MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteoradionecrosis

(UMLS:C0029461)

Definition:: Necrosis of bone following radiation injury.
UMLS ID:: C0029461
MeSH ID:: D010025

Classification 1:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.733.579

Classification 2:

Name:

Physical Phenomena
MeSH Tree Number(s):: G01.750.748.500.579

Synonym(s)

Osteoradionecrosis

Radiation necrosis of bone

injury radiation osteoradionecrosis

osteoradionecrosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 57	OFFSIDES US FAERS
2	Docetaxel	FAERS: 6	OFFSIDES US FAERS
3	Zoledronic Acid	FAERS: 6	OFFSIDES US FAERS
4	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 2	US FAERS
5	Bleomycin	FAERS: 2	US FAERS
6	Erlotinib Hydrochloride	FAERS: 2	US FAERS
7	Capecitabine	FAERS: 1	OFFSIDES US FAERS
8	Erlotinib Hydrochloride	FAERS: 1	US FAERS
9	Fluorouracil	FAERS: 1	US FAERS
10	HhAntag691	FAERS: 1	US FAERS
11	Pamidronate	FAERS: 1	US FAERS
12	Ruxolitinib phosphate	FAERS: 1	US FAERS
13	Ampicillin		OFFSIDES
14	Aprepitant		OFFSIDES
15	Ascorbic Acid		OFFSIDES
16	Azithromycin		OFFSIDES
17	Bortezomib		OFFSIDES
18	Calcium Carbonate		OFFSIDES
19	Calcium Citrate		OFFSIDES
20	Calcium Compounds		OFFSIDES
21	Cefaclor		OFFSIDES
22	Chlorhexidine		OFFSIDES
23	Ciclopirox		OFFSIDES
24	Cisapride		OFFSIDES
25	Clindamycin		OFFSIDES
26	Clotrimazole		OFFSIDES
27	Cortisone		OFFSIDES
28	Cortisone		OFFSIDES
29	Dermazin		OFFSIDES
30	Diflunisal		OFFSIDES
31	Doxazosin		OFFSIDES
32	Doxepin		OFFSIDES
33	Doxorubicin		OFFSIDES
34	Doxycycline		OFFSIDES
35	Dutasteride		OFFSIDES
36	Ephedrine		OFFSIDES
37	Ertapenem		OFFSIDES
38	Ethylene Glycol		OFFSIDES
39	Famciclovir		OFFSIDES
40	Fenofibrate		OFFSIDES
41	Fludrocortisone		OFFSIDES
42	Flurazepam		OFFSIDES
43	Fulvestrant		OFFSIDES
44	Hydralazine		OFFSIDES
45	Hydrochlorothiazide		OFFSIDES
46	Indapamide		OFFSIDES
47	Isradipine		OFFSIDES
48	Ketoconazole		OFFSIDES
49	Lenalidomide		OFFSIDES
50	Letrozole		OFFSIDES
51	Linezolid		OFFSIDES
52	Meperidine		OFFSIDES
53	Methotrexate		OFFSIDES
54	Methylprednisolone Acetate		OFFSIDES
55	Metoclopramide		OFFSIDES
56	Metolazone		OFFSIDES
57	Minocycline		OFFSIDES
58	Mycophenolic Acid		OFFSIDES
59	Nabumetone		OFFSIDES
60	Niacin		OFFSIDES
61	Nitrofurantoin		OFFSIDES
62	Norethindrone Acetate		OFFSIDES
63	Palonosetron		OFFSIDES
64	Pamidronate		OFFSIDES
65	Pantoprazole		OFFSIDES
66	Penicillin V		OFFSIDES
67	Pentoxifylline		OFFSIDES
68	Progesterone		OFFSIDES
69	Pyridoxine		OFFSIDES
70	Raloxifene Hydrochloride		OFFSIDES
71	Risperidone		OFFSIDES
72	Scopolamine		OFFSIDES
73	Selenium		OFFSIDES
74	Sulbactam		OFFSIDES
75	Sulfamethoxazole		OFFSIDES
76	Tamoxifen		OFFSIDES
77	Terazosin		OFFSIDES
78	Thalidomide		OFFSIDES
79	Timolol		OFFSIDES
80	Ubiquinone		OFFSIDES
81	alfuzosin		OFFSIDES
82	azelastine		OFFSIDES
83	carbidopa, levodopa drug combination		OFFSIDES
84	chlorhexidine gluconate		OFFSIDES
85	dolasetron		OFFSIDES
86	montelukast		OFFSIDES
87	montelukast		OFFSIDES
88	valdecoxib		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Neoplasms, Radiation-Induced	38%
2	Cardiotoxicity	31%
3	Leukemia, Radiation-Induced	30.7%
4	Radiation Pneumonitis	30.3%
5	Radiation Fibrosis	30.3%
6	Abnormalities, Radiation-Induced	25.8%
7	Radiation Injuries, Experimental	25.6%
8	Frostbite	18%
9	Athletic Injuries	14.5%
10	Hand Injuries	14.5%
11	Soft Tissue Injuries	14.5%
12	Sprain	14.5%
13	Sprains and Strains	14.5%
14	Tendon Injuries	14.5%
15	Laceration	14.5%
16	Wounds, Penetrating	14.5%
17	Heat Cramps	14.5%
18	Rupture	14.5%
19	Crush syndrome	13.9%
20	Femoral Fractures	13.9%
21	Tibial Fractures	13.9%
22	Hip Fractures	13.6%
23	Chilblains	12%
24	Spinal Fractures	12%
25	Trauma, Nervous System	11.2%
26	Hip Dislocation	11%
27	Shoulder Dislocation	11%
28	Splenic Rupture	11%
29	Hip Dysplasia	11%
30	Bites and Stings	10.8%
31	Extravasation of Diagnostic and Therapeutic Materials	10.8%
32	Vascular System Injuries	10.8%
33	Tympanic Membrane Perforation	10.8%
34	Tooth Injuries	10.8%
35	Asphyxia	10.6%
36	Esophageal Perforation	10.6%
37	Shock, Traumatic	10.6%
38	Self Mutilation	10.5%
39	Iliotibial Band Syndrome	10.1%
40	Human Bite	9.2%
41	Contusions	9.2%
42	Decompression Sickness	9.2%
43	Finger Injuries	9.2%
44	Flail Chest	9.2%
45	Fractures, Closed	9.2%
46	Pathological fracture	9.2%
47	Heart Injuries	9.2%
48	Heat Exhaustion	9.2%
49	Heat Stroke	9.2%
50	Knee Injuries	9.2%
51	Foot Injuries	9.2%
52	Decapitation	9.2%
53	Ankle Fracture	9.2%
54	Avulsion fracture	9.2%
55	Compression fracture	9.2%
56	Osteoporotic Fractures	9.2%
57	Spinal Cord Injuries	8.5%
58	Drowning	8.4%
59	Eye Burns	8.3%
60	Splenosis	8%
61	Craniocerebral Trauma	7%
62	Tendinitis	7%
63	Lung Injury	7%
64	Tendinopathy	7%
65	Foreign-Body Reaction	6.8%
66	Insect Bites and Stings	6.8%
67	Paralysis, Obstetric	6.8%
68	Sunburn	6.8%
69	Tooth Avulsion	6.8%
70	Conus Medullaris Syndrome	6.8%
71	Near Drowning	6.8%
72	Pseudarthrosis	6.7%
73	Smoke Inhalation Injury	6.7%
74	Brain Concussion	6.3%
75	Brain Contusion	5.7%
76	Peripheral Nerve Injuries	5.5%
77	Medial Tibial Stress Syndrome	5.5%
78	Uterine Rupture	5.4%
79	Central Cord Syndrome	5.4%
80	Facial Injuries	5%
81	Granuloma, Foreign-Body	5%
82	Enthesopathy	5%
83	Uterine Perforation	5%
84	Aortic Rupture	4.4%
85	Brain Injuries	4%
86	Coma, Post-Head Injury	4%
87	Carpal Tunnel Syndrome	4%
88	Brain Hemorrhage, Traumatic	3.6%
89	Eye Injuries	3.4%
90	Brain Injuries, Diffuse	3.3%
91	Traumatic Brain Injury	3.3%
92	Cubital Tunnel Syndrome	3.3%
93	Diffuse Axonal Injury	2.9%
94	Vertebral Artery Dissection	2.8%
95	Pneumocephalus	2.8%
96	Olfactory Nerve Injuries	2.8%
97	Cerebrospinal Fluid Otorrhea	2.7%
98	Cerebrospinal Fluid Rhinorrhea	2.7%
99	Epilepsy, Post-Traumatic	2.7%
100	Corneal Scar	2.5%
101	Carotid Artery Injuries	2.5%
102	Facial Nerve Injuries	2.4%
103	Corneal Perforation	2.3%
104	Hematoma, Subdural	2%
105	Hematoma, Epidural, Cranial	2%
106	Hematoma, Subdural, Intracranial	1.8%
107	Hematoma, Subdural, Chronic	1.8%
108	Hematoma, Subdural, Acute	1.8%
109	Subarachnoid Hemorrhage, Traumatic	1.8%
110	Carotid Artery, Internal, Dissection	1.8%

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