MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Crush syndrome

(UMLS:C0010392)

Definition:: Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.
UMLS ID:: C0010392
MeSH ID:: D003444

Classification:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.257.500|C26.797.240

Synonym(s)

Crush syndrome

Bywaters

Bywaters' syndrome

Crush kidney

Ischaemic muscular necrosis syndrome

Ischemic muscular necrosis syndrome

Renal failure following crushing injury

crush syndrome

crush syndromes

10.

crush; syndrome

11.

crushing injury; syndrome

12.

crushing syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Simvastatin	FAERS: 5	US FAERS
2	Methadone	FAERS: 1	US FAERS
3	Olanzapine	FAERS: 1	US FAERS
4	Quetiapine Fumarate	FAERS: 1	US FAERS
5	Sunitinib	FAERS: 1	US FAERS
6	Vinorelbine	FAERS: 1	US FAERS
7	Ambroxol		OFFSIDES
8	Bromazepam		OFFSIDES
9	Ephedrine		OFFSIDES
10	Oxazepam		OFFSIDES
11	Phenprocoumon		OFFSIDES
12	Piperacillin		OFFSIDES
13	ethyl loflazepate		OFFSIDES
14	etizolam		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Frostbite	37%
2	Athletic Injuries	30%
3	Hand Injuries	30%
4	Soft Tissue Injuries	30%
5	Sprain	30%
6	Sprains and Strains	30%
7	Tendon Injuries	30%
8	Laceration	30%
9	Wounds, Penetrating	30%
10	Heat Cramps	30%
11	Rupture	30%
12	Femoral Fractures	28.6%
13	Tibial Fractures	28.6%
14	Hip Fractures	27.8%
15	Chilblains	24.6%
16	Spinal Fractures	24.6%
17	Trauma, Nervous System	23.1%
18	Hip Dislocation	22.5%
19	Shoulder Dislocation	22.5%
20	Splenic Rupture	22.5%
21	Hip Dysplasia	22.5%
22	Bites and Stings	22.2%
23	Extravasation of Diagnostic and Therapeutic Materials	22.2%
24	Vascular System Injuries	22.2%
25	Tympanic Membrane Perforation	22.2%
26	Tooth Injuries	22.2%
27	Asphyxia	21.8%
28	Esophageal Perforation	21.8%
29	Self Mutilation	21.6%
30	Iliotibial Band Syndrome	20.7%
31	Human Bite	19%
32	Contusions	19%
33	Decompression Sickness	19%
34	Finger Injuries	19%
35	Flail Chest	19%
36	Fractures, Closed	19%
37	Pathological fracture	19%
38	Heart Injuries	19%
39	Heat Exhaustion	19%
40	Heat Stroke	19%
41	Knee Injuries	19%
42	Foot Injuries	19%
43	Decapitation	19%
44	Ankle Fracture	19%
45	Avulsion fracture	19%
46	Compression fracture	19%
47	Osteoporotic Fractures	19%
48	Spinal Cord Injuries	17.4%
49	Drowning	17.1%
50	Eye Burns	17%
51	Splenosis	16.3%
52	Crush syndrome	14.3%
53	Craniocerebral Trauma	14.3%
54	Tendinitis	14.3%
55	Lung Injury	14.3%
56	Tendinopathy	14.3%
57	Foreign-Body Reaction	14%
58	Insect Bites and Stings	14%
59	Paralysis, Obstetric	14%
60	Sunburn	14%
61	Tooth Avulsion	14%
62	Conus Medullaris Syndrome	14%
63	Pseudarthrosis	14%
64	Smoke Inhalation Injury	14%
65	Near Drowning	13.9%
66	Osteoradionecrosis	13.9%
67	Radiation injury	13.9%
68	Brain Concussion	12.8%
69	Brain Contusion	11.6%
70	Neoplasms, Radiation-Induced	11.5%
71	Peripheral Nerve Injuries	11.3%
72	Medial Tibial Stress Syndrome	11.3%
73	Uterine Rupture	11%
74	Central Cord Syndrome	11%
75	Shock, Traumatic	10.9%
76	Facial Injuries	10.3%
77	Granuloma, Foreign-Body	10.3%
78	Enthesopathy	10.3%
79	Uterine Perforation	10.2%
80	Cardiotoxicity	9.4%
81	Leukemia, Radiation-Induced	9.2%
82	Radiation Pneumonitis	9.1%
83	Radiation Fibrosis	9.1%
84	Aortic Rupture	9%
85	Brain Injuries	8.2%
86	Coma, Post-Head Injury	8.1%
87	Carpal Tunnel Syndrome	8.1%
88	Abnormalities, Radiation-Induced	7.8%
89	Radiation Injuries, Experimental	7.7%
90	Brain Hemorrhage, Traumatic	7.3%
91	Eye Injuries	7%
92	Brain Injuries, Diffuse	6.7%
93	Traumatic Brain Injury	6.7%
94	Cubital Tunnel Syndrome	6.7%
95	Diffuse Axonal Injury	6%
96	Vertebral Artery Dissection	5.7%
97	Pneumocephalus	5.6%
98	Olfactory Nerve Injuries	5.6%
99	Cerebrospinal Fluid Otorrhea	5.6%
100	Cerebrospinal Fluid Rhinorrhea	5.6%
101	Epilepsy, Post-Traumatic	5.6%
102	Corneal Scar	5.1%
103	Carotid Artery Injuries	5%
104	Facial Nerve Injuries	4.8%
105	Corneal Perforation	4.7%
106	Hematoma, Subdural	4.1%
107	Hematoma, Epidural, Cranial	4.1%
108	Hematoma, Subdural, Intracranial	3.7%
109	Hematoma, Subdural, Chronic	3.7%
110	Hematoma, Subdural, Acute	3.7%
111	Subarachnoid Hemorrhage, Traumatic	3.6%
112	Carotid Artery, Internal, Dissection	3.6%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234