MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acute Lung Injury

(UMLS:C0242488)

Definition:: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
UMLS ID:: C0242488
MeSH ID:: D055371

Classification:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.520.500

Synonym(s)

Acute Lung Injury

ALI - Acute lung injury

Acute lung injury

acute injury lung

acute lung injury

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Acetaminophen	FAERS: 33		US FAERS
2	Metformin	FAERS: 14		US FAERS
3	Bupropion	FAERS: 10		US FAERS
4	Amiodarone	FAERS: 9		US FAERS
5	Morphine	FAERS: 7		US FAERS
6	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 6		US FAERS
7	Bortezomib	FAERS: 5		US FAERS
8	Mesalamine	FAERS: 5		US FAERS
9	Docetaxel	FAERS: 4		US FAERS
10	Oxycodone	FAERS: 4		US FAERS
11	Amlodipine	FAERS: 3		US FAERS
12	Azacitidine	FAERS: 3		US FAERS
13	Everolimus	FAERS: 3		US FAERS
14	Paclitaxel	FAERS: 3		US FAERS
15	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 2		US FAERS
16	Amiodarone	FAERS: 2		US FAERS
17	Diltiazem	FAERS: 2		US FAERS
18	Fentanyl	FAERS: 2		US FAERS
19	Gefitinib	FAERS: 2		US FAERS
20	Methadone	FAERS: 2		US FAERS
21	Methotrexate	FAERS: 2		US FAERS
22	Sertraline	FAERS: 2		US FAERS
23	Tinzaparin	FAERS: 2		US FAERS
24	Valproic Acid	FAERS: 2		US FAERS
25	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	21473879	CTD US FAERS
26	Amitriptyline	FAERS: 1		US FAERS
27	Amlodipine	FAERS: 1		US FAERS
28	Atorvastatin	FAERS: 1		US FAERS
29	Crizotinib	FAERS: 1		US FAERS
30	Cyclophosphamide	FAERS: 1		US FAERS
31	Cytarabine	FAERS: 1		US FAERS
32	Daptomycin	FAERS: 1		US FAERS
33	Daptomycin	FAERS: 1		US FAERS
34	Dextroamphetamine	FAERS: 1		US FAERS
35	Dimethyl Fumarate	FAERS: 1		US FAERS
36	Doxorubicin	FAERS: 1		US FAERS
37	Dronedarone	FAERS: 1		US FAERS
38	Erlotinib Hydrochloride	FAERS: 1		US FAERS
39	Erlotinib Hydrochloride	FAERS: 1		US FAERS
40	Fluoxetine	FAERS: 1		US FAERS
41	Imatinib Mesylate	FAERS: 1		US FAERS
42	Itraconazole	FAERS: 1		US FAERS
43	Lamotrigine	FAERS: 1		US FAERS
44	Lapatinib	FAERS: 1		US FAERS
45	Levofloxacin	FAERS: 1		US FAERS
46	Lorazepam	FAERS: 1		US FAERS
47	Metformin	FAERS: 1		US FAERS
48	Methylprednisolone Acetate	FAERS: 1		US FAERS
49	Metoprolol	FAERS: 1		US FAERS
50	Mycophenolic Acid	FAERS: 1		US FAERS
51	Oseltamivir	FAERS: 1		US FAERS
52	PCI 32765	FAERS: 1		US FAERS
53	Tamoxifen	FAERS: 1		US FAERS
54	Tapentadol	FAERS: 1		US FAERS
55	Ticagrelor	FAERS: 1		US FAERS
56	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
57	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
58	ambrisentan	FAERS: 1		US FAERS
59	amitriptyline, chlordiazepoxide drug combination	FAERS: 1		US FAERS
60	cabazitaxel	FAERS: 1		US FAERS
61	ceftaroline fosamil	FAERS: 1		US FAERS
62	gemcitabine	FAERS: 1		US FAERS
63	iopromide	FAERS: 1		US FAERS
64	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC		24963491	CTD
65	1-nitronaphthalene		15204773	CTD
66	3-xylene		15204773	CTD
67	Acrolein		20525806 21297076 27592100	CTD
68	Alcohols		20159407	CTD
69	Ambroxol		15970105	CTD
70	Amifostine		19010997	CTD
71	Amoxicillin-Potassium Clavulanate Combination		19078840	CTD
72	Asbestos, Crocidolite		15298984	CTD
73	Ascorbic Acid		15612528	CTD
74	Aspirin		19809160	CTD
75	Benzo(a)pyrene		28032951	CTD
76	Bleomycin		17118201 19362168 22687607	CTD
77	Carbon		27129695	CTD
78	Chlorine		View details 16625121 19041527 20601635 20819911 21131444 25456270 25497111	CTD
79	Dexamethasone		View details 11778176 21511011 25080890 25497111 25891457 30102002	CTD
80	Dexmedetomidine		30102002	CTD
81	Diacetyl		27851905	CTD
82	Dobutamine		17522573	CTD
83	Fingolimod Hydrochloride		24893116	CTD
84	Formaldehyde		25845602	CTD
85	Hesperidin		17400256	CTD
86	Hydrochloric Acid		View details 11850527 11953099 15970105 16759491 19060228 19094174 19760209 24122261	CTD
87	Hydrocortisone		19078840	CTD
88	Hydrogen Sulfide		24722316	CTD
89	Mannitol		21748612	CTD
90	Mechlorethamine		26273949 30060251	CTD
91	Mifepristone		24812154	CTD
92	Mustard Gas		27617619	CTD
93	NSC 23766		21511011	CTD
94	Nickel		12540486 16166738	CTD
95	Nitric Acid		18842383 19078840	CTD
96	Nitric Oxide		8643465	CTD
97	Nitrogen Dioxide		16049373	CTD
98	Oleic Acid		3789173	CTD
99	Oxygen		View details 1559913 16625121 16759491 19078840 23637810 24571919 26722498	CTD
100	Paraquat		View details 19712760 20004239 20498031 21941782 23603004 24535699 24812154 24893116 24963491 25304964 25338942 25461551 25579023 25674253 25815693 25891457 26313688 26708779 26722498 26813466 27014807 27890776 28131803 28363843 28474156 28480221 28600744 30967525	CTD
101	Phosgene		24280380 25456270 25870319	CTD
102	Prednisolone		19078840	CTD
103	Propofol		21307008	CTD
104	Quercetin		25413579 27525872	CTD
105	Resveratrol		View details 16488442 21284090 22646800 23625030 24818579 26708779	CTD
106	Rutin		25080890	CTD
107	Saponins		26363199	CTD
108	Simvastatin		20452610	CTD
109	Soman		23886498	CTD
110	Synephrine		24487736	CTD
111	TO-901317		21939782 28480221	CTD
112	Taurine		19362168	CTD
113	Thalidomide		25579023	CTD
114	Troglitazone		21153920	CTD
115	allyl sulfide		25891457	CTD
116	benzamide		8643465	CTD
117	cardamonin		22696397	CTD
118	cefprozil	Canada Vigilance: 2		Canada Vigilance
119	chloroacetic acid		16898262	CTD
120	crocetin		21925167	CTD
121	diallyl trisulfide		17448272	CTD
122	epigallocatechin gallate		27890776	CTD
123	geraniol		29050341	CTD
124	icariin		25323330	CTD
125	kaempferol		30769083	CTD
126	naphthalene		View details 2050025 19880587 20554700 26840748	CTD
127	naringin		23603004	CTD
128	nickel sulfate		View details 11751209 11954676 12718980 16100012 18467339 19131640	CTD
129	phenanthridone		8643465	CTD
130	phosphine		29251003	CTD
131	pimagedine		24280380	CTD
132	pirinixic acid		18653653	CTD
133	pyrazolanthrone		28474156	CTD
134	rhodioloside		25674253	CTD
135	sodium bisulfide		24722316	CTD
136	tezosentan		16625121	CTD
137	turmeric extract		25461551 29480285	CTD
138	verlukast		17118201	CTD
139	wogonin		26213241 26892447	CTD
140	zileuton		17118201	CTD
141	zinc protoporphyrin		27830717	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Pneumoconiosis	35.1%
2	Atelectasis	31%
3	Pulmonary Hypertension	31%
4	Pulmonary Alveolar Proteinosis	31%
5	Pulmonary Edema	31%
6	Pulmonary Fibrosis	31%
7	Hamman-Rich syndrome	31%
8	Lung Diseases, Interstitial	31%
9	Lung Diseases, Obstructive	31%
10	Pneumonia	27.9%
11	Lobar Pneumonia	27.9%
12	Respiratory Distress Syndrome, Adult	27.9%
13	Pneumonitis	27.9%
14	Radiation Pneumonitis	26.8%
15	Radiation Fibrosis	26.8%
16	Asbestosis	25%
17	Berylliosis	25%
18	Silicosis	25%
19	Bronchopulmonary Dysplasia	23.1%
20	Idiopathic Pulmonary Fibrosis	23.1%
21	Lung Diseases, Fungal	21.1%
22	Hepatopulmonary Syndrome	20.9%
23	Bronchitis	20.7%
24	Respiratory Distress Syndrome, Newborn	20.7%
25	Lung Abscess	20.5%
26	Lung Neoplasms	20.5%
27	Tuberculosis, Pulmonary	20.4%
28	Pulmonary Embolism	20.2%
29	Pulmonary Eosinophilia	20.1%
30	Eosinophilic Pneumonia	20.1%
31	Chronic Obstructive Airway Disease	20%
32	Middle Lobe Syndrome	20%
33	Meconium Aspiration Syndrome	19.5%
34	Bronchopneumonia	18.6%
35	Bronchial Diseases	18.5%
36	Pleural Diseases	18.5%
37	Respiration Disorders	18.5%
38	Thoracic Diseases	18.5%
39	Tracheal Diseases	18.5%
40	Aspiration Pneumonia	17.8%
41	Bronchitis, Chronic	17.1%
42	Asthma	16.3%
43	Pleuropneumonia	16%
44	Hemoptysis	15.3%
45	Pulmonary Emphysema	14.8%
46	Bronchiolitis	14%
47	Pneumonia, Viral	14%
48	Pleurisy	14%
49	Tracheitis	14%
50	Persistent Fetal Circulation Syndrome	13.6%
51	Pneumonia, Bacterial	13.6%
52	Histiocytosis, Langerhans-Cell	13.3%
53	Pulmonary Aspergillosis	13.3%
54	Bronchopulmonary Aspergillosis	13.3%
55	Hyaline Membrane Disease	13.2%
56	Sarcoidosis, Pulmonary	13.2%
57	Multiple Pulmonary Nodules	13.2%
58	Pulmonary Infarction	13.1%
59	Pneumonia, Lipid	13%
60	Laryngeal Diseases	12.8%
61	Nose Diseases	12.8%
62	Cystic Fibrosis	12.7%
63	Tracheobronchomegaly	12.5%
64	Respiratory Tract Infections	12.2%
65	Granuloma, Respiratory Tract	11.9%
66	Respiratory Hypersensitivity	11.9%
67	Respiratory Tract Fistula	11.9%
68	Scimitar Syndrome	11.7%
69	Acute Chest Syndrome	11.4%
70	Bronchiolitis Obliterans	11.4%
71	Laryngitis	10.5%
72	Rhinitis	10.5%
73	Vocal Cord Dysfunction	10.5%
74	Aspergillosis, Allergic Bronchopulmonary	10.5%
75	Altitude Sickness	10.3%
76	Bronchospasm	10.3%
77	Bronchiectasis	10.3%
78	Chylothorax	10.3%
79	Hydropneumothorax	10.3%
80	Hydrothorax	10.3%
81	Pneumothorax	10.3%
82	Respiratory Insufficiency	10.3%
83	Tracheal Stenosis	10.3%
84	Bronchial Hyperreactivity	10.3%
85	Respiratory Depression	10.3%
86	Respiratory Failure	10.3%
87	Bronchial Fistula	10.3%
88	Pleural Neoplasms	10.3%
89	Granulomatosis with polyangiitis	9.9%
90	Granuloma, Laryngeal	9.1%
91	Farmer's Lung	8.6%
92	Sinusitis	8.5%
93	Bronchial Neoplasms	8.4%
94	Choanal Atresia	8.3%
95	Laryngocele	8.3%
96	Tracheal Neoplasms	8.2%
97	Anti-Glomerular Basement Membrane Disease	7.9%
98	Pleural Effusion, Malignant	7.9%
99	Blastomycosis	7.5%
100	Invasive Pulmonary Aspergillosis	7.4%
101	Primary Ciliary Dyskinesia	7.2%
102	Granuloma, Lethal Midline	7%
103	Laryngeal Edema	7%
104	Nose Deformities, Acquired	7%
105	Respiratory Aspiration	7%
106	Laryngeal neoplasm	6.9%
107	Apnea	6.8%
108	Cheyne-Stokes Respiration	6.8%
109	Common Cold	6.8%
110	Dyspnea	6.8%
111	Hemothorax	6.8%
112	Hyperventilation	6.8%
113	Influenza	6.8%
114	Mouth Breathing	6.8%
115	Tachypnea	6.8%
116	Catarrh	6.8%
117	Severe Acute Respiratory Syndrome	6.7%
118	Laryngopharyngeal Reflux	6.7%
119	Airway Obstruction	6.7%
120	Choking	6.7%
121	Epiglottitis	6.7%
122	Laryngospasm	6.7%
123	Mediastinitis	6.7%
124	Asthma, Exercise-Induced	6.6%
125	Status Asthmaticus	6.6%
126	Asthma, Occupational	5.5%
127	Pharyngitis	5.3%
128	Laryngostenosis	5.2%
129	Nasal Polyps	5.2%
130	Nose Neoplasms	5.1%
131	Rhinoscleroma	5.1%
132	Pertussis	5%
133	Eosinophilic Granuloma	5%
134	Paranasal Sinus Neoplasms	5%
135	Hoarseness	4.8%
136	Hay fever	4.6%
137	Rhinitis, Allergic, Perennial	4.6%
138	Mediastinal Cyst	4.5%
139	Pericardial Cyst	4.5%
140	Thymic Cyst	4.5%
141	Croup	4.4%
142	Mediastinal Emphysema	4.4%
143	Rhinitis, Vasomotor	4.4%
144	Asthma, Aspirin-Induced	4.4%
145	Hypoventilation	4.4%
146	Acidosis, Respiratory	4.4%
147	Alkalosis, Respiratory	4.4%
148	Sleep Apnea Syndromes	4.4%
149	Voice Disorders	4.2%
150	Voice Disturbance	4.2%
151	Kartagener Syndrome	4.1%
152	Epistaxis	4.1%
153	Maxillary Sinus Neoplasms	3.6%
154	Laryngomalacia	3.4%
155	Vocal Cord Paralysis	3.4%
156	Tonsillitis	3.3%
157	Dyspnea, Paroxysmal	3.3%
158	Respiratory Paralysis	3.3%
159	Sleep Apnea, Obstructive	3.2%
160	Sleep Apnea, Central	3.2%
161	Aphonia	2.6%
162	Retropharyngeal Abscess	2.6%
163	Dysphonia	2.6%
164	Bronchomalacia	2.6%
165	Tracheomalacia	2.6%
166	Nasopharyngitis	2.2%
167	Peritonsillar Abscess	1.9%

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