoplasms	13.9%
92	Transfusion-Related Acute Lung Injury	12.8%
93	Granuloma, Laryngeal	12.7%
94	Invasive Pulmonary Aspergillosis	12.5%
95	Sinusitis	12.1%
96	Anti-Glomerular Basement Membrane Disease	12.1%
97	Pleural Effusion, Malignant	12%
98	Bronchial Neoplasms	11.9%
99	Blastomycosis	11.4%
100	Choanal Atresia	11.3%
101	Laryngocele	11.3%
102	Tracheal Neoplasms	11%
103	Airway Obstruction	10.3%
104	Choking	10.3%
105	Epiglottitis	10.3%
106	Mediastinitis	10.3%
107	Laryngospasm	10.2%
108	Asthma, Exercise-Induced	10%
109	Status Asthmaticus	10%
110	Granuloma, Lethal Midline	9.5%
111	Laryngeal Edema	9.5%
112	Nose Deformities, Acquired	9.5%
113	Respiratory Aspiration	9.5%
114	Laryngeal neoplasm	9.4%
115	Apnea	9.3%
116	Cheyne-Stokes Respiration	9.3%
117	Common Cold	9.3%
118	Dyspnea	9.3%
119	Hemothorax	9.3%
120	Hyperventilation	9.3%
121	Influenza	9.3%
122	Mouth Breathing	9.3%
123	Tachypnea	9.3%
124	Catarrh	9.3%
125	Severe Acute Respiratory Syndrome	9.1%
126	Laryngopharyngeal Reflux	9.1%
127	Primary Ciliary Dyskinesia	8.8%
128	Eosinophilic Granuloma	8.4%
129	Asthma, Occupational	8.4%
130	Paranasal Sinus Neoplasms	7.5%
131	Hay fever	7.3%
132	Rhinitis, Allergic, Perennial	7.3%
133	Pharyngitis	7.1%
134	Laryngostenosis	7%
135	Nasal Polyps	7%
136	Mediastinal Cyst	7%
137	Pericardial Cyst	7%
138	Thymic Cyst	7%
139	Nose Neoplasms	6.9%
140	Pertussis	6.8%
141	Croup	6.8%
142	Mediastinal Emphysema	6.8%
143	Rhinitis, Vasomotor	6.8%
144	Hypoventilation	6.8%
145	Rhinoscleroma	6.8%
146	Hoarseness	6.8%
147	Acidosis, Respiratory	6.7%
148	Alkalosis, Respiratory	6.7%
149	Sleep Apnea Syndromes	6.7%
150	Asthma, Aspirin-Induced	6.7%
151	Maxillary Sinus Neoplasms	6.1%
152	Kartagener Syndrome	5.7%
153	Voice Disorders	5.6%
154	Voice Disturbance	5.6%
155	Epistaxis	5.6%
156	Sleep Apnea, Obstructive	5.5%
157	Sleep Apnea, Central	5.5%
158	Tonsillitis	5.1%
159	Dyspnea, Paroxysmal	5%
160	Respiratory Paralysis	5%
161	Laryngomalacia	4.7%
162	Vocal Cord Paralysis	4.6%
163	Aphonia	4%
164	Retropharyngeal Abscess	4%
165	Dysphonia	4%
166	Bronchomalacia	4%
167	Tracheomalacia	4%
168	Nasopharyngitis	3.4%
169	Peritonsillar Abscess	3.3%

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