Insulin Detemir
(UGOZVNFCFYTPAZ-IOXYNQHNSA-N)
Structure
- SMILES
- CCCCCCCCCCCCCC(=O)NCCCC[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](CC)C)NC(=O)CN)CCC(=O)O)CCC(=O)N)C(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(C)C)Cc1ccc(cc1)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)Cc1nc[nH]c1)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)N)CC(=O)N)CCC(=O)N)Cc1nc[nH]c1)CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)[C@H](CC)C)CO)[C@H](O)C)C(=O)N[C@H](C(=O)O)CC(=O)N)CCC(=O)O)CCCNC(=N)N)Cc1ccccc1)Cc1ccc(cc1)O
- Molecular Formula:
- C267H402N64O76S6
- Molecular Weight:
- 5916.820
- Log P:
- 10.5005
- Hydrogen Bond Acceptor:
- 144
- Hydrogen Bond Donor:
- 76
- TPSA:
- 2404.62
- CAS Number(s):
- 169148-63-4
Synonym(s)
1.
Insulin Detemir
2.
12C-Lys(B29)-DB30I
3.
B29-tetradecanoyl-Lys-B30-des-Ala-insulin
4.
Basal Insulin Detemir
5.
Des-(B30)-insulin, Lys(B29)-tetradecanoyl
6.
Insulin, Tetradecanoyl-Lys(B29)-des-Ala(B30)
7.
Insulin, Tetradecanoyllysyl(B29)-desalanyl(B30)
8.
Levemir
9.
NN 304
10.
NN-304
11.
NN304
12.
B29 tetradecanoyl Lys B30 des Ala insulin
13.
Detemir, Basal Insulin
14.
Detemir, Insulin
15.
Insulin Detemir, Basal
External Link(s)
| MeSH | D000069057 |
| PubChem Compound | 16137271 72941722 |
| CHEMBL | CHEMBL2104391 |
| Therapeutic Target Database | D0QE5U |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Blood glucose increased | FAERS: 1048 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 2 | Blood glucose decreased | FAERS: 152 | US FAERS | |
| 3 | Injection site erythema | FAERS: 135 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 4 | Dizziness | FAERS: 108 | US FAERS | |
| 5 | Injection site pain | FAERS: 108 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 6 | Injection site mass | FAERS: 96 | US FAERS | |
| 7 | Malaise | FAERS: 96 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 8 | Drug ineffective | FAERS: 93 Canada Vigilance: 9 | Canada Vigilance US FAERS | |
| 9 | Device Failure | FAERS: 86 | US FAERS | |
| 10 | Injection site pruritus | FAERS: 83 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 11 | Device malfunction | FAERS: 78 | US FAERS | |
| 12 | Pruritus | FAERS: 78 | US FAERS | |
| 13 | Blood glucose fluctuation | FAERS: 70 | US FAERS | |
| 14 | Cerebrovascular accident | FAERS: 70 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 15 | Product quality issue | FAERS: 68 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 16 | Headache | FAERS: 64 | US FAERS | |
| 17 | Nausea | FAERS: 63 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 18 | Asthenia | FAERS: 61 | US FAERS | |
| 19 | Injection site bruising | FAERS: 58 | US FAERS | |
| 20 | Visual Impairment | FAERS: 58 | US FAERS | |
| 21 | Fatigue | FAERS: 54 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 22 | Urticaria | FAERS: 54 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 23 | Hypersensitivity | FAERS: 52 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 24 | Feeling abnormal | FAERS: 48 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 25 | Injection site irritation | FAERS: 47 | US FAERS | |
| 26 | Weight decreased | FAERS: 47 | US FAERS | |
| 27 | Tremor | FAERS: 46 | US FAERS | |
| 28 | Diabetes mellitus inadequate control | FAERS: 45 | US FAERS | |
| 29 | Injection Site Reaction | FAERS: 43 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 30 | Diabetic Ketoacidosis | FAERS: 38 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 31 | Myocardial Infarction | FAERS: 35 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 32 | Injection site urticaria | FAERS: 34 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 33 | Erythema | FAERS: 33 | US FAERS | |
| 34 | Pain | FAERS: 33 | US FAERS | |
| 35 | Unevaluable event | FAERS: 31 | US FAERS | |
| 36 | Peripheral swelling | FAERS: 30 | US FAERS | |
| 37 | Vomiting | FAERS: 28 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 38 | Cataract | FAERS: 27 | US FAERS | |
| 39 | Drug dose omission | FAERS: 27 | US FAERS | |
| 40 | Drug exposure during pregnancy | FAERS: 26 | US FAERS | |
| 41 | Arthralgia | FAERS: 25 | US FAERS | |
| 42 | Incorrect dose administered | FAERS: 25 | US FAERS | |
| 43 | Nasopharyngitis | FAERS: 24 | US FAERS | |
| 44 | Palpitations | FAERS: 24 | US FAERS | |
| 45 | Somnolence | FAERS: 24 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 46 | Pneumonia | FAERS: 23 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 47 | Anxiety | FAERS: 21 | US FAERS | |
| 48 | Chest Pain | FAERS: 21 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 49 | Swelling | FAERS: 21 | US FAERS | |
| 50 | Burning sensation | FAERS: 20 | US FAERS | |
| 51 | Constipation | FAERS: 20 | US FAERS | |
| 52 | Urinary tract infection | FAERS: 20 | US FAERS | |
| 53 | Abdominal discomfort | FAERS: 19 | US FAERS | |
| 54 | Blindness | FAERS: 19 | US FAERS | |
| 55 | Influenza | FAERS: 18 | US FAERS | |
| 56 | Blood glucose abnormal | FAERS: 17 | US FAERS | |
| 57 | Hunger | FAERS: 17 | US FAERS | |
| 58 | Injection site nodule | FAERS: 17 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 59 | Myalgia | FAERS: 17 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 60 | Arthritis | FAERS: 16 | US FAERS | |
| 61 | Cellulitis | FAERS: 16 | US FAERS | |
| 62 | Dehydration | FAERS: 16 | US FAERS | |
| 63 | Dementia | FAERS: 16 | US FAERS | |
| 64 | Joint swelling | FAERS: 16 | US FAERS | |
| 65 | Device leakage | FAERS: 15 | US FAERS | |
| 66 | Dysgeusia | FAERS: 15 | US FAERS | |
| 67 | Infection | FAERS: 14 | US FAERS | |
| 68 | Injection site warmth | FAERS: 13 | US FAERS | |
| 69 | Pregnancy | FAERS: 13 | US FAERS | |
| 70 | Syncope | FAERS: 13 | US FAERS | |
| 71 | Alopecia | FAERS: 12 | US FAERS | |
| 72 | Amnesia | FAERS: 12 | US FAERS | |
| 73 | Angioedema | FAERS: 12 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 74 | Atrial Fibrillation | FAERS: 12 | US FAERS | |
| 75 | Incorrect dose administered by device | FAERS: 12 | US FAERS | |
| 76 | Nervousness | FAERS: 12 | US FAERS | |
| 77 | Pancreatitis | FAERS: 12 | US FAERS | |
| 78 | Stress | FAERS: 12 | US FAERS | |
| 79 | Abdominal Pain | FAERS: 11 | US FAERS | |
| 80 | Diabetic Retinopathy | FAERS: 11 | US FAERS | |
| 81 | Injection site inflammation | FAERS: 11 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 82 | Memory impairment | FAERS: 11 | US FAERS | |
| 83 | Night sweats | FAERS: 11 | US FAERS | |
| 84 | Product dose omission | FAERS: 11 | US FAERS | |
| 85 | Wrong technique in product usage process | FAERS: 11 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 86 | Back Pain | FAERS: 10 | US FAERS | |
| 87 | Chest discomfort | FAERS: 10 | US FAERS | |
| 88 | Chills | FAERS: 10 | US FAERS | |
| 89 | Macular degeneration | FAERS: 10 | US FAERS | |
| 90 | Skin reaction | FAERS: 10 | US FAERS | |
| 91 | Wheezing | FAERS: 10 | US FAERS | |
| 92 | Cardiac Arrest | FAERS: 9 | US FAERS | |
| 93 | Flatulence | FAERS: 9 | US FAERS | |
| 94 | Flushing | FAERS: 9 | US FAERS | |
| 95 | Product storage error | FAERS: 9 | US FAERS | |
| 96 | Adverse event | FAERS: 8 | US FAERS | |
| 97 | Disability | FAERS: 8 | US FAERS | |
| 98 | Dysphonia | FAERS: 8 | US FAERS | |
| 99 | Injection site hypersensitivity | FAERS: 8 | US FAERS | |
| 100 | Sinusitis | FAERS: 8 | US FAERS | |
| 101 | Device breakage | FAERS: 7 | US FAERS | |
| 102 | Dysarthria | FAERS: 7 | US FAERS | |
| 103 | Hypersomnia | FAERS: 7 | US FAERS | |
| 104 | Injection site extravasation | FAERS: 7 | US FAERS | |
| 105 | Accidental overdose | FAERS: 6 | US FAERS | |
| 106 | Cataract operation | FAERS: 6 | US FAERS | |
| 107 | Deafness | FAERS: 6 | US FAERS | |
| 108 | Disorientation | FAERS: 6 | US FAERS | |
| 109 | Eructation | FAERS: 6 | US FAERS | |
| 110 | Eye irritation | FAERS: 6 | US FAERS | |
| 111 | Incorrect product storage | FAERS: 6 | US FAERS | |
| 112 | Injury associated with device | FAERS: 6 | US FAERS | |
| 113 | Limb discomfort | FAERS: 6 | US FAERS | |
| 114 | Lip swelling | FAERS: 6 | US FAERS | |
| 115 | Liquid product physical issue | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 116 | Oropharyngeal pain | FAERS: 6 | US FAERS | |
| 117 | Pancreatic carcinoma | FAERS: 6 | US FAERS | |
| 118 | Renal pain | FAERS: 6 | US FAERS | |
| 119 | Sepsis | FAERS: 6 | US FAERS | |
| 120 | Agitation | FAERS: 5 | US FAERS | |
| 121 | Arthropathy | FAERS: 5 | US FAERS | |
| 122 | Bronchitis | FAERS: 5 | US FAERS | |
| 123 | Diabetic Foot | FAERS: 5 | US FAERS | |
| 124 | Dry skin | FAERS: 5 | US FAERS | |
| 125 | Expired drug administered | FAERS: 5 | US FAERS | |
| 126 | Eye pain | FAERS: 5 | US FAERS | |
| 127 | Glaucoma | FAERS: 5 | US FAERS | |
| 128 | Inflammation | FAERS: 5 | US FAERS | |
| 129 | Injection site infection | FAERS: 5 | US FAERS | |
| 130 | Intentional dose omission | FAERS: 5 | US FAERS | |
| 131 | Lethargy | FAERS: 5 | US FAERS | |
| 132 | Musculoskeletal Pain | FAERS: 5 | US FAERS | |
| 133 | Neck Pain | FAERS: 5 | US FAERS | |
| 134 | Needle issue | FAERS: 5 | US FAERS | |
| 135 | Photophobia | FAERS: 5 | US FAERS | |
| 136 | Urinary Incontinence | FAERS: 5 | US FAERS | |
| 137 | Asthma | FAERS: 4 | US FAERS | |
| 138 | Cerebral Infarction | FAERS: 4 | US FAERS | |
| 139 | Diplopia | FAERS: 4 | US FAERS | |
| 140 | Drug dispensing error | FAERS: 4 | US FAERS | |
| 141 | Dysuria | FAERS: 4 | US FAERS | |
| 142 | Hepatitis C | FAERS: 4 | US FAERS | |
| 143 | Hypotension | FAERS: 4 | US FAERS | |
| 144 | Injection site cellulitis | FAERS: 4 | US FAERS | |
| 145 | Injection site injury | FAERS: 4 | US FAERS | |
| 146 | Injection site vesicles | FAERS: 4 | US FAERS | |
| 147 | Intentional product misuse | FAERS: 4 | US FAERS | |
| 148 | Lipodystrophy acquired | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 149 | Lipohypertrophy | FAERS: 4 | US FAERS | |
| 150 | Malabsorption from injection site | FAERS: 4 | US FAERS | |
| 151 | Overdose | FAERS: 4 | US FAERS | |
| 152 | Pharmaceutical product complaint | FAERS: 4 | US FAERS | |
| 153 | Pre-Eclampsia | FAERS: 4 | US FAERS | |
| 154 | Product container issue | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 155 | Pulmonary Embolism | FAERS: 4 | US FAERS | |
| 156 | Rheumatoid Arthritis | FAERS: 4 | US FAERS | |
| 157 | Skin lesion | FAERS: 4 | US FAERS | |
| 158 | Suicide attempt | FAERS: 4 | US FAERS | |
| 159 | Tinnitus | FAERS: 4 | US FAERS | |
| 160 | Wrong technique in device usage process | FAERS: 4 | US FAERS | |
| 161 | Acne | FAERS: 3 | US FAERS | |
| 162 | Alanine Aminotransferase Increased | FAERS: 3 | US FAERS | |
| 163 | Angina Pectoris | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 164 | Blood alkaline phosphatase increased | FAERS: 3 | US FAERS | |
| 165 | Blood cholesterol increased | FAERS: 3 | US FAERS | |
| 166 | Blood potassium decreased | FAERS: 3 | US FAERS | |
| 167 | Carpal Tunnel Syndrome | FAERS: 3 | US FAERS | |
| 168 | Deep Vein Thrombosis | FAERS: 3 | US FAERS | |
| 169 | Depressed Level of Consciousness | FAERS: 3 | US FAERS | |
| 170 | Diverticulitis | FAERS: 3 | US FAERS | |
| 171 | Drug prescribing error | FAERS: 3 | US FAERS | |
| 172 | Dyspepsia | FAERS: 3 | US FAERS | |
| 173 | Epistaxis | FAERS: 3 | US FAERS | |
| 174 | Erectile dysfunction | FAERS: 3 | US FAERS | |
| 175 | Expired product administered | FAERS: 3 | US FAERS | |
| 176 | Extra dose administered | FAERS: 3 | US FAERS | |
| 177 | Feeling jittery | FAERS: 3 | US FAERS | |
| 178 | Food craving | FAERS: 3 | US FAERS | |
| 179 | Gastric Dilatation | FAERS: 3 | US FAERS | |
| 180 | Gastroenteritis | FAERS: 3 | US FAERS | |
| 181 | Hospice Care | FAERS: 3 | US FAERS | |
| 182 | Hypokinesia | FAERS: 3 | US FAERS | |
| 183 | Induration | FAERS: 3 | US FAERS | |
| 184 | Injection site abscess | FAERS: 3 | US FAERS | |
| 185 | Insulin Resistance | FAERS: 3 | US FAERS | |
| 186 | Intentional product use issue | FAERS: 3 | US FAERS | |
| 187 | Intestinal Obstruction | FAERS: 3 | US FAERS | |
| 188 | Irritable Bowel Syndrome | FAERS: 3 | US FAERS | |
| 189 | Laceration | FAERS: 3 | US FAERS | |
| 190 | Limb injury | FAERS: 3 | US FAERS | |
| 191 | Limb mass | FAERS: 3 | US FAERS | |
| 192 | Liver Abscess | FAERS: 3 | US FAERS | |
| 193 | Low birth weight baby | FAERS: 3 | US FAERS | |
| 194 | Multiple Sclerosis | FAERS: 3 | US FAERS | |
| 195 | Muscle Rigidity | FAERS: 3 | US FAERS | |
| 196 | Muscle strain | FAERS: 3 | US FAERS | |
| 197 | Muscle tightness | FAERS: 3 | US FAERS | |
| 198 | Musculoskeletal stiffness | FAERS: 3 | US FAERS | |
| 199 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 200 | Pain of skin | FAERS: 3 | US FAERS | |
| 201 | Pharyngitis | FAERS: 3 | US FAERS | |
| 202 | Poor peripheral circulation | FAERS: 3 | US FAERS | |
| 203 | Poor quality sleep | FAERS: 3 | US FAERS | |
| 204 | Product substitution issue | FAERS: 3 | US FAERS | |
| 205 | Pulmonary Fibrosis | FAERS: 3 | US FAERS | |
| 206 | Restless Legs Syndrome | FAERS: 3 | US FAERS | |
| 207 | Skin Ulcer | FAERS: 3 | US FAERS | |
| 208 | Sluggishness | FAERS: 3 | US FAERS | |
| 209 | Thirst | FAERS: 3 | US FAERS | |
| 210 | Throat irritation | FAERS: 3 | US FAERS | |
| 211 | Wrong technique in drug usage process | FAERS: 3 | US FAERS | |
| 212 | furuncle | FAERS: 3 | US FAERS | |
| 213 | Abscess | FAERS: 2 | US FAERS | |
| 214 | Accidental exposure to product | FAERS: 2 | US FAERS | |
| 215 | Accidental needle stick | FAERS: 2 | US FAERS | |
| 216 | Acute kidney injury | FAERS: 2 | US FAERS | |
| 217 | Akinesia | FAERS: 2 | US FAERS | |
| 218 | Appendicitis | FAERS: 2 | US FAERS | |
| 219 | Aspartate Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 220 | Back disorder | FAERS: 2 | US FAERS | |
| 221 | Bedridden | FAERS: 2 | US FAERS | |
| 222 | Blood creatinine increased | FAERS: 2 | US FAERS | |
| 223 | Bone pain | FAERS: 2 | US FAERS | |
| 224 | Cardiac Flutter | FAERS: 2 | US FAERS | |
| 225 | Cardiac discomfort | FAERS: 2 | US FAERS | |
| 226 | Cholelithiasis | FAERS: 2 | US FAERS | |
| 227 | Cold sweat | FAERS: 2 | US FAERS | |
| 228 | Coronary Artery Disease | FAERS: 2 | US FAERS | |
| 229 | Cystitis | FAERS: 2 | US FAERS | |
| 230 | Cyst | FAERS: 2 | US FAERS | |
| 231 | Dermatitis acneiform | FAERS: 2 | US FAERS | |
| 232 | Diabetic ulcer | FAERS: 2 | US FAERS | |
| 233 | Discomfort | FAERS: 2 | US FAERS | |
| 234 | Drug administration error | FAERS: 2 | US FAERS | |
| 235 | Eclampsia | FAERS: 2 | US FAERS | |
| 236 | Eczema | FAERS: 2 | US FAERS | |
| 237 | Feeling Cold | FAERS: 2 | US FAERS | |
| 238 | Feeling of body temperature change | FAERS: 2 | US FAERS | |
| 239 | Gastrointestinal Pain | FAERS: 2 | US FAERS | |
| 240 | Gout | FAERS: 2 | US FAERS | |
| 241 | Head discomfort | FAERS: 2 | US FAERS | |
| 242 | Incoherent | FAERS: 2 | US FAERS | |
| 243 | Incorrect route of drug administration | FAERS: 2 | US FAERS | |
| 244 | Injection site laceration | FAERS: 2 | US FAERS | |
| 245 | Laryngitis | FAERS: 2 | US FAERS | |
| 246 | Local reaction | FAERS: 2 | US FAERS | |
| 247 | Lymphadenopathy | FAERS: 2 | US FAERS | |
| 248 | Medial Tibial Stress Syndrome | FAERS: 2 | US FAERS | |
| 249 | Medical device complication | FAERS: 2 | US FAERS | |
| 250 | Medication Error | FAERS: 2 | US FAERS | |
| 251 | Mental impairment | FAERS: 2 | US FAERS | |
| 252 | Mouth swelling | FAERS: 2 | US FAERS | |
| 253 | Multiple allergies | FAERS: 2 | US FAERS | |
| 254 | Neonatal respiratory failure | FAERS: 2 | US FAERS | |
| 255 | Pancreatic Neoplasm | FAERS: 2 | US FAERS | |
| 256 | Peripheral artery occlusion | FAERS: 2 | US FAERS | |
| 257 | Prescription drug used without a prescription | FAERS: 2 | US FAERS | |
| 258 | Product contamination | FAERS: 2 | US FAERS | |
| 259 | Product label confusion | FAERS: 2 | US FAERS | |
| 260 | Product use issue | FAERS: 2 | US FAERS | |
| 261 | Psoriasis | FAERS: 2 | US FAERS | |
| 262 | Pulmonary Hypertension | FAERS: 2 | US FAERS | |
| 263 | Respiratory Failure | FAERS: 2 | US FAERS | |
| 264 | Respiratory tract congestion | FAERS: 2 | US FAERS | |
| 265 | Retinal Detachment | FAERS: 2 | US FAERS | |
| 266 | Skin hypertrophy | FAERS: 2 | US FAERS | |
| 267 | Skin irritation | FAERS: 2 | US FAERS | |
| 268 | Spinal column injury | FAERS: 2 | US FAERS | |
| 269 | Spinal column stenosis | FAERS: 2 | US FAERS | |
| 270 | Stevens-Johnson Syndrome | FAERS: 2 | US FAERS | |
| 271 | Sudden death | FAERS: 2 | US FAERS | |
| 272 | Tachycardia | FAERS: 2 | US FAERS | |
| 273 | Therapy cessation | FAERS: 2 | US FAERS | |
| 274 | Therapy change | FAERS: 2 | US FAERS | |
| 275 | Thrombosis | FAERS: 2 | US FAERS | |
| 276 | Ulcer | FAERS: 2 | US FAERS | |
| 277 | Upper-airway cough syndrome | FAERS: 2 | US FAERS | |
| 278 | Vertigo | FAERS: 2 | US FAERS | |
| 279 | Vitreous floaters | FAERS: 2 | US FAERS | |
| 280 | Wrong drug administered | FAERS: 2 | US FAERS | |
| 281 | jaundice | FAERS: 2 | US FAERS | |
| 282 | oligodendroglioma | FAERS: 2 | US FAERS | |
| 283 | Abasia | FAERS: 1 | US FAERS | |
| 284 | Abdominal mass | FAERS: 1 | US FAERS | |
| 285 | Abdominal tenderness | FAERS: 1 | US FAERS | |
| 286 | Abnormal weight gain | FAERS: 1 | US FAERS | |
| 287 | Abortion complete | FAERS: 1 | US FAERS | |
| 288 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 289 | Ageusia | FAERS: 1 | US FAERS | |
| 290 | Allergic sinusitis | FAERS: 1 | US FAERS | |
| 291 | Altered state of consciousness | FAERS: 1 | US FAERS | |
| 292 | Altered visual depth perception | FAERS: 1 | US FAERS | |
| 293 | Amputation | FAERS: 1 | US FAERS | |
| 294 | Anencephaly | FAERS: 1 | US FAERS | |
| 295 | Aneurysm | FAERS: 1 | US FAERS | |
| 296 | Anger | FAERS: 1 | US FAERS | |
| 297 | Angioplasty | FAERS: 1 | US FAERS | |
| 298 | Ankle Fracture | FAERS: 1 | US FAERS | |
| 299 | Anorectal discomfort | FAERS: 1 | US FAERS | |
| 300 | Anti-insulin antibody increased | FAERS: 1 | US FAERS | |
| 301 | Anti-insulin antibody positive | FAERS: 1 | US FAERS | |
| 302 | Aphonia | FAERS: 1 | US FAERS | |
| 303 | Application site acne | FAERS: 1 | US FAERS | |
| 304 | Application site pain | FAERS: 1 | US FAERS | |
| 305 | Arterial therapeutic procedure | FAERS: 1 | US FAERS | |
| 306 | Arthropod sting | FAERS: 1 | US FAERS | |
| 307 | Asthenopia | FAERS: 1 | US FAERS | |
| 308 | Benign neoplasm of thyroid gland | FAERS: 1 | US FAERS | |
| 309 | Blood Glucose | FAERS: 1 | US FAERS | |
| 310 | Blood blister | FAERS: 1 | US FAERS | |
| 311 | Blood glucagon increased | FAERS: 1 | US FAERS | |
| 312 | Blood insulin abnormal | FAERS: 1 | US FAERS | |
| 313 | Blood ketone body | FAERS: 1 | US FAERS | |
| 314 | Blood ketone body increased | FAERS: 1 | US FAERS | |
| 315 | Blood ketone body present | FAERS: 1 | US FAERS | |
| 316 | Blood pH decreased | FAERS: 1 | US FAERS | |
| 317 | Blood potassium increased | FAERS: 1 | US FAERS | |
| 318 | Blood sodium decreased | FAERS: 1 | US FAERS | |
| 319 | Blood sodium increased | FAERS: 1 | US FAERS | |
| 320 | Blood urine present | FAERS: 1 | US FAERS | |
| 321 | Bone density abnormal | FAERS: 1 | US FAERS | |
| 322 | Bowel movement irregularity | FAERS: 1 | US FAERS | |
| 323 | Bronchopneumonia | FAERS: 1 | US FAERS | |
| 324 | Bursitis | FAERS: 1 | US FAERS | |
| 325 | Cerebral disorder | FAERS: 1 | US FAERS | |
| 326 | Chemotherapy | FAERS: 1 | US FAERS | |
| 327 | Choking sensation | FAERS: 1 | US FAERS | |
| 328 | Chromaturia | FAERS: 1 | US FAERS | |
| 329 | Coccidioidomycosis | FAERS: 1 | US FAERS | |
| 330 | Colitis | FAERS: 1 | US FAERS | |
| 331 | Completed Suicide | FAERS: 1 | US FAERS | |
| 332 | Congenital Hypothyroidism | FAERS: 1 | US FAERS | |
| 333 | Congenital cerebral cyst | FAERS: 1 | US FAERS | |
| 334 | Dandy-Walker Syndrome | FAERS: 1 | US FAERS | |
| 335 | Dermal absorption impaired | FAERS: 1 | US FAERS | |
| 336 | Dermatitis | FAERS: 1 | US FAERS | |
| 337 | Dermo-hypodermitis | FAERS: 1 | US FAERS | |
| 338 | Device defective | FAERS: 1 | US FAERS | |
| 339 | Device dispensing error | FAERS: 1 | US FAERS | |
| 340 | Device physical property issue | FAERS: 1 | US FAERS | |
| 341 | Device use error | FAERS: 1 | US FAERS | |
| 342 | Diabetic Amyotrophy | FAERS: 1 | US FAERS | |
| 343 | Diabetic foetopathy | FAERS: 1 | US FAERS | |
| 344 | Diabetic metabolic decompensation | FAERS: 1 | US FAERS | |
| 345 | Drooling | FAERS: 1 | US FAERS | |
| 346 | Drug administered in wrong device | FAERS: 1 | US FAERS | |
| 347 | Drug effect delayed | FAERS: 1 | US FAERS | |
| 348 | Drug effect incomplete | FAERS: 1 | US FAERS | |
| 349 | Drug withdrawal syndrome | FAERS: 1 | US FAERS | |
| 350 | Dysphemia | FAERS: 1 | US FAERS | |
| 351 | Emergency Care | FAERS: 1 | US FAERS | |
| 352 | Emotional poverty | FAERS: 1 | US FAERS | |
| 353 | Endodontic procedure | FAERS: 1 | US FAERS | |
| 354 | Enterococcal infection | FAERS: 1 | US FAERS | |
| 355 | Epigastric discomfort | FAERS: 1 | US FAERS | |
| 356 | Epilepsy | FAERS: 1 | US FAERS | |
| 357 | Essential Tremor | FAERS: 1 | US FAERS | |
| 358 | Expired device used | FAERS: 1 | US FAERS | |
| 359 | Exposure via ingestion | FAERS: 1 | US FAERS | |
| 360 | Eye Burns | FAERS: 1 | US FAERS | |
| 361 | Eye Infection | FAERS: 1 | US FAERS | |
| 362 | Eye inflammation | FAERS: 1 | US FAERS | |
| 363 | Eyelid irritation | FAERS: 1 | US FAERS | |
| 364 | Eyelids pruritus | FAERS: 1 | US FAERS | |
| 365 | Facial Pain | FAERS: 1 | US FAERS | |
| 366 | Female sexual dysfunction | FAERS: 1 | US FAERS | |
| 367 | Fibromyalgia | FAERS: 1 | US FAERS | |
| 368 | Fibrosis | FAERS: 1 | US FAERS | |
| 369 | Foaming at mouth | FAERS: 1 | US FAERS | |
| 370 | Food Allergy | FAERS: 1 | US FAERS | |
| 371 | Food Poisoning | FAERS: 1 | US FAERS | |
| 372 | Fracture of clavicle due to birth trauma | FAERS: 1 | US FAERS | |
| 373 | Gait inability | FAERS: 1 | US FAERS | |
| 374 | Gamma-Glutamyltransferase Increased | FAERS: 1 | US FAERS | |
| 375 | Gangrene | FAERS: 1 | US FAERS | |
| 376 | Gastrointestinal carcinoma | FAERS: 1 | US FAERS | |
| 377 | Gastrointestinal inflammation | FAERS: 1 | US FAERS | |
| 378 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 379 | Gingivitis | FAERS: 1 | US FAERS | |
| 380 | Hearing aid user | FAERS: 1 | US FAERS | |
| 381 | Hepatitis | FAERS: 1 | US FAERS | |
| 382 | Hepatomegaly | FAERS: 1 | US FAERS | |
| 383 | Hypermetabolism | FAERS: 1 | US FAERS | |
| 384 | Hyperpyrexia | FAERS: 1 | US FAERS | |
| 385 | Hyperthyroidism | FAERS: 1 | US FAERS | |
| 386 | Hyperventilation | FAERS: 1 | US FAERS | |
| 387 | Hypogeusia | FAERS: 1 | US FAERS | |
| 388 | Hypophagia | FAERS: 1 | US FAERS | |
| 389 | Hypothermia neonatal | FAERS: 1 | US FAERS | |
| 390 | Hysterectomy | FAERS: 1 | US FAERS | |
| 391 | Immature respiratory system | FAERS: 1 | US FAERS | |
| 392 | Implant site pruritus | FAERS: 1 | US FAERS | |
| 393 | Inadequate aseptic technique in use of product | FAERS: 1 | US FAERS | |
| 394 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 395 | Incontinence | FAERS: 1 | US FAERS | |
| 396 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 397 | Increased upper airway secretion | FAERS: 1 | US FAERS | |
| 398 | Infrequent bowel movements | FAERS: 1 | US FAERS | |
| 399 | Initial insomnia | FAERS: 1 | US FAERS | |
| 400 | Injection site cyst | FAERS: 1 | US FAERS | |
| 401 | Injection site discomfort | FAERS: 1 | US FAERS | |
| 402 | Injection site eczema | FAERS: 1 | US FAERS | |
| 403 | Injection site hypertrophy | FAERS: 1 | US FAERS | |
| 404 | Injection site necrosis | FAERS: 1 | US FAERS | |
| 405 | Injection site scar | FAERS: 1 | US FAERS | |
| 406 | Injury asphyxiation | FAERS: 1 | US FAERS | |
| 407 | Intellectual Disability | FAERS: 1 | US FAERS | |
| 408 | Intercepted drug dispensing error | FAERS: 1 | US FAERS | |
| 409 | Intervertebral Disc Degeneration | FAERS: 1 | US FAERS | |
| 410 | Intracranial Aneurysm | FAERS: 1 | US FAERS | |
| 411 | Iron deficiency | FAERS: 1 | US FAERS | |
| 412 | Irregular breathing | FAERS: 1 | US FAERS | |
| 413 | Joint injury | FAERS: 1 | US FAERS | |
| 414 | Joint stiffness | FAERS: 1 | US FAERS | |
| 415 | Ketoacidosis | FAERS: 1 | US FAERS | |
| 416 | Labyrinthitis | FAERS: 1 | US FAERS | |
| 417 | Leukocytoclastic vasculitis | FAERS: 1 | US FAERS | |
| 418 | Lipoatrophy | FAERS: 1 | US FAERS | |
| 419 | Loss of personal independence in daily activities | FAERS: 1 | US FAERS | |
| 420 | Lung carcinoma cell type unspecified stage II | FAERS: 1 | US FAERS | |
| 421 | Lymphocytosis | FAERS: 1 | US FAERS | |
| 422 | Malnutrition | FAERS: 1 | US FAERS | |
| 423 | Maternal exposure during pregnancy | FAERS: 1 | US FAERS | |
| 424 | Meningitis | FAERS: 1 | US FAERS | |
| 425 | Menopause | FAERS: 1 | US FAERS | |
| 426 | Metabolic acidosis | FAERS: 1 | US FAERS | |
| 427 | Micturition frequency decreased | FAERS: 1 | US FAERS | |
| 428 | Middle insomnia | FAERS: 1 | US FAERS | |
| 429 | Mole excision | FAERS: 1 | US FAERS | |
| 430 | Monoplegia | FAERS: 1 | US FAERS | |
| 431 | Moyamoya Disease | FAERS: 1 | US FAERS | |
| 432 | Multiple sclerosis relapse | FAERS: 1 | US FAERS | |
| 433 | Myelofibrosis | FAERS: 1 | US FAERS | |
| 434 | Myopia | FAERS: 1 | US FAERS | |
| 435 | Neonatal infection | FAERS: 1 | US FAERS | |
| 436 | Nerve injury | FAERS: 1 | US FAERS | |
| 437 | No adverse event | FAERS: 1 | US FAERS | |
| 438 | Nodule | FAERS: 1 | US FAERS | |
| 439 | Nonspecific reaction | FAERS: 1 | US FAERS | |
| 440 | Obesity | FAERS: 1 | US FAERS | |
| 441 | Obsessive-Compulsive Disorder | FAERS: 1 | US FAERS | |
| 442 | Occupational exposure to product | FAERS: 1 | US FAERS | |
| 443 | Oligohydramnios | FAERS: 1 | US FAERS | |
| 444 | Onychoclasis | FAERS: 1 | US FAERS | |
| 445 | Ophthalmoplegia | FAERS: 1 | US FAERS | |
| 446 | Oral mucosal eruption | FAERS: 1 | US FAERS | |
| 447 | Oral pain | FAERS: 1 | US FAERS | |
| 448 | Osteolysis | FAERS: 1 | US FAERS | |
| 449 | Osteomyelitis | FAERS: 1 | US FAERS | |
| 450 | Osteoporosis | FAERS: 1 | US FAERS | |
| 451 | Otitis Media | FAERS: 1 | US FAERS | |
| 452 | Pallor | FAERS: 1 | US FAERS | |
| 453 | Pancreatectomy | FAERS: 1 | US FAERS | |
| 454 | Pancreatic Insufficiency | FAERS: 1 | US FAERS | |
| 455 | Panniculitis | FAERS: 1 | US FAERS | |
| 456 | Paranasal sinus discomfort | FAERS: 1 | US FAERS | |
| 457 | Paresis | FAERS: 1 | US FAERS | |
| 458 | Peripheral arthritis | FAERS: 1 | US FAERS | |
| 459 | Peritonitis | FAERS: 1 | US FAERS | |
| 460 | Phlebitis | FAERS: 1 | US FAERS | |
| 461 | Pneumothorax | FAERS: 1 | US FAERS | |
| 462 | Polymyalgia Rheumatica | FAERS: 1 | US FAERS | |
| 463 | Polyneuropathy | FAERS: 1 | US FAERS | |
| 464 | Poor quality drug administered | FAERS: 1 | US FAERS | |
| 465 | Post procedural swelling | FAERS: 1 | US FAERS | |
| 466 | Prerenal failure | FAERS: 1 | US FAERS | |
| 467 | Presyncope | FAERS: 1 | US FAERS | |
| 468 | Product administered at inappropriate site | FAERS: 1 | US FAERS | |
| 469 | Product contamination microbial | FAERS: 1 | US FAERS | |
| 470 | Product dispensing error | FAERS: 1 | US FAERS | |
| 471 | Product formulation issue | FAERS: 1 | US FAERS | |
| 472 | Product leakage | FAERS: 1 | US FAERS | |
| 473 | Product packaging quantity issue | FAERS: 1 | US FAERS | |
| 474 | Product prescribing error | FAERS: 1 | US FAERS | |
| 475 | Product use complaint | FAERS: 1 | US FAERS | |
| 476 | Prolactinoma | FAERS: 1 | US FAERS | |
| 477 | Pulmonary congestion | FAERS: 1 | US FAERS | |
| 478 | Rash erythematous | FAERS: 1 | US FAERS | |
| 479 | Reaction to drug excipients | FAERS: 1 | US FAERS | |
| 480 | Reaction to preservatives | FAERS: 1 | US FAERS | |
| 481 | Rectocele | FAERS: 1 | US FAERS | |
| 482 | Respiratory distress | FAERS: 1 | US FAERS | |
| 483 | Respiratory papilloma | FAERS: 1 | US FAERS | |
| 484 | Retching | FAERS: 1 | US FAERS | |
| 485 | Rotator cuff syndrome | FAERS: 1 | US FAERS | |
| 486 | Salivary gland pain | FAERS: 1 | US FAERS | |
| 487 | Sciatica | FAERS: 1 | US FAERS | |
| 488 | Secretion discharge | FAERS: 1 | US FAERS | |
| 489 | Sensorimotor disorder | FAERS: 1 | US FAERS | |
| 490 | Septic Shock | FAERS: 1 | US FAERS | |
| 491 | Serotonin Syndrome | FAERS: 1 | US FAERS | |
| 492 | Shock | FAERS: 1 | US FAERS | |
| 493 | Sick Sinus Syndrome | FAERS: 1 | US FAERS | |
| 494 | Simple Partial Seizures | FAERS: 1 | US FAERS | |
| 495 | Skin Induration | FAERS: 1 | US FAERS | |
| 496 | Skin nodule | FAERS: 1 | US FAERS | |
| 497 | Skin tightness | FAERS: 1 | US FAERS | |
| 498 | Spina Bifida | FAERS: 1 | US FAERS | |
| 499 | Stillbirth | FAERS: 1 | US FAERS | |
| 500 | Sunburn | FAERS: 1 | US FAERS | |
| 501 | Suspected product contamination | FAERS: 1 | US FAERS | |
| 502 | Suspected transmission of an infectious agent via product | FAERS: 1 | US FAERS | |
| 503 | Swelling of eyelid | FAERS: 1 | US FAERS | |
| 504 | Synovial Cyst | FAERS: 1 | US FAERS | |
| 505 | T-Cell Lymphoma | FAERS: 1 | US FAERS | |
| 506 | Temperature intolerance | FAERS: 1 | US FAERS | |
| 507 | Terminal state | FAERS: 1 | US FAERS | |
| 508 | Therapeutic reaction time decreased | FAERS: 1 | US FAERS | |
| 509 | Therapeutic response unexpected | FAERS: 1 | US FAERS | |
| 510 | Throat cancer | FAERS: 1 | US FAERS | |
| 511 | Tinea cruris | FAERS: 1 | US FAERS | |
| 512 | Tongue biting | FAERS: 1 | US FAERS | |
| 513 | Tongue discomfort | FAERS: 1 | US FAERS | |
| 514 | Tooth Extraction | FAERS: 1 | US FAERS | |
| 515 | Tooth Loss | FAERS: 1 | US FAERS | |
| 516 | Toothache | FAERS: 1 | US FAERS | |
| 517 | Toxicity to various agents | FAERS: 1 | US FAERS | |
| 518 | Unresponsive to stimuli | FAERS: 1 | US FAERS | |
| 519 | Urinary tract obstruction | FAERS: 1 | US FAERS | |
| 520 | Uveitis | FAERS: 1 | US FAERS | |
| 521 | VIIth nerve paralysis | FAERS: 1 | US FAERS | |
| 522 | Vascular occlusion | FAERS: 1 | US FAERS | |
| 523 | Vasculitis | FAERS: 1 | US FAERS | |
| 524 | Ventricular hypoplasia | FAERS: 1 | US FAERS | |
| 525 | Vitiligo | FAERS: 1 | US FAERS | |
| 526 | Vulvovaginal pruritus | FAERS: 1 | US FAERS | |
| 527 | Wheelchair user | FAERS: 1 | US FAERS | |
| 528 | White matter lesion | FAERS: 1 | US FAERS | |
| 529 | cancer surgery | FAERS: 1 | US FAERS | |
| 530 | gallbladder neoplasm | FAERS: 1 | US FAERS | |
| 531 | Blood thyroid stimulating hormone increased | Canada Vigilance: 1 | Canada Vigilance | |
| 532 | Drug specific antibody present | Canada Vigilance: 3 | Canada Vigilance | |
| 533 | Product complaint | Canada Vigilance: 1 | Canada Vigilance | |
| 534 | Therapeutic product effect decreased | Canada Vigilance: 3 | Canada Vigilance | |
| 535 | Therapeutic product effect incomplete | Canada Vigilance: 1 | Canada Vigilance |
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