MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Idiopathic Pulmonary Fibrosis

(UMLS:C1800706)

Definition:: A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
UMLS ID:: C1800706
MeSH ID:: D054990

Classification:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.483.487.500|C08.381.765.500

Synonym(s)

Idiopathic Pulmonary Fibrosis

ALVEOLITIS FIBROSING

ALVEOLITIS, CHRONIC DIFFUSE FIBROSING

ALVEOLITIS, CHRONIC DIFFUSE SCLEROSING

ALVEOLITIS, FIBROSING

CFA - Cryptogenic fibrosing alveolitis

Carrington-Liebow syndrome

Cryptogenic fibrosing alveolitis

FIBROSIS, IDIOPATHIC PULMONARY

10.

Fibrosing alveolitis

11.

IPF - Idiopathic pulmonary fibrosis

12.

Idiopathic fibrosing alveolitis

13.

Idiopathic fibrosing alveolitis, chronic form

14.

Idiopathic pulmonary fibrosis

15.

PULMONARY FIBROSIS IDIOPATHIC

16.

PULMONARY FIBROSIS, IDIOPATHIC

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	pirfenidone	FAERS: 81 Canada Vigilance: 3	30481203	CTD Canada Vigilance US FAERS
2	ambrisentan	FAERS: 38		US FAERS
3	nintedanib	FAERS: 32		US FAERS
4	Simvastatin	FAERS: 11		US FAERS
5	Bosentan	FAERS: 10		US FAERS
6	macitentan	FAERS: 5		US FAERS
7	Acetylcysteine	FAERS: 4		US FAERS
8	Teriparatide	FAERS: 4		US FAERS
9	tofacitinib	FAERS: 4		US FAERS
10	Everolimus	FAERS: 3		US FAERS
11	Mycophenolic Acid	FAERS: 3		US FAERS
12	Sildenafil Citrate	FAERS: 3		US FAERS
13	Warfarin	FAERS: 3		US FAERS
14	gemcitabine	FAERS: 3		US FAERS
15	Amiodarone	FAERS: 2		US FAERS
16	Amiodarone	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
17	Bleomycin	FAERS: 2		US FAERS
18	Cyclosporine	FAERS: 2		US FAERS
19	Dabigatran	FAERS: 2		US FAERS
20	Dronedarone	FAERS: 2		US FAERS
21	Fluorouracil	FAERS: 2		US FAERS
22	Fluoxetine	FAERS: 2		US FAERS
23	Fluticasone-Salmeterol Drug Combination	FAERS: 2		US FAERS
24	Imatinib Mesylate	FAERS: 2		US FAERS
25	Insulin Glargine	FAERS: 2		US FAERS
26	LCZ 696	FAERS: 2		US FAERS
27	Methotrexate	FAERS: 2		US FAERS
28	Nitrofurantoin	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
29	PCI 32765	FAERS: 2		US FAERS
30	Ranolazine	FAERS: 2		US FAERS
31	Rosiglitazone	FAERS: 2		US FAERS
32	Sulfasalazine	FAERS: 2		SIDER US FAERS
33	Thalidomide	FAERS: 2		US FAERS
34	Warfarin	FAERS: 2		US FAERS
35	apremilast	FAERS: 2		US FAERS
36	rofecoxib	FAERS: 2		US FAERS
37	treprostinil	FAERS: 2		US FAERS
38	Acetaminophen	FAERS: 1		US FAERS
39	CID 129626832	FAERS: 1		US FAERS
40	Dasatinib	FAERS: 1		US FAERS
41	Diltiazem	FAERS: 1		US FAERS
42	Fexofenadine hydrochloride and pseudoephedrine hydrochloride	FAERS: 1		US FAERS
43	Fractals	FAERS: 1		US FAERS
44	Hydroxyurea	FAERS: 1		US FAERS
45	Iloprost	FAERS: 1		US FAERS
46	Memantine	FAERS: 1		US FAERS
47	Mesalamine	FAERS: 1		SIDER US FAERS
48	Methotrexate	FAERS: 1		US FAERS
49	Methylphenidate	FAERS: 1		US FAERS
50	Methylprednisolone Hemisuccinate	FAERS: 1		US FAERS
51	Nitrofurantoin (monohydrate/macrocrystals)	FAERS: 1		US FAERS
52	Nitroxyl	FAERS: 1		US FAERS
53	Omeprazole	FAERS: 1		US FAERS
54	Paclitaxel	FAERS: 1		US FAERS
55	Pemetrexed	FAERS: 1		US FAERS
56	Piroxicam	FAERS: 1		US FAERS
57	Prednisolone	FAERS: 1		US FAERS
58	Prednisone	FAERS: 1		US FAERS
59	Pregabalin	FAERS: 1		US FAERS
60	Rivastigmine	FAERS: 1		US FAERS
61	Sunitinib	FAERS: 1		US FAERS
62	Tacrolimus	FAERS: 1		US FAERS
63	Tiotropium Bromide	FAERS: 1		US FAERS
64	Valsartan	FAERS: 1		SIDER US FAERS
65	apixaban	FAERS: 1		US FAERS
66	gemcitabine	FAERS: 1		US FAERS
67	rasagiline	FAERS: 1		US FAERS
68	Bleomycin		21131602 28434932	CTD SIDER
69	Dinoprostone		28434932	CTD
70	Panobinostat		30481203	CTD
71	Sirolimus	Canada Vigilance: 1		Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Pneumonia	37.6%
2	Lobar Pneumonia	37.6%
3	Respiratory Distress Syndrome, Adult	37.6%
4	Pneumonitis	37.6%
5	Pneumoconiosis	37.2%
6	Atelectasis	37.1%
7	Pulmonary Hypertension	37.1%
8	Pulmonary Alveolar Proteinosis	37.1%
9	Pulmonary Edema	37.1%
10	Lung Diseases, Obstructive	37.1%
11	Lung Diseases, Fungal	30.3%
12	Radiation Pneumonitis	30%
13	Radiation Fibrosis	30%
14	Respiratory Distress Syndrome, Newborn	29.9%
15	Lung Abscess	29.7%
16	Lung Neoplasms	29.7%
17	Tuberculosis, Pulmonary	29.6%
18	Bronchitis	29.3%
19	Lung Injury	28.2%
20	Hepatopulmonary Syndrome	28.2%
21	Pulmonary Embolism	27.5%
22	Pulmonary Eosinophilia	27.4%
23	Eosinophilic Pneumonia	27.4%
24	Histiocytosis, Langerhans-Cell	27.3%
25	Sarcoidosis, Pulmonary	27%
26	Bronchopneumonia	26.2%
27	Asbestosis	25.2%
28	Berylliosis	25.2%
29	Silicosis	25.2%
30	Asthma	24.2%
31	Bronchitis, Chronic	24%
32	Pleuropneumonia	23.2%
33	Aspiration Pneumonia	23.1%
34	Chronic Obstructive Airway Disease	23.1%
35	Middle Lobe Syndrome	23.1%
36	Acute Lung Injury	23.1%
37	Bronchial Diseases	22.4%
38	Pleural Diseases	22.4%
39	Respiration Disorders	22.4%
40	Thoracic Diseases	22.4%
41	Tracheal Diseases	22.4%
42	Hemoptysis	22.1%
43	Granulomatosis with polyangiitis	21.6%
44	Lung Diseases, Interstitial	20.2%
45	Pneumonia, Viral	19.3%
46	Bronchiolitis	19.1%
47	Cystic Fibrosis	19.1%
48	Tracheobronchomegaly	18.9%
49	Pleurisy	18.8%
50	Tracheitis	18.8%
51	Pneumonia, Bacterial	18.8%
52	Scimitar Syndrome	18.6%
53	Hyaline Membrane Disease	18.4%
54	Multiple Pulmonary Nodules	18.4%
55	Acute Chest Syndrome	18.2%
56	Anti-Glomerular Basement Membrane Disease	18.1%
57	Persistent Fetal Circulation Syndrome	17.6%
58	Laryngeal Diseases	17.4%
59	Nose Diseases	17.4%
60	Pulmonary Aspergillosis	17.4%
61	Bronchopulmonary Aspergillosis	17.4%
62	Pulmonary Infarction	17.1%
63	Pulmonary Fibrosis	16.9%
64	Hamman-Rich syndrome	16.9%
65	Respiratory Tract Infections	16.8%
66	Farmer's Lung	16.5%
67	Granuloma, Respiratory Tract	16.5%
68	Respiratory Hypersensitivity	16.5%
69	Respiratory Tract Fistula	16.5%
70	Pulmonary Emphysema	16.3%
71	Pneumonia, Lipid	16.3%
72	Meconium Aspiration Syndrome	15.6%
73	Aspergillosis, Allergic Bronchopulmonary	15.6%
74	Laryngitis	15.2%
75	Rhinitis	15.2%
76	Vocal Cord Dysfunction	15.2%
77	Bronchial Fistula	14.9%
78	Pleural Neoplasms	14.9%
79	Idiopathic Pulmonary Fibrosis	14.8%
80	Granuloma, Laryngeal	14.1%
81	Bronchiolitis Obliterans	13.8%
82	Choanal Atresia	12.6%
83	Laryngocele	12.6%
84	Altitude Sickness	12.4%
85	Bronchospasm	12.4%
86	Bronchiectasis	12.4%
87	Chylothorax	12.4%
88	Hydropneumothorax	12.4%
89	Hydrothorax	12.4%
90	Pneumothorax	12.4%
91	Respiratory Insufficiency	12.4%
92	Tracheal Neoplasms	12.4%
93	Tracheal Stenosis	12.4%
94	Bronchial Hyperreactivity	12.4%
95	Respiratory Depression	12.4%
96	Respiratory Failure	12.4%
97	Bronchopulmonary Dysplasia	12.3%
98	Sinusitis	12.1%
99	Bronchial Neoplasms	12%
100	Blastomycosis	11.5%
101	Pleural Effusion, Malignant	11.5%
102	Primary Ciliary Dyskinesia	11.2%
103	Eosinophilic Granuloma	10.8%
104	Laryngeal neoplasm	10.8%
105	Transfusion-Related Acute Lung Injury	10%
106	Invasive Pulmonary Aspergillosis	9.8%
107	Granuloma, Lethal Midline	9.4%
108	Laryngeal Edema	9.4%
109	Nose Deformities, Acquired	9.4%
110	Respiratory Aspiration	9.4%
111	Laryngospasm	9.3%
112	Apnea	9.2%
113	Cheyne-Stokes Respiration	9.2%
114	Common Cold	9.2%
115	Dyspnea	9.2%
116	Hemothorax	9.2%
117	Hyperventilation	9.2%
118	Influenza	9.2%
119	Mouth Breathing	9.2%
120	Tachypnea	9.2%
121	Catarrh	9.2%
122	Asthma, Exercise-Induced	9.2%
123	Status Asthmaticus	9.2%
124	Severe Acute Respiratory Syndrome	9.1%
125	Laryngopharyngeal Reflux	9.1%
126	Nose Neoplasms	8.3%
127	Rhinoscleroma	8.2%
128	Asthma, Occupational	7.9%
129	Paranasal Sinus Neoplasms	7.7%
130	Airway Obstruction	7.7%
131	Choking	7.7%
132	Epiglottitis	7.7%
133	Mediastinitis	7.7%
134	Pharyngitis	7.6%
135	Hoarseness	7.5%
136	Laryngostenosis	7.5%
137	Nasal Polyps	7.5%
138	Pertussis	7.3%
139	Kartagener Syndrome	6.9%
140	Asthma, Aspirin-Induced	6.6%
141	Hay fever	6.5%
142	Rhinitis, Allergic, Perennial	6.5%
143	Voice Disorders	6.3%
144	Voice Disturbance	6.3%
145	Epistaxis	6.2%
146	Mediastinal Cyst	5.9%
147	Pericardial Cyst	5.9%
148	Thymic Cyst	5.9%
149	Croup	5.8%
150	Mediastinal Emphysema	5.8%
151	Rhinitis, Vasomotor	5.8%
152	Hypoventilation	5.8%
153	Acidosis, Respiratory	5.7%
154	Alkalosis, Respiratory	5.7%
155	Sleep Apnea Syndromes	5.7%
156	Maxillary Sinus Neoplasms	5.4%
157	Laryngomalacia	5.4%
158	Vocal Cord Paralysis	5.3%
159	Tonsillitis	4.6%
160	Dyspnea, Paroxysmal	4.6%
161	Respiratory Paralysis	4.6%
162	Sleep Apnea, Obstructive	4%
163	Sleep Apnea, Central	4%
164	Aphonia	3.8%
165	Retropharyngeal Abscess	3.8%
166	Dysphonia	3.8%
167	Bronchomalacia	3.8%
168	Tracheomalacia	3.8%
169	Nasopharyngitis	3.3%
170	Peritonsillar Abscess	2.7%

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