MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Keratoconjunctivitis Sicca

(UMLS:C0022575)

Definition:: Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.
UMLS ID:: C0022575
MeSH ID:: D007638

Classification:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.187.183.394.500|C11.204.564.585.630|C11.496.260.394

Synonym(s)

Keratoconjunctivitis Sicca

Dry eyes

KCS - Keratoconjunctivitis sicca

KERATOCONJUNCTIVITIS SICCA

Keratoconjunctivitis sicca

kcs

kerato conjunctivitis sicca

keratoconjunctivitis sicca

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin	FAERS: 29		US FAERS
2	Norgestrel	FAERS: 7		US FAERS
3	Teriparatide	FAERS: 7		US FAERS
4	Amoxicillin-Potassium Clavulanate Combination	FAERS: 5		US FAERS
5	Acitretin	FAERS: 3		US FAERS
6	Atomoxetine Hydrochloride	FAERS: 3		US FAERS
7	Ortho Evra	FAERS: 3		US FAERS
8	Paroxetine	FAERS: 3		US FAERS
9	Tiotropium Bromide	FAERS: 3		US FAERS
10	Atorvastatin	FAERS: 2		US FAERS
11	Bimatoprost	FAERS: 2		US FAERS
12	Capecitabine	FAERS: 2		US FAERS
13	Deferoxamine	FAERS: 2		US FAERS
14	Erlotinib Hydrochloride	FAERS: 2		US FAERS
15	Exenatide	FAERS: 2		US FAERS
16	Ezetimibe	FAERS: 2		US FAERS
17	Gefitinib	FAERS: 2		US FAERS
18	Lamotrigine	FAERS: 2		US FAERS
19	Letrozole	FAERS: 2		US FAERS
20	Nevirapine	FAERS: 2		US FAERS
21	Phenytoin	FAERS: 2		US FAERS
22	Risedronic Acid	FAERS: 2		US FAERS
23	Rosuvastatin Calcium	FAERS: 2		US FAERS
24	dorzolamide	FAERS: 2		US FAERS
25	rofecoxib	FAERS: 2		US FAERS
26	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1		US FAERS
27	Allopurinol	FAERS: 1		US FAERS
28	Amoxicillin	FAERS: 1		US FAERS
29	Anastrozole	FAERS: 1		US FAERS
30	Carboplatin	FAERS: 1		US FAERS
31	Carvedilol	FAERS: 1		US FAERS
32	Citalopram	FAERS: 1		US FAERS
33	Cytarabine	FAERS: 1		US FAERS
34	Doxycycline	FAERS: 1		US FAERS
35	Enfuvirtide	FAERS: 1		US FAERS
36	Irbesartan	FAERS: 1		US FAERS
37	Ketotifen	FAERS: 1		US FAERS
38	Latanoprost	FAERS: 1		US FAERS
39	Leuprolide	FAERS: 1		US FAERS
40	Levofloxacin	FAERS: 1		US FAERS
41	Metoclopramide	FAERS: 1		US FAERS
42	NuvaRing	FAERS: 1		US FAERS
43	Octreotide	FAERS: 1		US FAERS
44	Ondansetron	FAERS: 1		US FAERS
45	Oxcarbazepine	FAERS: 1		US FAERS
46	Pregabalin	FAERS: 1		US FAERS
47	Thalidomide	FAERS: 1		US FAERS
48	Timolol	FAERS: 1		US FAERS
49	Tolterodine Tartrate	FAERS: 1		US FAERS
50	Travoprost	FAERS: 1		SIDER US FAERS
51	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1		US FAERS
52	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
53	Zoledronic Acid	FAERS: 1		US FAERS
54	fluticasone furoate	FAERS: 1		US FAERS
55	pimecrolimus	FAERS: 1		US FAERS
56	tegaserod	FAERS: 1		US FAERS
57	valdecoxib	FAERS: 1		US FAERS
58	Atropine			SIDER
59	Brimonidine Tartrate			SIDER
60	Bupropion			SIDER
61	Cyclosporine		15604871	CTD
62	Erlotinib Hydrochloride			SIDER
63	Felbamate		11518421	CTD
64	Ketoconazole			SIDER
65	Lasofoxifene			SIDER
66	Moxifloxacin			SIDER
67	Paclitaxel			SIDER
68	Scopolamine		15604871	CTD
69	brinzolamide			SIDER
70	oxybutynin			SIDER
71	ropinirole			SIDER
72	sitaxsentan			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Xerophthalmia	40%
2	Corneal Ulcer	24.4%
3	Asthenopia	24.1%
4	Eyelid Diseases	24.1%
5	Lens Diseases	24.1%
6	Ocular Hypertension	24.1%
7	Ocular Hypotension	24.1%
8	Retinal Diseases	24.1%
9	Scleral Diseases	24.1%
10	Vitreous Detachment	24.1%
11	Posterior Vitreous Detachment	24.1%
12	Iridocorneal endothelial syndrome	24%
13	Dacryocystitis	23.3%
14	Lacrimal Duct Obstruction	23.3%
15	Corneal edema	21.7%
16	Corneal Opacity	21.7%
17	Keratoconus	21.7%
18	Pterygium	21.7%
19	Corneal Neovascularization	21.7%
20	Pinguecula	21.7%
21	Retinal Degeneration	21.6%
22	Retinal Dysplasia	20.3%
23	Corneal Scar	19.9%
24	Eye Abnormalities	19.4%
25	Eye Infection	19.4%
26	Eye Manifestations	19.4%
27	Eye Neoplasms	19.4%
28	Optic Neuropathy	19.4%
29	Trachoma	18.8%
30	Acanthamoeba Keratitis	18.1%
31	Keratitis, Herpetic	18%
32	Blepharophimosis	18%
33	Uveal Neoplasms	18%
34	Eyelid Neoplasms	17.9%
35	Retinal Hemorrhage	17.9%
36	Bacterial conjunctivitis	17.8%
37	Aniridia	17.6%
38	Pemphigoid, Benign Mucous Membrane	17.3%
39	Low Tension Glaucoma	17.3%
40	Corneal Endothelial Cell Loss	17.3%
41	Conjunctival Diseases	16.4%
42	Corneal Diseases	16.4%
43	Ocular Motility Disorders	16.3%
44	Cyclophoria	16.3%
45	Pupil Disorders	16.1%
46	Eye Hemorrhage	15.9%
47	Vision Disorders	15.8%
48	Metamorphopsia	15.8%
49	Visual Impairment	15.8%
50	Eye Injuries	15.7%
51	Lacrimal Apparatus Diseases	15.5%
52	Duane Retraction Syndrome	15.4%
53	Choroid Hemorrhage	14.4%
54	Angioid Streaks	13.3%
55	Anisometropia	13.3%
56	Aphakia	13.3%
57	Astigmatism	13.3%
58	Blepharitis	13.3%
59	Blepharoptosis	13.3%
60	Blepharospasm	13.3%
61	Choroid Diseases	13.3%
62	Ectropion	13.3%
63	Enophthalmos	13.3%
64	Entropion	13.3%
65	Episcleritis	13.3%
66	Exophthalmos	13.3%
67	Glaucoma	13.3%
68	Iris Diseases	13.3%
69	Lens dislocation	13.3%
70	Lens Subluxation	13.3%
71	Mydriasis	13.3%
72	Myopia	13.3%
73	Presbyopia	13.3%
74	Retinal Detachment	13.3%
75	Retinitis	13.3%
76	Scleritis	13.3%
77	Uveitis	13.3%
78	Orbital Pseudotumor	13.3%
79	Cataract	13.3%
80	Trichiasis	13.3%
81	Retinitis Pigmentosa	12.7%
82	Pigmentary retinopathy	12.7%
83	Sicca Syndrome	12.4%
84	Sjogren's Syndrome	12.4%
85	Hordeolum	12.3%
86	Color blindness	12.2%
87	Corneal Perforation	12.1%
88	Retinoblastoma	11.8%
89	Chorioretinitis	11.8%
90	Anophthalmos	10.7%
91	Endophthalmitis	10.7%
92	Microphthalmos	10.7%
93	Optic Atrophy	10.7%
94	Optic Neuritis	10.7%
95	Papilledema	10.7%
96	Retinal Artery Occlusion	10.7%
97	Retinopathy of Prematurity	10.7%
98	Strabismus	10.7%
99	Tolosa-Hunt Syndrome	10.7%
100	Orbital Cellulitis	10.7%
101	Retinal Vasculitis	10.7%
102	Hypertensive Retinopathy	10.7%
103	Retrobulbar Hemorrhage	10.7%
104	Hyphema	10.6%
105	Retinal Neovascularization	10.6%
106	Vitreous Hemorrhage	10.6%
107	Choroiditis	10.1%
108	Iridocyclitis	10.1%
109	Iritis	10.1%
110	Pars Planitis	10.1%
111	Cytomegalovirus Retinitis	9.5%
112	Ophthalmia Neonatorum	9.4%
113	Keratoconjunctivitis	9.2%
114	Conjunctivitis	9.2%
115	Keratitis	9.2%
116	Optic Neuropathy, Ischemic	9%
117	Anterior Ischemic Optic Neuropathy	9%
118	Retinal Vein Occlusion	8.9%
119	Anisocoria	8.8%
120	Diabetic Retinopathy	8.8%
121	Tonic Pupil	8.8%
122	Eye pain	8.8%
123	Orbital Myositis	8.8%
124	Diplopia	8.8%
125	Scotoma	8.8%
126	Photophobia	8.8%
127	Amaurosis	8.8%
128	Blindness	8.8%
129	Keratoconjunctivitis Sicca	8.7%
130	Dry Eye Syndromes	8.3%
131	Angle Closure Glaucoma	8.2%
132	Glaucoma, Open-Angle	8.2%
133	Macular degeneration	8.2%
134	Panuveitis	8.2%
135	Retinal Drusen	8.2%
136	Retinal Necrosis Syndrome, Acute	8.2%
137	Retinoschisis	8.2%
138	Exfoliation Syndrome	8.2%
139	Ophthalmoplegia	7.6%
140	External Ophthalmoplegia	7.6%
141	Amblyopia	7.5%
142	Panophthalmitis	6.8%
143	Esotropia	6.5%
144	Exotropia	6.5%
145	Choroidal Neovascularization	6.5%
146	Aicardi's syndrome	5.9%
147	Anterior uveitis	5.7%
148	Uveitis, Posterior	5.7%
149	Uveomeningoencephalitic Syndrome	5.6%
150	CHARGE Syndrome	5.6%
151	Optic Atrophy, Hereditary, Leber	5.5%
152	Congenital nystagmus	5.5%
153	Herpes Zoster Ophthalmicus	5.5%
154	Hemianopsia	5.4%
155	Amaurosis Fugax	5.4%
156	Blindness, Cortical	5.4%
157	Opsoclonus-Myoclonus Syndrome	5.3%
158	Albinism	5.3%
159	Graves Disease	4.8%
160	Miller Fisher Syndrome	4.7%
161	Horner Syndrome	4.7%
162	Mandibulofacial Dysostosis	4.6%
163	Ophthalmoplegic Migraine	3.3%
164	Progressive supranuclear palsy	3.3%
165	Kearns-Sayre syndrome	3.1%
166	Neuromyelitis Optica	3%
167	Alstrom Syndrome	2.7%
168	Optic Nerve Glioma	2.5%
169	Behcet Syndrome	2%

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