MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Presbyopia

(UMLS:C0033075)

Definition:: The normal decreasing elasticity of the crystalline lens that leads to loss of accommodation.
UMLS ID:: C0033075
MeSH ID:: D011305

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.744.786

Synonym(s)

Presbyopia

PRESBYOPIA

presbyopia

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 13	US FAERS
2	Fingolimod Hydrochloride	FAERS: 12 Canada Vigilance: 1	Canada Vigilance US FAERS
3	Tadalafil	FAERS: 5	OFFSIDES US FAERS
4	Imatinib Mesylate	FAERS: 3	US FAERS
5	Atorvastatin	FAERS: 2	US FAERS
6	Moxifloxacin	FAERS: 2	US FAERS
7	Ondansetron	FAERS: 2	US FAERS
8	Rosuvastatin Calcium	FAERS: 2	US FAERS
9	4-hydroxybutyric acid	FAERS: 1	US FAERS
10	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
11	Amiodarone	FAERS: 1	US FAERS
12	Azithromycin	FAERS: 1	US FAERS
13	Choline fenofibrate	FAERS: 1	US FAERS
14	Crizotinib	FAERS: 1	US FAERS
15	Ganfort	FAERS: 1	US FAERS
16	Liraglutide	FAERS: 1	US FAERS
17	Paroxetine	FAERS: 1	US FAERS
18	Paroxetine	FAERS: 1	US FAERS
19	Pilocarpine	FAERS: 1	US FAERS
20	Quetiapine Fumarate	FAERS: 1	US FAERS
21	Restasis	FAERS: 1	US FAERS
22	Sertraline	FAERS: 1	US FAERS
23	Sotalol	FAERS: 1	US FAERS
24	Tamsulosin	FAERS: 1	US FAERS
25	Tamsulosin	FAERS: 1	US FAERS
26	Teriparatide	FAERS: 1	US FAERS
27	Tiotropium Bromide	FAERS: 1	US FAERS
28	niraparib	FAERS: 1	US FAERS
29	rofecoxib	FAERS: 1	OFFSIDES US FAERS
30	Acitretin		OFFSIDES
31	Ampicillin		OFFSIDES
32	Aripiprazole		OFFSIDES
33	Benztropine		OFFSIDES
34	Bimatoprost		OFFSIDES
35	Bromocriptine		OFFSIDES
36	Budesonide		OFFSIDES
37	Bupropion		OFFSIDES
38	Buspirone		OFFSIDES
39	Cefixime		OFFSIDES
40	Cefuroxime		OFFSIDES
41	Chlorhexidine		OFFSIDES
42	Chlorpromazine		OFFSIDES
43	Chlorthalidone		OFFSIDES
44	Chlorzoxazone		OFFSIDES
45	Clotrimazole		OFFSIDES
46	Codeine		OFFSIDES
47	Dapsone		OFFSIDES
48	Deferoxamine		OFFSIDES
49	Dextromethorphan		OFFSIDES
50	Dioctyl Sulfosuccinic Acid		OFFSIDES
51	Docusate sodium		OFFSIDES
52	Doxepin		OFFSIDES
53	Doxycycline		OFFSIDES
54	Erythromycin		OFFSIDES
55	Estrogens, Conjugated (USP)		OFFSIDES
56	Etodolac		OFFSIDES
57	Fenofibrate		OFFSIDES
58	Fluphenazine		OFFSIDES
59	Gabapentin		OFFSIDES
60	Glipizide		OFFSIDES
61	Ipratropium		OFFSIDES
62	Isosorbide		OFFSIDES
63	Lansoprazole		OFFSIDES
64	Lenalidomide		OFFSIDES
65	Lorazepam		OFFSIDES
66	Meclizine		OFFSIDES
67	Meperidine		OFFSIDES
68	Methocarbamol		OFFSIDES
69	Methylprednisolone Acetate		OFFSIDES
70	Methylprednisolone		OFFSIDES
71	Nabumetone		OFFSIDES
72	Nevirapine		OFFSIDES
73	Nisoldipine		OFFSIDES
74	Nitrofurantoin		OFFSIDES
75	Norgestrel		OFFSIDES
76	Oxaprozin		OFFSIDES
77	Oxazepam		OFFSIDES
78	Pamidronate		OFFSIDES
79	Penicillin V		OFFSIDES
80	Penicillins		OFFSIDES
81	Perphenazine		OFFSIDES
82	Piroxicam		OFFSIDES
83	Potassium		OFFSIDES
84	Pramipexole		OFFSIDES
85	Raloxifene Hydrochloride		OFFSIDES
86	Ramipril		OFFSIDES
87	Sitagliptin Phosphate		OFFSIDES
88	Sulfamethoxazole		OFFSIDES
89	Sulfasalazine		OFFSIDES
90	Sulindac		OFFSIDES
91	Tamoxifen		OFFSIDES
92	Terbutaline		OFFSIDES
93	Thalidomide		OFFSIDES
94	Thioridazine		OFFSIDES
95	Thiothixene		OFFSIDES
96	Timolol		OFFSIDES
97	Topiramate		SIDER
98	Travoprost		OFFSIDES
99	Trifluoperazine		OFFSIDES
100	Trimethoprim		OFFSIDES
101	Vinorelbine		OFFSIDES
102	Zoledronic Acid		OFFSIDES
103	benzonatate		OFFSIDES
104	carbidopa, levodopa drug combination		OFFSIDES
105	cefuroxime axetil		OFFSIDES
106	chlorhexidine gluconate		OFFSIDES
107	fludarabine		OFFSIDES
108	gemcitabine		OFFSIDES
109	metaxalone		OFFSIDES
110	moexipril		OFFSIDES
111	nefazodone		OFFSIDES
112	pimecrolimus		OFFSIDES
113	ramelteon		OFFSIDES
114	reviparin		OFFSIDES
115	ropinirole		OFFSIDES
116	sennoside A&B		OFFSIDES
117	telithromycin		OFFSIDES
118	valdecoxib		OFFSIDES
119	zaleplon		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Anisometropia	42.9%
2	Astigmatism	42.9%
3	Myopia	42.9%
4	Asthenopia	23.1%
5	Conjunctival Diseases	23.1%
6	Corneal Diseases	23.1%
7	Eyelid Diseases	23.1%
8	Lacrimal Apparatus Diseases	23.1%
9	Lens Diseases	23.1%
10	Ocular Hypertension	23.1%
11	Ocular Hypotension	23.1%
12	Retinal Diseases	23.1%
13	Scleral Diseases	23.1%
14	Vitreous Detachment	23.1%
15	Posterior Vitreous Detachment	23.1%
16	Retinal Degeneration	19%
17	Xerophthalmia	16.3%
18	Low Tension Glaucoma	16.3%
19	Iridocorneal endothelial syndrome	16.3%
20	Eye Abnormalities	15%
21	Eye Infection	15%
22	Eye Manifestations	15%
23	Eye Neoplasms	15%
24	Optic Neuropathy	15%
25	Angioid Streaks	14.3%
26	Aphakia	14.3%
27	Blepharitis	14.3%
28	Blepharoptosis	14.3%
29	Blepharospasm	14.3%
30	Choroid Diseases	14.3%
31	Conjunctivitis	14.3%
32	Corneal edema	14.3%
33	Corneal Opacity	14.3%
34	Dacryocystitis	14.3%
35	Dry Eye Syndromes	14.3%
36	Ectropion	14.3%
37	Enophthalmos	14.3%
38	Entropion	14.3%
39	Episcleritis	14.3%
40	Exophthalmos	14.3%
41	Glaucoma	14.3%
42	Iris Diseases	14.3%
43	Keratitis	14.3%
44	Keratoconus	14.3%
45	Lacrimal Duct Obstruction	14.3%
46	Lens dislocation	14.3%
47	Lens Subluxation	14.3%
48	Mydriasis	14.3%
49	Pterygium	14.3%
50	Retinal Detachment	14.3%
51	Retinitis	14.3%
52	Scleritis	14.3%
53	Uveitis	14.3%
54	Corneal Neovascularization	14.3%
55	Orbital Pseudotumor	14.3%
56	Cataract	14.3%
57	Pinguecula	14.3%
58	Trichiasis	14.3%
59	Blepharophimosis	14%
60	Uveal Neoplasms	14%
61	Retinal Dysplasia	14%
62	Eyelid Neoplasms	13.9%
63	Retinal Hemorrhage	13.9%
64	Keratoconjunctivitis	13.6%
65	Keratoconjunctivitis Sicca	13.3%
66	Aniridia	12.6%
67	Chorioretinitis	12.6%
68	Corneal Ulcer	12.1%
69	Choroid Hemorrhage	12%
70	Choroiditis	11.7%
71	Iridocyclitis	11.7%
72	Iritis	11.7%
73	Pars Planitis	11.7%
74	Duane Retraction Syndrome	11.1%
75	Ocular Motility Disorders	11.1%
76	Retinitis Pigmentosa	11.1%
77	Cyclophoria	11.1%
78	Pigmentary retinopathy	11.1%
79	Pupil Disorders	10.9%
80	Corneal Scar	10.9%
81	Eye Hemorrhage	10.7%
82	Vision Disorders	10.6%
83	Metamorphopsia	10.6%
84	Visual Impairment	10.6%
85	Eye Injuries	10.5%
86	Angle Closure Glaucoma	10.3%
87	Glaucoma, Open-Angle	10.3%
88	Macular degeneration	10.3%
89	Panuveitis	10.3%
90	Retinal Drusen	10.3%
91	Retinal Necrosis Syndrome, Acute	10.3%
92	Retinoschisis	10.3%
93	Exfoliation Syndrome	10.3%
94	Hordeolum	9.5%
95	Color blindness	9.4%
96	Anophthalmos	9.3%
97	Endophthalmitis	9.3%
98	Microphthalmos	9.3%
99	Optic Atrophy	9.3%
100	Optic Neuritis	9.3%
101	Papilledema	9.3%
102	Pemphigoid, Benign Mucous Membrane	9.3%
103	Retinal Artery Occlusion	9.3%
104	Retinopathy of Prematurity	9.3%
105	Strabismus	9.3%
106	Tolosa-Hunt Syndrome	9.3%
107	Orbital Cellulitis	9.3%
108	Retinal Vasculitis	9.3%
109	Hypertensive Retinopathy	9.3%
110	Retrobulbar Hemorrhage	9.3%
111	Corneal Endothelial Cell Loss	9.3%
112	Hyphema	9.2%
113	Retinal Neovascularization	9.2%
114	Vitreous Hemorrhage	9.2%
115	Trachoma	8.5%
116	Anterior uveitis	8.5%
117	Uveitis, Posterior	8.5%
118	Retinoblastoma	8.3%
119	Acanthamoeba Keratitis	8.2%
120	Keratitis, Herpetic	8.2%
121	Cytomegalovirus Retinitis	8.2%
122	Bacterial conjunctivitis	8.1%
123	Corneal Perforation	7.9%
124	Optic Neuropathy, Ischemic	7%
125	Anterior Ischemic Optic Neuropathy	7%
126	Retinal Vein Occlusion	6.9%
127	Anisocoria	6.8%
128	Diabetic Retinopathy	6.8%
129	Tonic Pupil	6.8%
130	Eye pain	6.8%
131	Orbital Myositis	6.8%
132	Diplopia	6.8%
133	Scotoma	6.8%
134	Photophobia	6.8%
135	Amaurosis	6.8%
136	Blindness	6.8%
137	Esotropia	6.7%
138	Exotropia	6.7%
139	Choroidal Neovascularization	6.7%
140	Panophthalmitis	6.1%
141	Ophthalmoplegia	5.4%
142	External Ophthalmoplegia	5.4%
143	Amblyopia	5.4%
144	Uveomeningoencephalitic Syndrome	5.2%
145	CHARGE Syndrome	5.2%
146	Congenital nystagmus	5.1%
147	Herpes Zoster Ophthalmicus	5.1%
148	Hemianopsia	5%
149	Amaurosis Fugax	4.9%
150	Blindness, Cortical	4.9%
151	Ophthalmia Neonatorum	4.7%
152	Optic Atrophy, Hereditary, Leber	4.5%
153	Graves Disease	4.1%
154	Horner Syndrome	4%
155	Mandibulofacial Dysostosis	3.9%
156	Aicardi's syndrome	3.9%
157	Opsoclonus-Myoclonus Syndrome	3.4%
158	Albinism	3.3%
159	Miller Fisher Syndrome	2.9%
160	Sicca Syndrome	2.8%
161	Sjogren's Syndrome	2.8%
162	Kearns-Sayre syndrome	2.8%
163	Ophthalmoplegic Migraine	2.5%
164	Progressive supranuclear palsy	2.5%
165	Neuromyelitis Optica	2.2%
166	Behcet Syndrome	2.2%
167	Alstrom Syndrome	2%
168	Optic Nerve Glioma	1.8%

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