MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Xerophthalmia

(UMLS:C0043349)

Definition:: Dryness of the eye surfaces caused by deficiency of tears or conjunctival secretions. It may be associated with vitamin A deficiency, trauma, or any condition in which the eyelids do not close completely.
UMLS ID:: C0043349
MeSH ID:: D014985

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.187.810|C11.496.260.892

Synonym(s)

Xerophthalmia

Conjunctival Xerosis

Tear film insufficiency

Tear film insufficiency, NOS

Tear film insufficiency, unspecified

XEROPHTHALMIA

xerophthalmia

xerophthalmia (etiology)

xerophthalmia (manifestation)

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ciprofloxacin	FAERS: 5		US FAERS
2	Isotretinoin	FAERS: 4	2931989	CTD US FAERS
3	Aripiprazole	FAERS: 2		US FAERS
4	Citalopram	FAERS: 2		US FAERS
5	Erlotinib Hydrochloride	FAERS: 2		US FAERS
6	Methylprednisolone Acetate	FAERS: 2		US FAERS
7	Norgestrel	FAERS: 2		US FAERS
8	Thyroxine	FAERS: 2		US FAERS
9	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		SIDER US FAERS
10	Acitretin	FAERS: 1		SIDER US FAERS
11	Afatinib	FAERS: 1		US FAERS
12	Amiodarone	FAERS: 1		US FAERS
13	Amlodipine	FAERS: 1		SIDER US FAERS
14	Atorvastatin	FAERS: 1		US FAERS
15	Citalopram	FAERS: 1		US FAERS
16	Dasatinib	FAERS: 1		US FAERS
17	Finasteride	FAERS: 1		US FAERS
18	Gabapentin	FAERS: 1		US FAERS
19	Hydroxychloroquine	FAERS: 1		US FAERS
20	Imatinib Mesylate	FAERS: 1		US FAERS
21	Insulin Glargine	FAERS: 1		US FAERS
22	Methylprednisolone Hemisuccinate	FAERS: 1		US FAERS
23	Paroxetine	FAERS: 1		US FAERS
24	Pregabalin	FAERS: 1		US FAERS
25	Risperidone	FAERS: 1		SIDER US FAERS
26	Tadalafil	FAERS: 1		US FAERS
27	Triumeq	FAERS: 1		US FAERS
28	Vemurafenib	FAERS: 1		US FAERS
29	Vortioxetine	FAERS: 1		US FAERS
30	fesoterodine	FAERS: 1		US FAERS
31	regorafenib	FAERS: 1		US FAERS
32	ribociclib	FAERS: 1		US FAERS
33	Anethole Trithione		6358997 19957670	CTD
34	Betahistine			OFFSIDES
35	Bosentan			SIDER
36	Cetirizine			SIDER
37	Citalopram			SIDER
38	Clonazepam			SIDER
39	Cyclosporine		17120751	CTD
40	Didanosine			OFFSIDES
41	Estradiol	Canada Vigilance: 2		Canada Vigilance
42	Gliclazide			SIDER
43	Indinavir			OFFSIDES
44	Memantine			SIDER
45	Oxcarbazepine			SIDER
46	Progesterone			SIDER
47	Rilmenidine			OFFSIDES
48	Saquinavir			SIDER
49	Scopolamine		17120751	CTD
50	Sertraline			SIDER
51	Tacrolimus		20233105	CTD
52	Tenofovir			OFFSIDES
53	Tolterodine Tartrate			SIDER
54	Topiramate			SIDER
55	Zalcitabine			SIDER
56	azelastine			SIDER
57	cevimeline			SIDER
58	efavirenz			OFFSIDES
59	eprosartan			SIDER
60	retinol palmitate		10979654	CTD
61	ropinirole			SIDER
62	trovafloxacin			SIDER
63	valdecoxib			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Keratoconjunctivitis Sicca	40%
2	Conjunctivitis	34.9%
3	Pterygium	34.9%
4	Pinguecula	34.9%
5	Dacryocystitis	30.2%
6	Lacrimal Duct Obstruction	30.2%
7	Keratoconjunctivitis	27.1%
8	Asthenopia	26.8%
9	Corneal Diseases	26.8%
10	Eyelid Diseases	26.8%
11	Lens Diseases	26.8%
12	Ocular Hypertension	26.8%
13	Ocular Hypotension	26.8%
14	Retinal Diseases	26.8%
15	Scleral Diseases	26.8%
16	Vitreous Detachment	26.8%
17	Posterior Vitreous Detachment	26.8%
18	Pemphigoid, Benign Mucous Membrane	25.9%
19	Retinal Degeneration	24.6%
20	Retinal Dysplasia	20.8%
21	Low Tension Glaucoma	20.7%
22	Iridocorneal endothelial syndrome	20.7%
23	Eye Abnormalities	20%
24	Eye Infection	20%
25	Eye Manifestations	20%
26	Eye Neoplasms	20%
27	Optic Neuropathy	20%
28	Blepharophimosis	19.4%
29	Uveal Neoplasms	19.4%
30	Eyelid Neoplasms	19.3%
31	Retinal Hemorrhage	19.3%
32	Aniridia	18.6%
33	Bacterial conjunctivitis	17.9%
34	Trachoma	16.5%
35	Corneal Ulcer	16.4%
36	Choroid Hemorrhage	16.3%
37	Angioid Streaks	16.3%
38	Anisometropia	16.3%
39	Aphakia	16.3%
40	Astigmatism	16.3%
41	Blepharitis	16.3%
42	Blepharoptosis	16.3%
43	Blepharospasm	16.3%
44	Choroid Diseases	16.3%
45	Corneal edema	16.3%
46	Corneal Opacity	16.3%
47	Ectropion	16.3%
48	Enophthalmos	16.3%
49	Entropion	16.3%
50	Episcleritis	16.3%
51	Exophthalmos	16.3%
52	Glaucoma	16.3%
53	Iris Diseases	16.3%
54	Keratitis	16.3%
55	Keratoconus	16.3%
56	Lens dislocation	16.3%
57	Lens Subluxation	16.3%
58	Mydriasis	16.3%
59	Myopia	16.3%
60	Presbyopia	16.3%
61	Retinal Detachment	16.3%
62	Retinitis	16.3%
63	Scleritis	16.3%
64	Uveitis	16.3%
65	Corneal Neovascularization	16.3%
66	Orbital Pseudotumor	16.3%
67	Cataract	16.3%
68	Trichiasis	16.3%
69	Chorioretinitis	16.3%
70	Duane Retraction Syndrome	16.1%
71	Ocular Motility Disorders	15.9%
72	Cyclophoria	15.9%
73	Corneal Scar	15.8%
74	Pupil Disorders	15.7%
75	Eye Hemorrhage	15.5%
76	Vision Disorders	15.4%
77	Metamorphopsia	15.4%
78	Visual Impairment	15.4%
79	Eye Injuries	15.3%
80	Retinitis Pigmentosa	15%
81	Pigmentary retinopathy	15%
82	Pars Planitis	14.8%
83	Lacrimal Apparatus Diseases	14.6%
84	Choroiditis	14.2%
85	Iridocyclitis	14.2%
86	Iritis	14.2%
87	Sicca Syndrome	14.1%
88	Sjogren's Syndrome	14.1%
89	Hordeolum	13.6%
90	Color blindness	13.4%
91	Retinoblastoma	12.5%
92	Conjunctival Diseases	12.2%
93	Anophthalmos	12.1%
94	Endophthalmitis	12.1%
95	Microphthalmos	12.1%
96	Optic Atrophy	12.1%
97	Optic Neuritis	12.1%
98	Papilledema	12.1%
99	Retinal Artery Occlusion	12.1%
100	Retinopathy of Prematurity	12.1%
101	Strabismus	12.1%
102	Tolosa-Hunt Syndrome	12.1%
103	Orbital Cellulitis	12.1%
104	Retinal Vasculitis	12.1%
105	Hypertensive Retinopathy	12.1%
106	Retrobulbar Hemorrhage	12.1%
107	Corneal Endothelial Cell Loss	12.1%
108	Hyphema	12%
109	Retinal Neovascularization	12%
110	Vitreous Hemorrhage	12%
111	Acanthamoeba Keratitis	11.4%
112	Angle Closure Glaucoma	11.4%
113	Glaucoma, Open-Angle	11.4%
114	Macular degeneration	11.4%
115	Panuveitis	11.4%
116	Retinal Drusen	11.4%
117	Retinal Necrosis Syndrome, Acute	11.4%
118	Retinoschisis	11.4%
119	Exfoliation Syndrome	11.4%
120	Keratitis, Herpetic	11.3%
121	Cytomegalovirus Retinitis	11.3%
122	Corneal Perforation	11%
123	Ophthalmia Neonatorum	10.7%
124	Xerophthalmia	10.3%
125	Optic Neuropathy, Ischemic	9.7%
126	Anterior Ischemic Optic Neuropathy	9.7%
127	Retinal Vein Occlusion	9.6%
128	Anisocoria	9.5%
129	Diabetic Retinopathy	9.5%
130	Tonic Pupil	9.5%
131	Eye pain	9.5%
132	Orbital Myositis	9.5%
133	Diplopia	9.4%
134	Scotoma	9.4%
135	Photophobia	9.4%
136	Amaurosis	9.4%
137	Blindness	9.4%
138	Dry Eye Syndromes	9.3%
139	Anterior uveitis	9%
140	Uveitis, Posterior	9%
141	Panophthalmitis	8.7%
142	Esotropia	8.4%
143	Exotropia	8.4%
144	Choroidal Neovascularization	8.4%
145	Ophthalmoplegia	7.9%
146	External Ophthalmoplegia	7.9%
147	Amblyopia	7.8%
148	Uveomeningoencephalitic Syndrome	6.8%
149	CHARGE Syndrome	6.8%
150	Congenital nystagmus	6.8%
151	Herpes Zoster Ophthalmicus	6.8%
152	Hemianopsia	6.6%
153	Amaurosis Fugax	6.6%
154	Blindness, Cortical	6.6%
155	Optic Atrophy, Hereditary, Leber	6.6%
156	Aicardi's syndrome	6%
157	Graves Disease	5.7%
158	Horner Syndrome	5.6%
159	Mandibulofacial Dysostosis	5.5%
160	Opsoclonus-Myoclonus Syndrome	5.2%
161	Albinism	5.2%
162	Miller Fisher Syndrome	4.6%
163	Kearns-Sayre syndrome	4.1%
164	Ophthalmoplegic Migraine	3.7%
165	Progressive supranuclear palsy	3.7%
166	Neuromyelitis Optica	3.3%
167	Alstrom Syndrome	3%
168	Behcet Syndrome	2.9%
169	Optic Nerve Glioma	2.7%

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