MetaADEDB 2.0 @ LMMD
lamivudine, zidovudine drug combination
(GLWHPRRGGYLLRV-XLPZGREQSA-N)
Structure
SMILES
[N-]=[N+]=N[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cc(C)c(=O)[nH]c1=O
Molecular Formula:
C10H16N5O13P3
Molecular Weight:
507.181
Log P:
-0.3925
Hydrogen Bond Acceptor:
15
Hydrogen Bond Donor:
5
TPSA:
303.09
CAS Number(s):
92586-35-1
Synonym(s)
1.
lamivudine, zidovudine drug combination
2.
Combivir
External Link(s)
MeSHC109078
PubChem Compound72187
BindingDB50370476
CHEMBLCHEMBL193952
ZINC13455082
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug exposure during pregnancyFAERS: 11OFFSIDES
US FAERS
2NauseaFAERS: 11
Canada Vigilance: 1		Canada Vigilance
US FAERS
3FatigueFAERS: 9OFFSIDES
US FAERS
4DizzinessFAERS: 8OFFSIDES
US FAERS
5HeadacheFAERS: 8US FAERS
6MalaiseFAERS: 7US FAERS
7Mitochondrial cytopathyFAERS: 5US FAERS
8PancytopeniaFAERS: 5US FAERS
9AstheniaFAERS: 4OFFSIDES
US FAERS
10VomitingFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
11AlopeciaFAERS: 3US FAERS
12Diabetes MellitusFAERS: 3US FAERS
13Hospice CareFAERS: 3US FAERS
14Neonatal disorderFAERS: 3US FAERS
15PruritusFAERS: 3US FAERS
16AnxietyFAERS: 2US FAERS
17Blood creatinine increasedFAERS: 2US FAERS
18Chest PainFAERS: 2US FAERS
19Dawn phenomenonFAERS: 2OFFSIDES
US FAERS
20DementiaFAERS: 2US FAERS
21Drug dose omissionFAERS: 2US FAERS
22DysgeusiaFAERS: 2US FAERS
23ErythropeniaFAERS: 2US FAERS
24GoutFAERS: 2US FAERS
25HypersensitivityFAERS: 2US FAERS
26LeukopeniaFAERS: 2US FAERS
27NephrolithiasisFAERS: 2US FAERS
28PainFAERS: 2US FAERS
29PallorFAERS: 2OFFSIDES
US FAERS
30PalpitationsFAERS: 2US FAERS
31PneumonitisFAERS: 2US FAERS
32Product quality issueFAERS: 2US FAERS
33Rehabilitation therapyFAERS: 2US FAERS
34RhabdomyolysisFAERS: 2US FAERS
35ThrombocytopeniaFAERS: 2US FAERS
36Trisomy 21FAERS: 2OFFSIDES
US FAERS
37AbasiaFAERS: 1US FAERS
38Abdominal PainFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
39Abdominal discomfortFAERS: 1US FAERS
40AgitationFAERS: 1US FAERS
41Alanine Aminotransferase IncreasedFAERS: 1OFFSIDES
US FAERS
42AmnesiaFAERS: 1US FAERS
43Angina PectorisFAERS: 1US FAERS
44AnosmiaFAERS: 1US FAERS
45ArthralgiaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
46ArthritisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
47Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
48Back PainFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
49Back disorderFAERS: 1US FAERS
50Bacterial test positiveFAERS: 1US FAERS
51BedriddenFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
52Biopsy kidney abnormalFAERS: 1US FAERS
53Blood cholesterol increasedFAERS: 1US FAERS
54Bone painFAERS: 1US FAERS
55BronchospasmFAERS: 1US FAERS
56Burning sensationFAERS: 1US FAERS
57Cerebrovascular accidentFAERS: 1US FAERS
58Chest discomfortFAERS: 1US FAERS
59ChillsFAERS: 1US FAERS
60Congenital mitochondrial cytopathyFAERS: 1OFFSIDES
US FAERS
61ConstipationFAERS: 1US FAERS
62Device related infectionFAERS: 1US FAERS
63DisabilityFAERS: 1US FAERS
64DiscomfortFAERS: 1US FAERS
65Drug administration errorFAERS: 1US FAERS
66Drug ineffectiveFAERS: 1US FAERS
67Drug resistanceFAERS: 1US FAERS
68DysmorphismFAERS: 1US FAERS
69DysuriaFAERS: 1US FAERS
70Ectopic PregnancyFAERS: 1US FAERS
71Eye painFAERS: 1US FAERS
72Flank PainFAERS: 1US FAERS
73Gait inabilityFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
74GastritisFAERS: 1US FAERS
75Gastrointestinal toxicityFAERS: 1US FAERS
76General physical health deteriorationFAERS: 1US FAERS
77Glomerular Filtration RateFAERS: 1US FAERS
78Histiocytosis haematophagicFAERS: 1US FAERS
79HyperreflexiaFAERS: 1US FAERS
80HypothyroidismFAERS: 1US FAERS
81Immune Reconstitution Inflammatory SyndromeFAERS: 1US FAERS
82Impaired self-careFAERS: 1US FAERS
83Inability to afford medicationFAERS: 1US FAERS
84Incision site painFAERS: 1US FAERS
85Increased upper airway secretionFAERS: 1US FAERS
86InflammationFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
87Intentional product misuseFAERS: 1US FAERS
88LethargyFAERS: 1OFFSIDES
US FAERS
89Leukocytoclastic vasculitisFAERS: 1US FAERS
90Lipodystrophy acquiredFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
91MacrocytosisFAERS: 1OFFSIDES
US FAERS
92Memory impairmentFAERS: 1US FAERS
93Mental RetardationFAERS: 1US FAERS
94MicrocephalyFAERS: 1OFFSIDES
US FAERS
95Mood swingsFAERS: 1US FAERS
96Multiple SclerosisFAERS: 1US FAERS
97Musculoskeletal PainFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
98MyalgiaFAERS: 1US FAERS
99Myocardial InfarctionFAERS: 1US FAERS
100Myoclonic EpilepsyFAERS: 1US FAERS
101MyoclonusFAERS: 1US FAERS
102MyopathyFAERS: 1US FAERS
103MyositisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
104NasopharyngitisFAERS: 1US FAERS
105NeuropathyFAERS: 1US FAERS
106NeutropeniaFAERS: 1US FAERS
107Neutrophil count decreasedFAERS: 1OFFSIDES
US FAERS
108Night sweatsFAERS: 1US FAERS
109OsteoporosisFAERS: 1US FAERS
110OverdoseFAERS: 1US FAERS
111PancreatitisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
112ParaplegiaFAERS: 1US FAERS
113Personality ChangeFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
114Pharmaceutical product complaintFAERS: 1US FAERS
115Renal painFAERS: 1US FAERS
116Respiratory tract congestionFAERS: 1US FAERS
117Right ventricular failureFAERS: 1US FAERS
118Spinal column stenosisFAERS: 1US FAERS
119SpondylolisthesisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
120Stevens-Johnson SyndromeFAERS: 1US FAERS
121StillbirthFAERS: 1US FAERS
122TachycardiaFAERS: 1US FAERS
123Therapy cessationFAERS: 1US FAERS
124UlcerFAERS: 1US FAERS
125UrticariaFAERS: 1US FAERS
126Vaginal DischargeFAERS: 1US FAERS
127Viral load increasedFAERS: 1US FAERS
128Viral upper respiratory tract infectionFAERS: 1US FAERS
129White blood cell count decreasedFAERS: 1US FAERS
130jaundiceFAERS: 1US FAERS
131nervous system disorderFAERS: 1US FAERS
13217-hydroxyprogesterone increasedOFFSIDES
133Acoustic stimulation tests abnormalOFFSIDES
134Acquired Protein S DeficiencyOFFSIDES
135Acute fatty liver of pregnancyOFFSIDES
136Acute otitis mediaOFFSIDES
137Acute respiratory failureOFFSIDES
138Adrenal cystOFFSIDES
139Adrenogenital SyndromeOFFSIDES
140AkinesiaOFFSIDES
141Alcohol interactionOFFSIDES
142Alcohol problemOFFSIDES
143AlveolitisOFFSIDES
144Ammonia increasedOFFSIDES
145Amniotic Band SyndromeOFFSIDES
146Amniotic cavity disorderOFFSIDES
147AnencephalyOFFSIDES
148AneurysmOFFSIDES
149AnoxiaOFFSIDES
150Anticholinergic SyndromeOFFSIDES
151AphagiaOFFSIDES
152Aplasia Cutis CongenitaOFFSIDES
153Application site rashOFFSIDES
154AscitesOFFSIDES
155AtherosclerosisOFFSIDES
156Atrioventricular Septal DefectOFFSIDES
157Bacterial sepsisOFFSIDES
158Biliary tract infectionOFFSIDES
159Biopsy bile duct abnormalOFFSIDES
160Biopsy bone marrow abnormalOFFSIDES
161Biopsy liver abnormalOFFSIDES
162Blood alcohol increasedOFFSIDES
163Blood amino acid level increasedOFFSIDES
164Blood amylase increasedOFFSIDES
165Blood blisterOFFSIDES
166Blood cortisol increasedOFFSIDES
167Blood count abnormalOFFSIDES
168Blood creatine phosphokinase MB increasedOFFSIDES
169Blood creatine phosphokinase increasedOFFSIDES
170Blood erythropoietin increasedOFFSIDES
171Blood fibrinogen increasedOFFSIDES
172Blood immunoglobulin M decreasedOFFSIDES
173Blood iron increasedOFFSIDES
174Blood ketone body increasedOFFSIDES
175Blood lactate dehydrogenase increasedOFFSIDES
176Body temperature fluctuationOFFSIDES
177Bone marrow depressionOFFSIDES
178Bone marrow toxicityOFFSIDES
179Brain natriuretic peptide increasedOFFSIDES
180BronchiectasisOFFSIDES
181Cardiac HypertrophyOFFSIDES
182Cataract operationOFFSIDES
183CatatoniaOFFSIDES
184Cerebellar HypoplasiaOFFSIDES
185Cerebral ventricle dilatationOFFSIDES
186Choking sensationOFFSIDES
187Cholecystitis infectiveOFFSIDES
188ChordeeOFFSIDES
189ChorioamnionitisOFFSIDES
190ChromaturiaOFFSIDES
191Coagulation factor VIII level decreasedOFFSIDES
192Complication of deliveryOFFSIDES
193Complications of maternal exposure to therapeutic drugsOFFSIDES
194Conduct DisorderOFFSIDES
195ConfabulationOFFSIDES
196Congenital HydrocephalusOFFSIDES
197Congenital abdominal herniaOFFSIDES
198Congenital acrochordonOFFSIDES
199Congenital androgen deficiencyOFFSIDES
200Congenital cerebral cystOFFSIDES
201Congenital choroid plexus cystOFFSIDES
202Congenital hepatobiliary anomalyOFFSIDES
203Congenital hepatomegalyOFFSIDES
204Congenital hydronephrosisOFFSIDES
205Congenital pulmonary hypertensionOFFSIDES
206Congenital pyelocaliectasisOFFSIDES
207Congenital tricuspid valve incompetenceOFFSIDES
208Congenital urinary tract obstructionOFFSIDES
209Consciousness fluctuatingOFFSIDES
210CraniosynostosisOFFSIDES
211CryingOFFSIDES
212CryptorchidismOFFSIDES
213Cystic FibrosisOFFSIDES
214CystOFFSIDES
215Cytomegalovirus enterocolitisOFFSIDES
216Cytomegalovirus testOFFSIDES
217DeafnessOFFSIDES
218Decreased LibidoOFFSIDES
219Dengue FeverOFFSIDES
220Dental abscessOFFSIDES
221DextrocardiaOFFSIDES
222Disseminated Intravascular CoagulationOFFSIDES
223Drug exposure before pregnancyOFFSIDES
224Drug screen positiveOFFSIDES
225Drug withdrawal headacheOFFSIDES
226DysmenorrheaOFFSIDES
227DyspepsiaOFFSIDES
228Ear dischargeOFFSIDES
229Echocardiogram abnormalOFFSIDES
230Echography abnormalOFFSIDES
231Ejection Fraction DecreasedOFFSIDES
232Electrocardiogram ST segment abnormalOFFSIDES
233Electrocardiogram changeOFFSIDES
234EncephalitisOFFSIDES
235Epidural lipomatosisOFFSIDES
236Erectile dysfunctionOFFSIDES
237Erosive gastritisOFFSIDES
238Facial NeuralgiaOFFSIDES
239Factor II deficiencyOFFSIDES
240Factor V deficiencyOFFSIDES
241Factor VIII inhibitionOFFSIDES
242False positive laboratory resultOFFSIDES
243FasciitisOFFSIDES
244Fat redistributionOFFSIDES
245Febrile bone marrow aplasiaOFFSIDES
246Full blood count decreasedOFFSIDES
247Full blood count increasedOFFSIDES
248Gallop rhythm presentOFFSIDES
249Gastric fluid analysis abnormalOFFSIDES
250GastroenteritisOFFSIDES
251Gastrointestinal inflammationOFFSIDES
252Gestational DiabetesOFFSIDES
253GoiterOFFSIDES
254GonorrheaOFFSIDES
255Gram stain negativeOFFSIDES
256HELLP SyndromeOFFSIDES
257HaematotoxicityOFFSIDES
258Head circumference abnormalOFFSIDES
259Hepatic congestionOFFSIDES
260Hepatic displacementOFFSIDES
261Hepatic siderosisOFFSIDES
262Hepatitis EOFFSIDES
263HepatitisOFFSIDES
264Hepatojugular refluxOFFSIDES
265HepatotoxicityOFFSIDES
266Hilar lymphadenopathyOFFSIDES
267Hip surgeryOFFSIDES
268HydrocephalusOFFSIDES
269HydronephrosisOFFSIDES
270Hyperemesis GravidarumOFFSIDES
271HyperlipasaemiaOFFSIDES
272Hypogonadotropic hypogonadismOFFSIDES
273HypospadiasOFFSIDES
274Imminent abortionOFFSIDES
275Inappropriate affectOFFSIDES
276Insulin-requiring type 2 diabetes mellitusOFFSIDES
277Kaolin cephalin clotting time prolongedOFFSIDES
278Lactate pyruvate ratio increasedOFFSIDES
279Late developerOFFSIDES
280Left Ventricular HypertrophyOFFSIDES
281Leukopenia neonatalOFFSIDES
282LipaseOFFSIDES
283LipohypertrophyOFFSIDES
284Live BirthOFFSIDES
285LividityOFFSIDES
286LymphedemaOFFSIDES
287MalariaOFFSIDES
288Malignant tumour excisionOFFSIDES
289Mastication disorderOFFSIDES
290Mechanical ventilationOFFSIDES
291Meconium abnormalOFFSIDES
292Meconium peritonitisOFFSIDES
293MeningoceleOFFSIDES
294Methylmalonic aciduriaOFFSIDES
295MononeuritisOFFSIDES
296Multiple MyelomaOFFSIDES
297Neonatal aspirationOFFSIDES
298Neuromyelitis OpticaOFFSIDES
299Neuropathic painOFFSIDES
300Neuropathic ulcerOFFSIDES
301Neutropenic sepsisOFFSIDES
302Neutrophil count abnormalOFFSIDES
303Nicotine DependenceOFFSIDES
304Normal deliveryOFFSIDES
305OligohydramniosOFFSIDES
306Optic AtrophyOFFSIDES
307Optic NeuropathyOFFSIDES
308OrthopneaOFFSIDES
309PO2 abnormalOFFSIDES
310PapillomaOFFSIDES
311ParanoiaOFFSIDES
312Parvovirus B19 serology positiveOFFSIDES
313Pericardial effusionOFFSIDES
314Periodontal destructionOFFSIDES
315Perirectal abscessOFFSIDES
316PharyngotonsillitisOFFSIDES
317PhimosisOFFSIDES
318PhlebitisOFFSIDES
319Placental InsufficiencyOFFSIDES
320PlasmacytosisOFFSIDES
321PneumothoraxOFFSIDES
322PolydactylyOFFSIDES
323PolyhydramniosOFFSIDES
324Portal Vein ThrombosisOFFSIDES
325Pre-EclampsiaOFFSIDES
326Prescribed overdoseOFFSIDES
327PriapismOFFSIDES
328Protein total decreasedOFFSIDES
329Prothrombin level decreasedOFFSIDES
330PsoriasisOFFSIDES
331Pulmonary Valve StenosisOFFSIDES
332Pulmonary arterial pressureOFFSIDES
333Pulmonary artery stenosisOFFSIDES
334Pus in stoolOFFSIDES
335Radial nerve palsyOFFSIDES
336Respiratory depth decreasedOFFSIDES
337ReticulocytopeniaOFFSIDES
338Retinoblastoma bilateralOFFSIDES
339Retinogram abnormalOFFSIDES
340RetrognathiaOFFSIDES
341RhinitisOFFSIDES
342Right Ventricular HypertrophyOFFSIDES
343Right atrial dilatationOFFSIDES
344Right ventricular systolic pressure increasedOFFSIDES
345Scan abdomen abnormalOFFSIDES
346SchistosomiasisOFFSIDES
347Semen volume decreasedOFFSIDES
348Septic arthritis staphylococcalOFFSIDES
349Skin hypertrophyOFFSIDES
350Skin neoplasm excisionOFFSIDES
351Spina BifidaOFFSIDES
352Spinal StenosisCanada Vigilance: 1Canada Vigilance
353Staphylococcal abscessOFFSIDES
354Syphilis test positiveOFFSIDES
355TalipesOFFSIDES
356ThrombophlebitisOFFSIDES
357Thyroglossal CystOFFSIDES
358TinnitusOFFSIDES
359Tracheal StenosisOFFSIDES
360Trisomy 15OFFSIDES
361Ultrasound antenatal screenOFFSIDES
362Ultrasound scan abnormalOFFSIDES
363Umbilical cord vascular disorderOFFSIDES
364Umbilical herniaOFFSIDES
365UnderweightOFFSIDES
366Vaginal burning sensationOFFSIDES
367Vanishing bile duct syndromeOFFSIDES
368Ventricular hypokinesiaOFFSIDES
369Vitamin B 12 DeficiencyOFFSIDES
370Wound InfectionOFFSIDES
371furuncleOFFSIDES
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