MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Iridocorneal endothelial syndrome

(UMLS:C1096100)

Definition:: A grouping of three closely linked conditions: iris nevus (or Cogan-Reese) syndrome, Chandler Syndrome, and essential (progressive) iris atrophy. The most common features of this syndrome are the movement of endothelial cells off the cornea onto the iris leading to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil. The abnormal cell movement plugs fluid outflow channels of the eye causing GLAUCOMA.
UMLS ID:: C1096100
MeSH ID:: D057129

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.204.497|C11.941.375.322

Synonym(s)

Iridocorneal endothelial syndrome

Chandler's (PA) syndrome

ICE - Irido-corneo-endothelial syndrome

ICE - Iridocorneal endothelial syndrome

ICE syndrome - Iridio-corneo-endothelial syndrome

Irido-corneo-endothelial syndrome

Iridocorneal Endothelial Syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dronedarone	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Exfoliation Syndrome	38.6%
2	Iridocyclitis	38.5%
3	Iritis	38.5%
4	Corneal edema	34.9%
5	Corneal Opacity	34.9%
6	Keratitis	34.9%
7	Keratoconus	34.9%
8	Corneal Neovascularization	34.9%
9	Aniridia	30.4%
10	Choroid Diseases	30.2%
11	Uveitis	30.2%
12	Uveal Neoplasms	27.8%
13	Keratoconjunctivitis	27.1%
14	Asthenopia	26.8%
15	Conjunctival Diseases	26.8%
16	Eyelid Diseases	26.8%
17	Lacrimal Apparatus Diseases	26.8%
18	Lens Diseases	26.8%
19	Ocular Hypertension	26.8%
20	Ocular Hypotension	26.8%
21	Retinal Diseases	26.8%
22	Scleral Diseases	26.8%
23	Vitreous Detachment	26.8%
24	Posterior Vitreous Detachment	26.8%
25	Corneal Endothelial Cell Loss	25.9%
26	Pars Planitis	25.7%
27	Choroiditis	25.1%
28	Corneal Scar	24.9%
29	Corneal Ulcer	24.7%
30	Retinal Degeneration	24.6%
31	Keratoconjunctivitis Sicca	24%
32	Chorioretinitis	23.2%
33	Choroid Hemorrhage	21.8%
34	Retinal Dysplasia	20.8%
35	Xerophthalmia	20.7%
36	Low Tension Glaucoma	20.7%
37	Panuveitis	20.5%
38	Eye Abnormalities	20%
39	Eye Infection	20%
40	Eye Manifestations	20%
41	Eye Neoplasms	20%
42	Optic Neuropathy	20%
43	Blepharophimosis	19.4%
44	Eyelid Neoplasms	19.3%
45	Retinal Hemorrhage	19.3%
46	Trachoma	19%
47	Acanthamoeba Keratitis	18.2%
48	Keratitis, Herpetic	18.1%
49	Corneal Perforation	17.6%
50	Angioid Streaks	16.3%
51	Anisometropia	16.3%
52	Aphakia	16.3%
53	Astigmatism	16.3%
54	Blepharitis	16.3%
55	Blepharoptosis	16.3%
56	Blepharospasm	16.3%
57	Conjunctivitis	16.3%
58	Dacryocystitis	16.3%
59	Dry Eye Syndromes	16.3%
60	Ectropion	16.3%
61	Enophthalmos	16.3%
62	Entropion	16.3%
63	Episcleritis	16.3%
64	Exophthalmos	16.3%
65	Glaucoma	16.3%
66	Lacrimal Duct Obstruction	16.3%
67	Lens dislocation	16.3%
68	Lens Subluxation	16.3%
69	Mydriasis	16.3%
70	Myopia	16.3%
71	Presbyopia	16.3%
72	Pterygium	16.3%
73	Retinal Detachment	16.3%
74	Retinitis	16.3%
75	Scleritis	16.3%
76	Orbital Pseudotumor	16.3%
77	Cataract	16.3%
78	Pinguecula	16.3%
79	Trichiasis	16.3%
80	Duane Retraction Syndrome	16.1%
81	Ocular Motility Disorders	15.9%
82	Cyclophoria	15.9%
83	Anterior uveitis	15.7%
84	Uveitis, Posterior	15.7%
85	Pupil Disorders	15.7%
86	Eye Hemorrhage	15.5%
87	Vision Disorders	15.4%
88	Metamorphopsia	15.4%
89	Visual Impairment	15.4%
90	Eye Injuries	15.3%
91	Choroidal Neovascularization	15.1%
92	Retinitis Pigmentosa	15%
93	Pigmentary retinopathy	15%
94	Hordeolum	13.6%
95	Color blindness	13.4%
96	Retinoblastoma	12.5%
97	Uveomeningoencephalitic Syndrome	12.3%
98	Corneal Diseases	12.2%
99	Anophthalmos	12.1%
100	Endophthalmitis	12.1%
101	Microphthalmos	12.1%
102	Optic Atrophy	12.1%
103	Optic Neuritis	12.1%
104	Papilledema	12.1%
105	Pemphigoid, Benign Mucous Membrane	12.1%
106	Retinal Artery Occlusion	12.1%
107	Retinopathy of Prematurity	12.1%
108	Strabismus	12.1%
109	Tolosa-Hunt Syndrome	12.1%
110	Orbital Cellulitis	12.1%
111	Retinal Vasculitis	12.1%
112	Hypertensive Retinopathy	12.1%
113	Retrobulbar Hemorrhage	12.1%
114	Hyphema	12%
115	Retinal Neovascularization	12%
116	Vitreous Hemorrhage	12%
117	Angle Closure Glaucoma	11.4%
118	Glaucoma, Open-Angle	11.4%
119	Macular degeneration	11.4%
120	Retinal Drusen	11.4%
121	Retinal Necrosis Syndrome, Acute	11.4%
122	Retinoschisis	11.4%
123	Cytomegalovirus Retinitis	11.3%
124	Bacterial conjunctivitis	11.2%
125	Panophthalmitis	10.9%
126	Iridocorneal endothelial syndrome	10.3%
127	Optic Neuropathy, Ischemic	9.7%
128	Anterior Ischemic Optic Neuropathy	9.7%
129	Retinal Vein Occlusion	9.6%
130	Anisocoria	9.5%
131	Diabetic Retinopathy	9.5%
132	Tonic Pupil	9.5%
133	Eye pain	9.5%
134	Orbital Myositis	9.5%
135	Diplopia	9.4%
136	Scotoma	9.4%
137	Photophobia	9.4%
138	Amaurosis	9.4%
139	Blindness	9.4%
140	Iris Diseases	9.3%
141	Esotropia	8.4%
142	Exotropia	8.4%
143	Ophthalmoplegia	7.9%
144	External Ophthalmoplegia	7.9%
145	Amblyopia	7.8%
146	CHARGE Syndrome	6.8%
147	Congenital nystagmus	6.8%
148	Herpes Zoster Ophthalmicus	6.8%
149	Hemianopsia	6.6%
150	Ophthalmia Neonatorum	6.6%
151	Amaurosis Fugax	6.6%
152	Blindness, Cortical	6.6%
153	Optic Atrophy, Hereditary, Leber	6.6%
154	Aicardi's syndrome	6%
155	Graves Disease	5.7%
156	Horner Syndrome	5.6%
157	Mandibulofacial Dysostosis	5.5%
158	Opsoclonus-Myoclonus Syndrome	5.2%
159	Albinism	5.2%
160	Behcet Syndrome	5%
161	Miller Fisher Syndrome	4.6%
162	Sicca Syndrome	4.1%
163	Sjogren's Syndrome	4.1%
164	Kearns-Sayre syndrome	4.1%
165	Ophthalmoplegic Migraine	3.7%
166	Progressive supranuclear palsy	3.7%
167	Neuromyelitis Optica	3.3%
168	Alstrom Syndrome	3%
169	Optic Nerve Glioma	2.7%

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