MetaADEDB 2.0 @ LMMD
isosorbide-5-mononitrate
(YWXYYJSYQOXTPL-SLPGGIOYSA-N)
Structure
SMILES
[O-][N+](=O)O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O
Type(s)
Approved
ATC code(s)
C01DA14
Molecular Formula:
C6H9NO6
Molecular Weight:
191.139
Log P:
-0.7550
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
93.74
CAS Number(s):
16051-77-7
Synonym(s)
1.
isosorbide-5-mononitrate
2.
5-ISMN
3.
5-ISMN Durules
4.
Elantan
5.
Imdur
6.
Ismo
7.
Monizid
8.
Mono Mac 50D
9.
Monoket
10.
Mononit
11.
Olicard 40
12.
Olicard-retard
13.
isosorbide mononitrate
14.
isosorbide-5-nitrate
15.
monocinque
External Link(s)
MeSHC030397
PubChem Compound27661
ChEBI6062
CHEMBLCHEMBL1311
DrugBankDB01020
DrugCentral1506
IUPHAR/BPS Guide to PHARMACOLOGY7052
KEGGcpd:C07714
dr:D00630
Therapeutic Target DatabaseD0YS7D
ZINC1849548
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Product quality issueFAERS: 144OFFSIDES
US FAERS
2DizzinessFAERS: 66OFFSIDES
SIDER
US FAERS
3HeadacheFAERS: 57
Canada Vigilance: 1

View details

1760829
2506059
3325229
8686962
9689421
9798584
16723101
18521538
20567177
 		CTD
SIDER
Canada Vigilance
US FAERS
4HypotensionFAERS: 3217632098CTD
SIDER
US FAERS
5SyncopeFAERS: 29SIDER
US FAERS
6Myocardial InfarctionFAERS: 243585391CTD
SIDER
US FAERS
7Chest PainFAERS: 23OFFSIDES
SIDER
US FAERS
8AstheniaFAERS: 18OFFSIDES
SIDER
US FAERS
9NauseaFAERS: 17OFFSIDES
SIDER
US FAERS
10Incorrect dose administeredFAERS: 15OFFSIDES
US FAERS
11Pharmaceutical product complaintFAERS: 15US FAERS
12Angina PectorisFAERS: 13

View details

1760829
3147892
3325229
8686962
9411825
10678861
 		CTD
SIDER
US FAERS
13Cerebrovascular accidentFAERS: 13SIDER
US FAERS
14PalpitationsFAERS: 13SIDER
US FAERS
15FatigueFAERS: 11OFFSIDES
SIDER
US FAERS
16Product substitution issueFAERS: 11
Canada Vigilance: 1		Canada Vigilance
US FAERS
17PainFAERS: 10SIDER
US FAERS
18Feeling abnormalFAERS: 9SIDER
US FAERS
19Drug ineffectiveFAERS: 8US FAERS
20MalaiseFAERS: 8SIDER
US FAERS
21OverdoseFAERS: 8US FAERS
22Chest discomfortFAERS: 7US FAERS
23PruritusFAERS: 6SIDER
US FAERS
24AnorexiaFAERS: 5OFFSIDES
SIDER
US FAERS
25LethargyFAERS: 5OFFSIDES
US FAERS
26TachycardiaFAERS: 5SIDER
US FAERS
27VomitingFAERS: 5SIDER
US FAERS
28AnxietyFAERS: 4SIDER
US FAERS
29Cold sweatFAERS: 4OFFSIDES
SIDER
US FAERS
30Unresponsive to stimuliFAERS: 4OFFSIDES
US FAERS
31UrticariaFAERS: 4US FAERS
32VertigoFAERS: 4SIDER
US FAERS
33Abdominal discomfortFAERS: 3US FAERS
34Disease ProgressionFAERS: 3US FAERS
35Drug dispensing errorFAERS: 3US FAERS
36General physical health deteriorationFAERS: 3US FAERS
37Medication ErrorFAERS: 3US FAERS
38Musculoskeletal PainFAERS: 3SIDER
US FAERS
39NervousnessFAERS: 3SIDER
US FAERS
40PneumoniaFAERS: 3SIDER
US FAERS
41PresyncopeFAERS: 3US FAERS
42Product solubility abnormalFAERS: 3US FAERS
43Suicide attemptFAERS: 3US FAERS
44Visual ImpairmentFAERS: 3SIDER
US FAERS
45Wrong technique in drug usage processFAERS: 3US FAERS
46Abdominal PainFAERS: 29798584CTD
OFFSIDES
SIDER
US FAERS
47AlopeciaFAERS: 2US FAERS
48ArthritisFAERS: 2SIDER
US FAERS
49Back PainFAERS: 2SIDER
US FAERS
50BlindnessFAERS: 2US FAERS
51Blood pressure inadequately controlledFAERS: 2US FAERS
52BradycardiaFAERS: 215662077CTD
OFFSIDES
SIDER
US FAERS
53Burning sensationFAERS: 2US FAERS
54ConstipationFAERS: 2SIDER
US FAERS
55Diabetes mellitus inadequate controlFAERS: 2OFFSIDES
US FAERS
56DiplopiaFAERS: 2SIDER
US FAERS
57DisorientationFAERS: 2US FAERS
58DyspepsiaFAERS: 2OFFSIDES
SIDER
US FAERS
59Eye painFAERS: 2US FAERS
60HypersensitivityFAERS: 2SIDER
US FAERS
61HypersomniaFAERS: 2US FAERS
62InfluenzaFAERS: 2US FAERS
63Limb injuryFAERS: 2US FAERS
64Medication residue presentFAERS: 2US FAERS
65Middle insomniaFAERS: 2US FAERS
66Night sweatsFAERS: 2US FAERS
67PallorFAERS: 2OFFSIDES
SIDER
US FAERS
68Poor quality drug administeredFAERS: 2US FAERS
69Product label issueFAERS: 2US FAERS
70Renal painFAERS: 2US FAERS
71Respiratory DepressionFAERS: 2US FAERS
72ShockFAERS: 2SIDER
US FAERS
73Sinus ArrhythmiaFAERS: 2US FAERS
74SomnolenceFAERS: 2SIDER
US FAERS
75Sudden Cardiac DeathFAERS: 2US FAERS
76Therapeutic response unexpected with drug substitutionFAERS: 2US FAERS
77AbasiaFAERS: 1US FAERS
78Accidental overdoseFAERS: 1US FAERS
79Activities of daily living impairedFAERS: 1US FAERS
80Acute Coronary SyndromeFAERS: 1SIDER
US FAERS
81Acute myocardial infarctionFAERS: 1OFFSIDES
SIDER
US FAERS
82Altered state of consciousnessFAERS: 1US FAERS
83AmputationFAERS: 1US FAERS
84AneurysmFAERS: 1US FAERS
85AnhedoniaFAERS: 1US FAERS
86ArthropathyFAERS: 1SIDER
US FAERS
87Back disorderFAERS: 1US FAERS
88BedriddenFAERS: 1US FAERS
89Blood glucose fluctuationFAERS: 1US FAERS
90Blood glucose increasedFAERS: 1US FAERS
91BradyphreniaFAERS: 1US FAERS
92Cardiac ArrestFAERS: 1US FAERS
93CardiomegalyFAERS: 1US FAERS
94ChromaturiaFAERS: 1US FAERS
95Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
96ClaustrophobiaFAERS: 1US FAERS
97ColitisFAERS: 1OFFSIDES
US FAERS
98Coronary Artery DiseaseFAERS: 1US FAERS
99CryingFAERS: 1US FAERS
100DeafnessFAERS: 1US FAERS
101DehydrationFAERS: 1OFFSIDES
US FAERS
102DeliriumFAERS: 1US FAERS
103DisabilityFAERS: 1US FAERS
104DiscomfortFAERS: 1SIDER
US FAERS
105Drug DependenceFAERS: 1US FAERS
106EczemaFAERS: 1SIDER
US FAERS
107Electrocardiogram abnormalFAERS: 1SIDER
US FAERS
108Emotional distressFAERS: 1OFFSIDES
US FAERS
109Erectile dysfunctionFAERS: 1SIDER
US FAERS
110ErythemaFAERS: 1US FAERS
111Feeling ColdFAERS: 1US FAERS
112Feeling jitteryFAERS: 1US FAERS
113FractureFAERS: 1US FAERS
114GoutFAERS: 1OFFSIDES
SIDER
US FAERS
115Hypoaesthesia facialFAERS: 1US FAERS
116HypophagiaFAERS: 1OFFSIDES
US FAERS
117HypoventilationFAERS: 1US FAERS
118Impaired driving abilityFAERS: 1US FAERS
119Inappropriate schedule of drug administrationFAERS: 1US FAERS
120Incorrect product dosage form administeredFAERS: 1US FAERS
121Incorrect product formulation administeredFAERS: 1US FAERS
122Initial insomniaFAERS: 1US FAERS
123Intentional misuseFAERS: 1US FAERS
124Intentional product misuseFAERS: 1US FAERS
125Intercepted drug dispensing errorFAERS: 1US FAERS
126Joint injuryFAERS: 1OFFSIDES
US FAERS
127Joint swellingFAERS: 1US FAERS
128Lid lagFAERS: 1US FAERS
129Limb discomfortFAERS: 1OFFSIDES
US FAERS
130Medical device complicationFAERS: 1OFFSIDES
US FAERS
131Medication residueFAERS: 1US FAERS
132Mental status changesFAERS: 1OFFSIDES
US FAERS
133Musculoskeletal chest painFAERS: 1US FAERS
134MyalgiaFAERS: 1SIDER
US FAERS
135Neck PainFAERS: 1SIDER
US FAERS
136NeuralgiaFAERS: 1OFFSIDES
US FAERS
137ObstructionFAERS: 1OFFSIDES
US FAERS
138OliguriaFAERS: 1US FAERS
139Open woundFAERS: 1US FAERS
140Performance status decreasedFAERS: 1US FAERS
141PneumoperitoneumFAERS: 1US FAERS
142PneumothoraxFAERS: 1US FAERS
143Product packaging issueFAERS: 1US FAERS
144Product taste abnormalFAERS: 1US FAERS
145Reaction to drug excipientsFAERS: 1US FAERS
146Respiratory arrestFAERS: 1US FAERS
147Respiratory distressFAERS: 1US FAERS
148Similar reaction on previous exposure to drugFAERS: 1US FAERS
149Sinus bradycardiaFAERS: 1OFFSIDES
US FAERS
150Sjogren's SyndromeFAERS: 1US FAERS
151Skin UlcerFAERS: 1SIDER
US FAERS
152SluggishnessFAERS: 1US FAERS
153Stool analysis abnormalFAERS: 1OFFSIDES
US FAERS
154SwellingFAERS: 1US FAERS
155ThrombosisFAERS: 1US FAERS
156TinnitusFAERS: 1SIDER
US FAERS
157TremorFAERS: 1SIDER
US FAERS
158Unevaluable eventFAERS: 1OFFSIDES
US FAERS
159Wrong technique in product usage processFAERS: 1US FAERS
160Abnormal visionSIDER
161Acid refluxOFFSIDES
162AcneSIDER
163Acute kidney injury15662077CTD
164Acute prerenal failureOFFSIDES
165Acute respiratory failureOFFSIDES
166Acute sinusitisOFFSIDES
167AgitationSIDER
168Alanine Aminotransferase IncreasedSIDER
169AlbuminuriaSIDER
170AlveolitisOFFSIDES
171Amaurosis FugaxSIDER
172AmblyopiaOFFSIDES
SIDER
173AmnesiaSIDER
174AmyloidosisOFFSIDES
175Angina pectoris aggravatedSIDER
176AngioedemaOFFSIDES
177Ankle reconstructionOFFSIDES
178Anorectal discomfortSIDER
179Anoxic EncephalopathyOFFSIDES
180Anticoagulation drug level below therapeuticOFFSIDES
181Aortic AneurysmOFFSIDES
182Aortic aneurysm repairOFFSIDES
183Aortic valve calcificationOFFSIDES
184Aortic valve sclerosisOFFSIDES
185ApathyOFFSIDES
186Arterial bypass operationOFFSIDES
187Arteriogram coronary abnormalOFFSIDES
188ArteriosclerosisOFFSIDES
189Arteriovenous fistula thrombosisOFFSIDES
190Arteriovenous fistulaOFFSIDES
191ArthralgiaSIDER
192Aspartate Aminotransferase IncreasedSIDER
193Aspiration PneumoniaOFFSIDES
194AsthmaOFFSIDES
SIDER
195AtelectasisOFFSIDES
196AtherosclerosisOFFSIDES
197Atrial FibrillationSIDER
198Atrial FlutterOFFSIDES
199Atrial arrhythmiaSIDER
200Atrial tachycardiaOFFSIDES
201Atrioventricular BlockOFFSIDES
SIDER
202Atrophic vulvovaginitisSIDER
203Autonomic neuropathySIDER
204BREAST PAIN FEMALESIDER
205Bacteria sputum identifiedOFFSIDES
206Bacterial pyelonephritisOFFSIDES
207Bacterial test positiveOFFSIDES
208Biliary ColicSIDER
209Bladder DiverticulumSIDER
210Bladder neck obstructionOFFSIDES
211Blood 1,25-dihydroxycholecalciferol decreasedOFFSIDES
212Blood GlucoseOFFSIDES
213Blood creatine phosphokinase MM increasedOFFSIDES
214Blood creatine phosphokinase increasedOFFSIDES
215Blood creatinine increasedOFFSIDES
216Blood lactate dehydrogenase increasedOFFSIDES
217Blood magnesium decreasedOFFSIDES
218Blood pH increasedOFFSIDES
219Blood potassium increasedOFFSIDES
220Blood sodiumOFFSIDES
221Blood urea increasedOFFSIDES
222Blood uric acidOFFSIDES
223Blurred visionOFFSIDES
224Bone density decreasedOFFSIDES
225Brain DeathOFFSIDES
226Brain natriuretic peptide increasedOFFSIDES
227BronchitisOFFSIDES
SIDER
228BronchopneumoniaOFFSIDES
229BronchospasmSIDER
230Carbon Monoxide PoisoningOFFSIDES
231Cardiac TamponadeOFFSIDES
232Cardiac asthmaOFFSIDES
233Cardioactive drug level increasedOFFSIDES
234CataractOFFSIDES
235CellulitisOFFSIDES
236Central line infectionOFFSIDES
237Chemotherapeutic drug level increasedOFFSIDES
238ChillsSIDER
239Choking sensationOFFSIDES
240CholecystitisOFFSIDES
SIDER
241Chronic Obstructive Airway DiseaseOFFSIDES
242Chronic left ventricular failureOFFSIDES
243Chronic respiratory failureOFFSIDES
244Chronic sinusitisOFFSIDES
245Clostridium difficile colitisOFFSIDES
246ConfabulationOFFSIDES
247Congenital tricuspid valve incompetenceOFFSIDES
248ConjunctivitisSIDER
249Creatinine renal clearance decreasedOFFSIDES
250Culture positiveOFFSIDES
251Depressed Level of ConsciousnessOFFSIDES
252DermatitisSIDER
253Device malfunctionOFFSIDES
254Device related infectionOFFSIDES
255DiabetesOFFSIDES
256Diabetes MellitusSIDER
257Diabetic RetinopathyOFFSIDES
258Diarrhea15662077CTD
OFFSIDES
259Disturbance in sexual arousalSIDER
260DiverticulosisOFFSIDES
261Dry gangreneOFFSIDES
262Duodenal UlcerSIDER
263DysgeusiaSIDER
264DysuriaSIDER
265Ejection Fraction DecreasedOFFSIDES
266Electrocardiogram changeOFFSIDES
267Electromechanical dissociationOFFSIDES
268Enterobacter pneumoniaOFFSIDES
269Enterococcal infectionOFFSIDES
270Eosinophilic PneumoniaOFFSIDES
271Eosinophilic myocarditisOFFSIDES
272EpistaxisOFFSIDES
SIDER
273Erosive gastritisOFFSIDES
274EructationSIDER
275Escherichia infectionOFFSIDES
276Esophageal and Gastric Varices17098669CTD
277ExophthalmosOFFSIDES
278Extremity necrosisOFFSIDES
279Fear of weight gainOFFSIDES
280Flank PainOFFSIDES
281FlatulenceOFFSIDES
SIDER
282Fluid overloadOFFSIDES
283FlushingSIDER
284FormicationOFFSIDES
285Frozen shoulderSIDER
286Fungal test positiveOFFSIDES
287Gamma-Glutamyltransferase IncreasedSIDER
288GangreneOFFSIDES
289Gastric ulcerOFFSIDES
SIDER
290GastritisSIDER
291Gastrointestinal PainSIDER
292GlossitisSIDER
293GlycosuriaSIDER
294Granulocyte count increasedOFFSIDES
295GranulocytosisOFFSIDES
296Heart sounds abnormalSIDER
297HeartburnSIDER
298Hemorrhage12475399CTD
299Heparin-induced thrombocytopeniaOFFSIDES
300HepatitisOFFSIDES
301HepatomegalySIDER
302Herpes Zoster OticusOFFSIDES
303HydrocephalusOFFSIDES
304HypercapniaOFFSIDES
305HypokinesiaSIDER
306HypoxiaOFFSIDES
307Impaired gastric emptyingOFFSIDES
308Implant expulsionOFFSIDES
309Implant site reactionOFFSIDES
310Implantable defibrillator insertionOFFSIDES
311Incision site infectionOFFSIDES
312IncontinenceOFFSIDES
313InfectionSIDER
314Influenza-like symptomsSIDER
315Intention tremorOFFSIDES
316Intermittent ClaudicationSIDER
317Intervertebral Disc DegenerationOFFSIDES
318Intervertebral disc disorderOFFSIDES
319Intestinal ObstructionSIDER
320Intra-aortic balloon placementOFFSIDES
321IntubationOFFSIDES
322Kidney FailureOFFSIDES
323LacerationOFFSIDES
324Leg UlcerSIDER
325LeukocytosisSIDER
326LeukopeniaSIDER
327Livedo ReticularisOFFSIDES
328Lumbar spine flatteningOFFSIDES
329MalnutritionSIDER
330MarasmusOFFSIDES
331MeningiomaOFFSIDES
332Mental impairmentOFFSIDES
333Metabolic acidosisOFFSIDES
334MetamorphopsiaOFFSIDES
335MetatarsalgiaOFFSIDES
336Mitral valve sclerosisOFFSIDES
337Mood swingsSIDER
338MucormycosisOFFSIDES
339Multi-organ disorderOFFSIDES
340Multiple drug overdose intentionalOFFSIDES
341Muscle WeaknessOFFSIDES
342Musculoskeletal discomfortSIDER
343Musculoskeletal stiffnessSIDER
344MyelodysplasiaOFFSIDES
345Myocardial Ischemia

View details

3086899
9411825
10892660
14603907
 		CTD
346MyositisSIDER
347Nasal discomfortOFFSIDES
348Neck stiffnessSIDER
349NephrolithiasisSIDER
350NeuritisSIDER
351Non-cardiac chest painOFFSIDES
352Nuchal RigiditySIDER
353Occult blood positiveOFFSIDES
354OpisthotonusOFFSIDES
355Oral polypectomyOFFSIDES
356Orbital infectionOFFSIDES
357OrthopneaOFFSIDES
358PCO2 decreasedOFFSIDES
359Pancreatic NeoplasmOFFSIDES
360PancreatitisOFFSIDES
361ParesisSIDER
362ParophthalmiaOFFSIDES
363Percutaneous Coronary InterventionOFFSIDES
364PeriarthritisSIDER
365Peripheral arterial occlusive diseaseOFFSIDES
366Peripheral occlusive diseaseOFFSIDES
367PharyngitisSIDER
368Pharyngolaryngeal PainOFFSIDES
369PhotophobiaSIDER
370Pituitary Apoplexy3585391CTD
371PolyuriaSIDER
372Post procedural infectionOFFSIDES
373Post procedural myocardial infarctionOFFSIDES
374Prostate cancer recurrentOFFSIDES
375Pulmonary Embolism17632098CTD
376Pulmonary HypertensionOFFSIDES
377PurpuraSIDER
378RalesSIDER
379Rash erythematousSIDER
380Rectal tenesmusSIDER
381Renal Artery StenosisOFFSIDES
382Renal cystOFFSIDES
383Renal tubular necrosisOFFSIDES
384Respiratory FailureOFFSIDES
385Retinal artery embolismOFFSIDES
386Retinal pigment epithelial tearOFFSIDES
387Retroperitoneal lymphadenopathyOFFSIDES
388RhabdomyolysisOFFSIDES
389RhinitisSIDER
390Sensation of warmthSIDER
391Sinoatrial BlockOFFSIDES
392Sinus operationOFFSIDES
393Sinus rhythmOFFSIDES
394SinusitisSIDER
395Skin noduleSIDER
396Soft Tissue InjuriesOFFSIDES
397Sputum culture positiveOFFSIDES
398StressOFFSIDES
399Substance Withdrawal Syndrome3147892CTD
400Superficial ThrombophlebitisOFFSIDES
401Supraventricular tachycardiaOFFSIDES
SIDER
402SweatingSIDER
403SynovitisOFFSIDES
404Tachycardia, Ventricular16945804CTD
405Tardive DyskinesiaOFFSIDES
406TensionSIDER
407Testicular massOFFSIDES
408ThirstSIDER
409ThrombocytopeniaSIDER
410Tinea CapitisOFFSIDES
411TorticollisSIDER
412TracheitisOFFSIDES
413Troponin TOFFSIDES
414Troponin increasedOFFSIDES
415Tympanic Membrane PerforationSIDER
416Ureteral stent insertionOFFSIDES
417Urinary tract infection enterococcalOFFSIDES
418Urinary tract infectionSIDER
419Urine output increasedSIDER
420Urine sodium abnormalOFFSIDES
421Vascular purpuraSIDER
422VasospasmOFFSIDES
SIDER
423Venous stenosisOFFSIDES
424Ventricular FibrillationOFFSIDES
425Ventricular hypokinesiaOFFSIDES
426Weight decreasedSIDER
427Wound InfectionOFFSIDES
428angiogramOFFSIDES
429carbuncleOFFSIDES
430muscle injuryOFFSIDES
431nervous system disorderSIDER
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