MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Retinal Degeneration

(UMLS:C0035304)

Definition:: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
UMLS ID:: C0035304
MeSH ID:: D012162

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.270.612|C11.768.585

Synonym(s)

Retinal Degeneration

Degeneration Of Retina

Degeneration of retina

Degeneration of retina, NOS

RETINA DEGENERATION

RETINAL DEGENERATION

Retina degeneration

Retina, Degeneration Of

Retinal degeneration

10.

Retinal degeneration, NOS

11.

degeneration retina

12.

degeneration retinal

13.

degeneration; retina

14.

retina degeneration

15.

retina; degeneration

16.

retinal degeneration

17.

retinal degenerations

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Verteporfin	FAERS: 19		US FAERS
2	Fingolimod Hydrochloride	FAERS: 13 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Hydroxychloroquine	FAERS: 13		US FAERS
4	Arthrotec	FAERS: 9		US FAERS
5	Diclofenac	FAERS: 6		US FAERS
6	Melphalan	FAERS: 6		US FAERS
7	Anastrozole	FAERS: 5		OFFSIDES US FAERS
8	Didanosine	FAERS: 5		SIDER US FAERS
9	Isotretinoin	FAERS: 5		US FAERS
10	Omeprazole	FAERS: 5		US FAERS
11	Triamcinolone Acetonide	FAERS: 5		US FAERS
12	Triamcinolone	FAERS: 5		US FAERS
13	ezogabine	FAERS: 5		US FAERS
14	Quinine	FAERS: 4		US FAERS
15	Sildenafil Citrate	FAERS: 4		US FAERS
16	Alendronate	FAERS: 3		US FAERS
17	Aripiprazole	FAERS: 3		US FAERS
18	Deferoxamine	FAERS: 3	6739047	CTD OFFSIDES SIDER US FAERS
19	Rosiglitazone	FAERS: 3		US FAERS
20	Terbinafine	FAERS: 3		OFFSIDES US FAERS
21	Topiramate	FAERS: 3		US FAERS
22	Vigabatrin	FAERS: 3 Canada Vigilance: 2	15329067	CTD SIDER Canada Vigilance US FAERS
23	Clozapine	FAERS: 2		OFFSIDES US FAERS
24	Dexamethasone	FAERS: 2		US FAERS
25	Erlotinib Hydrochloride	FAERS: 2		US FAERS
26	Fluocinolone Acetonide	FAERS: 2		US FAERS
27	Hydroxychloroquine	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
28	Imatinib Mesylate	FAERS: 2		US FAERS
29	Indocyanine Green	FAERS: 2		US FAERS
30	Lenalidomide	FAERS: 2		US FAERS
31	Letrozole	FAERS: 2		US FAERS
32	NuvaRing	FAERS: 2		US FAERS
33	Paclitaxel	FAERS: 2		US FAERS
34	Quinine	FAERS: 2		US FAERS
35	Risperidone	FAERS: 2		US FAERS
36	Sirolimus	FAERS: 2		US FAERS
37	Tamoxifen	FAERS: 2		US FAERS
38	Teriparatide	FAERS: 2		US FAERS
39	chloroquine diphosphate	FAERS: 2		US FAERS
40	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
41	Avalide	FAERS: 1		US FAERS
42	Carbamazepine	FAERS: 1		US FAERS
43	Cefuroxime	FAERS: 1		US FAERS
44	Cinacalcet	FAERS: 1		US FAERS
45	Deferasirox	FAERS: 1		US FAERS
46	Dimethyl Fumarate	FAERS: 1		US FAERS
47	Esomeprazole	FAERS: 1		US FAERS
48	Finasteride	FAERS: 1		US FAERS
49	Gabapentin	FAERS: 1		SIDER US FAERS
50	Leuprolide	FAERS: 1		US FAERS
51	Methylprednisolone Acetate	FAERS: 1		US FAERS
52	Metoprolol	FAERS: 1		US FAERS
53	Mitomycin	FAERS: 1		US FAERS
54	Mycophenolic Acid	FAERS: 1		US FAERS
55	Quetiapine Fumarate	FAERS: 1		US FAERS
56	Raloxifene Hydrochloride	FAERS: 1		US FAERS
57	Sorafenib	FAERS: 1		US FAERS
58	Timolol	FAERS: 1		US FAERS
59	Tiotropium Bromide	FAERS: 1		US FAERS
60	Travoprost	FAERS: 1		US FAERS
61	Zidovudine	FAERS: 1		US FAERS
62	atovaquone, proguanil drug combination	FAERS: 1		US FAERS
63	brinzolamide	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
64	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
65	dorzolamide	FAERS: 1		US FAERS
66	exemestane	FAERS: 1		US FAERS
67	fexofenadine	FAERS: 1		US FAERS
68	ixazomib	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
69	patiromer	FAERS: 1		US FAERS
70	teriflunomide	FAERS: 1		US FAERS
71	4,4'-diaminodiphenylmethane		3692021	CTD
72	9-cis-retinal		17003450	CTD
73	Chloroquine			OFFSIDES
74	Cyclophosphamide			OFFSIDES
75	Doxepin			OFFSIDES
76	Edaravone		28703795	CTD
77	Fenretinide		16303925	CTD
78	Formoterol Fumarate			OFFSIDES
79	GNE-617		25505128	CTD
80	Gemfibrozil			OFFSIDES
81	Ipratropium			OFFSIDES
82	Lansoprazole			SIDER
83	Lisinopril			OFFSIDES
84	Maneb		15901622	CTD
85	Methylene Blue		19384599	CTD
86	Methylnitrosourea		18155124 18172121	CTD
87	Niacin		8593127	CTD
88	Ofloxacin		18715887	CTD
89	Paraquat		16458197 24586289	CTD
90	Polylysine			OFFSIDES
91	Pregabalin			SIDER
92	Rabeprazole			SIDER
93	Retinaldehyde		25331497	CTD
94	Ribavirin			OFFSIDES
95	Rotenone		19384599	CTD
96	Salmeterol Xinafoate			OFFSIDES
97	Streptozocin		12592403	CTD
98	Tamoxifen			OFFSIDES
99	Thioridazine		8780438	CTD
100	Tretinoin			OFFSIDES
101	Vincristine		813350 1497023	CTD
102	Ziram		15901622	CTD
103	benphothiamine		12592403	CTD
104	efavirenz			OFFSIDES
105	fosamprenavir			OFFSIDES
106	levocabastine			OFFSIDES
107	mancozeb		15901622	CTD
108	nefazodone			OFFSIDES
109	prednisolone acetate			OFFSIDES
110	rasagiline			SIDER
111	tauroursodeoxycholic acid		17213800	CTD
112	tegaserod			OFFSIDES
113	zafirlukast			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Retinal Dysplasia	40%
2	Angioid Streaks	38.1%
3	Retinal Detachment	38.1%
4	Retinitis	38.1%
5	Retinal Hemorrhage	33.6%
6	Asthenopia	30%
7	Conjunctival Diseases	30%
8	Corneal Diseases	30%
9	Eyelid Diseases	30%
10	Lacrimal Apparatus Diseases	30%
11	Lens Diseases	30%
12	Ocular Hypertension	30%
13	Ocular Hypotension	30%
14	Scleral Diseases	30%
15	Vitreous Detachment	30%
16	Posterior Vitreous Detachment	30%
17	Aniridia	29.7%
18	Chorioretinitis	28.6%
19	Retinal Artery Occlusion	28.1%
20	Retinopathy of Prematurity	28.1%
21	Retinal Vasculitis	28.1%
22	Hypertensive Retinopathy	28.1%
23	Duane Retraction Syndrome	27.9%
24	Retinal Necrosis Syndrome, Acute	27.9%
25	Retinal Neovascularization	27.8%
26	Retinitis Pigmentosa	25.5%
27	Pigmentary retinopathy	25.5%
28	Retinoblastoma	25.3%
29	Xerophthalmia	24.6%
30	Low Tension Glaucoma	24.6%
31	Iridocorneal endothelial syndrome	24.6%
32	Color blindness	22.7%
33	Blepharophimosis	22.5%
34	Uveal Neoplasms	22.5%
35	Eyelid Neoplasms	22.4%
36	Retinal Vein Occlusion	22.3%
37	Eye Abnormalities	22.2%
38	Eye Infection	22.2%
39	Eye Manifestations	22.2%
40	Eye Neoplasms	22.2%
41	Optic Neuropathy	22.2%
42	Diabetic Retinopathy	22.1%
43	Keratoconjunctivitis Sicca	21.6%
44	Keratoconjunctivitis	20.7%
45	Cytomegalovirus Retinitis	20.6%
46	Corneal Ulcer	19.4%
47	Choroid Hemorrhage	19.3%
48	Anisometropia	19%
49	Aphakia	19%
50	Astigmatism	19%
51	Blepharitis	19%
52	Blepharoptosis	19%
53	Blepharospasm	19%
54	Choroid Diseases	19%
55	Conjunctivitis	19%
56	Corneal edema	19%
57	Corneal Opacity	19%
58	Dacryocystitis	19%
59	Dry Eye Syndromes	19%
60	Ectropion	19%
61	Enophthalmos	19%
62	Entropion	19%
63	Episcleritis	19%
64	Exophthalmos	19%
65	Glaucoma	19%
66	Iris Diseases	19%
67	Keratitis	19%
68	Keratoconus	19%
69	Lacrimal Duct Obstruction	19%
70	Lens dislocation	19%
71	Lens Subluxation	19%
72	Mydriasis	19%
73	Myopia	19%
74	Presbyopia	19%
75	Pterygium	19%
76	Scleritis	19%
77	Uveitis	19%
78	Corneal Neovascularization	19%
79	Orbital Pseudotumor	19%
80	Cataract	19%
81	Pinguecula	19%
82	Trichiasis	19%
83	Pars Planitis	19%
84	Corneal Scar	18.3%
85	Choroiditis	17.9%
86	Iridocyclitis	17.9%
87	Iritis	17.9%
88	Ocular Motility Disorders	17.6%
89	Cyclophoria	17.6%
90	Pupil Disorders	17.4%
91	Eye Hemorrhage	17.1%
92	Vision Disorders	17%
93	Metamorphopsia	17%
94	Visual Impairment	17%
95	Eye Injuries	16.9%
96	CHARGE Syndrome	16.7%
97	Hordeolum	16%
98	Retinal Diseases	15%
99	Trachoma	15%
100	Retinal Degeneration	14.3%
101	Anophthalmos	14%
102	Endophthalmitis	14%
103	Microphthalmos	14%
104	Optic Atrophy	14%
105	Optic Neuritis	14%
106	Papilledema	14%
107	Pemphigoid, Benign Mucous Membrane	14%
108	Strabismus	14%
109	Tolosa-Hunt Syndrome	14%
110	Orbital Cellulitis	14%
111	Retrobulbar Hemorrhage	14%
112	Corneal Endothelial Cell Loss	14%
113	Angle Closure Glaucoma	14%
114	Glaucoma, Open-Angle	14%
115	Panuveitis	14%
116	Exfoliation Syndrome	14%
117	Hyphema	13.9%
118	Vitreous Hemorrhage	13.9%
119	Acanthamoeba Keratitis	13.8%
120	Aicardi's syndrome	13.7%
121	Keratitis, Herpetic	13.7%
122	Bacterial conjunctivitis	13.6%
123	Corneal Perforation	13.4%
124	Mandibulofacial Dysostosis	13.3%
125	Optic Atrophy, Hereditary, Leber	12.5%
126	Albinism	12%
127	Anterior uveitis	11.5%
128	Uveitis, Posterior	11.5%
129	Optic Neuropathy, Ischemic	11.3%
130	Anterior Ischemic Optic Neuropathy	11.3%
131	Anisocoria	11%
132	Tonic Pupil	11%
133	Eye pain	11%
134	Orbital Myositis	11%
135	Panophthalmitis	10.9%
136	Diplopia	10.9%
137	Scotoma	10.9%
138	Photophobia	10.9%
139	Amaurosis	10.9%
140	Blindness	10.9%
141	Esotropia	10.3%
142	Exotropia	10.3%
143	Choroidal Neovascularization	10.3%
144	Ophthalmoplegia	9.1%
145	External Ophthalmoplegia	9.1%
146	Amblyopia	9.1%
147	Ophthalmia Neonatorum	8.3%
148	Uveomeningoencephalitic Syndrome	8.3%
149	Congenital nystagmus	8.3%
150	Herpes Zoster Ophthalmicus	8.2%
151	Hemianopsia	8.1%
152	Amaurosis Fugax	8%
153	Blindness, Cortical	8%
154	Alstrom Syndrome	7.2%
155	Macular degeneration	7%
156	Retinal Drusen	7%
157	Retinoschisis	7%
158	Graves Disease	6.9%
159	Horner Syndrome	6.8%
160	Opsoclonus-Myoclonus Syndrome	6%
161	Miller Fisher Syndrome	5.3%
162	Sicca Syndrome	5%
163	Sjogren's Syndrome	5%
164	Ophthalmoplegic Migraine	4.5%
165	Progressive supranuclear palsy	4.4%
166	Neuromyelitis Optica	4%
167	Kearns-Sayre syndrome	3.9%
168	Behcet Syndrome	3.8%
169	Optic Nerve Glioma	3.3%

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