MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Keratoconus

(UMLS:C0022578)

Definition:: A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)
UMLS ID:: C0022578
MeSH ID:: D007640

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.204.627

Synonym(s)

Keratoconus

Bulging cornea

Conical cornea

Cornea conical

KERATOCONUS

Keratoconus, NOS

Keratoconus, unspecified

conical cornea

conical; cornea

10.

cornea; conical

11.

keratoconus

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Isotretinoin	FAERS: 7 Canada Vigilance: 1	Canada Vigilance US FAERS
2	Methylphenidate	FAERS: 3	US FAERS
3	Colchicine	FAERS: 2	US FAERS
4	Dutasteride	FAERS: 2	US FAERS
5	Latanoprost	FAERS: 2	US FAERS
6	Quetiapine Fumarate	FAERS: 2	US FAERS
7	Tacrolimus	FAERS: 2	US FAERS
8	Valsartan	FAERS: 2	US FAERS
9	Acitretin	FAERS: 1	US FAERS
10	Amiodarone	FAERS: 1	US FAERS
11	Amiodarone	FAERS: 1	US FAERS
12	Chlorpromazine	FAERS: 1	US FAERS
13	Clonazepam	FAERS: 1	US FAERS
14	Crizotinib	FAERS: 1	US FAERS
15	Cyclosporine	FAERS: 1	US FAERS
16	Fluocinolone Acetonide	FAERS: 1	US FAERS
17	Glatiramer Acetate	FAERS: 1	US FAERS
18	Glycopyrrolate	FAERS: 1	US FAERS
19	Methylprednisolone	FAERS: 1	US FAERS
20	Olanzapine	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
21	Olopatadine Hydrochloride	FAERS: 1	US FAERS
22	Pregabalin	FAERS: 1	US FAERS
23	Quetiapine Fumarate	FAERS: 1	US FAERS
24	Citalopram		SIDER
25	Lamotrigine		OFFSIDES
26	Tretinoin		OFFSIDES
27	epinastine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Corneal edema	42.9%
2	Corneal Opacity	42.9%
3	Keratitis	42.9%
4	Corneal Neovascularization	42.9%
5	Iridocorneal endothelial syndrome	34.9%
6	Corneal Endothelial Cell Loss	27.9%
7	Keratoconjunctivitis	27.3%
8	Asthenopia	23.1%
9	Conjunctival Diseases	23.1%
10	Eyelid Diseases	23.1%
11	Lacrimal Apparatus Diseases	23.1%
12	Lens Diseases	23.1%
13	Ocular Hypertension	23.1%
14	Ocular Hypotension	23.1%
15	Retinal Diseases	23.1%
16	Scleral Diseases	23.1%
17	Vitreous Detachment	23.1%
18	Posterior Vitreous Detachment	23.1%
19	Corneal Ulcer	22.4%
20	Corneal Scar	21.8%
21	Keratoconjunctivitis Sicca	21.7%
22	Retinal Degeneration	19%
23	Acanthamoeba Keratitis	16.4%
24	Keratitis, Herpetic	16.3%
25	Xerophthalmia	16.3%
26	Low Tension Glaucoma	16.3%
27	Trachoma	16%
28	Corneal Perforation	15.8%
29	Eye Abnormalities	15%
30	Eye Infection	15%
31	Eye Manifestations	15%
32	Eye Neoplasms	15%
33	Optic Neuropathy	15%
34	Angioid Streaks	14.3%
35	Anisometropia	14.3%
36	Aphakia	14.3%
37	Astigmatism	14.3%
38	Blepharitis	14.3%
39	Blepharoptosis	14.3%
40	Blepharospasm	14.3%
41	Choroid Diseases	14.3%
42	Conjunctivitis	14.3%
43	Dacryocystitis	14.3%
44	Dry Eye Syndromes	14.3%
45	Ectropion	14.3%
46	Enophthalmos	14.3%
47	Entropion	14.3%
48	Episcleritis	14.3%
49	Exophthalmos	14.3%
50	Glaucoma	14.3%
51	Iris Diseases	14.3%
52	Lacrimal Duct Obstruction	14.3%
53	Lens dislocation	14.3%
54	Lens Subluxation	14.3%
55	Mydriasis	14.3%
56	Myopia	14.3%
57	Presbyopia	14.3%
58	Pterygium	14.3%
59	Retinal Detachment	14.3%
60	Retinitis	14.3%
61	Scleritis	14.3%
62	Uveitis	14.3%
63	Orbital Pseudotumor	14.3%
64	Cataract	14.3%
65	Pinguecula	14.3%
66	Trichiasis	14.3%
67	Blepharophimosis	14%
68	Uveal Neoplasms	14%
69	Retinal Dysplasia	14%
70	Eyelid Neoplasms	13.9%
71	Retinal Hemorrhage	13.9%
72	Aniridia	12.6%
73	Chorioretinitis	12.6%
74	Choroid Hemorrhage	12%
75	Choroiditis	11.7%
76	Iridocyclitis	11.7%
77	Iritis	11.7%
78	Pars Planitis	11.7%
79	Duane Retraction Syndrome	11.1%
80	Ocular Motility Disorders	11.1%
81	Retinitis Pigmentosa	11.1%
82	Cyclophoria	11.1%
83	Pigmentary retinopathy	11.1%
84	Pupil Disorders	10.9%
85	Eye Hemorrhage	10.7%
86	Vision Disorders	10.6%
87	Metamorphopsia	10.6%
88	Visual Impairment	10.6%
89	Eye Injuries	10.5%
90	Angle Closure Glaucoma	10.3%
91	Glaucoma, Open-Angle	10.3%
92	Macular degeneration	10.3%
93	Panuveitis	10.3%
94	Retinal Drusen	10.3%
95	Retinal Necrosis Syndrome, Acute	10.3%
96	Retinoschisis	10.3%
97	Exfoliation Syndrome	10.3%
98	Hordeolum	9.5%
99	Color blindness	9.4%
100	Anophthalmos	9.3%
101	Endophthalmitis	9.3%
102	Microphthalmos	9.3%
103	Optic Atrophy	9.3%
104	Optic Neuritis	9.3%
105	Papilledema	9.3%
106	Pemphigoid, Benign Mucous Membrane	9.3%
107	Retinal Artery Occlusion	9.3%
108	Retinopathy of Prematurity	9.3%
109	Strabismus	9.3%
110	Tolosa-Hunt Syndrome	9.3%
111	Orbital Cellulitis	9.3%
112	Retinal Vasculitis	9.3%
113	Hypertensive Retinopathy	9.3%
114	Retrobulbar Hemorrhage	9.3%
115	Hyphema	9.2%
116	Retinal Neovascularization	9.2%
117	Vitreous Hemorrhage	9.2%
118	Anterior uveitis	8.5%
119	Uveitis, Posterior	8.5%
120	Retinoblastoma	8.3%
121	Cytomegalovirus Retinitis	8.2%
122	Bacterial conjunctivitis	8.1%
123	Optic Neuropathy, Ischemic	7%
124	Anterior Ischemic Optic Neuropathy	7%
125	Retinal Vein Occlusion	6.9%
126	Anisocoria	6.8%
127	Diabetic Retinopathy	6.8%
128	Tonic Pupil	6.8%
129	Eye pain	6.8%
130	Orbital Myositis	6.8%
131	Diplopia	6.8%
132	Scotoma	6.8%
133	Photophobia	6.8%
134	Amaurosis	6.8%
135	Blindness	6.8%
136	Esotropia	6.7%
137	Exotropia	6.7%
138	Choroidal Neovascularization	6.7%
139	Panophthalmitis	6.1%
140	Ophthalmoplegia	5.4%
141	External Ophthalmoplegia	5.4%
142	Amblyopia	5.4%
143	Uveomeningoencephalitic Syndrome	5.2%
144	CHARGE Syndrome	5.2%
145	Congenital nystagmus	5.1%
146	Herpes Zoster Ophthalmicus	5.1%
147	Hemianopsia	5%
148	Amaurosis Fugax	4.9%
149	Blindness, Cortical	4.9%
150	Ophthalmia Neonatorum	4.7%
151	Optic Atrophy, Hereditary, Leber	4.5%
152	Graves Disease	4.1%
153	Horner Syndrome	4%
154	Mandibulofacial Dysostosis	3.9%
155	Aicardi's syndrome	3.9%
156	Opsoclonus-Myoclonus Syndrome	3.4%
157	Albinism	3.3%
158	Miller Fisher Syndrome	2.9%
159	Sicca Syndrome	2.8%
160	Sjogren's Syndrome	2.8%
161	Kearns-Sayre syndrome	2.8%
162	Ophthalmoplegic Migraine	2.5%
163	Progressive supranuclear palsy	2.5%
164	Neuromyelitis Optica	2.2%
165	Behcet Syndrome	2.2%
166	Alstrom Syndrome	2%
167	Optic Nerve Glioma	1.8%

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