MetaADEDB 2.0 @ LMMD
Propylthiouracil
(KNAHARQHSZJURB-UHFFFAOYSA-N)
Structure
SMILES
CCCc1cc(=O)[nH]c(=S)[nH]1
Type(s)
Approved; Investigational
ATC code(s)
H03BA02
Molecular Formula:
C7H10N2OS
Molecular Weight:
170.232
Log P:
1.3850
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
2
TPSA:
80.74
CAS Number(s):
51-52-5; 500-50-5; 53939-84-7
Synonym(s)
1.
Propylthiouracil
2.
6-Propyl-2-Thiouracil
3.
6 Propyl 2 Thiouracil
External Link(s)
MeSHD011441
PubChem Compound657298
BindingDB50133597
ChEBI8502
CHEMBLCHEMBL1518
DrugBankDB00550
DrugCentral2308
IUPHAR/BPS Guide to PHARMACOLOGY6650
KEGGcpd:C07569
dr:D00562
Therapeutic Target DatabaseD0K2MK
D00MIN
ZINC4640636
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Anti-neutrophil cytoplasmic antibody positive vasculitisFAERS: 34OFFSIDES
US FAERS
2NauseaFAERS: 15OFFSIDES
SIDER
US FAERS
3VasculitisFAERS: 13

View details

CTD
SIDER
US FAERS
4VomitingFAERS: 13
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
5ArthralgiaFAERS: 12
Canada Vigilance: 4

View details

CTD
SIDER
Canada Vigilance
US FAERS
6HeadacheFAERS: 12
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
7jaundiceFAERS: 12
Canada Vigilance: 3

View details

CTD
SIDER
Canada Vigilance
US FAERS
8Leukocytoclastic vasculitisFAERS: 11SIDER
US FAERS
9AgranulocytosisFAERS: 9
Canada Vigilance: 8

View details

CTD
SIDER
Canada Vigilance
US FAERS
10AstheniaFAERS: 9
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
11Abdominal PainFAERS: 815822032
15879050
CTD
US FAERS
12Alanine Aminotransferase IncreasedFAERS: 8US FAERS
13Aspartate Aminotransferase IncreasedFAERS: 7
Canada Vigilance: 2
Canada Vigilance
US FAERS
14FatigueFAERS: 7
Canada Vigilance: 1
4172680
16425441
CTD
OFFSIDES
Canada Vigilance
US FAERS
15Hepatic EncephalopathyFAERS: 7

View details

CTD
US FAERS
16Hepatic necrosisFAERS: 7OFFSIDES
US FAERS
17HyperthyroidismFAERS: 7

View details

CTD
US FAERS
18HypothyroidismFAERS: 7
Canada Vigilance: 1

View details

CTD
Canada Vigilance
US FAERS
19MalaiseFAERS: 7US FAERS
20Respiratory FailureFAERS: 7OFFSIDES
US FAERS
21Blood thyroid stimulating hormone decreasedFAERS: 6US FAERS
22HepatotoxicityFAERS: 6
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
23Mental status changesFAERS: 6OFFSIDES
US FAERS
24Pyoderma GangrenosumFAERS: 6US FAERS
25TachycardiaFAERS: 6US FAERS
26White blood cell count decreasedFAERS: 6US FAERS
27Blood albumin decreasedFAERS: 5OFFSIDES
US FAERS
28Drug ineffectiveFAERS: 5
Canada Vigilance: 6
Canada Vigilance
US FAERS
29GlomerulonephritisFAERS: 5

View details

CTD
SIDER
US FAERS
30HepatitisFAERS: 5
Canada Vigilance: 2

View details

CTD
SIDER
Canada Vigilance
US FAERS
31Lupus-like syndromeFAERS: 5SIDER
US FAERS
32PruritusFAERS: 5
Canada Vigilance: 10
Canada Vigilance
SIDER
US FAERS
33Acute kidney injuryFAERS: 4

View details

CTD
US FAERS
34CardiomegalyFAERS: 4US FAERS
35ChillsFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
36Deafness NeurosensoryFAERS: 4US FAERS
37Disseminated Intravascular CoagulationFAERS: 45316762
10684339
CTD
US FAERS
38Drug exposure during pregnancyFAERS: 4OFFSIDES
US FAERS
39MyalgiaFAERS: 4
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
40Ocular icterusFAERS: 4OFFSIDES
US FAERS
41PancytopeniaFAERS: 4
Canada Vigilance: 2
4172680
6054594
17415292
CTD
Canada Vigilance
US FAERS
42Pulmonary renal syndromeFAERS: 4US FAERS
43Septic ShockFAERS: 4OFFSIDES
US FAERS
44ThrombocytopeniaFAERS: 4
Canada Vigilance: 1
566489CTD
SIDER
Canada Vigilance
US FAERS
45Weight decreasedFAERS: 4US FAERS
46AscitesFAERS: 3US FAERS
47Autoimmune hepatitisFAERS: 3OFFSIDES
US FAERS
48CholestasisFAERS: 38191137
11144016
14530534
CTD
US FAERS
49Congenital HypothyroidismFAERS: 331068541CTD
US FAERS
50General physical health deteriorationFAERS: 3US FAERS
51PalpitationsFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
52Pharyngolaryngeal PainFAERS: 3US FAERS
53PneumoniaFAERS: 3US FAERS
54ProteinuriaFAERS: 3

View details

CTD
US FAERS
55Pulmonary vasculitisFAERS: 3US FAERS
56StomatitisFAERS: 3US FAERS
57AlopeciaFAERS: 2SIDER
US FAERS
58Aplasia Cutis CongenitaFAERS: 2US FAERS
59Blood alkaline phosphatase increasedFAERS: 2US FAERS
60Blood immunoglobulin A increasedFAERS: 2US FAERS
61Chest PainFAERS: 2US FAERS
62Cholestatic liver injuryFAERS: 2US FAERS
63ChromaturiaFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
64Congenital intestinal obstructionFAERS: 2US FAERS
65Disease recurrenceFAERS: 2US FAERS
66DizzinessFAERS: 2OFFSIDES
US FAERS
67EndotheliomatosisFAERS: 2US FAERS
68EpistaxisFAERS: 24172680CTD
US FAERS
69Escherichia infectionFAERS: 2US FAERS
70ExophthalmosFAERS: 2OFFSIDES
US FAERS
71Febrile NeutropeniaFAERS: 2US FAERS
72HypersensitivityFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
73InflammationFAERS: 29181282CTD
US FAERS
74Joint swellingFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
75Maternal exposure during pregnancyFAERS: 2US FAERS
76NecrosisFAERS: 2

View details

CTD
US FAERS
77NeutropeniaFAERS: 2
Canada Vigilance: 1
12521217CTD
Canada Vigilance
US FAERS
78PallorFAERS: 24172680CTD
OFFSIDES
US FAERS
79PolydactylyFAERS: 2US FAERS
80PolyhydramniosFAERS: 2US FAERS
81Protein urine presentFAERS: 2US FAERS
82PyelectasiaFAERS: 2OFFSIDES
US FAERS
83Rash erythematousFAERS: 2
Canada Vigilance: 3
Canada Vigilance
US FAERS
84Skin UlcerFAERS: 29893462CTD
SIDER
US FAERS
85Skin lesionFAERS: 2OFFSIDES
US FAERS
86SwellingFAERS: 2US FAERS
87Toxicity to various agentsFAERS: 2US FAERS
88Abdominal discomfortFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
89Activated partial thromboplastin time abnormalFAERS: 1US FAERS
90AgeusiaFAERS: 1SIDER
US FAERS
91Alcohol test false positiveFAERS: 1US FAERS
92Ammonia increasedFAERS: 1US FAERS
93Anal UlcerFAERS: 1US FAERS
94AngioedemaFAERS: 1US FAERS
95AnorexiaFAERS: 116425441CTD
OFFSIDES
US FAERS
96Antiphospholipid SyndromeFAERS: 115822032
15879050
18044264
CTD
US FAERS
97AnxietyFAERS: 1US FAERS
98Apgar score abnormalFAERS: 1US FAERS
99AphoniaFAERS: 1US FAERS
100Aphthous StomatitisFAERS: 1OFFSIDES
US FAERS
101ArthritisFAERS: 1

View details

CTD
US FAERS
102AsterixisFAERS: 1US FAERS
103Atrial FibrillationFAERS: 1US FAERS
104Bacillus infectionFAERS: 1US FAERS
105Back PainFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
106Band neutrophil percentage increasedFAERS: 1OFFSIDES
US FAERS
107Bilirubin conjugated increasedFAERS: 1US FAERS
108Biopsy kidney abnormalFAERS: 1US FAERS
109Blood alcohol increasedFAERS: 1US FAERS
110Blood lactate dehydrogenase increasedFAERS: 1OFFSIDES
US FAERS
111Blood pH increasedFAERS: 1US FAERS
112Blood thyroid stimulating hormone abnormalFAERS: 1US FAERS
113Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
114Blood urea increasedFAERS: 1US FAERS
115BradycardiaFAERS: 1US FAERS
116BronchiectasisFAERS: 1US FAERS
117CachexiaFAERS: 1US FAERS
118Cardiac ArrestFAERS: 1US FAERS
119CholelithiasisFAERS: 1US FAERS
120ChoreaFAERS: 1US FAERS
121ClubbingFAERS: 1OFFSIDES
US FAERS
122Complement factor C4 decreasedFAERS: 1US FAERS
123Congenital intestinal malformationFAERS: 1US FAERS
124ConstipationFAERS: 1US FAERS
125Cryoglobulins presentFAERS: 1US FAERS
126DehydrationFAERS: 1US FAERS
127Depressed Level of ConsciousnessFAERS: 1US FAERS
128Dermatitis acneiformFAERS: 1US FAERS
129DermatitisFAERS: 1
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
130DiscomfortFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
131Double stranded DNA antibody positiveFAERS: 1US FAERS
132Drug screen false positiveFAERS: 1US FAERS
133Drug screen positiveFAERS: 1US FAERS
134Drug toxicityFAERS: 1OFFSIDES
US FAERS
135Ejection Fraction DecreasedFAERS: 1US FAERS
136Embolic strokeFAERS: 1US FAERS
137Enterococcal infectionFAERS: 1US FAERS
138Epidermal necrosisFAERS: 1US FAERS
139Epstein-Barr virus antibody positiveFAERS: 1US FAERS
140Erythema NodosumFAERS: 1SIDER
US FAERS
141Erythroid series abnormalFAERS: 1US FAERS
142Fibrin D dimer increasedFAERS: 1US FAERS
143FormicationFAERS: 1US FAERS
144GangreneFAERS: 1US FAERS
145Gastric ulcerFAERS: 1US FAERS
146Gastrointestinal inflammationFAERS: 1US FAERS
147Graft dysfunctionFAERS: 1US FAERS
148HepatomegalyFAERS: 128108177CTD
US FAERS
149Hyperdynamic precordiumFAERS: 1US FAERS
150HypoxiaFAERS: 110846402
15114849
CTD
OFFSIDES
US FAERS
151Idiopathic capillaritisFAERS: 1US FAERS
152Idiosyncratic drug reactionFAERS: 1US FAERS
153InfectionFAERS: 1US FAERS
154IntussusceptionFAERS: 1US FAERS
155Left atrial dilatationFAERS: 1US FAERS
156LethargyFAERS: 1US FAERS
157LeukopeniaFAERS: 1
Canada Vigilance: 5
6179348
6892530
CTD
SIDER
Canada Vigilance
US FAERS
158Live BirthFAERS: 1US FAERS
159Liver transplant rejectionFAERS: 1US FAERS
160Lung consolidationFAERS: 1US FAERS
161Maternal exposure timing unspecifiedFAERS: 1US FAERS
162Musculoskeletal PainFAERS: 1US FAERS
163Musculoskeletal stiffnessFAERS: 1US FAERS
164Neonatal aspirationFAERS: 1US FAERS
165Neonatal multi-organ failureFAERS: 1US FAERS
166NephritisFAERS: 1566489
11307296
CTD
SIDER
US FAERS
167Neurological examination abnormalFAERS: 1US FAERS
168Neutrophil count decreasedFAERS: 1OFFSIDES
US FAERS
169Neutrophil percentage decreasedFAERS: 1US FAERS
170Neutrophil percentage increasedFAERS: 1US FAERS
171Neutrophilic dermatosisFAERS: 1US FAERS
172NoduleFAERS: 1US FAERS
173OsteitisFAERS: 1US FAERS
174Osteonecrosis of JawFAERS: 1US FAERS
175Otitis MediaFAERS: 1US FAERS
176OverdoseFAERS: 1US FAERS
177PO2 decreasedFAERS: 1US FAERS
178PainFAERS: 1US FAERS
179Pericardial effusionFAERS: 1OFFSIDES
US FAERS
180PhotophobiaFAERS: 1US FAERS
181Plasma cells presentFAERS: 1US FAERS
182PneumonitisFAERS: 1US FAERS
183PolychondritisFAERS: 1US FAERS
184Post procedural bile leakFAERS: 1US FAERS
185Post procedural complicationFAERS: 1US FAERS
186PregnancyFAERS: 1US FAERS
187Product substitution issueFAERS: 1US FAERS
188Productive CoughFAERS: 1US FAERS
189Protein total decreasedFAERS: 1US FAERS
190Prothrombin time abnormalFAERS: 1US FAERS
191Pulmonary arterial pressure increasedFAERS: 1US FAERS
192Pulmonary toxicityFAERS: 1US FAERS
193PurpuraFAERS: 1
Canada Vigilance: 1
4172680
9247777
9893462
CTD
Canada Vigilance
US FAERS
194PurulenceFAERS: 1OFFSIDES
US FAERS
195Refusal of treatment by relativeFAERS: 1US FAERS
196Respiratory distressFAERS: 1US FAERS
197Restrictive pulmonary diseaseFAERS: 1US FAERS
198Reticulocyte count increasedFAERS: 1US FAERS
199Right atrial dilatationFAERS: 1US FAERS
200Sinus TachycardiaFAERS: 1US FAERS
201SinusitisFAERS: 1US FAERS
202Skin necrosisFAERS: 1US FAERS
203Skin test positiveFAERS: 1US FAERS
204SplenomegalyFAERS: 16892530CTD
SIDER
US FAERS
205Temperature intoleranceFAERS: 1US FAERS
206TremorFAERS: 1US FAERS
207Tri-iodothyronine abnormalFAERS: 1US FAERS
208Tri-iodothyronine uptake increasedFAERS: 1US FAERS
209TrichorrhexisFAERS: 1US FAERS
210UlcerFAERS: 1

View details

CTD
US FAERS
211Ultrasound liver abnormalFAERS: 1US FAERS
212Urine alcohol test positiveFAERS: 1US FAERS
213Urine ketone body presentFAERS: 1US FAERS
214UrticariaFAERS: 1
Canada Vigilance: 8
14530534
15785249
CTD
SIDER
Canada Vigilance
US FAERS
215Vasculitis gastrointestinalFAERS: 1US FAERS
216Visual disturbanceFAERS: 1US FAERS
217WheezingFAERS: 1US FAERS
218Abdominal tendernessOFFSIDES
219Accidental exposureOFFSIDES
220Acute myocardial infarctionOFFSIDES
221Anemia, Hemolytic1110434
11922496
CTD
222Anemia

View details

CTD
223Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

View details

CTD
224Anti-thyroid antibody positiveOFFSIDES
225AnuriaOFFSIDES
226ArteriosclerosisOFFSIDES
227Atherosclerosis19931584CTD
228Atrial FlutterOFFSIDES
229Atrial hypertrophyOFFSIDES
230Atrial tachycardiaOFFSIDES
231Blood 25-hydroxycholecalciferol decreasedOFFSIDES
232Blood Coagulation Disorders19483382
20575220
CTD
233Blood acid phosphatase increasedCanada Vigilance: 1Canada Vigilance
234Blood sodiumOFFSIDES
235Blood thyroid stimulating hormoneOFFSIDES
236Blurred visionOFFSIDES
237Body TemperatureOFFSIDES
238Bone Marrow Diseases6054594
19493451
CTD
239Brain Diseases21964421CTD
240Brain Injuries25825206CTD
241Breech PresentationOFFSIDES
242Cardiac TamponadeOFFSIDES
243Cardiovascular Abnormalities16498810CTD
244Catalepsy18661784
19340585
CTD
245Cerebral Hemorrhage12549809CTD
246Chemical and Drug Induced Liver Injury

View details

CTD
247CholecystitisOFFSIDES
248CirrhosisOFFSIDES
249Classical Lissencephalies and Subcortical Band Heterotopias27216871CTD
250Cold sweatOFFSIDES
251Congenital heart diseaseOFFSIDES
252Congenital tricuspid valve incompetenceOFFSIDES
253Cryoglobulinemia566489CTD
254Dandy-Walker SyndromeOFFSIDES
255Diarrhea15822032CTD
256Diastolic dysfunctionOFFSIDES
257DiplopiaOFFSIDES
258DrowsinessSIDER
259Drug ToleranceOFFSIDES
260Drug dispensing errorOFFSIDES
261Drug exposure before pregnancyOFFSIDES
262DysgeusiaCanada Vigilance: 11754991CTD
SIDER
Canada Vigilance
263DyspepsiaSIDER
264Dyspnea

View details

CTD
265Echocardiogram abnormalOFFSIDES
266Edema12549809CTD
267EmbolismOFFSIDES
268Epigastric distressSIDER
269Erectile dysfunctionOFFSIDES
270Erythema3528517
16847204
CTD
271ErythropeniaOFFSIDES
272Euthyroid Sick Syndromes8542214CTD
273Exanthema

View details

CTD
274Fetal Growth Retardation22529993CTD
275Fever

View details

CTD
276FibromyalgiaCanada Vigilance: 1Canada Vigilance
277Gingival Hemorrhage4172680CTD
278GlobulinuriaOFFSIDES
279Goiter1110434
5659292
10911406
CTD
OFFSIDES
280Granulomatosis with polyangiitis9806373CTD
281GranulomaOFFSIDES
282Graves Disease

View details

CTD
283Hearing Loss, Bilateral15583443CTD
284Hematuria

View details

CTD
285Hemoptysis1424898
12857055
16409836
CTD
286Hemorrhage

View details

CTD
287Hepatitis, Chronic1147734
6893265
8876856
CTD
288Hypergammaglobulinemia12521217CTD
289HyporeflexiaOFFSIDES
290Immune Complex Diseases17472842CTD
291Injection site erythemaOFFSIDES
292Intention tremorOFFSIDES
293Intestinal Diseases15822032CTD
294Ischemia15701768CTD
295Jaundice, Obstructive3528517CTD
296Joint stiffnessCanada Vigilance: 1Canada Vigilance
297Kidney Failure, Chronic10344375CTD
298Kidney FailureOFFSIDES
299Leukocytosis1806466CTD
300Leukopenia neonatalOFFSIDES
301Liver Failure, Acute

View details

CTD
302Liver Failure

View details

CTD
303Lung Neoplasms9037862CTD
304Lung diseases

View details

CTD
305Lupus Erythematosus, Systemic2484903
16425441
16887463
CTD
306Lupus Nephritis9219172CTD
307LymphadenopathyCanada Vigilance: 1Canada Vigilance
SIDER
308Lymphatic Diseases17415292CTD
309Lymphocyte count decreasedOFFSIDES
310Malformations of Cortical Development28973696CTD
311Maternal use of illicit drugsOFFSIDES
312Meningitis17329921CTD
313Middle insomniaOFFSIDES
314Motor Disorders27413119CTD
315MucormycosisOFFSIDES
316Multiple Pulmonary Nodules19260531CTD
317Multiple SclerosisOFFSIDES
318Musculoskeletal discomfortSIDER
319Myocarditis9219172CTD
320Myositis566489CTD
321Neonatal tachycardiaOFFSIDES
322Nephritis, Interstitial

View details

CTD
323Nervous tensionOFFSIDES
324NeuritisSIDER
325Nose Diseases9181282
16498810
CTD
326Oral Ulcer11380496
16405633
CTD
327Oral polypectomyOFFSIDES
328Oropharyngeal painCanada Vigilance: 1Canada Vigilance
329ParanoiaOFFSIDES
330Pericarditis3763985
11250767
CTD
331Peripheral Nervous System Diseases1339201CTD
332PharyngitisCanada Vigilance: 3Canada Vigilance
333Post procedural infectionOFFSIDES
334Precancerous Conditions19497425CTD
335Prenatal Exposure Delayed Effects

View details

CTD
336Procedural complicationOFFSIDES
337Pulmonary artery stenosisOFFSIDES
338Reflex, Abnormal18661784
19340585
CTD
339Renal Insufficiency9247777
16409836
CTD
340Respiratory Insufficiency1424898
16498810
CTD
341Right Ventricular HypertrophyOFFSIDES
342Scleritis9181282CTD
343Seizures15331149CTD
344Serositis9219172CTD
345Sinus bradycardiaOFFSIDES
346Sinus headacheOFFSIDES
347Skin reactionCanada Vigilance: 1Canada Vigilance
348SomnolenceSIDER
349Stevens-Johnson Syndrome11014318CTD
350Superior Vena Cava Syndrome7471870CTD
351Synovitis6850193CTD
352Systemic Vasculitis12549809CTD
353Systemic lupus erythematosus rashCanada Vigilance: 1Canada Vigilance
354Thrombosis6892530CTD
355Thyroid Diseases21800831CTD
356Thyroid Hormone Metabolism, Abnormal27216871CTD
357Thyrotoxicosis

View details

CTD
358Tinnitus15760792CTD
359Traumatic liver injurySIDER
360Uterine RuptureOFFSIDES
361Vasculitis, Central Nervous System15687828CTD
362Vasculitis, Leukocytoclastic, Cutaneous

View details

CTD
363Ventricular Dysfunction, Left21217071CTD
364Vertigo15760792CTD
SIDER
365Visual ImpairmentCanada Vigilance: 3Canada Vigilance
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120141

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.