MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Heat Exhaustion

(UMLS:C0018839)

Definition:: A clinical syndrome caused by heat stress, such as over-exertion in a hot environment or excessive exposure to sun. It is characterized by SWEATING, water (volume) depletion, salt depletion, cool clammy skin, NAUSEA, and HEADACHE.
UMLS ID:: C0018839
MeSH ID:: D006359

Classification:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.522.250

Synonym(s)

Heat Exhaustion

HEAT EXHAUSTION

HEAT PROSTRATION

Heat exhaustion

Heat exhaustion, NOS

Heat exhaustion, unspecified

Heat prostration

Heat prostration, NOS

exhaustion heat

10.

exhaustion; heat

11.

heat exhaustion

12.

heat prostration

13.

heat; exhaustion

14.

heat; prostration

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Fingolimod Hydrochloride	FAERS: 10 Canada Vigilance: 1	Canada Vigilance US FAERS
2	Glatiramer Acetate	FAERS: 6	US FAERS
3	Clozapine	FAERS: 5	US FAERS
4	Dimethyl Fumarate	FAERS: 5	US FAERS
5	Atomoxetine Hydrochloride	FAERS: 4	US FAERS
6	Bosentan	FAERS: 3	US FAERS
7	Isotretinoin	FAERS: 3	US FAERS
8	Teriparatide	FAERS: 3	US FAERS
9	ambrisentan	FAERS: 3	US FAERS
10	teriflunomide	FAERS: 3	US FAERS
11	tofacitinib	FAERS: 3	US FAERS
12	Buprenorphine	FAERS: 2	US FAERS
13	Lenalidomide	FAERS: 2	OFFSIDES US FAERS
14	Metoclopramide	FAERS: 2	US FAERS
15	Varenicline	FAERS: 2	US FAERS
16	montelukast	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
17	rofecoxib	FAERS: 2	OFFSIDES US FAERS
18	2-[(E)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid;(2S)-2,6-diaminohexanoic acid	FAERS: 1	US FAERS
19	4-Aminopyridine	FAERS: 1	US FAERS
20	Abiraterone Acetate	FAERS: 1	US FAERS
21	Acetaminophen	FAERS: 1	US FAERS
22	Adzenys XR-ODT	FAERS: 1	US FAERS
23	Amlodipine	FAERS: 1	US FAERS
24	Anoro Ellipta	FAERS: 1	US FAERS
25	Aripiprazole	FAERS: 1	SIDER US FAERS
26	Atorvastatin	FAERS: 1	US FAERS
27	Baclofen	FAERS: 1	US FAERS
28	Canagliflozin	FAERS: 1	US FAERS
29	Citalopram	FAERS: 1	US FAERS
30	Deamino Arginine Vasopressin	FAERS: 1	US FAERS
31	Diovan Hct	FAERS: 1	US FAERS
32	Donepezil	FAERS: 1	US FAERS
33	Duloxetine Hydrochloride	FAERS: 1	US FAERS
34	Latanoprost	FAERS: 1	US FAERS
35	Lisdexamfetamine Dimesylate	FAERS: 1	US FAERS
36	Lisinopril	FAERS: 1	US FAERS
37	Loratadine	FAERS: 1	US FAERS
38	Lurasidone Hydrochloride	FAERS: 1	US FAERS
39	Methylphenidate	FAERS: 1	US FAERS
40	Mirtazapine	FAERS: 1	US FAERS
41	Morphine	FAERS: 1	US FAERS
42	Norgestrel	FAERS: 1	US FAERS
43	Omeprazole	FAERS: 1	US FAERS
44	Oxcarbazepine	FAERS: 1	US FAERS
45	Paroxetine	FAERS: 1	US FAERS
46	Procarbazine	FAERS: 1	US FAERS
47	Quetiapine Fumarate	FAERS: 1	US FAERS
48	Sitagliptin Phosphate	FAERS: 1	US FAERS
49	Sorafenib	FAERS: 1	US FAERS
50	Thyroxine	FAERS: 1	US FAERS
51	Tolterodine Tartrate	FAERS: 1	US FAERS
52	acetaminophen, aspirin, caffeine drug combination	FAERS: 1	US FAERS
53	apremilast	FAERS: 1	US FAERS
54	carbidopa, levodopa drug combination	FAERS: 1	US FAERS
55	darifenacin	FAERS: 1	US FAERS
56	prednisolone acetate	FAERS: 1	US FAERS
57	sofosbuvir-velpatasvir drug combination	FAERS: 1	US FAERS
58	testosterone 17 beta-cypionate	FAERS: 1	US FAERS
59	Chlorhexidine		OFFSIDES
60	Clonidine		OFFSIDES
61	Dipyridamole		OFFSIDES
62	Dutasteride		OFFSIDES
63	Erlotinib Hydrochloride		OFFSIDES
64	Erlotinib Hydrochloride		OFFSIDES
65	Estramustine phosphate		OFFSIDES
66	Estramustine		OFFSIDES
67	Fondaparinux		OFFSIDES
68	Imipramine		OFFSIDES
69	Ketoconazole		OFFSIDES
70	Ketoprofen		OFFSIDES
71	Lansoprazole		OFFSIDES
72	Maraviroc		SIDER
73	Modafinil		OFFSIDES
74	Naltrexone		SIDER
75	Octreotide		OFFSIDES
76	Orlistat		OFFSIDES
77	Pamidronate		OFFSIDES
78	Pyridoxine		OFFSIDES
79	Scopolamine		SIDER
80	Trihexyphenidyl		OFFSIDES
81	Vancomycin		OFFSIDES
82	Varenicline		OFFSIDES
83	chlorhexidine gluconate		OFFSIDES
84	miglitol		OFFSIDES
85	tizanidine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Heat Stroke	42.9%
2	Frostbite	25%
3	Athletic Injuries	23.1%
4	Hand Injuries	23.1%
5	Soft Tissue Injuries	23.1%
6	Sprain	23.1%
7	Sprains and Strains	23.1%
8	Tendon Injuries	23.1%
9	Laceration	23.1%
10	Wounds, Penetrating	23.1%
11	Rupture	23.1%
12	Crush syndrome	19%
13	Femoral Fractures	19%
14	Tibial Fractures	19%
15	Hip Fractures	17.2%
16	Chilblains	16.3%
17	Spinal Fractures	16.3%
18	Trauma, Nervous System	15.8%
19	Bites and Stings	15%
20	Extravasation of Diagnostic and Therapeutic Materials	15%
21	Vascular System Injuries	15%
22	Tympanic Membrane Perforation	15%
23	Tooth Injuries	15%
24	Asphyxia	14.6%
25	Esophageal Perforation	14.6%
26	Shock, Traumatic	14.6%
27	Self Mutilation	14.5%
28	Human Bite	14.3%
29	Contusions	14.3%
30	Decompression Sickness	14.3%
31	Finger Injuries	14.3%
32	Flail Chest	14.3%
33	Fractures, Closed	14.3%
34	Pathological fracture	14.3%
35	Heart Injuries	14.3%
36	Knee Injuries	14.3%
37	Foot Injuries	14.3%
38	Decapitation	14.3%
39	Ankle Fracture	14.3%
40	Avulsion fracture	14.3%
41	Compression fracture	14.3%
42	Osteoporotic Fractures	14.3%
43	Hip Dislocation	14%
44	Shoulder Dislocation	14%
45	Splenic Rupture	14%
46	Hip Dysplasia	14%
47	Iliotibial Band Syndrome	13.6%
48	Spinal Cord Injuries	10.9%
49	Drowning	10.7%
50	Eye Burns	10.5%
51	Pseudarthrosis	10.3%
52	Smoke Inhalation Injury	10.3%
53	Splenosis	10.1%
54	Craniocerebral Trauma	9.5%
55	Tendinitis	9.5%
56	Lung Injury	9.5%
57	Tendinopathy	9.5%
58	Foreign-Body Reaction	9.3%
59	Insect Bites and Stings	9.3%
60	Paralysis, Obstetric	9.3%
61	Sunburn	9.3%
62	Tooth Avulsion	9.3%
63	Conus Medullaris Syndrome	9.3%
64	Near Drowning	9.2%
65	Osteoradionecrosis	9.2%
66	Radiation injury	8.3%
67	Brain Concussion	7.2%
68	Neoplasms, Radiation-Induced	7.2%
69	Peripheral Nerve Injuries	7%
70	Medial Tibial Stress Syndrome	7%
71	Brain Contusion	6.9%
72	Uterine Rupture	6.8%
73	Central Cord Syndrome	6.8%
74	Facial Injuries	6.8%
75	Granuloma, Foreign-Body	6.8%
76	Enthesopathy	6.8%
77	Uterine Perforation	6.7%
78	Cardiotoxicity	5.6%
79	Leukemia, Radiation-Induced	5.5%
80	Radiation Pneumonitis	5.4%
81	Radiation Fibrosis	5.4%
82	Aortic Rupture	5.4%
83	Brain Injuries	5.1%
84	Coma, Post-Head Injury	5%
85	Carpal Tunnel Syndrome	5%
86	Abnormalities, Radiation-Induced	4.5%
87	Radiation Injuries, Experimental	4.4%
88	Eye Injuries	4.4%
89	Brain Injuries, Diffuse	4.1%
90	Traumatic Brain Injury	4.1%
91	Cubital Tunnel Syndrome	4.1%
92	Brain Hemorrhage, Traumatic	4.1%
93	Diffuse Axonal Injury	3.7%
94	Pneumocephalus	3.4%
95	Olfactory Nerve Injuries	3.3%
96	Cerebrospinal Fluid Otorrhea	3.3%
97	Cerebrospinal Fluid Rhinorrhea	3.3%
98	Vertebral Artery Dissection	3.3%
99	Epilepsy, Post-Traumatic	3.3%
100	Corneal Scar	3.1%
101	Carotid Artery Injuries	2.8%
102	Corneal Perforation	2.8%
103	Facial Nerve Injuries	2.8%
104	Hematoma, Subdural	2.3%
105	Hematoma, Epidural, Cranial	2.3%
106	Hematoma, Subdural, Intracranial	2.1%
107	Hematoma, Subdural, Chronic	2.1%
108	Hematoma, Subdural, Acute	2.1%
109	Subarachnoid Hemorrhage, Traumatic	2%
110	Carotid Artery, Internal, Dissection	2%

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