MetaADEDB 2.0 @ LMMD
Leuprolide
(GFIJNRVAKGFPGQ-LIJARHBVSA-N)
Structure
SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)CO)CC(C)C)CC(C)C)CCCN=C(N)N
Type(s)
Approved; Investigational
ATC code(s)
L02AE02; L02AE51
Molecular Formula:
C59H84N16O12
Molecular Weight:
1209.400
Log P:
3.3564
Hydrogen Bond Acceptor:
26
Hydrogen Bond Donor:
15
TPSA:
431.54
CAS Number(s):
53714-56-0
Synonym(s)
1.
Leuprolide
2.
Leuprorelin
3.
A-43818
4.
Enantone
5.
Leuprolide Acetate
6.
Leuprolide Monoacetate
7.
Leuprolide, (DL-Leu)-Isomer
8.
Leuprolide, (L-Leu)-Isomer
9.
Lupron
10.
TAP-144
11.
A 43818
12.
A43818
13.
Acetate, Leuprolide
14.
Monoacetate, Leuprolide
15.
TAP 144
16.
TAP144
External Link(s)
MeSHD016729
PubChem Compound657181
BindingDB50369395
ChEBI6427
CHEMBLCHEMBL1201199
DrugBankDB00007
DrugCentral1559
IUPHAR/BPS Guide to PHARMACOLOGY1175
Therapeutic Target DatabaseD0U5FF
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1treatment failureFAERS: 28US FAERS
2Product quality issueFAERS: 18US FAERS
3Product dosage form issueFAERS: 8US FAERS
4DizzinessFAERS: 6SIDER
US FAERS
5Drug ineffectiveFAERS: 6US FAERS
6HeadacheFAERS: 59628521CTD
SIDER
US FAERS
7ArthralgiaFAERS: 48425646CTD
SIDER
US FAERS
8NauseaFAERS: 4SIDER
US FAERS
9AstheniaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
10Blood testosterone abnormalFAERS: 3US FAERS
11Cutaneous sarcoidosisFAERS: 3US FAERS
12EuthanasiaFAERS: 3US FAERS
13FatigueFAERS: 3SIDER
US FAERS
14Injection site noduleFAERS: 3US FAERS
15Ovarian Hyperstimulation SyndromeFAERS: 3US FAERS
16PainFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
17PolyuriaFAERS: 3US FAERS
18Product use issueFAERS: 3US FAERS
19VomitingFAERS: 3SIDER
US FAERS
20AgitationFAERS: 2SIDER
US FAERS
21Back PainFAERS: 2SIDER
US FAERS
22Blood testosterone decreasedFAERS: 2SIDER
US FAERS
23Blood testosterone increasedFAERS: 2SIDER
US FAERS
24Cerebrovascular accidentFAERS: 2SIDER
US FAERS
25Chest PainFAERS: 2SIDER
US FAERS
26Circumstance or information capable of leading to medication errorFAERS: 2US FAERS
27Diabetes MellitusFAERS: 2SIDER
US FAERS
28Disease recurrenceFAERS: 2US FAERS
29General physical health deteriorationFAERS: 2US FAERS
30HypotensionFAERS: 2SIDER
US FAERS
31Injection site erythemaFAERS: 2US FAERS
32Injection site painFAERS: 2SIDER
US FAERS
33OverweightFAERS: 2US FAERS
34ParanoiaFAERS: 2US FAERS
35Renal cancer metastaticFAERS: 2US FAERS
36Therapeutic product effect decreasedFAERS: 2US FAERS
37Acute kidney injuryFAERS: 1US FAERS
38Acute myocardial infarctionFAERS: 1US FAERS
39Anaphylactic shockFAERS: 1SIDER
US FAERS
40AnhedoniaFAERS: 1US FAERS
41Antiandrogen therapyFAERS: 1US FAERS
42AnxietyFAERS: 1SIDER
US FAERS
43ApathyFAERS: 1US FAERS
44Bladder painFAERS: 1SIDER
US FAERS
45Blood cholesterol increasedFAERS: 1US FAERS
46Bone density decreasedFAERS: 1SIDER
US FAERS
47Bone painFAERS: 1SIDER
US FAERS
48BradycardiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
49Cardiac ArrestFAERS: 1US FAERS
50Cerebellar infarctionFAERS: 1US FAERS
51Cerebral atrophyFAERS: 1US FAERS
52Choking sensationFAERS: 1US FAERS
53Deep Vein ThrombosisFAERS: 1SIDER
US FAERS
54DiplopiaFAERS: 1US FAERS
55DiscomfortFAERS: 1SIDER
US FAERS
56Disease ProgressionFAERS: 1US FAERS
57Drug dose omissionFAERS: 1US FAERS
58DysarthriaFAERS: 1US FAERS
59DysphoniaFAERS: 1US FAERS
60DysuriaFAERS: 1SIDER
US FAERS
61Endometrial metaplasiaFAERS: 1US FAERS
62Epidermal necrosisFAERS: 1US FAERS
63Euphoric moodFAERS: 1SIDER
US FAERS
64Expired product administeredFAERS: 1US FAERS
65FractureFAERS: 1SIDER
US FAERS
66Growth retardationFAERS: 1SIDER
US FAERS
67HydronephrosisFAERS: 1US FAERS
68HypopituitarismFAERS: 1US FAERS
69HypothyroidismFAERS: 1US FAERS
70IleusFAERS: 1US FAERS
71IncontinenceFAERS: 1SIDER
US FAERS
72Incorrect product storageFAERS: 1US FAERS
73InfarctionFAERS: 1US FAERS
74Injection site eczemaFAERS: 1US FAERS
75Injection site granulomaFAERS: 1US FAERS
76Injection site hypersensitivityFAERS: 1US FAERS
77Injection site irritationFAERS: 1US FAERS
78Injection site warmthFAERS: 1SIDER
US FAERS
79LymphadenopathyFAERS: 1SIDER
US FAERS
80MalaiseFAERS: 1SIDER
US FAERS
81Male sexual dysfunctionFAERS: 1US FAERS
82Malignant neoplasm progressionFAERS: 1US FAERS
83Metastatic NeoplasmFAERS: 1US FAERS
84MetrorrhagiaFAERS: 110763848CTD
US FAERS
85Musculoskeletal stiffnessFAERS: 1SIDER
US FAERS
86MyopathyFAERS: 1SIDER
US FAERS
87NephrolithiasisFAERS: 1US FAERS
88Osteonecrosis of JawFAERS: 1US FAERS
89Pancreatic carcinomaFAERS: 1US FAERS
90ParakeratosisFAERS: 1US FAERS
91Penile burning sensationFAERS: 1US FAERS
92Pharmaceutical product complaintFAERS: 1US FAERS
93Pituitary enlargementFAERS: 1US FAERS
94Post procedural complicationFAERS: 1US FAERS
95PriapismFAERS: 1US FAERS
96Product compounding quality issueFAERS: 1US FAERS
97Product container seal issueFAERS: 1US FAERS
98Product measured potency issueFAERS: 1US FAERS
99Product physical issueFAERS: 1US FAERS
100Product use in unapproved indicationFAERS: 1US FAERS
101PsoriasisFAERS: 1US FAERS
102Pulmonary EmbolismFAERS: 1SIDER
US FAERS
103Secretory adenoma of pituitaryFAERS: 1US FAERS
104Sexual DysfunctionFAERS: 1US FAERS
105ShockFAERS: 1SIDER
US FAERS
106SomnolenceFAERS: 1SIDER
US FAERS
107TachycardiaFAERS: 1SIDER
US FAERS
108Therapy non-responderFAERS: 1US FAERS
109TremorFAERS: 1SIDER
US FAERS
110Unresponsive to stimuliFAERS: 1US FAERS
111Urethral ObstructionFAERS: 1US FAERS
112Urinary RetentionFAERS: 1SIDER
US FAERS
113Urinary tract infectionFAERS: 1SIDER
US FAERS
114UrticariaFAERS: 1SIDER
US FAERS
115VertigoFAERS: 1SIDER
US FAERS
116Visual disturbanceFAERS: 1US FAERS
117Weight decreasedFAERS: 1SIDER
US FAERS
118Wrong technique in product usage processFAERS: 1US FAERS
119Abdominal PainSIDER
120Abdominal discomfortSIDER
121Abnormal visionSIDER
122AbscessSIDER
123AcneSIDER
124Acute Coronary SyndromeSIDER
125Adenocarcinoma10763848
12820454
CTD
126AlopeciaSIDER
127AmblyopiaSIDER
128AmnesiaSIDER
129Anal FistulaSIDER
130Anemia12820454
17991572
18937151
CTD
131Angina Pectoris8030717CTD
SIDER
132AnorexiaSIDER
133AnosmiaSIDER
134Arterial thromboembolismSIDER
135ArthritisSIDER
136ArthropathySIDER
137AsthmaSIDER
138AtaxiaSIDER
139Atrial FibrillationSIDER
140Autistic Disorder17187010CTD
141Bipolar Disorder9951575CTD
142Bladder spasmSIDER
143Blood creatinine increasedSIDER
144Blood glucose increasedSIDER
145Blood potassium decreasedSIDER
146Blood urea increasedSIDER
147Body odorSIDER
148Breast tendernessSIDER
149BronchitisSIDER
150Burning sensationSIDER
151Ca++ increasedSIDER
152Carotid bruitSIDER
153Catalepsy19403167CTD
154Cerebral Hemorrhage12403969CTD
155Chest discomfortSIDER
156Chest tightnessSIDER
157ChillsSIDER
158Cognition Disorders8499680
12175403
15142146
CTD
159Cold sweatSIDER
160ColitisSIDER
161Common ColdSIDER
162ConstipationSIDER
163Cramps of lower extremitiesSIDER
164Creatinine increasedSIDER
165CryingSIDER
166DehydrationSIDER
167DementiaSIDER
168DermatitisSIDER
169DiabeticSIDER
170Distress gastrointestinalSIDER
171Disturbance in sexual arousalSIDER
172Dry skinSIDER
173Duodenal UlcerSIDER
174DysgeusiaSIDER
175DyspepsiaSIDER
176EcchymosisSIDER
177Endometriosis

View details

CTD
178Enlargement abdomenSIDER
179EosinophiliaSIDER
180EpididymitisSIDER
181EpistaxisSIDER
182Erectile dysfunction10221860
20707648
CTD
SIDER
183EructationSIDER
184Erythema MultiformeSIDER
185ErythemaSIDER
186Fatty Liver18097299CTD
187Feeling abnormalSIDER
188FeminizationSIDER
189FibromyalgiaSIDER
190FlatulenceSIDER
191FlushingSIDER
192GastroenteritisSIDER
193Gastrointestinal PainSIDER
194GingivitisSIDER
195Glucose increasedSIDER
196Headache dullSIDER
197Heart valve calcificationCanada Vigilance: 1Canada Vigilance
198HepatitisSIDER
199HepatomegalySIDER
200HerniaSIDER
201HirsutismSIDER
202HyperkeratosisSIDER
203HyperkinesiaSIDER
204HyperreflexiaSIDER
205HypersensitivitySIDER
206HypertrophySIDER
207HypogonadismSIDER
208HyporeflexiaSIDER
209IndurationSIDER
210InfectionSIDER
211Inflammation25462211CTD
SIDER
212InfluenzaSIDER
213Injection Site ReactionSIDER
214Injection site inflammationSIDER
215Intestinal ObstructionSIDER
216Intracranial Hypertension9413812CTD
217KeratosisSIDER
218LethargySIDER
219LeukocytosisSIDER
220LeukodermaSIDER
221LeukopeniaSIDER
222LightheadednessSIDER
223MalnutritionSIDER
224Memory Disorders8499680
8675575
12175403
CTD
225Mood swingsSIDER
226Musculoskeletal PainSIDER
227Musculoskeletal discomfortSIDER
228MyalgiaSIDER
229Myocardial Infarction8030717CTD
SIDER
230Myoma8425646CTD
231Myositis1954704CTD
232NasopharyngitisSIDER
233Neck PainSIDER
234Neoplasm Invasiveness17143537CTD
235NervousnessSIDER
236NeuropathySIDER
237Night sweatsSIDER
238Nocturia aggravatedSIDER
239NocturiaSIDER
240NoduleSIDER
241NumbnessSIDER
242ObesitySIDER
243OphthalmoplegiaSIDER
244OsteoporosisSIDER
245PallorSIDER
246PalpitationsSIDER
247Paresthesia lower limbSIDER
248Pedophilia16362253CTD
249Penile swellingSIDER
250Peptic UlcerSIDER
251PharyngitisSIDER
252PhlebitisSIDER
253Pituitary AdenomaSIDER
254Pituitary Apoplexy

View details

CTD
SIDER
255Pituitary Diseases12403969CTD
256Pituitary infarctionSIDER
257Pleural RubSIDER
258Pleuritic painSIDER
259PneumoniaSIDER
260Potassium lowSIDER
261Precocious PubertySIDER
262Prostatic Neoplasms

View details

CTD
263Prostatic painSIDER
264PruritusSIDER
265PubertySIDER
266Pulmonary FibrosisSIDER
267PurpuraSIDER
268PyuriaSIDER
269RalesSIDER
270Rectal FistulaSIDER
271Rectal polypSIDER
272Retinal Vein Occlusion18050813CTD
273RhinitisSIDER
274RhonchiSIDER
275Sensation of warmthSIDER
276Serum testosterone increasedSIDER
277SinusitisSIDER
278Skin carcinomaSIDER
279Skin hypertrophySIDER
280Sleep Initiation and Maintenance Disorders9628521CTD
281SpondylosisSIDER
282Sudden Cardiac DeathSIDER
283SweatingSIDER
284SwellingSIDER
285SyncopeSIDER
286Taste DisordersSIDER
287Taste sourSIDER
288TenosynovitisSIDER
289TensionSIDER
290ThirstSIDER
291ThrombocytopeniaSIDER
292ThrombophlebitisSIDER
293ThrombosisSIDER
294Thyroid NeoplasmSIDER
295Thyroid NoduleSIDER
296TinnitusSIDER
297Traumatic liver injurySIDER
298UlcerSIDER
299Urea increasedSIDER
300Uric acid increasedSIDER
301Urinary IncontinenceSIDER
302Uterine Neoplasms10763848CTD
303Vaginal DischargeSIDER
304Vascular purpuraSIDER
305Vasculitis, Leukocytoclastic, Cutaneous17611838CTD
306Vasodilation procedureSIDER
307VasodilationSIDER
308Venous Thrombosis18464947CTD
309Visual ImpairmentSIDER
310WheezingSIDER
311White blood cell count decreasedSIDER
312furuncleSIDER
313jaundiceSIDER
314nervous system disorderSIDER
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