MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Scleritis

(UMLS:C0036416)

Definition:: Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
UMLS ID:: C0036416
MeSH ID:: D015423

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.790.500

Synonym(s)

Scleritis

Inflammation of sclera

Inflammation of white of eye

SCLERITIS

Scleritis, NOS

Scleritis, unspecified

scleritis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Zoledronic Acid	FAERS: 30 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
2	Fingolimod Hydrochloride	FAERS: 6		US FAERS
3	Prednisone	FAERS: 6	12427239	CTD US FAERS
4	Latanoprost	FAERS: 5		US FAERS
5	Mitomycin	FAERS: 5		US FAERS
6	Triamcinolone Acetonide	FAERS: 5		US FAERS
7	Ibandronic Acid	FAERS: 4		US FAERS
8	Lamotrigine	FAERS: 4		US FAERS
9	Norgestrel	FAERS: 4		US FAERS
10	Isotretinoin	FAERS: 3		US FAERS
11	Lenalidomide	FAERS: 3		US FAERS
12	Methotrexate	FAERS: 3		US FAERS
13	Prednisolone	FAERS: 3		US FAERS
14	Rosuvastatin Calcium	FAERS: 3		US FAERS
15	Topiramate	FAERS: 3		US FAERS
16	tofacitinib	FAERS: 3		US FAERS
17	Alendronate	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
18	Dimethyl Fumarate	FAERS: 2		US FAERS
19	Eplerenone	FAERS: 2		US FAERS
20	Glatiramer Acetate	FAERS: 2		US FAERS
21	Levofloxacin	FAERS: 2		US FAERS
22	Mycophenolic Acid	FAERS: 2		US FAERS
23	Phenytoin	FAERS: 2		US FAERS
24	Tacrolimus	FAERS: 2		US FAERS
25	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 2		US FAERS
26	Voriconazole	FAERS: 2		SIDER US FAERS
27	Adzenys XR-ODT	FAERS: 1		US FAERS
28	Alendronate	FAERS: 1		US FAERS
29	Azithromycin	FAERS: 1		US FAERS
30	Cabergoline	FAERS: 1		US FAERS
31	Duloxetine Hydrochloride	FAERS: 1		US FAERS
32	Epinephrine	FAERS: 1		US FAERS
33	Fluocinolone Acetonide	FAERS: 1		US FAERS
34	Fluticasone	FAERS: 1		US FAERS
35	Hydroxychloroquine	FAERS: 1		US FAERS
36	Imiquimod	FAERS: 1		US FAERS
37	Leflunomide	FAERS: 1		OFFSIDES US FAERS
38	Methotrexate	FAERS: 1 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
39	Omeprazole	FAERS: 1		US FAERS
40	Pamidronate	FAERS: 1		US FAERS
41	Pamidronate	FAERS: 1		SIDER US FAERS
42	Restasis	FAERS: 1		US FAERS
43	Risedronic Acid	FAERS: 1		SIDER US FAERS
44	Sorafenib	FAERS: 1		US FAERS
45	Sulfasalazine	FAERS: 1		US FAERS
46	Thyroxine	FAERS: 1		US FAERS
47	Triamcinolone	FAERS: 1		US FAERS
48	Varenicline	FAERS: 1		US FAERS
49	Vemurafenib	FAERS: 1		US FAERS
50	apremilast	FAERS: 1		US FAERS
51	carfilzomib	FAERS: 1		US FAERS
52	dexamethasone 21-phosphate	FAERS: 1		US FAERS
53	nepafenac	FAERS: 1		OFFSIDES US FAERS
54	rofecoxib	FAERS: 1		US FAERS
55	Azathioprine			OFFSIDES
56	Chlorpromazine	Canada Vigilance: 1		Canada Vigilance
57	Cimetidine		6294351	CTD
58	Clomipramine			SIDER
59	Fluoxetine			SIDER
60	Flurbiprofen			OFFSIDES SIDER
61	Ibandronic Acid			OFFSIDES SIDER
62	Ibuprofen	Canada Vigilance: 1		Canada Vigilance
63	Ipratropium			OFFSIDES
64	Methamphetamine		19384581	CTD
65	Naproxen			SIDER
66	Prednisone acetate			OFFSIDES
67	Pregabalin			SIDER
68	Propylthiouracil		9181282	CTD
69	Ribavirin			OFFSIDES
70	Risedronic Acid	Canada Vigilance: 4		Canada Vigilance
71	Sevelamer			OFFSIDES
72	Terbinafine			OFFSIDES
73	Timolol			OFFSIDES
74	Triamterene			OFFSIDES
75	Venlafaxine Hydrochloride			SIDER
76	Zolpidem			SIDER
77	cevimeline			SIDER
78	gadoversetamide			OFFSIDES
79	lornoxicam			OFFSIDES
80	prednisolone acetate			OFFSIDES
81	zaleplon			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Asthenopia	23.1%
2	Conjunctival Diseases	23.1%
3	Corneal Diseases	23.1%
4	Eyelid Diseases	23.1%
5	Lacrimal Apparatus Diseases	23.1%
6	Lens Diseases	23.1%
7	Ocular Hypertension	23.1%
8	Ocular Hypotension	23.1%
9	Retinal Diseases	23.1%
10	Vitreous Detachment	23.1%
11	Posterior Vitreous Detachment	23.1%
12	Retinal Degeneration	19%
13	Xerophthalmia	16.3%
14	Low Tension Glaucoma	16.3%
15	Iridocorneal endothelial syndrome	16.3%
16	Eye Abnormalities	15%
17	Eye Infection	15%
18	Eye Manifestations	15%
19	Eye Neoplasms	15%
20	Optic Neuropathy	15%
21	Angioid Streaks	14.3%
22	Anisometropia	14.3%
23	Aphakia	14.3%
24	Astigmatism	14.3%
25	Blepharitis	14.3%
26	Blepharoptosis	14.3%
27	Blepharospasm	14.3%
28	Choroid Diseases	14.3%
29	Conjunctivitis	14.3%
30	Corneal edema	14.3%
31	Corneal Opacity	14.3%
32	Dacryocystitis	14.3%
33	Dry Eye Syndromes	14.3%
34	Ectropion	14.3%
35	Enophthalmos	14.3%
36	Entropion	14.3%
37	Exophthalmos	14.3%
38	Glaucoma	14.3%
39	Iris Diseases	14.3%
40	Keratitis	14.3%
41	Keratoconus	14.3%
42	Lacrimal Duct Obstruction	14.3%
43	Lens dislocation	14.3%
44	Lens Subluxation	14.3%
45	Mydriasis	14.3%
46	Myopia	14.3%
47	Presbyopia	14.3%
48	Pterygium	14.3%
49	Retinal Detachment	14.3%
50	Retinitis	14.3%
51	Uveitis	14.3%
52	Corneal Neovascularization	14.3%
53	Orbital Pseudotumor	14.3%
54	Cataract	14.3%
55	Pinguecula	14.3%
56	Trichiasis	14.3%
57	Blepharophimosis	14%
58	Uveal Neoplasms	14%
59	Retinal Dysplasia	14%
60	Eyelid Neoplasms	13.9%
61	Retinal Hemorrhage	13.9%
62	Keratoconjunctivitis	13.6%
63	Keratoconjunctivitis Sicca	13.3%
64	Aniridia	12.6%
65	Chorioretinitis	12.6%
66	Corneal Ulcer	12.1%
67	Choroid Hemorrhage	12%
68	Choroiditis	11.7%
69	Iridocyclitis	11.7%
70	Iritis	11.7%
71	Pars Planitis	11.7%
72	Duane Retraction Syndrome	11.1%
73	Ocular Motility Disorders	11.1%
74	Retinitis Pigmentosa	11.1%
75	Cyclophoria	11.1%
76	Pigmentary retinopathy	11.1%
77	Pupil Disorders	10.9%
78	Corneal Scar	10.9%
79	Eye Hemorrhage	10.7%
80	Vision Disorders	10.6%
81	Metamorphopsia	10.6%
82	Visual Impairment	10.6%
83	Eye Injuries	10.5%
84	Angle Closure Glaucoma	10.3%
85	Glaucoma, Open-Angle	10.3%
86	Macular degeneration	10.3%
87	Panuveitis	10.3%
88	Retinal Drusen	10.3%
89	Retinal Necrosis Syndrome, Acute	10.3%
90	Retinoschisis	10.3%
91	Exfoliation Syndrome	10.3%
92	Hordeolum	9.5%
93	Color blindness	9.4%
94	Anophthalmos	9.3%
95	Endophthalmitis	9.3%
96	Microphthalmos	9.3%
97	Optic Atrophy	9.3%
98	Optic Neuritis	9.3%
99	Papilledema	9.3%
100	Pemphigoid, Benign Mucous Membrane	9.3%
101	Retinal Artery Occlusion	9.3%
102	Retinopathy of Prematurity	9.3%
103	Strabismus	9.3%
104	Tolosa-Hunt Syndrome	9.3%
105	Orbital Cellulitis	9.3%
106	Retinal Vasculitis	9.3%
107	Hypertensive Retinopathy	9.3%
108	Retrobulbar Hemorrhage	9.3%
109	Corneal Endothelial Cell Loss	9.3%
110	Hyphema	9.2%
111	Retinal Neovascularization	9.2%
112	Vitreous Hemorrhage	9.2%
113	Trachoma	8.5%
114	Anterior uveitis	8.5%
115	Uveitis, Posterior	8.5%
116	Retinoblastoma	8.3%
117	Acanthamoeba Keratitis	8.2%
118	Keratitis, Herpetic	8.2%
119	Cytomegalovirus Retinitis	8.2%
120	Bacterial conjunctivitis	8.1%
121	Corneal Perforation	7.9%
122	Optic Neuropathy, Ischemic	7%
123	Anterior Ischemic Optic Neuropathy	7%
124	Retinal Vein Occlusion	6.9%
125	Anisocoria	6.8%
126	Diabetic Retinopathy	6.8%
127	Tonic Pupil	6.8%
128	Eye pain	6.8%
129	Orbital Myositis	6.8%
130	Diplopia	6.8%
131	Scotoma	6.8%
132	Photophobia	6.8%
133	Amaurosis	6.8%
134	Blindness	6.8%
135	Esotropia	6.7%
136	Exotropia	6.7%
137	Choroidal Neovascularization	6.7%
138	Panophthalmitis	6.1%
139	Ophthalmoplegia	5.4%
140	External Ophthalmoplegia	5.4%
141	Amblyopia	5.4%
142	Uveomeningoencephalitic Syndrome	5.2%
143	CHARGE Syndrome	5.2%
144	Congenital nystagmus	5.1%
145	Herpes Zoster Ophthalmicus	5.1%
146	Hemianopsia	5%
147	Amaurosis Fugax	4.9%
148	Blindness, Cortical	4.9%
149	Ophthalmia Neonatorum	4.7%
150	Optic Atrophy, Hereditary, Leber	4.5%
151	Graves Disease	4.1%
152	Horner Syndrome	4%
153	Mandibulofacial Dysostosis	3.9%
154	Aicardi's syndrome	3.9%
155	Opsoclonus-Myoclonus Syndrome	3.4%
156	Albinism	3.3%
157	Miller Fisher Syndrome	2.9%
158	Sicca Syndrome	2.8%
159	Sjogren's Syndrome	2.8%
160	Kearns-Sayre syndrome	2.8%
161	Ophthalmoplegic Migraine	2.5%
162	Progressive supranuclear palsy	2.5%
163	Neuromyelitis Optica	2.2%
164	Behcet Syndrome	2.2%
165	Alstrom Syndrome	2%
166	Optic Nerve Glioma	1.8%

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