MetaADEDB 2.0 @ LMMD
Isosorbide Dinitrate
(MOYKHGMNXAOIAT-JGWLITMVSA-N)
Structure
SMILES
[O-][N+](=O)O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O[N+](=O)[O-]
Type(s)
Approved; Investigational
ATC code(s)
C01DA08; C01DA58; C05AE02
Molecular Formula:
C6H8N2O8
Molecular Weight:
236.136
Log P:
-0.0158
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
0
TPSA:
128.56
CAS Number(s):
87-33-2
Synonym(s)
1.
Isosorbide Dinitrate
2.
Cardonit 40
3.
Dilatrate
4.
Iso-Bid
5.
Isodinit
6.
Isoket
7.
Isoket Retard-120
8.
Isomak R
9.
Isordil
10.
Isotrate
11.
Nitrosorbide
12.
Sorbitrate
13.
Sorbonit
14.
Dinitrate, Isosorbide
15.
Iso Bid
16.
IsoBid
17.
Isoket Retard 120
18.
Isoket Retard120
External Link(s)
MeSHD007548
PubChem Compound6883
ChEBI6061
CHEMBLCHEMBL6622
DrugBankDB00883
DrugCentral1505
IUPHAR/BPS Guide to PHARMACOLOGY7051
KEGGcpd:C07456
dr:D00516
Therapeutic Target DatabaseD0I1SK
ZINC18089317
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Product quality issueFAERS: 11US FAERS
2HypotensionFAERS: 7
Canada Vigilance: 10

View details

924082
2707271
5001608
6193361
6800317
7112489
7163080
11444498
16777088
 		CTD
Canada Vigilance
US FAERS
3Chest PainFAERS: 69617513CTD
OFFSIDES
US FAERS
4DizzinessFAERS: 6
Canada Vigilance: 3		Canada Vigilance
US FAERS
5NauseaFAERS: 5
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
6SyncopeFAERS: 5

View details

153098
924082
9796135
18760129
 		CTD
US FAERS
7Angina PectorisFAERS: 4

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1177792
2000524
2508936
3325229
3510989
3918653
6386704
6666231
6800251
7058754
7866603
8062500
8651088
8665335
9082601
9688432
9796135
10027656
10449212
10831492
15078580
18388107
 		CTD
US FAERS
8HeadacheFAERS: 4
Canada Vigilance: 17

View details

3325229
4570671
6800251
7002181
7515328
11193132
11740135
15747070
 		CTD
Canada Vigilance
US FAERS
9VomitingFAERS: 4
Canada Vigilance: 2		Canada Vigilance
US FAERS
10Chest discomfortFAERS: 3US FAERS
11HypersensitivityFAERS: 3US FAERS
12Product taste abnormalFAERS: 3US FAERS
13Acute myocardial infarctionFAERS: 2OFFSIDES
US FAERS
14Blood potassium decreasedFAERS: 2OFFSIDES
US FAERS
15Drug ineffectiveFAERS: 2US FAERS
16DysgeusiaFAERS: 2OFFSIDES
US FAERS
17FatigueFAERS: 2
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
18MalaiseFAERS: 2US FAERS
19Myocardial InfarctionFAERS: 2924082
2312209
2707271		CTD
US FAERS
20PsoriasisFAERS: 2OFFSIDES
US FAERS
21Suicide attemptFAERS: 2US FAERS
22Therapeutic response unexpected with drug substitutionFAERS: 2US FAERS
23Toxicity to various agentsFAERS: 2US FAERS
24Accidental exposure to productFAERS: 1US FAERS
25Aortic valve sclerosisFAERS: 1US FAERS
26ArthralgiaFAERS: 1US FAERS
27AstheniaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
28Back PainFAERS: 1US FAERS
29Blood cholesterol increasedFAERS: 1US FAERS
30Blood pressure immeasurableFAERS: 1US FAERS
31Cerebrovascular accidentFAERS: 1US FAERS
32Concomitant disease aggravatedFAERS: 1US FAERS
33Coronary Artery DiseaseFAERS: 1

View details

758516
7866603
9017773
10808734
 		CTD
US FAERS
34CyanosisFAERS: 1US FAERS
35DeafnessFAERS: 1US FAERS
36Diabetes mellitus inadequate controlFAERS: 1US FAERS
37Diastolic dysfunctionFAERS: 1OFFSIDES
US FAERS
38DisorientationFAERS: 1US FAERS
39Drug dispensing errorFAERS: 1US FAERS
40Drug effect incompleteFAERS: 1US FAERS
41Ear discomfortFAERS: 1US FAERS
42Ejection Fraction DecreasedFAERS: 1US FAERS
43Eye painFAERS: 1US FAERS
44Feeling abnormalFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
45Gastrointestinal sounds abnormalFAERS: 1US FAERS
46GlaucomaFAERS: 1US FAERS
47Head discomfortFAERS: 1US FAERS
48HypophagiaFAERS: 1US FAERS
49Incorrect dose administeredFAERS: 1US FAERS
50Intentional product misuseFAERS: 1US FAERS
51Intercepted product dispensing errorFAERS: 1US FAERS
52Left Ventricular HypertrophyFAERS: 1US FAERS
53LethargyFAERS: 1OFFSIDES
US FAERS
54Medication ErrorFAERS: 1US FAERS
55MetamorphopsiaFAERS: 1US FAERS
56Musculoskeletal PainFAERS: 1US FAERS
57MydriasisFAERS: 1US FAERS
58Neck PainFAERS: 1US FAERS
59OverdoseFAERS: 1US FAERS
60PresyncopeFAERS: 1US FAERS
61Product dispensing errorFAERS: 1US FAERS
62Product substitution issueFAERS: 1US FAERS
63PruritusFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
64Respiratory distressFAERS: 1US FAERS
65StomatitisFAERS: 1US FAERS
66TachycardiaFAERS: 116777088CTD
US FAERS
67Throat irritationFAERS: 1US FAERS
68Troponin increasedFAERS: 1US FAERS
69UrticariaFAERS: 13120959CTD
US FAERS
70Visual ImpairmentFAERS: 1US FAERS
71Abdominal PainCanada Vigilance: 1Canada Vigilance
OFFSIDES
72Abdominal discomfortCanada Vigilance: 1Canada Vigilance
73Abnormal visionOFFSIDES
74Accidental exposureOFFSIDES
75Acidosis3120959CTD
76Actinic keratosisOFFSIDES
77Acute Coronary SyndromeOFFSIDES
78Acute respiratory failureOFFSIDES
79Anemia, Hemolytic6401899CTD
80AnorexiaOFFSIDES
81AnuriaOFFSIDES
82Application site reactionOFFSIDES
83Arterial bypass operationOFFSIDES
84Arteriosclerosis ObliteransOFFSIDES
85Arteriovenous graft thrombosisOFFSIDES
86Aspartate aminotransferase decreasedOFFSIDES
87Aspiration PneumoniaOFFSIDES
88Atrioventricular Block2000524
3510989		CTD
89Blood GlucoseOFFSIDES
90Blood Platelet Disorders10808734CTD
91Blood albumin decreasedOFFSIDES
92Blood amylase decreasedOFFSIDES
93Blood chloride decreasedOFFSIDES
94Blood cholesterolOFFSIDES
95Blood count abnormalOFFSIDES
96Blood creatinine decreasedOFFSIDES
97Blood creatinine increasedOFFSIDES
98Blood fibrinogen increasedOFFSIDES
99Blood glucose decreasedOFFSIDES
100Blood insulinOFFSIDES
101Blood lactate dehydrogenase increasedOFFSIDES
102Blood magnesium decreasedOFFSIDES
103Blood phosphorus decreasedOFFSIDES
104Blood potassium increasedOFFSIDES
105Blood sodiumOFFSIDES
106Blood thyroid stimulating hormone increasedOFFSIDES
107Blood urea increasedOFFSIDES
108Blood uric acidOFFSIDES
109Bone painOFFSIDES
110BradycardiaCanada Vigilance: 6

View details

924082
3510989
6800317
7112489
7163080
 		CTD
OFFSIDES
Canada Vigilance
111Brain natriuretic peptide increasedOFFSIDES
112Breast CystOFFSIDES
113Cardioactive drug level above therapeuticOFFSIDES
114Cardiovascular insufficiencyOFFSIDES
115Carotid EndarterectomyOFFSIDES
116Cerebral atrophyOFFSIDES
117ChokingOFFSIDES
118Chronic Obstructive Airway DiseaseOFFSIDES
119Chronic left ventricular failureOFFSIDES
120Cluster Headache533253CTD
121Cold sweatCanada Vigilance: 1Canada Vigilance
OFFSIDES
122Coronary Stenosis7378214CTD
123DehydrationOFFSIDES
124Depressed Level of ConsciousnessOFFSIDES
125Depressed moodOFFSIDES
126DiarrheaOFFSIDES
127Disseminated Intravascular CoagulationOFFSIDES
128Dissociative disorderOFFSIDES
129DiverticulitisOFFSIDES
130Duodenal UlcerOFFSIDES
131DyspepsiaCanada Vigilance: 1Canada Vigilance
132Electrocardiogram PQ interval prolongedOFFSIDES
133Electromechanical dissociationOFFSIDES
134ErythemaCanada Vigilance: 1Canada Vigilance
135Esophageal StenosisOFFSIDES
136Esophageal and Gastric Varices1821463
8711338		CTD
137Flank PainOFFSIDES
138Fluid overloadOFFSIDES
139Foaming at mouthOFFSIDES
140Gastric mucosal lesionOFFSIDES
141GlossoptosisOFFSIDES
142Glycopeptide antibiotic resistant enterococcal infectionOFFSIDES
143Groin infectionOFFSIDES
144Hallucinations3432520CTD
145Heart failure

View details

2057035
2413305
3510989
3890506
6274182
17372175
 		CTD
146Hemifacial Spasm9617513CTD
147Hyperkalemia3120959CTD
148Hypotension, Orthostatic6666230
7112489
9796135		CTD
149HypoxiaOFFSIDES
150IncontinenceOFFSIDES
151Incorrect drug administration durationOFFSIDES
152Infected lymphoceleOFFSIDES
153Intermittent ClaudicationOFFSIDES
154Ischemia10449212CTD
155Joint InstabilityOFFSIDES
156Kidney FailureOFFSIDES
157Leishmaniasis, Visceral20576500CTD
158Limb operationOFFSIDES
159Lip erosionOFFSIDES
160LipaseOFFSIDES
161Lung infection pseudomonalOFFSIDES
162LymphangiomaOFFSIDES
163Mental status changesOFFSIDES
164Migraine Disorders6823259
8073911		CTD
165Mouth BreathingOFFSIDES
166Myocardial Ischemia

View details

1464343
2970388
3086899
3437668
7649677
8665335
9082601
18388107
 		CTD
167NasopharyngitisOFFSIDES
168Nephrogenic Fibrosing DermopathyOFFSIDES
169Neutrophil count decreasedOFFSIDES
170Oliguria3120959CTD
OFFSIDES
171Pain8796565CTD
172PallorCanada Vigilance: 2Canada Vigilance
173ParaplegiaOFFSIDES
174Paresis6823259CTD
175Pelvic fluid collectionOFFSIDES
176Performance status decreasedOFFSIDES
177Pericardial effusionOFFSIDES
178Pituitary Apoplexy11958251CTD
179Platelet count abnormalOFFSIDES
180PleurisyOFFSIDES
181Pre-Eclampsia12164565CTD
182Protein total increasedOFFSIDES
183Pulmonary Embolism7740511CTD
184Pulmonary HypertensionOFFSIDES
185RalesOFFSIDES
186Renal Insufficiency3120959CTD
187Renal cystOFFSIDES
188Renal tubular necrosisOFFSIDES
189Reperfusion Injury12409977CTD
190Respiratory FailureOFFSIDES
191Retrograde amnesiaOFFSIDES
192Serum SicknessOFFSIDES
193Skin tightnessOFFSIDES
194Stevens-Johnson SyndromeOFFSIDES
195Substance Withdrawal Syndrome8665335CTD
196Sudden Cardiac DeathOFFSIDES
197Synovial fluid red blood cells positiveOFFSIDES
198ThrombectomyOFFSIDES
199Thrombosis in deviceOFFSIDES
200Troponin I increasedOFFSIDES
201Vasoplegia syndromeOFFSIDES
202Ventricular Dysfunction, Left3890506CTD
203Ventricular FibrillationOFFSIDES
204Vertebral Artery StenosisOFFSIDES
205Wound infection pseudomonasOFFSIDES
206Wrong technique in drug usage processOFFSIDES
207effusionOFFSIDES
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