MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Tympanic Membrane Perforation

(UMLS:C0206504)

Definition:: A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.
UMLS ID:: C0206504
MeSH ID:: D018058

Classification 1:

Name:

Otorhinolaryngologic Diseases
MeSH Tree Number(s):: C09.218.903

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.930

Synonym(s)

Tympanic Membrane Perforation

PERFORATED TYMPANIC MEMBRANE

PERFORATION OF TYMPANIC MEMBRANE

Perforated eardrum

Perforation ear drum

Perforation of ear drum

Perforation of ear drum, NOS

Perforation of eardrum

Perforation of tympanic membrane

10.

Perforation of tympanic membrane, NOS

11.

Perforation of tympanic membrane, unspecified

12.

Perforation tympanic membrane

13.

Perforation;ear drum

14.

Perforation;tympanic membran

15.

RUPTURED EAR DRUM

16.

Rupture of ear drum

17.

Rupture of tympanic membrane

18.

TYMPANIC MEMBRANE PERFORATION

19.

TYMPANIC MEMBRANE, PERFORATION

20.

Tear of tympanic membrane

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 24	OFFSIDES US FAERS
2	Aspirin	FAERS: 19	US FAERS
3	Lenalidomide	FAERS: 16	US FAERS
4	Ondansetron	FAERS: 14	US FAERS
5	Dexamethasone	FAERS: 13	US FAERS
6	Carbamide Peroxide	FAERS: 10	OFFSIDES US FAERS
7	Omeprazole	FAERS: 9	US FAERS
8	Ciprodex	FAERS: 8 Canada Vigilance: 4	Canada Vigilance US FAERS
9	Valproic Acid	FAERS: 8	US FAERS
10	tofacitinib	FAERS: 7	US FAERS
11	Zoledronic Acid	FAERS: 5	OFFSIDES US FAERS
12	dexamethasone 21-phosphate	FAERS: 5	US FAERS
13	Teriparatide	FAERS: 4	US FAERS
14	ciprofloxacin, hydrocortisone drug combination	FAERS: 4	US FAERS
15	Dimethyl Fumarate	FAERS: 3	US FAERS
16	Fingolimod Hydrochloride	FAERS: 3	US FAERS
17	Fluoxetine	FAERS: 3	US FAERS
18	Glatiramer Acetate	FAERS: 3	US FAERS
19	Isotretinoin	FAERS: 3	US FAERS
20	Ruxolitinib phosphate	FAERS: 3	US FAERS
21	4-hydroxybutyric acid	FAERS: 2	US FAERS
22	Hydrocortisone	FAERS: 2 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
23	NuvaRing	FAERS: 2	US FAERS
24	PCI 32765	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
25	Sertraline	FAERS: 2	US FAERS
26	Valproic Acid	FAERS: 2	US FAERS
27	Varenicline	FAERS: 2	US FAERS
28	Venlafaxine Hydrochloride	FAERS: 2	US FAERS
29	ambrisentan	FAERS: 2	US FAERS
30	fexofenadine	FAERS: 2	US FAERS
31	macitentan	FAERS: 2	US FAERS
32	montelukast	FAERS: 2	US FAERS
33	teriflunomide	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
34	4-Aminopyridine	FAERS: 1	US FAERS
35	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
36	Amoxicillin-Potassium Clavulanate Combination	FAERS: 1	US FAERS
37	Aprepitant	FAERS: 1	US FAERS
38	Azithromycin	FAERS: 1	US FAERS
39	Beclomethasone	FAERS: 1	US FAERS
40	Betamethasone	FAERS: 1	US FAERS
41	Cefdinir	FAERS: 1	US FAERS
42	Clozapine	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
43	Dasatinib	FAERS: 1	US FAERS
44	Deferasirox	FAERS: 1	OFFSIDES US FAERS
45	Desflurane	FAERS: 1	US FAERS
46	Dextromethorphan	FAERS: 1	US FAERS
47	Diclofenac	FAERS: 1	US FAERS
48	Diovan Hct	FAERS: 1	US FAERS
49	Duloxetine Hydrochloride	FAERS: 1	US FAERS
50	Econazole	FAERS: 1	US FAERS
51	Erlotinib Hydrochloride	FAERS: 1	US FAERS
52	Finasteride	FAERS: 1	US FAERS
53	Fluticasone	FAERS: 1	US FAERS
54	Imatinib Mesylate	FAERS: 1	US FAERS
55	Insulin degludec	FAERS: 1	US FAERS
56	Insulin	FAERS: 1	US FAERS
57	Lansoprazole	FAERS: 1	US FAERS
58	Liraglutide	FAERS: 1	US FAERS
59	Meclizine	FAERS: 1	US FAERS
60	Medroxyprogesterone Acetate	FAERS: 1	US FAERS
61	Methotrexate	FAERS: 1	US FAERS
62	Methotrexate	FAERS: 1	US FAERS
63	Methylphenidate	FAERS: 1	US FAERS
64	Methylprednisolone Acetate	FAERS: 1	US FAERS
65	Methylprednisolone	FAERS: 1	US FAERS
66	Nicotine	FAERS: 1	US FAERS
67	Norgestrel	FAERS: 1	US FAERS
68	Octreotide	FAERS: 1	US FAERS
69	Pregabalin	FAERS: 1	US FAERS
70	Pseudoephedrine	FAERS: 1	US FAERS
71	Raloxifene Hydrochloride	FAERS: 1	US FAERS
72	Ribavirin	FAERS: 1	OFFSIDES US FAERS
73	Rivastigmine	FAERS: 1	US FAERS
74	Sildenafil Citrate	FAERS: 1	US FAERS
75	Sitagliptin Phosphate	FAERS: 1	OFFSIDES US FAERS
76	Sunitinib	FAERS: 1	US FAERS
77	Terbinafine	FAERS: 1	OFFSIDES US FAERS
78	Thalidomide	FAERS: 1	US FAERS
79	Tiotropium Bromide	FAERS: 1	US FAERS
80	Triamcinolone Acetonide	FAERS: 1	US FAERS
81	apixaban	FAERS: 1	US FAERS
82	apremilast	FAERS: 1	US FAERS
83	cabozantinib	FAERS: 1	US FAERS
84	fluticasone furoate	FAERS: 1	US FAERS
85	ledipasvir, sofosbuvir drug combination	FAERS: 1	US FAERS
86	niraparib	FAERS: 1	US FAERS
87	paricalcitol	FAERS: 1	US FAERS
88	pasireotide	FAERS: 1	US FAERS
89	pimavanserin	FAERS: 1	US FAERS
90	pomalidomide	FAERS: 1	US FAERS
91	rofecoxib	FAERS: 1	US FAERS
92	1,4-3,6-dianhydromannitol		SIDER
93	Amifostine		OFFSIDES
94	Amoxicillin		OFFSIDES
95	Bupropion		OFFSIDES
96	Cefixime		OFFSIDES
97	Chlorhexidine		SIDER
98	Citalopram		SIDER
99	Codeine		OFFSIDES
100	Dapsone		OFFSIDES
101	Diphenoxylate		OFFSIDES
102	Doxepin		SIDER
103	Erythromycin	Canada Vigilance: 1	Canada Vigilance OFFSIDES
104	Felbamate		OFFSIDES
105	Fluocinonide		OFFSIDES
106	Gabapentin		SIDER
107	Hydron;carbonate		OFFSIDES
108	Ketotifen		OFFSIDES
109	Leucovorin		OFFSIDES
110	Lisinopril		OFFSIDES
111	Neomycin		OFFSIDES
112	Polymyxin B		OFFSIDES
113	Prazepam		OFFSIDES
114	Prednisone acetate		OFFSIDES
115	Primidone		OFFSIDES
116	Salmeterol Xinafoate		OFFSIDES
117	Scopolamine		OFFSIDES
118	Sertraline		OFFSIDES
119	Sirolimus		OFFSIDES
120	Sodium Bicarbonate		OFFSIDES
121	Sulfamethoxazole		OFFSIDES
122	Sulfasalazine		OFFSIDES
123	candesartan		OFFSIDES
124	fexofenadine		OFFSIDES
125	fluocinolone		SIDER
126	isosorbide-5-mononitrate		SIDER
127	rifapentine		SIDER
128	tipepidine		OFFSIDES
129	tulobuterol		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Labyrinthitis	32.1%
2	Otosclerosis	30%
3	Tympanosclerosis	30%
4	Frostbite	26.9%
5	Ear Neoplasms	23%
6	Hip Fractures	22.9%
7	Crush syndrome	22.2%
8	Femoral Fractures	22.2%
9	Otomycosis	22.2%
10	Tibial Fractures	22.2%
11	Congenital Microtia	22.2%
12	Cochlear Diseases	22%
13	Otitis Externa	22%
14	Otitis Media	22%
15	Vestibular Diseases	22%
16	Endolymphatic Hydrops	22%
17	Athletic Injuries	21.1%
18	Hand Injuries	21.1%
19	Soft Tissue Injuries	21.1%
20	Sprain	21.1%
21	Sprains and Strains	21.1%
22	Tendon Injuries	21.1%
23	Laceration	21.1%
24	Wounds, Penetrating	21.1%
25	Heat Cramps	21.1%
26	Rupture	21.1%
27	Chilblains	20%
28	Spinal Fractures	20%
29	Meniere Disease	18.1%
30	Otitis Media with Effusion	18.1%
31	Iliotibial Band Syndrome	17.9%
32	Hip Dislocation	17.4%
33	Shoulder Dislocation	17.4%
34	Splenic Rupture	17.4%
35	Hip Dysplasia	17.4%
36	Dysacusis	17%
37	Vestibulocochlear Nerve Diseases	16.4%
38	Trauma, Nervous System	16%
39	Bites and Stings	15.4%
40	Extravasation of Diagnostic and Therapeutic Materials	15.4%
41	Vascular System Injuries	15.4%
42	Tooth Injuries	15.4%
43	Asphyxia	15.1%
44	Esophageal Perforation	15.1%
45	Shock, Traumatic	15.1%
46	Human Bite	15%
47	Contusions	15%
48	Decompression Sickness	15%
49	Finger Injuries	15%
50	Flail Chest	15%
51	Fractures, Closed	15%
52	Pathological fracture	15%
53	Heart Injuries	15%
54	Heat Exhaustion	15%
55	Heat Stroke	15%
56	Knee Injuries	15%
57	Foot Injuries	15%
58	Decapitation	15%
59	Ankle Fracture	15%
60	Avulsion fracture	15%
61	Compression fracture	15%
62	Osteoporotic Fractures	15%
63	Self Mutilation	15%
64	Eye Burns	14.3%
65	Herpes Zoster Oticus	14%
66	Splenosis	14%
67	Vestibular Neuronitis	13.3%
68	Hyperacusis	12.5%
69	Tinnitus	12.5%
70	Phonophobia	12.5%
71	Hearing Loss	12.5%
72	Pseudarthrosis	12.2%
73	Smoke Inhalation Injury	12.2%
74	Laryngeal Diseases	12%
75	Nose Diseases	12%
76	Pharyngeal Diseases	12%
77	Spinal Cord Injuries	11.9%
78	Drowning	11.8%
79	Brain Concussion	11.5%
80	Craniocerebral Trauma	11.1%
81	Tendinitis	11.1%
82	Lung Injury	11.1%
83	Tendinopathy	11.1%
84	Foreign-Body Reaction	10.9%
85	Insect Bites and Stings	10.9%
86	Paralysis, Obstetric	10.9%
87	Sunburn	10.9%
88	Tooth Avulsion	10.9%
89	Conus Medullaris Syndrome	10.9%
90	Near Drowning	10.8%
91	Osteoradionecrosis	10.8%
92	Vertigo	10.6%
93	Brain Contusion	10.5%
94	Mastoiditis	10.3%
95	Petrositis	10.3%
96	Deafness	10.3%
97	Hearing Loss, Sudden	10.3%
98	Hearing Loss, Bilateral	10.3%
99	Hearing Loss, High-Frequency	10.3%
100	Hearing Loss, Mixed Conductive-Sensorineural	10.3%
101	Hearing Loss, Unilateral	10.3%
102	Complete Hearing Loss	10.3%
103	Deaf Mutism	10.3%
104	Pharyngeal Neoplasms	9.6%
105	Radiation injury	9.5%
106	Facial Injuries	8.9%
107	Granuloma, Foreign-Body	8.9%
108	Enthesopathy	8.9%
109	Neoplasms, Radiation-Induced	8.9%
110	Uterine Perforation	8.8%
111	Peripheral Nerve Injuries	8.7%
112	Medial Tibial Stress Syndrome	8.7%
113	Uterine Rupture	8.5%
114	Central Cord Syndrome	8.5%
115	Laryngeal neoplasm	8.2%
116	Nasopharyngeal Neoplasms	7.7%
117	Primary Ciliary Dyskinesia	7.5%
118	Granuloma, Lethal Midline	7.4%
119	Laryngeal Edema	7.4%
120	Nose Deformities, Acquired	7.4%
121	Deglutition Disorders	7.3%
122	Cardiotoxicity	7.2%
123	Leukemia, Radiation-Induced	7.1%
124	Brain Injuries	7%
125	Radiation Pneumonitis	7%
126	Radiation Fibrosis	7%
127	Acoustic Neuroma	7%
128	Coma, Post-Head Injury	7%
129	Aortic Rupture	6.9%
130	Carpal Tunnel Syndrome	6.9%
131	Hypopharyngeal Neoplasms	6.9%
132	Hypopharyngeal Cancer	6.9%
133	Paranasal Sinus Neoplasms	6.8%
134	Brain Hemorrhage, Traumatic	6.7%
135	Eye Injuries	6.5%
136	Auditory Perceptual Disorders	6.3%
137	Nose Neoplasms	6.2%
138	Brain Injuries, Diffuse	6.2%
139	Traumatic Brain Injury	6.2%
140	Cubital Tunnel Syndrome	6.2%
141	Nasopharyngitis	5.9%
142	Abnormalities, Radiation-Induced	5.9%
143	Laryngitis	5.9%
144	Pharyngitis	5.9%
145	Rhinitis	5.9%
146	Vocal Cord Dysfunction	5.9%
147	Radiation Injuries, Experimental	5.9%
148	Diffuse Axonal Injury	5.8%
149	Laryngostenosis	5.8%
150	Nasal Polyps	5.8%
151	Tonsillar Neoplasms	5.7%
152	Maxillary Sinus Neoplasms	5.6%
153	Nasopharyngeal carcinoma	5.6%
154	Croup	5.4%
155	Rhinitis, Vasomotor	5.4%
156	Pneumocephalus	5.2%
157	Olfactory Nerve Injuries	5.2%
158	Cerebrospinal Fluid Otorrhea	5.1%
159	Cerebrospinal Fluid Rhinorrhea	5.1%
160	Epilepsy, Post-Traumatic	5.1%
161	Corneal Scar	5%
162	Vertebral Artery Dissection	4.9%
163	Choanal Atresia	4.8%
164	Voice Disorders	4.8%
165	Voice Disturbance	4.8%
166	Laryngocele	4.8%
167	Epistaxis	4.8%
168	Corneal Perforation	4.7%
169	Facial Nerve Injuries	4.4%
170	Sinusitis	4.3%
171	Laryngospasm	4.2%
172	Tonsillitis	4.2%
173	Carotid Artery Injuries	4.2%
174	Laryngomalacia	4.1%
175	Granuloma, Laryngeal	4.1%
176	Vocal Cord Paralysis	4%
177	Hematoma, Subdural	3.8%
178	Hematoma, Epidural, Cranial	3.8%
179	Hematoma, Subdural, Intracranial	3.5%
180	Hematoma, Subdural, Chronic	3.5%
181	Hematoma, Subdural, Acute	3.5%
182	Aphonia	3.5%
183	Retropharyngeal Abscess	3.5%
184	Dysphonia	3.5%
185	Lemierre Syndrome	3.4%
186	Subarachnoid Hemorrhage, Traumatic	3.3%
187	Carotid Artery, Internal, Dissection	3.3%
188	Rhinoscleroma	3.1%
189	Hay fever	2.8%
190	Rhinitis, Allergic, Perennial	2.8%
191	Peritonsillar Abscess	2.8%
192	Hoarseness	2.6%
193	Kartagener Syndrome	1.9%

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