MetaADEDB 2.0 @ LMMD
Bexarotene
(NAVMQTYZDKMPEU-UHFFFAOYSA-N)
Structure
SMILES
Cc1cc2c(cc1C(=C)c1ccc(cc1)C(=O)O)C(C)(C)CCC2(C)C
Type(s)
Approved; Investigational
ATC code(s)
L01XX25
Molecular Formula:
C24H28O2
Molecular Weight:
348.478
Log P:
6.1037
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
1
TPSA:
37.3
CAS Number(s):
153559-49-0; 166175-31-1
Synonym(s)
1.
Bexarotene
2.
3-methyl-TTNEB
3.
4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid
4.
LG69 compound
5.
LGD 1069
6.
LGD-1069
7.
LGD1069
8.
Targretin
External Link(s)
MeSHD000077610
PubChem Compound82146
BindingDB50032675
ChEBI50859
CHEMBLCHEMBL1023
DrugBankDB00307
DrugCentral361
IUPHAR/BPS Guide to PHARMACOLOGY2807
KEGGdr:D03106
Therapeutic Target DatabaseD0N0RU
ZINC1539579
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1HypothyroidismFAERS: 12SIDER
US FAERS
2HeadacheFAERS: 8SIDER
US FAERS
3NauseaFAERS: 8SIDER
US FAERS
4Blood triglycerides increasedFAERS: 7OFFSIDES
SIDER
US FAERS
5Drug ineffectiveFAERS: 6US FAERS
6LeukopeniaFAERS: 6SIDER
US FAERS
7Blood cholesterol increasedFAERS: 5US FAERS
8DehydrationFAERS: 5SIDER
US FAERS
9ErythemaFAERS: 5OFFSIDES
SIDER
US FAERS
10FatigueFAERS: 5OFFSIDES
SIDER
US FAERS
11Product substitution issueFAERS: 5US FAERS
12Abdominal discomfortFAERS: 4US FAERS
13LymphomaFAERS: 4US FAERS
14Product quality issueFAERS: 4US FAERS
15PruritusFAERS: 4SIDER
US FAERS
16Abdominal PainFAERS: 3OFFSIDES
SIDER
US FAERS
17Accidental exposure to productFAERS: 3US FAERS
18Atrial FibrillationFAERS: 3US FAERS
19Cerebrovascular accidentFAERS: 3SIDER
US FAERS
20DeafnessFAERS: 3SIDER
US FAERS
21LymphadenopathyFAERS: 3SIDER
US FAERS
22MyalgiaFAERS: 3SIDER
US FAERS
23PneumoniaFAERS: 3SIDER
US FAERS
24Retinoic acid syndromeFAERS: 3OFFSIDES
US FAERS
25SepsisFAERS: 3SIDER
US FAERS
26SwellingFAERS: 3US FAERS
27TinnitusFAERS: 3SIDER
US FAERS
28Urinary tract infectionFAERS: 3SIDER
US FAERS
29VomitingFAERS: 3SIDER
US FAERS
30treatment failureFAERS: 3US FAERS
31AcneFAERS: 2OFFSIDES
SIDER
US FAERS
32Blood glucose increasedFAERS: 2US FAERS
33CD4 Lymphocytes DecreasedFAERS: 2US FAERS
34ChillsFAERS: 2SIDER
US FAERS
35DiscomfortFAERS: 2SIDER
US FAERS
36Disease ProgressionFAERS: 2OFFSIDES
US FAERS
37DizzinessFAERS: 2SIDER
US FAERS
38Drug toxicityFAERS: 2US FAERS
39Dry skinFAERS: 2SIDER
US FAERS
40DyspepsiaFAERS: 2SIDER
US FAERS
41GlomerulonephritisFAERS: 2OFFSIDES
US FAERS
42HypervitaminosisFAERS: 2OFFSIDES
US FAERS
43HypohidrosisFAERS: 2US FAERS
44HypoxiaFAERS: 2OFFSIDES
US FAERS
45LethargyFAERS: 2SIDER
US FAERS
46Memory impairmentFAERS: 2US FAERS
47Mycosis FungoidesFAERS: 2OFFSIDES
US FAERS
48No adverse eventFAERS: 2US FAERS
49Pericardial effusionFAERS: 2OFFSIDES
US FAERS
50PregnancyFAERS: 2US FAERS
51Product dose omissionFAERS: 2US FAERS
52Product leakageFAERS: 2US FAERS
53Product physical issueFAERS: 2US FAERS
54Product use complaintFAERS: 2US FAERS
55Pulmonary FibrosisFAERS: 2US FAERS
56Respiratory FailureFAERS: 2US FAERS
57Skin irritationFAERS: 2US FAERS
58Squamous cell carcinomaFAERS: 2US FAERS
59Transaminases increasedFAERS: 2US FAERS
60Visual ImpairmentFAERS: 2US FAERS
61Weight decreasedFAERS: 2SIDER
US FAERS
62White blood cell count decreasedFAERS: 2US FAERS
63AgitationFAERS: 1SIDER
US FAERS
64ApathyFAERS: 1US FAERS
65Application site drynessFAERS: 1US FAERS
66Application site erythemaFAERS: 1US FAERS
67ArthralgiaFAERS: 1SIDER
US FAERS
68AstheniaFAERS: 1OFFSIDES
SIDER
US FAERS
69Back PainFAERS: 1SIDER
US FAERS
70Basal cell carcinomaFAERS: 1US FAERS
71Blood cholesterol abnormalFAERS: 1OFFSIDES
US FAERS
72Blood thyroid stimulating hormone decreasedFAERS: 1US FAERS
73Blood triglycerides abnormalFAERS: 1US FAERS
74Blood urine presentFAERS: 1OFFSIDES
US FAERS
75Bowel movement irregularityFAERS: 1US FAERS
76Cataract operationFAERS: 1US FAERS
77CataractFAERS: 1SIDER
US FAERS
78Chest PainFAERS: 1SIDER
US FAERS
79Chest discomfortFAERS: 1US FAERS
80CholecystitisFAERS: 1SIDER
US FAERS
81ConstipationFAERS: 1SIDER
US FAERS
82DermatitisFAERS: 1SIDER
US FAERS
83Diffuse Large B-Cell LymphomaFAERS: 1US FAERS
84DiverticulitisFAERS: 1OFFSIDES
US FAERS
85Drug dose omissionFAERS: 1US FAERS
86DysuriaFAERS: 1SIDER
US FAERS
87EosinophiliaFAERS: 1SIDER
US FAERS
88EpidermolysisFAERS: 1US FAERS
89Erectile dysfunctionFAERS: 1SIDER
US FAERS
90ErysipelasFAERS: 1US FAERS
91Fibrin D dimer increasedFAERS: 1US FAERS
92General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
93GranulomaFAERS: 1US FAERS
94HepatitisFAERS: 1US FAERS
95Histiocytosis haematophagicFAERS: 1US FAERS
96Incorrect dose administeredFAERS: 1US FAERS
97InfarctionFAERS: 1US FAERS
98InfectionFAERS: 1SIDER
US FAERS
99Insurance issueFAERS: 1US FAERS
100LeukocytosisFAERS: 1US FAERS
101Lower respiratory tract infectionFAERS: 1US FAERS
102LymphocytosisFAERS: 1SIDER
US FAERS
103MalaiseFAERS: 1SIDER
US FAERS
104Medication ErrorFAERS: 1US FAERS
105MetastasisFAERS: 1US FAERS
106Musculoskeletal chest painFAERS: 1US FAERS
107NecrosisFAERS: 1US FAERS
108NeutropeniaFAERS: 1SIDER
US FAERS
109Night sweatsFAERS: 1US FAERS
110Pain of skinFAERS: 1US FAERS
111PainFAERS: 1OFFSIDES
SIDER
US FAERS
112PancytopeniaFAERS: 1SIDER
US FAERS
113Pathogen resistanceFAERS: 1US FAERS
114Pneumocystis jiroveci pneumoniaFAERS: 1US FAERS
115Poor quality product administeredFAERS: 1US FAERS
116Post procedural complicationFAERS: 1US FAERS
117Product physical consistency issueFAERS: 1US FAERS
118PseudolymphomaFAERS: 1SIDER
US FAERS
119RetchingFAERS: 1US FAERS
120Secondary hypothyroidismFAERS: 1US FAERS
121Sezary cells increasedFAERS: 1US FAERS
122ShockFAERS: 1SIDER
US FAERS
123Skin reactionFAERS: 1US FAERS
124SomnolenceFAERS: 1SIDER
US FAERS
125Suicide attemptFAERS: 1US FAERS
126T-Cell LymphomaFAERS: 1OFFSIDES
US FAERS
127Therapy cessationFAERS: 1US FAERS
128ThrombocytopeniaFAERS: 1SIDER
US FAERS
129Thyroid hormones decreasedFAERS: 1US FAERS
130UlcerFAERS: 1US FAERS
131Urinary RetentionFAERS: 1SIDER
US FAERS
132UrticariaFAERS: 1US FAERS
133VertigoFAERS: 1SIDER
US FAERS
134AbasiaOFFSIDES
135Abnormal visionOFFSIDES
136AbscessOFFSIDES
137AcanthosisOFFSIDES
138Acid refluxOFFSIDES
139Actinic keratosisOFFSIDES
140Acute Coronary SyndromeOFFSIDES
141Alanine Aminotransferase IncreasedSIDER
142AlbuminuriaSIDER
143AlopeciaSIDER
144Amylase increasedSIDER
145Anemia17630414CTD
146Angina PectorisSIDER
147Anorectal discomfortOFFSIDES
SIDER
148AnorexiaSIDER
149AnxietyOFFSIDES
SIDER
150ArthritisSIDER
151ArthropathySIDER
152Aspartate Aminotransferase IncreasedSIDER
153AtaxiaSIDER
154Bacterial disease carrierOFFSIDES
155BlepharitisSIDER
156BlepharospasmOFFSIDES
157Blood GlucoseOFFSIDES
158Blood alkaline phosphatase increasedOFFSIDES
SIDER
159Blood and lymphatic system disordersSIDER
160Blood cholesterolOFFSIDES
161Blood creatinine increasedSIDER
162Blood lactate dehydrogenase increasedSIDER
163Blood thromboplastin decreasedSIDER
164Blood triglyceridesOFFSIDES
165Body odorSIDER
166Bone marrow depressionSIDER
167Bone painSIDER
168BronchitisOFFSIDES
SIDER
169CarcinomaSIDER
170CellulitisSIDER
171Cerebral cystOFFSIDES
172CheilitisSIDER
173Choking sensationOFFSIDES
174ChoroiditisOFFSIDES
175Circumoral paresthesiaSIDER
176ColitisSIDER
177ConfabulationOFFSIDES
178Conjunctival primary acquired melanosisOFFSIDES
179ConjunctivitisSIDER
180Corneal lesionSIDER
181Cramps of lower extremitiesSIDER
182Creatinine increasedSIDER
183DemyelinationOFFSIDES
184Depressed Level of ConsciousnessSIDER
185Depressed moodOFFSIDES
186Disturbance in sexual arousalSIDER
187Drug withdrawal headacheOFFSIDES
188DysgeusiaSIDER
189Ear and labyrinth disordersSIDER
190EcchymosisSIDER
191EczemaOFFSIDES
192EmbolismOFFSIDES
193Emotional distressOFFSIDES
194Enlargement abdomenSIDER
195EpistaxisSIDER
196EructationSIDER
197ExcoriationSIDER
198Eye painSIDER
199FastingSIDER
200Febrile NeutropeniaSIDER
201Feeling abnormalSIDER
202FlatulenceSIDER
203Food AllergyOFFSIDES
204FurunculosisSIDER
205GastroenteritisSIDER
206Gastrointestinal PainSIDER
207Genital HerpesOFFSIDES
208GingivitisSIDER
209GoutSIDER
210HerniaOFFSIDES
211Hypercholesterolemia21163938CTD
212HyperpigmentationOFFSIDES
213Hyperplasia17630414CTD
214HypersensitivitySIDER
215HyperthyroidismSIDER
216Hypertriglyceridemia21163938CTD
217InfluenzaSIDER
218Joint Range of Motion DecreasedOFFSIDES
219Joint sprainOFFSIDES
220Keratitis siccaOFFSIDES
221KeratitisSIDER
222Lacrimal structural disorderSIDER
223Lactic dehydrogenase activity increasedSIDER
224LaryngospasmSIDER
225Lipase increasedSIDER
226Lung Neoplasms17849452
21163938		CTD
227Lymphocytic infiltrationOFFSIDES
228Lymphoma, T-Cell, Cutaneous

View details

11161223
16634713
19067706
23292798
 		CTD
229Malformations of Cortical Development9006080CTD
230MalnutritionSIDER
231Mammary Neoplasms, Experimental15591091
19196722
19196723		CTD
232Mood swingsSIDER
233Multiple allergiesOFFSIDES
234Muscle WeaknessOFFSIDES
235Muscle necrosisOFFSIDES
236Musculoskeletal discomfortSIDER
237Myoglobin blood increasedOFFSIDES
238Neoplasms, Hormone-Dependent19196722CTD
239NephrolithiasisOFFSIDES
240NervousnessSIDER
241NeuritisSIDER
242NeuropathySIDER
243NocturiaSIDER
244NystagmusSIDER
245Oral candidiasisSIDER
246OrthopneaOFFSIDES
247OsteopeniaOFFSIDES
248Otitis ExternaSIDER
249PallorSIDER
250PalpitationsSIDER
251PancreatitisSIDER
252ParacentesisOFFSIDES
253Pelvic PainSIDER
254PetechiaeSIDER
255PharyngitisSIDER
256Polydactyly9006080CTD
257PolyuriaSIDER
258PsoriasisSIDER
259Pulmonary HypertensionOFFSIDES
260PurpuraSIDER
261Rash bullousSIDER
262Recall phenomenonOFFSIDES
263Rectal tenesmusSIDER
264RednessSIDER
265RhinitisSIDER
266RhinorrheaOFFSIDES
267Right ventricular failureSIDER
268ScotomaSIDER
269SinusitisOFFSIDES
SIDER
270Skin UlcerSIDER
271Skin hypertrophySIDER
272Skin lesionOFFSIDES
273Skin noduleSIDER
274StomatitisSIDER
275StressOFFSIDES
276StuporSIDER
277Subcutaneous AbscessOFFSIDES
278SweatingSIDER
279SyncopeSIDER
280TachycardiaSIDER
281TensionSIDER
282Therapeutic response unexpectedOFFSIDES
283ThirstSIDER
284ThrombocytosisSIDER
285Thromboplastin decreasedSIDER
286Urinary IncontinenceSIDER
287Urine output increasedSIDER
288Vascular anomalySIDER
289Vascular purpuraSIDER
290Visual disturbanceOFFSIDES
291Weight GainOFFSIDES
292colonoscopyOFFSIDES
293effusionOFFSIDES
294furuncleOFFSIDES
SIDER
295jaundiceSIDER
296nervous system disorderSIDER
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