MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Astigmatism

(UMLS:C0004106)

Definition:: Unequal curvature of the refractive surfaces of the eye. Thus a point source of light cannot be brought to a point focus on the retina but is spread over a more or less diffuse area. This results from the radius of curvature in one plane being longer or shorter than the radius at right angles to it. (Dorland, 27th ed)
UMLS ID:: C0004106
MeSH ID:: D001251

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.744.212

Synonym(s)

Astigmatism

ASTIGMATISM

Abnormal curving of the cornea or lens of the eye

Astigmatism, NOS

Astigmatism, unspecified

astigmatism

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Valproic Acid	FAERS: 77	11986102	CTD US FAERS
2	Valproic Acid	FAERS: 18		US FAERS
3	Alendronate	FAERS: 12		OFFSIDES US FAERS
4	Ondansetron	FAERS: 11		US FAERS
5	Fingolimod Hydrochloride	FAERS: 9		US FAERS
6	Isotretinoin	FAERS: 7		US FAERS
7	Sertraline	FAERS: 7		US FAERS
8	Methadone	FAERS: 6		US FAERS
9	Topiramate	FAERS: 6		US FAERS
10	Insulin Glargine	FAERS: 4		US FAERS
11	NuvaRing	FAERS: 4		US FAERS
12	Paroxetine	FAERS: 4		US FAERS
13	Carbamazepine	FAERS: 3		US FAERS
14	Latanoprost	FAERS: 3		US FAERS
15	Norgestrel	FAERS: 3		US FAERS
16	Pregabalin	FAERS: 3		OFFSIDES US FAERS
17	Tadalafil	FAERS: 3		US FAERS
18	Valsartan	FAERS: 3		US FAERS
19	Amiodarone	FAERS: 2		US FAERS
20	Diclofenac	FAERS: 2		US FAERS
21	Dimethyl Fumarate	FAERS: 2		US FAERS
22	Fexofenadine hydrochloride and pseudoephedrine hydrochloride	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
23	Ibandronic Acid	FAERS: 2		US FAERS
24	Lenalidomide	FAERS: 2		US FAERS
25	Methadone	FAERS: 2		US FAERS
26	Methylphenidate	FAERS: 2		US FAERS
27	Mitomycin	FAERS: 2		US FAERS
28	Norethindrone acetate and ethinyl estradiol	FAERS: 2		US FAERS
29	Valproic Acid	FAERS: 2		US FAERS
30	Vigabatrin	FAERS: 2		US FAERS
31	rimexolone	FAERS: 2		US FAERS
32	ziprasidone	FAERS: 2		US FAERS
33	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
34	Acetylcholine	FAERS: 1		US FAERS
35	Albuterol	FAERS: 1		US FAERS
36	Amantadine	FAERS: 1		US FAERS
37	Amiodarone	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
38	Aripiprazole	FAERS: 1		US FAERS
39	Azithromycin	FAERS: 1		US FAERS
40	Canagliflozin	FAERS: 1		US FAERS
41	Capecitabine	FAERS: 1		US FAERS
42	Celecoxib	FAERS: 1		US FAERS
43	Cilostazol	FAERS: 1		US FAERS
44	Ciprofloxacin	FAERS: 1		US FAERS
45	Clonazepam	FAERS: 1		US FAERS
46	Clopidogrel	FAERS: 1		US FAERS
47	Diovan Hct	FAERS: 1		US FAERS
48	Ergocalciferols	FAERS: 1		US FAERS
49	Febuxostat	FAERS: 1		US FAERS
50	Fluoxetine	FAERS: 1		US FAERS
51	Fluvoxamine	FAERS: 1		US FAERS
52	Gabapentin	FAERS: 1		OFFSIDES US FAERS
53	Gatifloxacin	FAERS: 1		US FAERS
54	Iloprost	FAERS: 1		US FAERS
55	Ivabradine	FAERS: 1		US FAERS
56	Lamotrigine	FAERS: 1		US FAERS
57	Minocycline	FAERS: 1		US FAERS
58	Mycophenolic Acid	FAERS: 1		US FAERS
59	Olanzapine	FAERS: 1		US FAERS
60	Olopatadine Hydrochloride	FAERS: 1		US FAERS
61	Omeprazole	FAERS: 1		US FAERS
62	Oseltamivir	FAERS: 1		US FAERS
63	Qsymia	FAERS: 1		US FAERS
64	Raloxifene Hydrochloride	FAERS: 1		US FAERS
65	Restasis	FAERS: 1		US FAERS
66	Sildenafil Citrate	FAERS: 1		US FAERS
67	Sulfamethoxazole	FAERS: 1		OFFSIDES US FAERS
68	Tamsulosin	FAERS: 1		US FAERS
69	Timolol	FAERS: 1		US FAERS
70	Tiotropium Bromide	FAERS: 1		US FAERS
71	Vardenafil Dihydrochloride	FAERS: 1		US FAERS
72	Verteporfin	FAERS: 1		US FAERS
73	Zanamivir	FAERS: 1		OFFSIDES US FAERS
74	apixaban	FAERS: 1		US FAERS
75	dorzolamide	FAERS: 1		US FAERS
76	ivacaftor	FAERS: 1		US FAERS
77	lumacaftor, ivacaftor drug combination	FAERS: 1		US FAERS
78	nepafenac	FAERS: 1		US FAERS
79	obeticholic acid	FAERS: 1		US FAERS
80	rofecoxib	FAERS: 1		US FAERS
81	telithromycin	FAERS: 1		US FAERS
82	tizanidine	FAERS: 1		OFFSIDES US FAERS
83	treprostinil	FAERS: 1		US FAERS
84	Acetazolamide			OFFSIDES
85	Amlodipine			OFFSIDES
86	Beclomethasone			OFFSIDES
87	Bimatoprost			OFFSIDES
88	Bortezomib			OFFSIDES
89	Brimonidine Tartrate			OFFSIDES
90	Bupropion			OFFSIDES
91	Calcitriol			OFFSIDES
92	Cephalexin			OFFSIDES
93	Chlorhexidine			OFFSIDES
94	Chlorzoxazone			OFFSIDES
95	Ciclopirox			OFFSIDES
96	Ciclopirox			OFFSIDES
97	Cocaine			OFFSIDES
98	Codeine			OFFSIDES
99	Cyproheptadine			OFFSIDES
100	Dapsone			OFFSIDES
101	Dasatinib			OFFSIDES
102	Deferoxamine			OFFSIDES
103	Docusate sodium			OFFSIDES
104	Doxepin			OFFSIDES
105	Etodolac			OFFSIDES
106	Fluorouracil			OFFSIDES
107	Flurazepam			OFFSIDES
108	Heroin			OFFSIDES
109	Hydroxyzine			OFFSIDES
110	Lapatinib			OFFSIDES
111	Lidoderm			OFFSIDES
112	Meperidine			OFFSIDES
113	Methylprednisolone Acetate			OFFSIDES
114	Mometasone Furoate			OFFSIDES
115	Nabumetone			OFFSIDES
116	Pamidronate			OFFSIDES
117	Penicillin V			OFFSIDES
118	Pentamidine			OFFSIDES
119	Piroxicam			OFFSIDES
120	Pyridoxine			OFFSIDES
121	Raloxifene Hydrochloride			OFFSIDES
122	Ramipril			OFFSIDES
123	Ribavirin			OFFSIDES
124	Rosiglitazone			OFFSIDES
125	Selenium			OFFSIDES
126	Sodium Bicarbonate			OFFSIDES
127	Sotalol			OFFSIDES
128	Tamoxifen			OFFSIDES
129	Terbutaline			OFFSIDES
130	Tetracycline			OFFSIDES
131	Timolol			OFFSIDES
132	Travoprost			OFFSIDES
133	Tretinoin			OFFSIDES
134	Trifluoperazine			OFFSIDES
135	Ubiquinone			OFFSIDES
136	Varenicline			OFFSIDES
137	Vinorelbine			OFFSIDES
138	Zoledronic Acid			OFFSIDES
139	carbidopa, levodopa drug combination			OFFSIDES
140	chlorhexidine gluconate			OFFSIDES
141	drospirenone and ethinyl estradiol combination	Canada Vigilance: 1		Canada Vigilance
142	fludarabine			OFFSIDES
143	metaxalone			OFFSIDES
144	nefazodone			OFFSIDES
145	norgestimate, ethinyl estradiol drug combination			OFFSIDES
146	pimecrolimus			OFFSIDES
147	reviparin			OFFSIDES
148	tipepidine			OFFSIDES
149	valdecoxib			OFFSIDES
150	zaleplon			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Anisometropia	42.9%
2	Myopia	42.9%
3	Presbyopia	42.9%
4	Asthenopia	23.1%
5	Conjunctival Diseases	23.1%
6	Corneal Diseases	23.1%
7	Eyelid Diseases	23.1%
8	Lacrimal Apparatus Diseases	23.1%
9	Lens Diseases	23.1%
10	Ocular Hypertension	23.1%
11	Ocular Hypotension	23.1%
12	Retinal Diseases	23.1%
13	Scleral Diseases	23.1%
14	Vitreous Detachment	23.1%
15	Posterior Vitreous Detachment	23.1%
16	Retinal Degeneration	19%
17	Xerophthalmia	16.3%
18	Low Tension Glaucoma	16.3%
19	Iridocorneal endothelial syndrome	16.3%
20	Eye Abnormalities	15%
21	Eye Infection	15%
22	Eye Manifestations	15%
23	Eye Neoplasms	15%
24	Optic Neuropathy	15%
25	Angioid Streaks	14.3%
26	Aphakia	14.3%
27	Blepharitis	14.3%
28	Blepharoptosis	14.3%
29	Blepharospasm	14.3%
30	Choroid Diseases	14.3%
31	Conjunctivitis	14.3%
32	Corneal edema	14.3%
33	Corneal Opacity	14.3%
34	Dacryocystitis	14.3%
35	Dry Eye Syndromes	14.3%
36	Ectropion	14.3%
37	Enophthalmos	14.3%
38	Entropion	14.3%
39	Episcleritis	14.3%
40	Exophthalmos	14.3%
41	Glaucoma	14.3%
42	Iris Diseases	14.3%
43	Keratitis	14.3%
44	Keratoconus	14.3%
45	Lacrimal Duct Obstruction	14.3%
46	Lens dislocation	14.3%
47	Lens Subluxation	14.3%
48	Mydriasis	14.3%
49	Pterygium	14.3%
50	Retinal Detachment	14.3%
51	Retinitis	14.3%
52	Scleritis	14.3%
53	Uveitis	14.3%
54	Corneal Neovascularization	14.3%
55	Orbital Pseudotumor	14.3%
56	Cataract	14.3%
57	Pinguecula	14.3%
58	Trichiasis	14.3%
59	Blepharophimosis	14%
60	Uveal Neoplasms	14%
61	Retinal Dysplasia	14%
62	Eyelid Neoplasms	13.9%
63	Retinal Hemorrhage	13.9%
64	Keratoconjunctivitis	13.6%
65	Keratoconjunctivitis Sicca	13.3%
66	Aniridia	12.6%
67	Chorioretinitis	12.6%
68	Corneal Ulcer	12.1%
69	Choroid Hemorrhage	12%
70	Choroiditis	11.7%
71	Iridocyclitis	11.7%
72	Iritis	11.7%
73	Pars Planitis	11.7%
74	Duane Retraction Syndrome	11.1%
75	Ocular Motility Disorders	11.1%
76	Retinitis Pigmentosa	11.1%
77	Cyclophoria	11.1%
78	Pigmentary retinopathy	11.1%
79	Pupil Disorders	10.9%
80	Corneal Scar	10.9%
81	Eye Hemorrhage	10.7%
82	Vision Disorders	10.6%
83	Metamorphopsia	10.6%
84	Visual Impairment	10.6%
85	Eye Injuries	10.5%
86	Angle Closure Glaucoma	10.3%
87	Glaucoma, Open-Angle	10.3%
88	Macular degeneration	10.3%
89	Panuveitis	10.3%
90	Retinal Drusen	10.3%
91	Retinal Necrosis Syndrome, Acute	10.3%
92	Retinoschisis	10.3%
93	Exfoliation Syndrome	10.3%
94	Hordeolum	9.5%
95	Color blindness	9.4%
96	Anophthalmos	9.3%
97	Endophthalmitis	9.3%
98	Microphthalmos	9.3%
99	Optic Atrophy	9.3%
100	Optic Neuritis	9.3%
101	Papilledema	9.3%
102	Pemphigoid, Benign Mucous Membrane	9.3%
103	Retinal Artery Occlusion	9.3%
104	Retinopathy of Prematurity	9.3%
105	Strabismus	9.3%
106	Tolosa-Hunt Syndrome	9.3%
107	Orbital Cellulitis	9.3%
108	Retinal Vasculitis	9.3%
109	Hypertensive Retinopathy	9.3%
110	Retrobulbar Hemorrhage	9.3%
111	Corneal Endothelial Cell Loss	9.3%
112	Hyphema	9.2%
113	Retinal Neovascularization	9.2%
114	Vitreous Hemorrhage	9.2%
115	Trachoma	8.5%
116	Anterior uveitis	8.5%
117	Uveitis, Posterior	8.5%
118	Retinoblastoma	8.3%
119	Acanthamoeba Keratitis	8.2%
120	Keratitis, Herpetic	8.2%
121	Cytomegalovirus Retinitis	8.2%
122	Bacterial conjunctivitis	8.1%
123	Corneal Perforation	7.9%
124	Optic Neuropathy, Ischemic	7%
125	Anterior Ischemic Optic Neuropathy	7%
126	Retinal Vein Occlusion	6.9%
127	Anisocoria	6.8%
128	Diabetic Retinopathy	6.8%
129	Tonic Pupil	6.8%
130	Eye pain	6.8%
131	Orbital Myositis	6.8%
132	Diplopia	6.8%
133	Scotoma	6.8%
134	Photophobia	6.8%
135	Amaurosis	6.8%
136	Blindness	6.8%
137	Esotropia	6.7%
138	Exotropia	6.7%
139	Choroidal Neovascularization	6.7%
140	Panophthalmitis	6.1%
141	Ophthalmoplegia	5.4%
142	External Ophthalmoplegia	5.4%
143	Amblyopia	5.4%
144	Uveomeningoencephalitic Syndrome	5.2%
145	CHARGE Syndrome	5.2%
146	Congenital nystagmus	5.1%
147	Herpes Zoster Ophthalmicus	5.1%
148	Hemianopsia	5%
149	Amaurosis Fugax	4.9%
150	Blindness, Cortical	4.9%
151	Ophthalmia Neonatorum	4.7%
152	Optic Atrophy, Hereditary, Leber	4.5%
153	Graves Disease	4.1%
154	Horner Syndrome	4%
155	Mandibulofacial Dysostosis	3.9%
156	Aicardi's syndrome	3.9%
157	Opsoclonus-Myoclonus Syndrome	3.4%
158	Albinism	3.3%
159	Miller Fisher Syndrome	2.9%
160	Sicca Syndrome	2.8%
161	Sjogren's Syndrome	2.8%
162	Kearns-Sayre syndrome	2.8%
163	Ophthalmoplegic Migraine	2.5%
164	Progressive supranuclear palsy	2.5%
165	Neuromyelitis Optica	2.2%
166	Behcet Syndrome	2.2%
167	Alstrom Syndrome	2%
168	Optic Nerve Glioma	1.8%

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