MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Corneal Ulcer

(UMLS:C0010043)

Definition:: Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.
UMLS ID:: C0010043
MeSH ID:: D003320

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.539.375.177

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.204.564.225|C11.294.177

Synonym(s)

Corneal Ulcer

CORNEAL ULCER

CORNEAL ULCERATION

Cornea--Ulcers

Corneal ulcer

Corneal ulcer, NOS

Corneal ulcer, unspecified

Corneal ulceration

Corneal ulcerations

10.

KERATITIS ULCERATIVE

11.

Ulcer, Corneal

12.

Ulcer;corneal

13.

Ulcerative keratitis

14.

cornea ulcer

15.

cornea ulcers

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Gabapentin	FAERS: 5		US FAERS
2	Diclofenac	FAERS: 2		OFFSIDES US FAERS
3	Gefitinib	FAERS: 2		US FAERS
4	Imatinib Mesylate	FAERS: 2		US FAERS
5	Latanoprost	FAERS: 2		US FAERS
6	Restasis	FAERS: 2		US FAERS
7	betamethasone sodium phosphate	FAERS: 2		US FAERS
8	Bimatoprost	FAERS: 1		OFFSIDES US FAERS
9	Budesonide	FAERS: 1		US FAERS
10	Fluticasone	FAERS: 1		US FAERS
11	Isotretinoin	FAERS: 1	19831559	CTD US FAERS
12	Ketorolac Tromethamine	FAERS: 1		US FAERS
13	Lidoderm	FAERS: 1		US FAERS
14	Methotrexate	FAERS: 1		US FAERS
15	Moxifloxacin	FAERS: 1		US FAERS
16	Riluzole	FAERS: 1		OFFSIDES US FAERS
17	Teriparatide	FAERS: 1		US FAERS
18	Valsartan	FAERS: 1		US FAERS
19	Vinorelbine	FAERS: 1		OFFSIDES US FAERS
20	Acenocoumarol			OFFSIDES
21	Acetazolamide			OFFSIDES
22	Acitretin			OFFSIDES
23	Amifostine			OFFSIDES
24	Amoxicillin			OFFSIDES
25	Anastrozole			OFFSIDES
26	Aprepitant			OFFSIDES
27	Atropine			OFFSIDES
28	Azathioprine			OFFSIDES
29	Benztropine			OFFSIDES
30	Betaxolol			OFFSIDES
31	Brimonidine Tartrate			OFFSIDES
32	Capsaicin		19553628	CTD
33	Cefdinir			OFFSIDES
34	Chloramphenicol			OFFSIDES
35	Clobazam			OFFSIDES
36	Cocaine		17052948 17721298 18206340	CTD
37	Dapsone			OFFSIDES
38	Deferasirox			OFFSIDES
39	Desflurane			OFFSIDES
40	Diosmin			OFFSIDES
41	Doxepin			OFFSIDES
42	Erlotinib Hydrochloride			OFFSIDES
43	Erlotinib Hydrochloride			OFFSIDES
44	Ertapenem			OFFSIDES
45	Erythromycin			OFFSIDES
46	Estrogens, Conjugated (USP)			OFFSIDES
47	Fluorometholone			OFFSIDES
48	Fluorouracil			OFFSIDES
49	Flurazepam			OFFSIDES
50	Fosfomycin			OFFSIDES
51	Gatifloxacin			OFFSIDES
52	Glutathione			OFFSIDES
53	Glyburide			OFFSIDES
54	Hydrocortisone			OFFSIDES
55	Hydromorphone			OFFSIDES
56	Irinotecan			OFFSIDES
57	Ketoconazole			OFFSIDES
58	Ketorolac			OFFSIDES
59	Lamotrigine			OFFSIDES
60	Leucovorin			OFFSIDES
61	Loteprednol Etabonate			OFFSIDES
62	Methamphetamine		19384581	CTD
63	Minocycline			OFFSIDES
64	Morphine			OFFSIDES
65	Moxifloxacin			OFFSIDES
66	Mycophenolic Acid			OFFSIDES
67	Neomycin			OFFSIDES
68	Nitrofurantoin			OFFSIDES
69	Nortriptyline			OFFSIDES
70	Ofloxacin			OFFSIDES
71	Olopatadine Hydrochloride			OFFSIDES
72	Pamidronate			OFFSIDES
73	Penicillins			OFFSIDES
74	Povidone-Iodine			OFFSIDES
75	Prednisone acetate			OFFSIDES
76	Progesterone			OFFSIDES
77	Saquinavir			OFFSIDES
78	Sirolimus			OFFSIDES
79	Stavudine			OFFSIDES
80	Sulindac			OFFSIDES
81	Sunitinib			OFFSIDES
82	Thiamine			OFFSIDES
83	Timolol			OFFSIDES
84	Tranexamic Acid			OFFSIDES
85	Travoprost			OFFSIDES
86	Tretinoin			OFFSIDES
87	alfuzosin			OFFSIDES
88	binedaline			OFFSIDES
89	brinzolamide			OFFSIDES
90	crotamiton			OFFSIDES
91	darifenacin			OFFSIDES
92	nepafenac			OFFSIDES
93	norgestimate, ethinyl estradiol drug combination			OFFSIDES
94	prednisolone acetate			OFFSIDES
95	rofecoxib			OFFSIDES
96	rotigotine			OFFSIDES
97	terconazole			OFFSIDES
98	tranilast			OFFSIDES
99	valdecoxib			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Endophthalmitis	39.7%
2	Keratoconjunctivitis	29.7%
3	Hordeolum	29.5%
4	Panophthalmitis	27.8%
5	Trachoma	27.6%
6	Bacterial conjunctivitis	27.3%
7	Acanthamoeba Keratitis	27.2%
8	Keratitis, Herpetic	27.1%
9	Iridocorneal endothelial syndrome	24.7%
10	Keratoconjunctivitis Sicca	24.4%
11	Corneal edema	22.4%
12	Corneal Opacity	22.4%
13	Keratoconus	22.4%
14	Corneal Neovascularization	22.4%
15	Asthenopia	19.6%
16	Conjunctival Diseases	19.6%
17	Eyelid Diseases	19.6%
18	Lacrimal Apparatus Diseases	19.6%
19	Lens Diseases	19.6%
20	Ocular Hypertension	19.6%
21	Ocular Hypotension	19.6%
22	Retinal Diseases	19.6%
23	Scleral Diseases	19.6%
24	Vitreous Detachment	19.6%
25	Posterior Vitreous Detachment	19.6%
26	Retinal Degeneration	19.4%
27	Corneal Scar	19.3%
28	Retinal Dysplasia	18.1%
29	Ophthalmia Neonatorum	18%
30	Corneal Endothelial Cell Loss	17.8%
31	Xerophthalmia	16.4%
32	Low Tension Glaucoma	16.4%
33	Aniridia	16.2%
34	Blepharophimosis	16.1%
35	Uveal Neoplasms	16.1%
36	Eyelid Neoplasms	16%
37	Retinal Hemorrhage	16%
38	Eye Abnormalities	15.7%
39	Eye Manifestations	15.7%
40	Eye Neoplasms	15.7%
41	Optic Neuropathy	15.7%
42	Pelvic Infection	15.5%
43	Wound Infection	15.5%
44	Soft Tissue Infection	15.5%
45	Community-Acquired Infections	15.5%
46	Cytomegalovirus Retinitis	15.5%
47	Duane Retraction Syndrome	13.7%
48	Choroid Hemorrhage	13.6%
49	Chorioretinitis	13.6%
50	Corneal Perforation	13.2%
51	Ocular Motility Disorders	13.1%
52	Cyclophoria	13.1%
53	Pupil Disorders	12.9%
54	Respiratory Tract Infections	12.9%
55	Eye Hemorrhage	12.8%
56	Vision Disorders	12.7%
57	Metamorphopsia	12.7%
58	Visual Impairment	12.7%
59	Eye Injuries	12.6%
60	Bone Diseases, Infectious	12.5%
61	Pregnancy Complications, Infectious	12.5%
62	Skin Diseases, Infectious	12.5%
63	Retinitis Pigmentosa	12.4%
64	Pigmentary retinopathy	12.4%
65	Herpes Zoster Ophthalmicus	12.4%
66	Pars Planitis	12.4%
67	Arthritis, Infectious	12.3%
68	Suppuration	12.3%
69	Cross Infection	12.2%
70	Septicemia	12.2%
71	Sepsis	12.2%
72	Angioid Streaks	12.1%
73	Anisometropia	12.1%
74	Aphakia	12.1%
75	Astigmatism	12.1%
76	Blepharitis	12.1%
77	Blepharoptosis	12.1%
78	Blepharospasm	12.1%
79	Choroid Diseases	12.1%
80	Conjunctivitis	12.1%
81	Dacryocystitis	12.1%
82	Dry Eye Syndromes	12.1%
83	Ectropion	12.1%
84	Enophthalmos	12.1%
85	Entropion	12.1%
86	Episcleritis	12.1%
87	Exophthalmos	12.1%
88	Glaucoma	12.1%
89	Iris Diseases	12.1%
90	Lacrimal Duct Obstruction	12.1%
91	Lens dislocation	12.1%
92	Lens Subluxation	12.1%
93	Mydriasis	12.1%
94	Myopia	12.1%
95	Presbyopia	12.1%
96	Pterygium	12.1%
97	Retinal Detachment	12.1%
98	Retinitis	12.1%
99	Scleritis	12.1%
100	Uveitis	12.1%
101	Orbital Pseudotumor	12.1%
102	Cataract	12.1%
103	Pinguecula	12.1%
104	Trichiasis	12.1%
105	Endotoxemia	11.6%
106	Cellulitis	11.6%
107	Color blindness	11.5%
108	Ulcerative stomatitis	11.5%
109	Choroiditis	11.4%
110	Iridocyclitis	11.4%
111	Iritis	11.4%
112	Retinoblastoma	11.3%
113	Opportunistic Infections	11%
114	Corneal Diseases	10.7%
115	Hidradenitis Suppurativa	10.4%
116	Urinary tract infection	10.3%
117	Dermatomycoses	10.2%
118	Skin Diseases, Bacterial	10.2%
119	Bacteremia	10.1%
120	Anophthalmos	9.6%
121	Microphthalmos	9.6%
122	Optic Atrophy	9.6%
123	Optic Neuritis	9.6%
124	Papilledema	9.6%
125	Pemphigoid, Benign Mucous Membrane	9.6%
126	Retinal Artery Occlusion	9.6%
127	Retinopathy of Prematurity	9.6%
128	Strabismus	9.6%
129	Tolosa-Hunt Syndrome	9.6%
130	Orbital Cellulitis	9.6%
131	Retinal Vasculitis	9.6%
132	Hypertensive Retinopathy	9.6%
133	Retrobulbar Hemorrhage	9.6%
134	Hyphema	9.5%
135	Retinal Neovascularization	9.5%
136	Vitreous Hemorrhage	9.5%
137	Mycetoma	9.4%
138	Sexually Transmitted Diseases	9.1%
139	Bacterial Infections	8.9%
140	Mycoses	8.9%
141	Fungemia	8.9%
142	Bacterial Endocarditis	8.8%
143	Angle Closure Glaucoma	8.5%
144	Glaucoma, Open-Angle	8.5%
145	Macular degeneration	8.5%
146	Panuveitis	8.5%
147	Retinal Drusen	8.5%
148	Retinal Necrosis Syndrome, Acute	8.5%
149	Pertussis	8.5%
150	Retinoschisis	8.5%
151	Exfoliation Syndrome	8.5%
152	Peritonitis	8.2%
153	Osteomyelitis	8.1%
154	Periostitis	8.1%
155	Surgical Wound Infection	8.1%
156	Candidiasis, Chronic Mucocutaneous	8.1%
157	Cutaneous Candidiasis	8.1%
158	Abscess	8.1%
159	Adnexitis	8.1%
160	Empyema	8.1%
161	Pelvic Inflammatory Disease	8.1%
162	Optic Neuropathy, Ischemic	8%
163	Anterior Ischemic Optic Neuropathy	8%
164	Retinal Vein Occlusion	8%
165	Joint Tuberculosis	7.9%
166	Tuberculosis, Osteoarticular	7.9%
167	Bone Tuberculosis	7.9%
168	Anisocoria	7.9%
169	Diabetic Retinopathy	7.9%
170	Tonic Pupil	7.9%
171	Eye pain	7.9%
172	Orbital Myositis	7.9%
173	Diplopia	7.8%
174	Scotoma	7.8%
175	Photophobia	7.8%
176	Amaurosis	7.8%
177	Blindness	7.8%
178	Erysipelas	7.6%
179	Staphylococcal Skin Infections	7.6%
180	Psoas Abscess	7.6%
181	Abdominal Abscess	7.6%
182	Candidemia	7.4%
183	Erythrasma	7.3%
184	Brain Abscess	7.2%
185	Chromoblastomycosis	7.2%
186	Dermatophytosis	7.2%
187	Sporotrichosis	7.2%
188	Tinea	7.2%
189	Tinea Versicolor	7.2%
190	Trichophytosis	7.2%
191	Hyalohyphomycosis	7.2%
192	Central Nervous System Infection	7.1%
193	Eye Infection	7.1%
194	Syphilis	6.9%
195	Keratitis	6.9%
196	Superinfection	6.9%
197	Central Nervous System Bacterial Infections	6.9%
198	Corneal Ulcer	6.8%
199	Ophthalmoplegia	6.8%
200	External Ophthalmoplegia	6.8%
201	Puerperal Infection	6.7%
202	Spondylitis	6.7%
203	Erythema Chronicum Migrans	6.7%
204	Anterior uveitis	6.7%
205	Uveitis, Posterior	6.7%
206	Amblyopia	6.7%
207	Esotropia	6.7%
208	Exotropia	6.7%
209	Choroidal Neovascularization	6.7%
210	Appendicitis	6.7%
211	Bacteriuria	6.7%
212	Pyuria	6.7%
213	Pyomyositis	6.7%
214	Endotoxic shock	6.6%
215	Septic Shock	6.6%
216	Toxic Shock Syndrome	6.6%
217	Ecthyma	6.6%
218	Subacute Bacterial Endocarditis	6.6%
219	Chlamydia Infections	6.6%
220	Gonorrhea	6.6%
221	Impetigo	6.5%
222	Blastomycosis	6.3%
223	Staphylococcal Scalded Skin Syndrome	6.1%
224	Diverticulitis	6%
225	Optic Atrophy, Hereditary, Leber	5.9%
226	Fusariosis	5.8%
227	Uveomeningoencephalitic Syndrome	5.7%
228	CHARGE Syndrome	5.7%
229	Arthritis, Reactive	5.7%
230	Congenital nystagmus	5.6%
231	Hemianopsia	5.5%
232	Amaurosis Fugax	5.5%
233	Blindness, Cortical	5.5%
234	Borrelia Infections	5.4%
235	Leptospirosis	5.4%
236	Furunculosis	5.4%
237	furuncle	5.4%
238	carbuncle	5.4%
239	Lymphogranuloma Venereum	5.3%
240	Aicardi's syndrome	5.3%
241	Rhinoscleroma	5.2%
242	Tuberculosis, Spinal	5.2%
243	Aspergillosis	5.2%
244	Candidiasis	5.2%
245	Coccidioidomycosis	5.2%
246	Histoplasmosis	5.2%
247	Paracoccidioidomycosis	5.2%
248	Zygomycosis	5.2%
249	Gram-Negative Bacterial Infections	5.2%
250	Gram-Positive Bacterial Infections	5.2%
251	Phaeohyphomycosis	5.2%
252	Pneumocystis Infections	5.2%
253	Lung Abscess	5.1%
254	AIDS-Related Opportunistic Infections	5.1%
255	Liver Abscess	5.1%
256	Diverticulum	5.1%
257	Diverticulosis	5.1%
258	Discitis	5%
259	Lyme Disease	5%
260	Mastoiditis	5%
261	Relapsing Fever	5%
262	Petrositis	5%
263	Tinea Capitis	5%
264	Onychomycosis	5%
265	Graves Disease	4.9%
266	Horner Syndrome	4.8%
267	Lyme Neuroborreliosis	4.7%
268	Mandibulofacial Dysostosis	4.7%
269	Opsoclonus-Myoclonus Syndrome	4.7%
270	Albinism	4.7%
271	Neuroaspergillosis	4.5%
272	Retropharyngeal Abscess	4.3%
273	Tinea Pedis	4.3%
274	Epidural Abscess	4.3%
275	Neurosyphilis	4.2%
276	Peritonsillar Abscess	4.2%
277	Miller Fisher Syndrome	4.2%
278	Otomycosis	4.2%
279	Erythema Induratum	4.2%
280	Piedra	4.1%
281	Central Nervous System Fungal Infections	4.1%
282	Bacterial Vaginosis	4.1%
283	Human Ehrlichiosis	4%
284	Invasive Pulmonary Aspergillosis	3.9%
285	Toxoplasmosis, Cerebral	3.8%
286	Kearns-Sayre syndrome	3.8%
287	Sicca Syndrome	3.7%
288	Sjogren's Syndrome	3.7%
289	Japanese Spotted Fever	3.7%
290	Lung Diseases, Fungal	3.5%
291	Human anaplasmosis	3.4%
292	Pneumonia, Bacterial	3.4%
293	Actinomycetales Infections	3.4%
294	Bordetella Infections	3.4%
295	Brucellosis	3.4%
296	Campylobacter infection	3.4%
297	Clostridium Infections	3.4%
298	Enterobacteriaceae Infections	3.4%
299	Listeriosis	3.4%
300	Mucormycosis	3.4%
301	Pseudomonas Infections	3.4%
302	Q Fever	3.4%
303	Staphylococcal Infections	3.4%
304	Streptococcal Infections	3.4%
305	Vibrio Infections	3.4%
306	Helicobacter Infections	3.4%
307	Bacillaceae Infections	3.4%
308	Neisseriaceae Infections	3.4%
309	Burkholderia Infections	3.4%
310	Clostridium difficile infection	3.4%
311	Flavobacteriaceae Infections	3.4%
312	Moraxellaceae Infections	3.4%
313	Burkholderia cepacia Infection	3.4%
314	Ophthalmoplegic Migraine	3.3%
315	Meningitis, Cryptococcal	3.3%
316	Progressive supranuclear palsy	3.3%
317	Rocky Mountain Spotted Fever	3.1%
318	Neuromyelitis Optica	3%
319	Liver Abscess, Amebic	2.8%
320	Meningitis, Listeria	2.8%
321	Erysipelothrix infection	2.8%
322	Syphilis, Congenital	2.8%
323	Alstrom Syndrome	2.7%
324	Oral candidiasis	2.7%
325	Pulmonary Aspergillosis	2.7%
326	Bronchopulmonary Aspergillosis	2.7%
327	Behcet Syndrome	2.6%
328	Meningitis, Haemophilus	2.6%
329	Meningitis, Pneumococcal	2.6%
330	Acinetobacter Infections	2.5%
331	Actinomycosis	2.5%
332	Bacteroides Infections	2.5%
333	Cholera	2.5%
334	Corynebacterium Infections	2.5%
335	Escherichia coli Infections	2.5%
336	Gas Gangrene	2.5%
337	Haemophilus Infections	2.5%
338	Klebsiella Infections	2.5%
339	Meningococcal Infections	2.5%
340	Mycobacterium Infections	2.5%
341	Mycoplasma Infections	2.5%
342	Nocardia Infections	2.5%
343	Pasteurella Infections	2.5%
344	Pneumococcal Infections	2.5%
345	Proteus Infections	2.5%
346	Rickettsia Infections	2.5%
347	Salmonella infections	2.5%
348	Scarlet Fever	2.5%
349	Scrub Typhus	2.5%
350	Tetanus	2.5%
351	Serratia Infections	2.5%
352	Ureaplasma Infections	2.5%
353	Pulmonary Nocardiosis	2.5%
354	Optic Nerve Glioma	2.5%
355	Meningitis, Bacterial	2.2%
356	Meningitis, Fungal	2.2%
357	Candidiasis, Vulvovaginal	2.2%
358	Tuberculosis, Meningeal	2.1%
359	Diphtheria	2.1%
360	Leprosy	2.1%
361	Mycobacterium Infections, Nontuberculous	2.1%
362	Psittacosis	2.1%
363	Paratyphoid Fever	2.1%
364	Plague	2.1%
365	Tuberculosis	2.1%
366	Typhoid Fever	2.1%
367	TYPHUS	2.1%
368	Yersinia pseudotuberculosis Infections	2.1%
369	Bubonic Plague	2.1%
370	Mycobacterium abscessus Infection	2.1%
371	Mycobacterium avium-intracellulare Infection	1.9%
372	Lymph Node Tuberculosis	1.9%
373	Tuberculosis, Miliary	1.9%
374	Tuberculosis, Multidrug-Resistant	1.9%
375	Leprosy, Multibacillary	1.9%
376	Latent Tuberculosis	1.9%
377	Borderline leprosy	1.8%
378	Leprosy, Lepromatous	1.8%
379	Tuberculoid leprosy	1.8%
380	Extensively Drug-Resistant Tuberculosis	1.8%
381	Salmonella Infections, Animal	1.7%
382	Rheumatic Fever	1.7%
383	Rheumatic Heart Disease	1.7%
384	Salmonella food poisoning	1.7%
385	Enterocolitis, Pseudomembranous	1.7%
386	pseudomembranous colitis	1.7%
387	Dysentery, Bacillary	1.7%
388	Tuberculosis, Gastrointestinal	1.5%
389	Tuberculosis, Central Nervous System	1.5%
390	Botulism	1.4%
391	Waterhouse-Friderichsen Syndrome	1.3%
392	Tuberculosis, Pulmonary	1.3%
393	Aspergillosis, Allergic Bronchopulmonary	1.3%
394	Lemierre Syndrome	0.9%
395	Tuberculosis, Renal	0.9%

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