estradiol, norethindrone drug combination
(NAUDKYVGHCCLOT-LAQCMFAESA-N)
Structure
- SMILES
- Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C.C#C[C@@]1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CCC2=CC(=O)CC[C@H]12)OC(=O)C
- Molecular Formula:
- C40H52O5
- Molecular Weight:
- 612.838
- Log P:
- 7.6725
- Hydrogen Bond Acceptor:
- 5
- Hydrogen Bond Donor:
- 2
- TPSA:
- 83.83
- CAS Number(s):
- 77728-33-7
Synonym(s)
1.
estradiol, norethindrone drug combination
2.
Estracomb TTS
3.
HRP 102
4.
HRP-102
5.
HRP102
6.
Mesigyna
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 5 Canada Vigilance: 46 | Canada Vigilance US FAERS | |
| 2 | Metrorrhagia | FAERS: 5 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 3 | Arthralgia | FAERS: 4 | US FAERS | |
| 4 | Cerebrovascular accident | FAERS: 4 | US FAERS | |
| 5 | Deep Vein Thrombosis | FAERS: 4 | US FAERS | |
| 6 | Headache | FAERS: 4 Canada Vigilance: 10 | Canada Vigilance US FAERS | |
| 7 | Palpitations | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 8 | Product quality issue | FAERS: 4 | US FAERS | |
| 9 | Abdominal Pain | FAERS: 3 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 10 | Alopecia | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 11 | Blood cholesterol increased | FAERS: 3 | US FAERS | |
| 12 | Impaired driving ability | FAERS: 3 | US FAERS | |
| 13 | Joint swelling | FAERS: 3 | US FAERS | |
| 14 | Limb injury | FAERS: 3 | US FAERS | |
| 15 | Liver scan abnormal | FAERS: 3 | US FAERS | |
| 16 | Malaise | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 17 | Peripheral embolism | FAERS: 3 | US FAERS | |
| 18 | Renal Colic | FAERS: 3 | US FAERS | |
| 19 | Vertigo | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 20 | Atrial Fibrillation | FAERS: 2 | US FAERS | |
| 21 | Blood alkaline phosphatase increased | FAERS: 2 | US FAERS | |
| 22 | Breast tenderness | FAERS: 2 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 23 | Cervical polyp | FAERS: 2 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 24 | Cholecystitis | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 25 | Cholelithiasis | FAERS: 2 | US FAERS | |
| 26 | Cholelithotomy | FAERS: 2 | US FAERS | |
| 27 | Gamma-Glutamyltransferase Increased | FAERS: 2 | US FAERS | |
| 28 | Incorrect dose administered | FAERS: 2 | US FAERS | |
| 29 | Joint stiffness | FAERS: 2 | US FAERS | |
| 30 | Limb discomfort | FAERS: 2 | US FAERS | |
| 31 | Night sweats | FAERS: 2 | US FAERS | |
| 32 | Pharmaceutical product complaint | FAERS: 2 | US FAERS | |
| 33 | Product use in unapproved indication | FAERS: 2 | US FAERS | |
| 34 | Transaminases increased | FAERS: 2 | US FAERS | |
| 35 | Abdominal discomfort | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 36 | Abnormal weight gain | FAERS: 1 | US FAERS | |
| 37 | Acne | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 38 | Acoustic Neuroma | FAERS: 1 | US FAERS | |
| 39 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 40 | Alanine Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 41 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 42 | Anxiety | FAERS: 1 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 43 | Application site discomfort | FAERS: 1 | US FAERS | |
| 44 | Application site eczema | FAERS: 1 | US FAERS | |
| 45 | Application site erythema | FAERS: 1 | US FAERS | |
| 46 | Application site exfoliation | FAERS: 1 | US FAERS | |
| 47 | Application site hypersensitivity | FAERS: 1 | US FAERS | |
| 48 | Application site pruritus | FAERS: 1 | US FAERS | |
| 49 | Arthritis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 50 | Aspartate Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 51 | Asthma | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 52 | Atrial Flutter | FAERS: 1 | US FAERS | |
| 53 | Axillary vein thrombosis | FAERS: 1 | US FAERS | |
| 54 | Breast Cyst | FAERS: 1 | US FAERS | |
| 55 | Cerebral Infarction | FAERS: 1 | US FAERS | |
| 56 | Chest Pain | FAERS: 1 | US FAERS | |
| 57 | Deafness | FAERS: 1 | US FAERS | |
| 58 | Diabetes Mellitus | FAERS: 1 | US FAERS | |
| 59 | Disease recurrence | FAERS: 1 | US FAERS | |
| 60 | Disorientation | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 61 | Dizziness | FAERS: 1 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 62 | Drug dispensing error | FAERS: 1 | US FAERS | |
| 63 | Drug dose omission | FAERS: 1 | US FAERS | |
| 64 | Dysarthria | FAERS: 1 | US FAERS | |
| 65 | Dysphonia | FAERS: 1 | US FAERS | |
| 66 | Emotional disorder | FAERS: 1 | US FAERS | |
| 67 | Erythema Multiforme | FAERS: 1 | US FAERS | |
| 68 | Erythema | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 69 | Fatigue | FAERS: 1 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 70 | Frontotemporal dementia | FAERS: 1 | US FAERS | |
| 71 | Gliosis | FAERS: 1 | US FAERS | |
| 72 | Hemiparesis | FAERS: 1 | US FAERS | |
| 73 | Hormone level abnormal | FAERS: 1 | US FAERS | |
| 74 | Hydrocephalus | FAERS: 1 | US FAERS | |
| 75 | Hypothyroidism | FAERS: 1 | US FAERS | |
| 76 | Inflammation | FAERS: 1 | US FAERS | |
| 77 | Influenza | FAERS: 1 | US FAERS | |
| 78 | Lethargy | FAERS: 1 | US FAERS | |
| 79 | Medication Error | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 80 | Meningioma | FAERS: 1 | US FAERS | |
| 81 | Myocardial Infarction | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 82 | Nausea | FAERS: 1 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 83 | Neurological examination abnormal | FAERS: 1 | US FAERS | |
| 84 | Otosclerosis | FAERS: 1 | US FAERS | |
| 85 | Pain | FAERS: 1 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 86 | Panic Disorder | FAERS: 1 | US FAERS | |
| 87 | Peripheral swelling | FAERS: 1 | US FAERS | |
| 88 | Poor quality sleep | FAERS: 1 | US FAERS | |
| 89 | Pregnancy | FAERS: 1 | US FAERS | |
| 90 | Product substitution issue | FAERS: 1 | US FAERS | |
| 91 | Prolapse repair | FAERS: 1 | US FAERS | |
| 92 | Pruritus | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 93 | Psychiatric symptom | FAERS: 1 | US FAERS | |
| 94 | Pulmonary Embolism | FAERS: 1 | US FAERS | |
| 95 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 96 | Skin lesion | FAERS: 1 | US FAERS | |
| 97 | Somnolence | FAERS: 1 | US FAERS | |
| 98 | Syncope | FAERS: 1 | US FAERS | |
| 99 | Therapeutic response unexpected with drug substitution | FAERS: 1 | US FAERS | |
| 100 | Thrombophlebitis | FAERS: 1 | US FAERS | |
| 101 | Tinnitus | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 102 | VIIth nerve paralysis | FAERS: 1 | US FAERS | |
| 103 | Visual Impairment | FAERS: 1 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 104 | Visual disturbance | FAERS: 1 | US FAERS | |
| 105 | nervous system disorder | FAERS: 1 | US FAERS | |
| 106 | Agitation | Canada Vigilance: 1 | Canada Vigilance | |
| 107 | Application site reaction | Canada Vigilance: 5 | Canada Vigilance | |
| 108 | Asthenia | Canada Vigilance: 1 | Canada Vigilance | |
| 109 | Atrophic vulvovaginitis | Canada Vigilance: 1 | Canada Vigilance | |
| 110 | Back Pain | Canada Vigilance: 2 | Canada Vigilance | |
| 111 | Blood pressure fluctuation | Canada Vigilance: 1 | Canada Vigilance | |
| 112 | Bone pain | Canada Vigilance: 1 | Canada Vigilance | |
| 113 | Burning sensation | Canada Vigilance: 1 | Canada Vigilance | |
| 114 | Chest discomfort | Canada Vigilance: 2 | Canada Vigilance | |
| 115 | Chills | Canada Vigilance: 3 | Canada Vigilance | |
| 116 | Constipation | Canada Vigilance: 1 | Canada Vigilance | |
| 117 | Crying | Canada Vigilance: 1 | Canada Vigilance | |
| 118 | Cyst | Canada Vigilance: 1 | Canada Vigilance | |
| 119 | Dental caries | Canada Vigilance: 1 | Canada Vigilance | |
| 120 | Dyspepsia | Canada Vigilance: 1 | Canada Vigilance | |
| 121 | Ear discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 122 | Endometrial Hyperplasia | Canada Vigilance: 1 | Canada Vigilance | |
| 123 | Eye irritation | Canada Vigilance: 1 | Canada Vigilance | |
| 124 | Feeling of body temperature change | Canada Vigilance: 1 | Canada Vigilance | |
| 125 | Flatulence | Canada Vigilance: 1 | Canada Vigilance | |
| 126 | Flushing | Canada Vigilance: 2 | Canada Vigilance | |
| 127 | Head discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 128 | Hypersensitivity | Canada Vigilance: 1 | Canada Vigilance | |
| 129 | Infection | Canada Vigilance: 1 | Canada Vigilance | |
| 130 | Malabsorption | Canada Vigilance: 1 | Canada Vigilance | |
| 131 | Menorrhagia | Canada Vigilance: 4 | Canada Vigilance | |
| 132 | Mood swings | Canada Vigilance: 5 | Canada Vigilance | |
| 133 | Musculoskeletal Pain | Canada Vigilance: 1 | Canada Vigilance | |
| 134 | Myalgia | Canada Vigilance: 2 | Canada Vigilance | |
| 135 | Neck Pain | Canada Vigilance: 1 | Canada Vigilance | |
| 136 | Nipple pain | Canada Vigilance: 1 | Canada Vigilance | |
| 137 | Pancreatitis | Canada Vigilance: 1 | Canada Vigilance | |
| 138 | Pericardial effusion | Canada Vigilance: 1 | Canada Vigilance | |
| 139 | Premenstrual syndrome | Canada Vigilance: 2 | Canada Vigilance | |
| 140 | Rash erythematous | Canada Vigilance: 2 | Canada Vigilance | |
| 141 | Sinusitis | Canada Vigilance: 1 | Canada Vigilance | |
| 142 | Skin reaction | Canada Vigilance: 2 | Canada Vigilance | |
| 143 | Swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 144 | Tachycardia | Canada Vigilance: 1 | Canada Vigilance | |
| 145 | Throat irritation | Canada Vigilance: 1 | Canada Vigilance | |
| 146 | Urinary tract infection | Canada Vigilance: 1 | Canada Vigilance | |
| 147 | Vomiting | Canada Vigilance: 2 | Canada Vigilance | |
| 148 | Vulvovaginal burning sensation | Canada Vigilance: 1 | Canada Vigilance | |
| 149 | Vulvovaginitis | Canada Vigilance: 1 | Canada Vigilance | |
| 150 | jaundice | Canada Vigilance: 1 | Canada Vigilance |
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