MetaADEDB 2.0 @ LMMD
Asthenopia
(UMLS:C0004095)
Definition:
Term generally used to describe complaints related to refractive error, ocular muscle imbalance, including pain or aching around the eyes, burning and itchiness of the eyelids, ocular fatigue, and headaches.
UMLS ID:
C0004095
MeSH ID:
D001248
Classification:
Name:
Eye Diseases
MeSH Tree Number(s):
C11.093
Synonym(s)
1.
Asthenopia
2.
ASTHENOPIA
3.
Accommodative asthenopia
4.
Accommodative strain
5.
Eye Strain
6.
Eye strain
7.
Eyestrain
8.
Simple eye strain
9.
Tired eyes
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1Fingolimod HydrochlorideFAERS: 62
Canada Vigilance: 5		Canada Vigilance
US FAERS
2RestasisFAERS: 49
Canada Vigilance: 1		Canada Vigilance
US FAERS
3LatanoprostFAERS: 32OFFSIDES
US FAERS
4BimatoprostFAERS: 31OFFSIDES
SIDER
US FAERS
5SertralineFAERS: 26US FAERS
6TeriparatideFAERS: 21US FAERS
7PregabalinFAERS: 18
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
8ThyroxineFAERS: 16US FAERS
9KetotifenFAERS: 15US FAERS
10NorgestrelFAERS: 15OFFSIDES
US FAERS
11Dimethyl FumarateFAERS: 14US FAERS
12lifitegrastFAERS: 13US FAERS
13LenalidomideFAERS: 11OFFSIDES
US FAERS
14VareniclineFAERS: 10
Canada Vigilance: 1		Canada Vigilance
US FAERS
15Sildenafil CitrateFAERS: 9SIDER
US FAERS
16LisinoprilFAERS: 8US FAERS
17MDV 3100FAERS: 8US FAERS
18Venlafaxine HydrochlorideFAERS: 8US FAERS
194-hydroxybutyric acidFAERS: 7US FAERS
20Duloxetine HydrochlorideFAERS: 7OFFSIDES
US FAERS
21Imatinib MesylateFAERS: 7US FAERS
22OctreotideFAERS: 7US FAERS
23TopiramateFAERS: 7OFFSIDES
US FAERS
24palbociclibFAERS: 7US FAERS
25GabapentinFAERS: 6US FAERS
26SertralineFAERS: 6US FAERS
27VemurafenibFAERS: 6US FAERS
28AripiprazoleFAERS: 5US FAERS
29Desvenlafaxine SuccinateFAERS: 5US FAERS
30Glatiramer AcetateFAERS: 5US FAERS
31LevofloxacinFAERS: 5US FAERS
32Solifenacin SuccinateFAERS: 5OFFSIDES
US FAERS
33TadalafilFAERS: 5US FAERS
34Tiotropium BromideFAERS: 5US FAERS
35Venlafaxine HydrochlorideFAERS: 5US FAERS
36ambrisentanFAERS: 5US FAERS
37apixabanFAERS: 5US FAERS
38telithromycinFAERS: 5OFFSIDES
US FAERS
39teriflunomideFAERS: 5US FAERS
404-AminopyridineFAERS: 4US FAERS
41Atomoxetine HydrochlorideFAERS: 4US FAERS
42AtorvastatinFAERS: 4US FAERS
43CetirizineFAERS: 4US FAERS
44CiprofloxacinFAERS: 4SIDER
US FAERS
45DiclofenacFAERS: 4US FAERS
46FentanylFAERS: 4US FAERS
47LCZ 696FAERS: 4US FAERS
48Loteprednol EtabonateFAERS: 4US FAERS
49Naphcon AFAERS: 4US FAERS
50NicotineFAERS: 4US FAERS
51ThyroxineFAERS: 4US FAERS
52TimololFAERS: 4
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
534-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamideFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
54Advil PMFAERS: 3US FAERS
55Brimonidine Tartrate, Timolol Maleate Drug CombinationFAERS: 3US FAERS
56DasatinibFAERS: 3US FAERS
57DichlorphenamideFAERS: 3US FAERS
58EverolimusFAERS: 3US FAERS
59Fluticasone-Salmeterol Drug CombinationFAERS: 3US FAERS
60LamotrigineFAERS: 3OFFSIDES
US FAERS
61LoratadineFAERS: 3US FAERS
62MoxifloxacinFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
63OmeprazoleFAERS: 3US FAERS
64ParoxetineFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
65Quetiapine FumarateFAERS: 3US FAERS
66Rosuvastatin CalciumFAERS: 3US FAERS
67TerbinafineFAERS: 3US FAERS
68TestosteroneFAERS: 3US FAERS
69TravoprostFAERS: 3OFFSIDES
SIDER
US FAERS
70Zoledronic AcidFAERS: 3US FAERS
71bupropion hydrochloride, naltrexone hydrochoride drug combinationFAERS: 3US FAERS
72tafluprostFAERS: 3US FAERS
73AdderallFAERS: 2US FAERS
74ArthrotecFAERS: 2US FAERS
75AtorvastatinFAERS: 2US FAERS
76AzithromycinFAERS: 2US FAERS
77Breo ElliptaFAERS: 2US FAERS
78BromocriptineFAERS: 2US FAERS
79BuprenorphineFAERS: 2US FAERS
80CitalopramFAERS: 2US FAERS
81ClopidogrelFAERS: 2US FAERS
82CrizotinibFAERS: 2US FAERS
83DroxidopaFAERS: 2US FAERS
84ExenatideFAERS: 2US FAERS
85FenofibrateFAERS: 2US FAERS
86FluticasoneFAERS: 2US FAERS
87IbuprofenFAERS: 2OFFSIDES
US FAERS
88LiraglutideFAERS: 2US FAERS
89Lisdexamfetamine DimesylateFAERS: 2US FAERS
90Loratadine and pseudoephedrine sulfateFAERS: 2US FAERS
91MethadoneFAERS: 2US FAERS
92MethylphenidateFAERS: 2US FAERS
93MetronidazoleFAERS: 2US FAERS
94ModafinilFAERS: 2US FAERS
95Mometasone FuroateFAERS: 2OFFSIDES
US FAERS
96NaphazolineFAERS: 2US FAERS
97NaproxenFAERS: 2US FAERS
98NiacinFAERS: 2US FAERS
99OlanzapineFAERS: 2US FAERS
100Olopatadine HydrochlorideFAERS: 2US FAERS
101Paliperidone PalmitateFAERS: 2US FAERS
102PantoprazoleFAERS: 2US FAERS
103Raloxifene HydrochlorideFAERS: 2US FAERS
104TacrolimusFAERS: 2US FAERS
105TimololFAERS: 2US FAERS
106Viekira PakFAERS: 2US FAERS
107VigabatrinFAERS: 2SIDER
US FAERS
108Vilazodone HydrochlorideFAERS: 2US FAERS
109VoriconazoleFAERS: 2US FAERS
110atovaquone, proguanil drug combinationFAERS: 2US FAERS
111diclofenac hydroxyethylpyrrolidineFAERS: 2US FAERS
112elbasvir-grazoprevir drug combinationFAERS: 2US FAERS
113fexofenadineFAERS: 2US FAERS
114ledipasvir, sofosbuvir drug combinationFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
115niraparibFAERS: 2US FAERS
116norgestimate, ethinyl estradiol drug combinationFAERS: 2US FAERS
117ponatinibFAERS: 2US FAERS
118regorafenibFAERS: 2US FAERS
119tofacitinibFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
120ziprasidoneFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
121AR-13324FAERS: 1US FAERS
122AcetaminophenFAERS: 1US FAERS
123AcyclovirFAERS: 1US FAERS
124Adzenys XR-ODTFAERS: 1US FAERS
125AlbuterolFAERS: 1US FAERS
126AlprazolamFAERS: 1US FAERS
127AmiodaroneFAERS: 1US FAERS
128AmlodipineFAERS: 1US FAERS
129Amoxicillin-Potassium Clavulanate CombinationFAERS: 1US FAERS
130AmphetamineFAERS: 1US FAERS
131AnastrozoleFAERS: 1US FAERS
132Anoro ElliptaFAERS: 1US FAERS
133ApomorphineFAERS: 1US FAERS
134Benicar hctFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
135BenztropineFAERS: 1US FAERS
136Brimonidine TartrateFAERS: 1US FAERS
137BudesonideFAERS: 1US FAERS
138CanagliflozinFAERS: 1US FAERS
139CitalopramFAERS: 1US FAERS
140CladribineFAERS: 1US FAERS
141ClonazepamFAERS: 1US FAERS
142DabigatranFAERS: 1US FAERS
143DapsoneFAERS: 1US FAERS
144DaptomycinFAERS: 1US FAERS
145Deamino Arginine VasopressinFAERS: 1US FAERS
146DeferasiroxFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
147DexlansoprazoleFAERS: 1US FAERS
148DigoxinFAERS: 1US FAERS
149DocetaxelFAERS: 1OFFSIDES
US FAERS
150DoxepinFAERS: 1OFFSIDES
US FAERS
151DoxycyclineFAERS: 1US FAERS
152Erlotinib HydrochlorideFAERS: 1US FAERS
153Ethylene GlycolFAERS: 1US FAERS
154FinasterideFAERS: 1US FAERS
155GefitinibFAERS: 1US FAERS
156GentamicinsFAERS: 1US FAERS
157HydralazineFAERS: 1US FAERS
158HydrocortisoneFAERS: 1US FAERS
159Ibandronic AcidFAERS: 1US FAERS
160Insulin DetemirFAERS: 1US FAERS
161Insulin GlargineFAERS: 1US FAERS
162IohexolFAERS: 1US FAERS
163IsotretinoinFAERS: 1US FAERS
164KetoconazoleFAERS: 1US FAERS
165LapatinibFAERS: 1US FAERS
166LorazepamFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
167Lurasidone HydrochlorideFAERS: 1US FAERS
168MefloquineFAERS: 1US FAERS
169MeloxicamFAERS: 1US FAERS
170MemantineFAERS: 1US FAERS
171MethotrexateFAERS: 1US FAERS
172MetoprololFAERS: 1US FAERS
173MirtazapineFAERS: 1US FAERS
174ModafinilFAERS: 1OFFSIDES
US FAERS
175MorphineFAERS: 1US FAERS
176NaltrexoneFAERS: 1US FAERS
177NaproxenFAERS: 1US FAERS
178NebivololFAERS: 1US FAERS
179Ortho EvraFAERS: 1US FAERS
180OxcarbazepineFAERS: 1US FAERS
181ParoxetineFAERS: 1US FAERS
182PemetrexedFAERS: 1US FAERS
183PromethazineFAERS: 1US FAERS
184PropranololFAERS: 1US FAERS
185Quetiapine FumarateFAERS: 1US FAERS
186RanolazineFAERS: 1US FAERS
187Ruxolitinib phosphateFAERS: 1US FAERS
188ScopolamineFAERS: 1US FAERS
189SimbrinzaFAERS: 1US FAERS
190Sitagliptin PhosphateFAERS: 1US FAERS
191SulfacetamideFAERS: 1US FAERS
192SulfasalazineFAERS: 1OFFSIDES
US FAERS
193SunitinibFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
194TamoxifenFAERS: 1US FAERS
195TetrabenazineFAERS: 1US FAERS
196TicagrelorFAERS: 1US FAERS
197Tolterodine TartrateFAERS: 1US FAERS
198TrazodoneFAERS: 1US FAERS
199TrazodoneFAERS: 1US FAERS
200Valproic AcidFAERS: 1US FAERS
201ValsartanFAERS: 1US FAERS
202Vardenafil DihydrochlorideFAERS: 1US FAERS
203VerteporfinFAERS: 1US FAERS
204Vortioxetine hydrobromideFAERS: 1US FAERS
205XulaneFAERS: 1US FAERS
206ZolpidemFAERS: 1US FAERS
207alcaftadineFAERS: 1US FAERS
208alfuzosinFAERS: 1US FAERS
209bromfenacFAERS: 1US FAERS
210cabozantinibFAERS: 1US FAERS
211carfilzomibFAERS: 1US FAERS
212cyclobenzaprineFAERS: 1US FAERS
213dabrafenibFAERS: 1US FAERS
214difluprednateFAERS: 1US FAERS
215dorzolamideFAERS: 1US FAERS
216gadobutrolFAERS: 1US FAERS
217macitentanFAERS: 1US FAERS
218montelukastFAERS: 1US FAERS
219nepafenacFAERS: 1OFFSIDES
US FAERS
220obeticholic acidFAERS: 1US FAERS
221osimertinibFAERS: 1US FAERS
222phendimetrazineFAERS: 1US FAERS
223pirfenidoneFAERS: 1US FAERS
224pomalidomideFAERS: 1US FAERS
225prednisolone phosphateFAERS: 1US FAERS
226rasagilineFAERS: 1US FAERS
227reviparinFAERS: 1US FAERS
228ropiniroleFAERS: 1US FAERS
229sibutramineFAERS: 1US FAERS
230sofosbuvir-velpatasvir drug combinationFAERS: 1US FAERS
231suvorexantFAERS: 1US FAERS
232tegaserodFAERS: 1US FAERS
233tizanidineFAERS: 1US FAERS
234tizanidineFAERS: 1US FAERS
235treprostinilFAERS: 1US FAERS
236Atomoxetine HydrochlorideOFFSIDES
237BetaxololSIDER
238BupivacaineOFFSIDES
239Butylscopolammonium BromideOFFSIDES
240CaffeineOFFSIDES
241CapecitabineOFFSIDES
242CarticaineOFFSIDES
243CimetidineOFFSIDES
244CitalopramSIDER
245DesogestrelOFFSIDES
246DiltiazemOFFSIDES
247DuotravCanada Vigilance: 1Canada Vigilance
248DutasterideOFFSIDES
249ErythromycinOFFSIDES
250FulvestrantOFFSIDES
251GlipizideOFFSIDES
252Hydron;carbonateOFFSIDES
253MagnesiumOFFSIDES
254MelatoninOFFSIDES
255Methylprednisolone AcetateOFFSIDES
256OctreotideCanada Vigilance: 2Canada Vigilance
257PamidronateOFFSIDES
258PropranololOFFSIDES
259PyrazinamideOFFSIDES
260PyridoxineOFFSIDES
261QuinidineOFFSIDES
262RibavirinOFFSIDES
263SulfateOFFSIDES
264TamsulosinOFFSIDES
265TerazosinOFFSIDES
266TolbutamideOFFSIDES
267TrihexyphenidylOFFSIDES
268TropicamideCanada Vigilance: 1Canada Vigilance
269VareniclineOFFSIDES
270ZolpidemSIDER
271azelastineOFFSIDES
272brinzolamideSIDER
273carbidopa, levodopa drug combinationOFFSIDES
274emedastineSIDER
275epalrestatOFFSIDES
276gadofosveset trisodiumSIDER
277gemcitabineOFFSIDES
278olmesartanOFFSIDES
279pegaptanibSIDER
280pitavastatinOFFSIDES
281torezolidSIDER
Similar ADE(s)
NameSemantic Similarity
1Conjunctival Diseases33.3%
2Corneal Diseases33.3%
3Eyelid Diseases33.3%
4Lacrimal Apparatus Diseases33.3%
5Lens Diseases33.3%
6Ocular Hypertension33.3%
7Ocular Hypotension33.3%
8Retinal Diseases33.3%
9Scleral Diseases33.3%
10Vitreous Detachment33.3%
11Posterior Vitreous Detachment33.3%
12Retinal Degeneration30%
13Xerophthalmia26.8%
14Low Tension Glaucoma26.8%
15Iridocorneal endothelial syndrome26.8%
16Keratoconjunctivitis Sicca24.1%
17Keratoconjunctivitis23.8%
18Chorioretinitis23.3%
19Angioid Streaks23.1%
20Anisometropia23.1%
21Aphakia23.1%
22Astigmatism23.1%
23Blepharitis23.1%
24Blepharoptosis23.1%
25Blepharospasm23.1%
26Choroid Diseases23.1%
27Conjunctivitis23.1%
28Corneal edema23.1%
29Corneal Opacity23.1%
30Dacryocystitis23.1%
31Dry Eye Syndromes23.1%
32Ectropion23.1%
33Enophthalmos23.1%
34Entropion23.1%
35Episcleritis23.1%
36Exophthalmos23.1%
37Glaucoma23.1%
38Iris Diseases23.1%
39Keratitis23.1%
40Keratoconus23.1%
41Lacrimal Duct Obstruction23.1%
42Lens dislocation23.1%
43Lens Subluxation23.1%
44Mydriasis23.1%
45Myopia23.1%
46Presbyopia23.1%
47Pterygium23.1%
48Retinal Detachment23.1%
49Retinitis23.1%
50Scleritis23.1%
51Uveitis23.1%
52Corneal Neovascularization23.1%
53Orbital Pseudotumor23.1%
54Cataract23.1%
55Pinguecula23.1%
56Trichiasis23.1%
57Pars Planitis22.3%
58Blepharophimosis21.8%
59Uveal Neoplasms21.8%
60Choroiditis21.6%
61Iridocyclitis21.6%
62Iritis21.6%
63Eyelid Neoplasms21.6%
64Retinal Hemorrhage21.6%
65Retinal Dysplasia21.4%
66Eye Abnormalities21.1%
67Eye Infection21.1%
68Eye Manifestations21.1%
69Eye Neoplasms21.1%
70Optic Neuropathy21.1%
71Aniridia20%
72Corneal Ulcer19.6%
73Choroid Hemorrhage19.5%
74Retinitis Pigmentosa18.6%
75Pigmentary retinopathy18.6%
76Angle Closure Glaucoma18.5%
77Glaucoma, Open-Angle18.5%
78Macular degeneration18.5%
79Panuveitis18.5%
80Retinal Drusen18.5%
81Retinal Necrosis Syndrome, Acute18.5%
82Retinoschisis18.5%
83Exfoliation Syndrome18.5%
84Duane Retraction Syndrome17.1%
85Corneal Scar16.8%
86Anterior uveitis16.4%
87Uveitis, Posterior16.4%
88Hordeolum15.4%
89Ocular Motility Disorders15.4%
90Cyclophoria15.4%
91Color blindness15.2%
92Pupil Disorders15.1%
93Eye Hemorrhage14.8%
94Vision Disorders14.7%
95Metamorphopsia14.7%
96Visual Impairment14.7%
97Anophthalmos14.6%
98Endophthalmitis14.6%
99Microphthalmos14.6%
100Optic Atrophy14.6%
101Optic Neuritis14.6%
102Papilledema14.6%
103Pemphigoid, Benign Mucous Membrane14.6%
104Retinal Artery Occlusion14.6%
105Retinopathy of Prematurity14.6%
106Strabismus14.6%
107Tolosa-Hunt Syndrome14.6%
108Orbital Cellulitis14.6%
109Retinal Vasculitis14.6%
110Hypertensive Retinopathy14.6%
111Retrobulbar Hemorrhage14.6%
112Corneal Endothelial Cell Loss14.6%
113Eye Injuries14.5%
114Hyphema14.5%
115Retinal Neovascularization14.5%
116Vitreous Hemorrhage14.5%
117Trachoma14.4%
118Acanthamoeba Keratitis14.1%
119Keratitis, Herpetic14%
120Cytomegalovirus Retinitis14%
121Bacterial conjunctivitis13.8%
122Corneal Perforation13.6%
123Retinoblastoma13.5%
124Esotropia11.8%
125Exotropia11.8%
126Choroidal Neovascularization11.8%
127Panophthalmitis11.2%
128Optic Neuropathy, Ischemic10.9%
129Anterior Ischemic Optic Neuropathy10.9%
130Retinal Vein Occlusion10.8%
131Anisocoria10.6%
132Diabetic Retinopathy10.6%
133Tonic Pupil10.6%
134Eye pain10.6%
135Orbital Myositis10.6%
136Diplopia10.5%
137Scotoma10.5%
138Photophobia10.5%
139Amaurosis10.5%
140Blindness10.5%
141Uveomeningoencephalitic Syndrome8.9%
142CHARGE Syndrome8.9%
143Congenital nystagmus8.8%
144Herpes Zoster Ophthalmicus8.8%
145Ophthalmia Neonatorum8.7%
146Hemianopsia8.6%
147Amaurosis Fugax8.5%
148Blindness, Cortical8.5%
149Ophthalmoplegia8.4%
150External Ophthalmoplegia8.4%
151Amblyopia8.3%
152Optic Atrophy, Hereditary, Leber7.9%
153Graves Disease7%
154Horner Syndrome6.9%
155Mandibulofacial Dysostosis6.8%
156Aicardi's syndrome6%
157Kearns-Sayre syndrome5.2%
158Opsoclonus-Myoclonus Syndrome5.1%
159Albinism5.1%
160Sicca Syndrome4.8%
161Sjogren's Syndrome4.8%
162Miller Fisher Syndrome4.5%
163Ophthalmoplegic Migraine4.3%
164Progressive supranuclear palsy4.2%
165Behcet Syndrome4.2%
166Neuromyelitis Optica3.7%
167Alstrom Syndrome3.3%
168Optic Nerve Glioma3%
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