MetaADEDB 2.0 @ LMMD
Carmustine
(DLGOEMSEDOSKAD-UHFFFAOYSA-N)
Structure
SMILES
ClCCNC(=O)N(CCCl)N=O
Type(s)
Approved; Investigational
ATC code(s)
L01AD01
Molecular Formula:
C5H9Cl2N3O2
Molecular Weight:
214.050
Log P:
1.5479
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
61.77
CAS Number(s):
154-93-8
Synonym(s)
1.
Carmustine
2.
BCNU
3.
1,3-Bis(2-Chloroethyl)-1-Nitrosourea
4.
BiCNU
5.
FIVB
6.
N,N'-Bis(2-Chloroethyl)-N-Nitrosourea
7.
Nitrumon
External Link(s)
MeSHD002330
PubChem Compound2578
BindingDB50015950
ChEBI3423
CHEMBLCHEMBL513
DrugBankDB00262
DrugCentral512
IUPHAR/BPS Guide to PHARMACOLOGY6800
KEGGcpd:C06873
dr:D00254
Therapeutic Target DatabaseD0S9UT
ZINC3830387
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1HemiplegiaFAERS: 28US FAERS
2PneumocephalusFAERS: 27US FAERS
3AphasiaFAERS: 18US FAERS
4Cerebral InfarctionFAERS: 16US FAERS
5Brain AbscessFAERS: 13US FAERS
6HeadacheFAERS: 129134180CTD
US FAERS
7Post procedural complicationFAERS: 11US FAERS
8Disease ProgressionFAERS: 9US FAERS
9Incision site infectionFAERS: 9US FAERS
10Wound InfectionFAERS: 9US FAERS
11InfectionFAERS: 8US FAERS
12MeningitisFAERS: 8US FAERS
13Intracranial HypotensionFAERS: 7US FAERS
14Altered state of consciousnessFAERS: 6US FAERS
15Pulmonary EmbolismFAERS: 6US FAERS
16Respiratory FailureFAERS: 6US FAERS
17Deep Vein ThrombosisFAERS: 5US FAERS
18Depressed Level of ConsciousnessFAERS: 5US FAERS
19EpilepsyFAERS: 5US FAERS
20HydrocephalusFAERS: 517334672CTD
US FAERS
21NecrosisFAERS: 516863996
18089819
CTD
US FAERS
22ThrombocytopeniaFAERS: 5
Canada Vigilance: 1

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CTD
Canada Vigilance
US FAERS
23VomitingFAERS: 52836567
6213670
CTD
US FAERS
24Wound dehiscenceFAERS: 5US FAERS
25Back PainFAERS: 4US FAERS
26Cerebral cystFAERS: 4US FAERS
27Circumstance or information capable of leading to medication errorFAERS: 4US FAERS
28Drug administration errorFAERS: 4US FAERS
29Implant site necrosisFAERS: 4US FAERS
30Implant site reactionFAERS: 4US FAERS
31Incorrect storage of drugFAERS: 4US FAERS
32NauseaFAERS: 4

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CTD
US FAERS
33OsteitisFAERS: 4US FAERS
34PneumoniaFAERS: 46354414CTD
US FAERS
35PneumonitisFAERS: 4US FAERS
36SepsisFAERS: 4US FAERS
37SomnolenceFAERS: 4US FAERS
38TachycardiaFAERS: 4US FAERS
39AgitationFAERS: 3US FAERS
40Burning sensationFAERS: 3US FAERS
41Central Nervous System InfectionFAERS: 3US FAERS
42Cerebrovascular accidentFAERS: 3US FAERS
43Drug ineffectiveFAERS: 3US FAERS
44ErythemaFAERS: 36213670CTD
US FAERS
45General physical health deteriorationFAERS: 3US FAERS
46HypotensionFAERS: 311219485CTD
US FAERS
47LeukopeniaFAERS: 34343318
7960606
CTD
US FAERS
48Malignant neoplasm progressionFAERS: 3US FAERS
49OsteomyelitisFAERS: 3US FAERS
50PancytopeniaFAERS: 310918425CTD
US FAERS
51Post procedural infectionFAERS: 3US FAERS
52PurulenceFAERS: 3US FAERS
53Respiratory distressFAERS: 3US FAERS
54Staphylococcus test positiveFAERS: 3US FAERS
55Status EpilepticusFAERS: 3US FAERS
56AbuliaFAERS: 2US FAERS
57AstheniaFAERS: 2US FAERS
58BradycardiaFAERS: 2US FAERS
59Cerebral vasoconstrictionFAERS: 2US FAERS
60Culture positiveFAERS: 2US FAERS
61CystFAERS: 2US FAERS
62Device related infectionFAERS: 2US FAERS
63Disseminated Intravascular CoagulationFAERS: 26845142CTD
US FAERS
64DizzinessFAERS: 2US FAERS
65Drug toxicityFAERS: 2US FAERS
66EncephalitisFAERS: 2US FAERS
67Expired product administeredFAERS: 2US FAERS
68External hydrocephalusFAERS: 2US FAERS
69Gaze palsyFAERS: 2US FAERS
70Glioblastoma MultiformeFAERS: 2US FAERS
71HypersensitivityFAERS: 2US FAERS
72HypoxiaFAERS: 2US FAERS
73Intracranial AneurysmFAERS: 2US FAERS
74Malignant GliomaFAERS: 2US FAERS
75Neurological decompensationFAERS: 2US FAERS
76NeutropeniaFAERS: 212494480
16520986
CTD
US FAERS
77Pericardial effusionFAERS: 218344943CTD
US FAERS
78Postoperative wound complicationFAERS: 2US FAERS
79Procedural complicationFAERS: 2US FAERS
80Product quality issueFAERS: 2US FAERS
81Pulmonary toxicityFAERS: 2US FAERS
82Radiation injuryFAERS: 2US FAERS
83SarcomaFAERS: 2US FAERS
84Tumour haemorrhageFAERS: 2US FAERS
85Abdominal PainFAERS: 1US FAERS
86Abdominal tendernessFAERS: 1US FAERS
87Activities of daily living impairedFAERS: 1US FAERS
88Adverse eventFAERS: 1US FAERS
89Alanine Aminotransferase IncreasedFAERS: 1US FAERS
90Alopecia AreataFAERS: 1US FAERS
91AngerFAERS: 1US FAERS
92Apparent life threatening eventFAERS: 1US FAERS
93ArthralgiaFAERS: 1US FAERS
94Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
95AsphyxiaFAERS: 1US FAERS
96BlindnessFAERS: 17023671
11020424
CTD
US FAERS
97Blood albumin decreasedFAERS: 1US FAERS
98Blood alkaline phosphatase increasedFAERS: 1US FAERS
99Blood amylase increasedFAERS: 1US FAERS
100Blood creatine phosphokinase increasedFAERS: 1US FAERS
101Blood fibrinogen increasedFAERS: 1US FAERS
102Blood glucose increasedFAERS: 1US FAERS
103Blood magnesium decreasedFAERS: 1US FAERS
104Blood phosphorus decreasedFAERS: 1US FAERS
105Blood potassium decreasedFAERS: 1US FAERS
106Blood sodium increasedFAERS: 1US FAERS
107BradyphreniaFAERS: 1US FAERS
108Brain empyemaFAERS: 1US FAERS
109BronchiectasisFAERS: 1US FAERS
110Candida pneumoniaFAERS: 1US FAERS
111Cardiovascular insufficiencyFAERS: 1US FAERS
112CellulitisFAERS: 1US FAERS
113Cerebral artery stenosisFAERS: 1US FAERS
114Cerebral atrophyFAERS: 1US FAERS
115Chest PainFAERS: 1US FAERS
116ChillsFAERS: 1US FAERS
117CholelithiasisFAERS: 1US FAERS
118ConjunctivitisFAERS: 1US FAERS
119Device breakageFAERS: 1US FAERS
120Diffuse alveolar damageFAERS: 1US FAERS
121DysgraphiaFAERS: 1US FAERS
122EmpyemaFAERS: 1US FAERS
123Enterococcal infectionFAERS: 1US FAERS
124EpistaxisFAERS: 1US FAERS
125Facial PainFAERS: 1US FAERS
126Fibrin D dimer increasedFAERS: 1US FAERS
127FlushingFAERS: 19134180CTD
US FAERS
128FolliculitisFAERS: 1US FAERS
129Frontotemporal dementiaFAERS: 1US FAERS
130Gastrointestinal hypomotilityFAERS: 1US FAERS
131GliosisFAERS: 1US FAERS
132Head discomfortFAERS: 1US FAERS
133HemiparesisFAERS: 1US FAERS
134Implant site abscessFAERS: 1US FAERS
135Implant site cystFAERS: 1US FAERS
136Implant site extravasationFAERS: 1US FAERS
137Implant site infectionFAERS: 1US FAERS
138Implant site swellingFAERS: 1US FAERS
139Incision site complicationFAERS: 1US FAERS
140InflammationFAERS: 1US FAERS
141Injection site extravasationFAERS: 1US FAERS
142MYELODYSPLASTIC SYNDROMEFAERS: 1US FAERS
143Medical device removalFAERS: 1US FAERS
144Memory impairmentFAERS: 1US FAERS
145MeningismFAERS: 1US FAERS
146MonoparesisFAERS: 1US FAERS
147MonoplegiaFAERS: 1US FAERS
148Musculoskeletal PainFAERS: 1US FAERS
149MydriasisFAERS: 1US FAERS
150Myoglobin blood increasedFAERS: 1US FAERS
151Nuchal RigidityFAERS: 1US FAERS
152Oral painFAERS: 1US FAERS
153PCO2 decreasedFAERS: 1US FAERS
154PO2 decreasedFAERS: 1US FAERS
155PancreatitisFAERS: 1US FAERS
156ParesisFAERS: 1US FAERS
157PhlebitisFAERS: 1US FAERS
158PneumothoraxFAERS: 1US FAERS
159Post procedural swellingFAERS: 1US FAERS
160Postoperative feverFAERS: 1US FAERS
161Prescribed underdoseFAERS: 1US FAERS
162Procedural site reactionFAERS: 1US FAERS
163Product administration errorFAERS: 1US FAERS
164Product storage errorFAERS: 1US FAERS
165Product use issueFAERS: 1US FAERS
166Propionibacterium infectionFAERS: 1US FAERS
167Propionibacterium test positiveFAERS: 1US FAERS
168Protein total decreasedFAERS: 1US FAERS
169PruritusFAERS: 1US FAERS
170Pulmonary FibrosisFAERS: 115286697
18528683
CTD
US FAERS
171Pulmonary InfarctionFAERS: 1US FAERS
172Purulent dischargeFAERS: 1US FAERS
173QuadriplegiaFAERS: 1US FAERS
174Radiation necrosisFAERS: 1US FAERS
175RestlessnessFAERS: 1US FAERS
176Septic ShockFAERS: 1US FAERS
177Simple Partial SeizuresFAERS: 1US FAERS
178Slow speechFAERS: 1US FAERS
179Soft tissue massFAERS: 1US FAERS
180Soft tissue necrosisFAERS: 1US FAERS
181SoporFAERS: 1US FAERS
182Stevens-Johnson SyndromeFAERS: 1US FAERS
183StressFAERS: 1US FAERS
184Sudden deathFAERS: 1US FAERS
185SwellingFAERS: 1US FAERS
186TinnitusFAERS: 1US FAERS
187ToothacheFAERS: 1US FAERS
188Vascular pseudoaneurysm rupturedFAERS: 1US FAERS
189VasospasmFAERS: 1US FAERS
190Venoocclusive diseaseFAERS: 1US FAERS
191Wrong technique in drug usage processFAERS: 1US FAERS
192nervous system disorderFAERS: 1US FAERS
193Adenocarcinoma6354414
17880193
CTD
194Anemia16520986CTD
195Anorexia6587202CTD
196Astrocytoma

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CTD
197Brain Diseases1870683
6385604
CTD
198Brain Edema17169765CTD
199Brain Ischemia2836567CTD
200Brain Neoplasms

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CTD
201Central Nervous System Neoplasms10918425
16864853
CTD
202Chemical and Drug Induced Liver Injury

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CTD
203Cholangiocarcinoma7046907CTD
204Cholestasis10445391
16005536
CTD
205Cognition Disorders20046642CTD
206Colonic Neoplasms14578471CTD
207Colorectal Neoplasms7960606CTD
208Confusion509386CTD
209Cystitis6134004CTD
210Dysuria6134004CTD
211Edema10773252CTD
212Ependymoma4343318CTD
213Eye pain509386
6213670
CTD
214Gastrointestinal Diseases7960606CTD
215Glioblastoma

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CTD
216Glioma

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CTD
217Hearing Loss8477204CTD
218Heart Diseases6354414CTD
219Hematuria6134004CTD
220Hemorrhage6134004CTD
221Hepatic Veno-Occlusive Disease2189592CTD
222Hodgkin Disease8477204CTD
223Hyperemia6421125CTD
224Hyperplasia16005536CTD
225Ischemia3340295
6213670
CTD
226Kidney Diseases8477204
16126841
CTD
227Leukemia L1210898797CTD
228Liver Cirrhosis, Experimental25380136CTD
229Liver diseases10918425CTD
230Lung Injury12114195
18528683
CTD
231Lung Neoplasms6354414
21789727
CTD
232Lung diseases3026626
10918425
CTD
233Lymphoma1655228
16864853
CTD
234Malformations of Cortical Development

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CTD
235Medulloblastoma4739170
15133626
16243814
CTD
236Memory Disorders20046642CTD
237Mouth Neoplasms12543247CTD
238Multiple Myeloma

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CTD
239Multiple Organ Failure10918425CTD
240Mycosis Fungoides16631939CTD
241Myocardial Ischemia1655228
12203142
CTD
242Neoplasm Metastasis509386
7960606
CTD
243Neoplasms, Experimental175631
14506174
CTD
244Neoplasms, Hormone-Dependent12058236CTD
245Neoplasms, Neuroepithelial12325066CTD
246Neoplasms

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CTD
247Nephritis, Interstitial7272960CTD
248Neurilemmoma175631CTD
249Optic Neuritis625262CTD
250Pain7046907CTD
251Papilledema2956289CTD
252Paresthesia9134180CTD
253Postoperative Complications10773252CTD
254Prenatal Exposure Delayed Effects20461523CTD
255Proteinuria11219485CTD
256Renal Insufficiency11219485CTD
257Retinal Artery Occlusion11020424CTD
258Retinal Diseases3340295
3808609
7023671
CTD
259Retinal Vasculitis6747681CTD
260Retinitis625262CTD
261Sarcoma, Experimental7107385CTD
262Seizures509386CTD
263Skin Neoplasms16631939CTD
264Spinal Cord Diseases11020424CTD
265Stomatitis10918425CTD
266Thromboembolism7960606CTD
267Thrombosis11020424CTD
268Uremia11219485CTD
269Vascular System Injuries2956289
6213670
CTD
270Vision Disorders

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CTD
271gliosarcoma

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CTD
272leukemia6354414
11960597
CTD
273melanoma

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CTD
274oligodendroglioma15332326CTD
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