MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Exfoliation Syndrome

(UMLS:C0206368)

Definition:: The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)
UMLS ID:: C0206368
MeSH ID:: D017889

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.941.375.285

Synonym(s)

Exfoliation Syndrome

Capsular exfoliation syndrome

EXFOLIATION SYNDROME

Exfoliation Glaucoma

Exfoliation glaucoma

Exfoliation syndrome

GLAUCOMA CAPSULARE

Glaucoma capsulare

Pseudoexfoliation glaucoma

10.

Pseudoexfoliation syndrome

11.

Secondary open-angle glaucoma with pseudoexfoliation

12.

capsular; glaucoma

13.

exfoliation syndrome

14.

glaucoma; capsular

15.

lens-induced open-angle glaucoma with pseudoexfoliation

16.

pseudo exfoliation syndrome

17.

pseudoexfoliation glaucoma

18.

pseudoexfoliation syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	brinzolamide	FAERS: 2		US FAERS
2	Alprazolam	FAERS: 1		US FAERS
3	Diltiazem	FAERS: 1		US FAERS
4	Restasis	FAERS: 1		US FAERS
5	Folic Acid		16504073	CTD
6	Homocysteine		16504073	CTD
7	Latanoprost		15002024	CTD
8	Pilocarpine		3321877	CTD
9	Timolol		3321877 15002024	CTD
10	dipivefrin		6639507	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Iridocyclitis	38.8%
2	Iritis	38.8%
3	Iridocorneal endothelial syndrome	38.6%
4	Choroid Diseases	31%
5	Uveitis	31%
6	Aniridia	22.7%
7	Choroiditis	21.3%
8	Uveal Neoplasms	20.7%
9	Panuveitis	20%
10	Pars Planitis	20%
11	Asthenopia	18.5%
12	Conjunctival Diseases	18.5%
13	Corneal Diseases	18.5%
14	Eyelid Diseases	18.5%
15	Lacrimal Apparatus Diseases	18.5%
16	Lens Diseases	18.5%
17	Ocular Hypertension	18.5%
18	Ocular Hypotension	18.5%
19	Retinal Diseases	18.5%
20	Scleral Diseases	18.5%
21	Vitreous Detachment	18.5%
22	Posterior Vitreous Detachment	18.5%
23	Chorioretinitis	16.1%
24	Choroid Hemorrhage	15.1%
25	Anterior uveitis	14.8%
26	Uveitis, Posterior	14.8%
27	Retinal Degeneration	14%
28	Choroidal Neovascularization	13.2%
29	Eye Abnormalities	12.2%
30	Eye Infection	12.2%
31	Eye Manifestations	12.2%
32	Eye Neoplasms	12.2%
33	Optic Neuropathy	12.2%
34	Xerophthalmia	11.4%
35	Low Tension Glaucoma	11.4%
36	Angioid Streaks	10.3%
37	Anisometropia	10.3%
38	Aphakia	10.3%
39	Astigmatism	10.3%
40	Blepharitis	10.3%
41	Blepharophimosis	10.3%
42	Blepharoptosis	10.3%
43	Blepharospasm	10.3%
44	Conjunctivitis	10.3%
45	Corneal edema	10.3%
46	Corneal Opacity	10.3%
47	Dacryocystitis	10.3%
48	Dry Eye Syndromes	10.3%
49	Ectropion	10.3%
50	Enophthalmos	10.3%
51	Entropion	10.3%
52	Episcleritis	10.3%
53	Exophthalmos	10.3%
54	Glaucoma	10.3%
55	Keratitis	10.3%
56	Keratoconus	10.3%
57	Lacrimal Duct Obstruction	10.3%
58	Lens dislocation	10.3%
59	Lens Subluxation	10.3%
60	Mydriasis	10.3%
61	Myopia	10.3%
62	Presbyopia	10.3%
63	Pterygium	10.3%
64	Retinal Detachment	10.3%
65	Retinal Dysplasia	10.3%
66	Retinitis	10.3%
67	Scleritis	10.3%
68	Corneal Neovascularization	10.3%
69	Orbital Pseudotumor	10.3%
70	Cataract	10.3%
71	Pinguecula	10.3%
72	Trichiasis	10.3%
73	Eyelid Neoplasms	10.3%
74	Retinal Hemorrhage	10.3%
75	Uveomeningoencephalitic Syndrome	10.2%
76	Ocular Motility Disorders	9.1%
77	Cyclophoria	9.1%
78	Pupil Disorders	8.9%
79	Keratoconjunctivitis	8.9%
80	Eye Hemorrhage	8.8%
81	Vision Disorders	8.7%
82	Metamorphopsia	8.7%
83	Visual Impairment	8.7%
84	Eye Injuries	8.6%
85	Corneal Ulcer	8.5%
86	Duane Retraction Syndrome	8.2%
87	Keratoconjunctivitis Sicca	8.2%
88	Corneal Scar	8.1%
89	Retinitis Pigmentosa	7.6%
90	Pigmentary retinopathy	7.6%
91	Anophthalmos	6.8%
92	Endophthalmitis	6.8%
93	Microphthalmos	6.8%
94	Optic Atrophy	6.8%
95	Optic Neuritis	6.8%
96	Papilledema	6.8%
97	Pemphigoid, Benign Mucous Membrane	6.8%
98	Retinal Artery Occlusion	6.8%
99	Retinopathy of Prematurity	6.8%
100	Strabismus	6.8%
101	Tolosa-Hunt Syndrome	6.8%
102	Orbital Cellulitis	6.8%
103	Retinal Vasculitis	6.8%
104	Hypertensive Retinopathy	6.8%
105	Retrobulbar Hemorrhage	6.8%
106	Corneal Endothelial Cell Loss	6.8%
107	Hyphema	6.7%
108	Retinal Neovascularization	6.7%
109	Vitreous Hemorrhage	6.7%
110	Hordeolum	6.7%
111	Angle Closure Glaucoma	6.7%
112	Glaucoma, Open-Angle	6.7%
113	Macular degeneration	6.7%
114	Retinal Drusen	6.7%
115	Retinal Necrosis Syndrome, Acute	6.7%
116	Retinoschisis	6.7%
117	Color blindness	6.6%
118	Panophthalmitis	6%
119	Retinoblastoma	5.8%
120	Trachoma	5.6%
121	Acanthamoeba Keratitis	5.4%
122	Keratitis, Herpetic	5.4%
123	Cytomegalovirus Retinitis	5.4%
124	Bacterial conjunctivitis	5.3%
125	Corneal Perforation	5.2%
126	Optic Neuropathy, Ischemic	5.2%
127	Anterior Ischemic Optic Neuropathy	5.2%
128	Retinal Vein Occlusion	5.1%
129	Anisocoria	5%
130	Diabetic Retinopathy	5%
131	Tonic Pupil	5%
132	Eye pain	5%
133	Orbital Myositis	5%
134	Diplopia	5%
135	Scotoma	5%
136	Photophobia	5%
137	Amaurosis	5%
138	Blindness	5%
139	Esotropia	4.4%
140	Exotropia	4.4%
141	Ophthalmoplegia	4%
142	External Ophthalmoplegia	4%
143	Amblyopia	4%
144	Behcet Syndrome	3.6%
145	CHARGE Syndrome	3.4%
146	Congenital nystagmus	3.4%
147	Herpes Zoster Ophthalmicus	3.3%
148	Hemianopsia	3.3%
149	Amaurosis Fugax	3.2%
150	Blindness, Cortical	3.2%
151	Aicardi's syndrome	2.9%
152	Optic Atrophy, Hereditary, Leber	2.9%
153	Ophthalmia Neonatorum	2.8%
154	Graves Disease	2.7%
155	Horner Syndrome	2.7%
156	Mandibulofacial Dysostosis	2.6%
157	Opsoclonus-Myoclonus Syndrome	2.5%
158	Albinism	2.5%
159	Miller Fisher Syndrome	2.2%
160	Sicca Syndrome	1.9%
161	Sjogren's Syndrome	1.9%
162	Ophthalmoplegic Migraine	1.7%
163	Progressive supranuclear palsy	1.6%
164	Kearns-Sayre syndrome	1.6%
165	Neuromyelitis Optica	1.5%
166	Alstrom Syndrome	1.3%
167	Optic Nerve Glioma	1.2%

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