MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Corneal Opacity

(UMLS:C0010038)

Definition:: Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.
UMLS ID:: C0010038
MeSH ID:: D003318

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.204.299

Synonym(s)

Corneal Opacity

CORNEAL OPACITY

CORNEAL OPACITY DISORDER

Corneal Haze

Corneal haze

Corneal opacities

Corneal opacity

Corneal opacity, NOS

Corneal opacity, unspecified

10.

Corneal subepithelial haze

11.

Leukoma

12.

Reduction of corneal clarity

13.

cornea opacity

14.

cornea; opacity

15.

corneal clouding

16.

corneal haze

17.

corneal opacities

18.

corneal opacity

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cefuroxime	FAERS: 23		US FAERS
2	Lamotrigine	FAERS: 13		US FAERS
3	Acetylcholine	FAERS: 12		US FAERS
4	Ciprofloxacin	FAERS: 12		SIDER US FAERS
5	Amiodarone	FAERS: 10		US FAERS
6	Dexamethasone	FAERS: 9		US FAERS
7	nepafenac	FAERS: 9		SIDER US FAERS
8	Carbamazepine	FAERS: 8		US FAERS
9	proxymetacaine	FAERS: 7 Canada Vigilance: 1		Canada Vigilance US FAERS
10	AR-13324	FAERS: 6		US FAERS
11	Cefuroxime	FAERS: 6		US FAERS
12	Latanoprost	FAERS: 6		US FAERS
13	besifloxacin	FAERS: 5		US FAERS
14	Acyclovir	FAERS: 4		US FAERS
15	Allopurinol	FAERS: 4		US FAERS
16	Alcohols	FAERS: 3		US FAERS
17	Bimatoprost	FAERS: 3		US FAERS
18	Bortezomib	FAERS: 3		US FAERS
19	Methotrexate	FAERS: 3		US FAERS
20	Mitomycin	FAERS: 3	16805119	CTD US FAERS
21	Omidria	FAERS: 3		US FAERS
22	Phenytoin	FAERS: 3		US FAERS
23	Povidone-Iodine	FAERS: 3		US FAERS
24	Topiramate	FAERS: 3		US FAERS
25	bromfenac	FAERS: 3		US FAERS
26	Amiodarone	FAERS: 2		US FAERS
27	Azithromycin	FAERS: 2		US FAERS
28	Ciloxan	FAERS: 2		US FAERS
29	Fluorouracil	FAERS: 2		US FAERS
30	Gatifloxacin	FAERS: 2		SIDER US FAERS
31	Isotretinoin	FAERS: 2	2931989	CTD US FAERS
32	Lidoderm	FAERS: 2		US FAERS
33	Tamoxifen	FAERS: 2		US FAERS
34	Timolol	FAERS: 2		US FAERS
35	proxymetacaine	FAERS: 2		US FAERS
36	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 1		US FAERS
37	Amlodipine	FAERS: 1		US FAERS
38	Carbachol	FAERS: 1		SIDER US FAERS
39	Cefixime	FAERS: 1		US FAERS
40	Chlorpromazine	FAERS: 1		US FAERS
41	Ciprodex	FAERS: 1		US FAERS
42	Cytarabine	FAERS: 1		US FAERS
43	Dasatinib	FAERS: 1		US FAERS
44	Dimethyl Fumarate	FAERS: 1		US FAERS
45	Dronedarone	FAERS: 1		US FAERS
46	Erlotinib Hydrochloride	FAERS: 1		US FAERS
47	Fentanyl	FAERS: 1		US FAERS
48	Hydroxyurea	FAERS: 1		US FAERS
49	Imatinib Mesylate	FAERS: 1		US FAERS
50	Imiquimod	FAERS: 1		US FAERS
51	Loteprednol Etabonate	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
52	Nifedipine	FAERS: 1		US FAERS
53	Oxaprozin	FAERS: 1		US FAERS
54	Pemetrexed	FAERS: 1		US FAERS
55	Prednisolone	FAERS: 1		US FAERS
56	Restasis	FAERS: 1		US FAERS
57	Tadalafil	FAERS: 1		US FAERS
58	Tamsulosin	FAERS: 1		US FAERS
59	Tiotropium Bromide	FAERS: 1		US FAERS
60	Tobramycin	FAERS: 1		US FAERS
61	Travoprost	FAERS: 1		US FAERS
62	Trifluridine	FAERS: 1		US FAERS
63	Vortioxetine	FAERS: 1		US FAERS
64	Warfarin	FAERS: 1		US FAERS
65	Zoledronic Acid	FAERS: 1		US FAERS
66	betamethasone sodium phosphate	FAERS: 1		US FAERS
67	captopril, hydrochlorothiazide drug combination	FAERS: 1		US FAERS
68	chlorhexidine gluconate	FAERS: 1		US FAERS
69	difluprednate	FAERS: 1		US FAERS
70	dorzolamide	FAERS: 1		US FAERS
71	lifitegrast	FAERS: 1		US FAERS
72	nitisinone	FAERS: 1		US FAERS
73	prednisolone acetate	FAERS: 1		US FAERS
74	prednisolone phosphate	FAERS: 1		US FAERS
75	tafluprost	FAERS: 1		US FAERS
76	telaprevir	FAERS: 1		US FAERS
77	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	Canada Vigilance: 1		Canada Vigilance
78	Acetylcholine			SIDER
79	Alendronate	Canada Vigilance: 1		Canada Vigilance
80	Amantadine			SIDER
81	Atorvastatin	Canada Vigilance: 1		Canada Vigilance
82	Chloroquine			SIDER
83	Cidofovir			SIDER
84	Clarithromycin			SIDER
85	Deferoxamine			SIDER
86	Diclofenac			SIDER
87	Fluoxetine	Canada Vigilance: 1		Canada Vigilance
88	Fluphenazine			SIDER
89	Flurbiprofen			SIDER
90	Memantine			SIDER
91	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine			SIDER
92	Naproxen			SIDER
93	Natamycin			SIDER
94	Prednisone	Canada Vigilance: 1		Canada Vigilance
95	Pregabalin	Canada Vigilance: 1		Canada Vigilance SIDER
96	Rabeprazole			SIDER
97	Toremifene			SIDER
98	Unoprostone			SIDER
99	Voriconazole			SIDER
100	cevimeline			SIDER
101	chloroquine diphosphate	Canada Vigilance: 1		Canada Vigilance
102	salmon calcitonin	Canada Vigilance: 1		Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Corneal edema	42.9%
2	Keratitis	42.9%
3	Keratoconus	42.9%
4	Corneal Neovascularization	42.9%
5	Iridocorneal endothelial syndrome	34.9%
6	Corneal Endothelial Cell Loss	27.9%
7	Keratoconjunctivitis	27.3%
8	Asthenopia	23.1%
9	Conjunctival Diseases	23.1%
10	Eyelid Diseases	23.1%
11	Lacrimal Apparatus Diseases	23.1%
12	Lens Diseases	23.1%
13	Ocular Hypertension	23.1%
14	Ocular Hypotension	23.1%
15	Retinal Diseases	23.1%
16	Scleral Diseases	23.1%
17	Vitreous Detachment	23.1%
18	Posterior Vitreous Detachment	23.1%
19	Corneal Ulcer	22.4%
20	Corneal Scar	21.8%
21	Keratoconjunctivitis Sicca	21.7%
22	Retinal Degeneration	19%
23	Acanthamoeba Keratitis	16.4%
24	Keratitis, Herpetic	16.3%
25	Xerophthalmia	16.3%
26	Low Tension Glaucoma	16.3%
27	Trachoma	16%
28	Corneal Perforation	15.8%
29	Eye Abnormalities	15%
30	Eye Infection	15%
31	Eye Manifestations	15%
32	Eye Neoplasms	15%
33	Optic Neuropathy	15%
34	Angioid Streaks	14.3%
35	Anisometropia	14.3%
36	Aphakia	14.3%
37	Astigmatism	14.3%
38	Blepharitis	14.3%
39	Blepharoptosis	14.3%
40	Blepharospasm	14.3%
41	Choroid Diseases	14.3%
42	Conjunctivitis	14.3%
43	Dacryocystitis	14.3%
44	Dry Eye Syndromes	14.3%
45	Ectropion	14.3%
46	Enophthalmos	14.3%
47	Entropion	14.3%
48	Episcleritis	14.3%
49	Exophthalmos	14.3%
50	Glaucoma	14.3%
51	Iris Diseases	14.3%
52	Lacrimal Duct Obstruction	14.3%
53	Lens dislocation	14.3%
54	Lens Subluxation	14.3%
55	Mydriasis	14.3%
56	Myopia	14.3%
57	Presbyopia	14.3%
58	Pterygium	14.3%
59	Retinal Detachment	14.3%
60	Retinitis	14.3%
61	Scleritis	14.3%
62	Uveitis	14.3%
63	Orbital Pseudotumor	14.3%
64	Cataract	14.3%
65	Pinguecula	14.3%
66	Trichiasis	14.3%
67	Blepharophimosis	14%
68	Uveal Neoplasms	14%
69	Retinal Dysplasia	14%
70	Eyelid Neoplasms	13.9%
71	Retinal Hemorrhage	13.9%
72	Aniridia	12.6%
73	Chorioretinitis	12.6%
74	Choroid Hemorrhage	12%
75	Choroiditis	11.7%
76	Iridocyclitis	11.7%
77	Iritis	11.7%
78	Pars Planitis	11.7%
79	Duane Retraction Syndrome	11.1%
80	Ocular Motility Disorders	11.1%
81	Retinitis Pigmentosa	11.1%
82	Cyclophoria	11.1%
83	Pigmentary retinopathy	11.1%
84	Pupil Disorders	10.9%
85	Eye Hemorrhage	10.7%
86	Vision Disorders	10.6%
87	Metamorphopsia	10.6%
88	Visual Impairment	10.6%
89	Eye Injuries	10.5%
90	Angle Closure Glaucoma	10.3%
91	Glaucoma, Open-Angle	10.3%
92	Macular degeneration	10.3%
93	Panuveitis	10.3%
94	Retinal Drusen	10.3%
95	Retinal Necrosis Syndrome, Acute	10.3%
96	Retinoschisis	10.3%
97	Exfoliation Syndrome	10.3%
98	Hordeolum	9.5%
99	Color blindness	9.4%
100	Anophthalmos	9.3%
101	Endophthalmitis	9.3%
102	Microphthalmos	9.3%
103	Optic Atrophy	9.3%
104	Optic Neuritis	9.3%
105	Papilledema	9.3%
106	Pemphigoid, Benign Mucous Membrane	9.3%
107	Retinal Artery Occlusion	9.3%
108	Retinopathy of Prematurity	9.3%
109	Strabismus	9.3%
110	Tolosa-Hunt Syndrome	9.3%
111	Orbital Cellulitis	9.3%
112	Retinal Vasculitis	9.3%
113	Hypertensive Retinopathy	9.3%
114	Retrobulbar Hemorrhage	9.3%
115	Hyphema	9.2%
116	Retinal Neovascularization	9.2%
117	Vitreous Hemorrhage	9.2%
118	Anterior uveitis	8.5%
119	Uveitis, Posterior	8.5%
120	Retinoblastoma	8.3%
121	Cytomegalovirus Retinitis	8.2%
122	Bacterial conjunctivitis	8.1%
123	Optic Neuropathy, Ischemic	7%
124	Anterior Ischemic Optic Neuropathy	7%
125	Retinal Vein Occlusion	6.9%
126	Anisocoria	6.8%
127	Diabetic Retinopathy	6.8%
128	Tonic Pupil	6.8%
129	Eye pain	6.8%
130	Orbital Myositis	6.8%
131	Diplopia	6.8%
132	Scotoma	6.8%
133	Photophobia	6.8%
134	Amaurosis	6.8%
135	Blindness	6.8%
136	Esotropia	6.7%
137	Exotropia	6.7%
138	Choroidal Neovascularization	6.7%
139	Panophthalmitis	6.1%
140	Ophthalmoplegia	5.4%
141	External Ophthalmoplegia	5.4%
142	Amblyopia	5.4%
143	Uveomeningoencephalitic Syndrome	5.2%
144	CHARGE Syndrome	5.2%
145	Congenital nystagmus	5.1%
146	Herpes Zoster Ophthalmicus	5.1%
147	Hemianopsia	5%
148	Amaurosis Fugax	4.9%
149	Blindness, Cortical	4.9%
150	Ophthalmia Neonatorum	4.7%
151	Optic Atrophy, Hereditary, Leber	4.5%
152	Graves Disease	4.1%
153	Horner Syndrome	4%
154	Mandibulofacial Dysostosis	3.9%
155	Aicardi's syndrome	3.9%
156	Opsoclonus-Myoclonus Syndrome	3.4%
157	Albinism	3.3%
158	Miller Fisher Syndrome	2.9%
159	Sicca Syndrome	2.8%
160	Sjogren's Syndrome	2.8%
161	Kearns-Sayre syndrome	2.8%
162	Ophthalmoplegic Migraine	2.5%
163	Progressive supranuclear palsy	2.5%
164	Neuromyelitis Optica	2.2%
165	Behcet Syndrome	2.2%
166	Alstrom Syndrome	2%
167	Optic Nerve Glioma	1.8%

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